{"id":"https://openalex.org/W7225339864","doi":"https://doi.org/10.21203/rs.3.rs-11335854/v1","title":"Longitudinal OCT/OCTA Imaging Reveals Early Neurovascular Dysfunction Associated with Ferroptosis-Related Metabolic Stress in Experimental Diabetic Retinopathy","display_name":"Longitudinal OCT/OCTA Imaging Reveals Early Neurovascular Dysfunction Associated with Ferroptosis-Related Metabolic Stress in Experimental Diabetic Retinopathy","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225339864","doi":"https://doi.org/10.21203/rs.3.rs-11335854/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11335854/v1","doi":"https://doi.org/10.21203/rs.3.rs-11335854/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11335854/v1","pdf_url":"https://www.researchsquare.com/article/rs-11335854/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11335854/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100569352","display_name":"Chuan Peng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67001856","display_name":"Shanghai Institute of Technology","ror":"https://ror.org/00fjzqj15","country_code":"CN","type":"education","lineage":["https://openalex.org/I67001856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CHUAN PENG","raw_affiliation_strings":["Shanghai Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Technology","institution_ids":["https://openalex.org/I67001856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129153216","display_name":"Xiangning Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XIANGNING WANG","raw_affiliation_strings":["Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123244735","display_name":"Jiabiao Liu","orcid":"https://orcid.org/0009-0005-3798-1417","observed_orcids":["https://orcid.org/0009-0005-3798-1417"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"JIABIAO LIU","raw_affiliation_strings":["Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160743785","display_name":"MINGJIE NI","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67001856","display_name":"Shanghai Institute of Technology","ror":"https://ror.org/00fjzqj15","country_code":"CN","type":"education","lineage":["https://openalex.org/I67001856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"MINGJIE NI","raw_affiliation_strings":["Shanghai Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Technology","institution_ids":["https://openalex.org/I67001856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160842297","display_name":"WENJUAN WU","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67001856","display_name":"Shanghai Institute of Technology","ror":"https://ror.org/00fjzqj15","country_code":"CN","type":"education","lineage":["https://openalex.org/I67001856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"WENJUAN WU","raw_affiliation_strings":["Shanghai Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Technology","institution_ids":["https://openalex.org/I67001856"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160825713","display_name":"SHENGXI MENG","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210144482","display_name":"Shanghai Sixth People's Hospital","ror":"https://ror.org/049zrh188","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210144482"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"SHENGXI MENG","raw_affiliation_strings":["Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Sixth People's Hospital, Shanghai Jiao Tong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210144482"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158475346","display_name":"Cuixia Dai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I67001856","display_name":"Shanghai Institute of Technology","ror":"https://ror.org/00fjzqj15","country_code":"CN","type":"education","lineage":["https://openalex.org/I67001856"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"CUIXIA DAI","raw_affiliation_strings":["Shanghai Institute of Technology"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Shanghai Institute of Technology","institution_ids":["https://openalex.org/I67001856"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10170","display_name":"Retinal Diseases and Treatments","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11438","display_name":"Retinal Imaging and Analysis","score":0.0066999997943639755,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diabetic-retinopathy","display_name":"diabetic retinopathy","score":1.0},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9990000128746033},{"id":"https://openalex.org/keywords/neurovascular-dysfunction","display_name":"neurovascular dysfunction","score":0.7979999780654907},{"id":"https://openalex.org/keywords/metabolic-stress","display_name":"metabolic stress","score":0.8009999990463257},{"id":"https://openalex.org/keywords/optical-coherence-tomography-angiography","display_name":"optical coherence tomography angiography","score":0.7239999771118164},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.875},{"id":"https://openalex.org/keywords/retinal-thinning","display_name":"retinal thinning","score":0.7260000109672546},{"id":"https://openalex.org/keywords/capillary-plexus","display_name":"capillary plexus","score":0.7440000176429749},{"id":"https://openalex.org/keywords/iron-accumulation","display_name":"iron accumulation","score":0.8330000042915344},{"id":"https://openalex.org/keywords/lipid-peroxidation","display_name":"lipid peroxidation","score":1.0},{"id":"https://openalex.org/keywords/antioxidant-capacity","display_name":"antioxidant capacity","score":0.9490000009536743},{"id":"https://openalex.org/keywords/liproxstatin-1","display_name":"liproxstatin-1","score":0.9580000042915344},{"id":"https://openalex.org/keywords/photopic-negative-response","display_name":"photopic negative response","score":0.8299999833106995},{"id":"https://openalex.org/keywords/streptozotocin-induced-diabetes","display_name":"streptozotocin-induced diabetes","score":0.9129999876022339},{"id":"https://openalex.org/keywords/longitudinal-imaging","display_name":"longitudinal imaging","score":0.44600000977516174}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7972999811172485},{"id":"https://openalex.org/C2779829184","wikidata":"https://www.wikidata.org/wiki/Q631361","display_name":"Diabetic retinopathy","level":3,"score":0.7890999913215637},{"id":"https://openalex.org/C2780827179","wikidata":"https://www.wikidata.org/wiki/Q422001","display_name":"Retinal","level":2,"score":0.5931000113487244},{"id":"https://openalex.org/C105572291","wikidata":"https://www.wikidata.org/wiki/Q7002775","display_name":"Neurovascular bundle","level":2,"score":0.5871999859809875},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.5562999844551086},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.5080999732017517},{"id":"https://openalex.org/C118487528","wikidata":"https://www.wikidata.org/wiki/Q161437","display_name":"Ophthalmology","level":1,"score":0.5054000020027161},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4738999903202057},{"id":"https://openalex.org/C2777093970","wikidata":"https://www.wikidata.org/wiki/Q169342","display_name":"Retina","level":2,"score":0.444599986076355},{"id":"https://openalex.org/C2776151105","wikidata":"https://www.wikidata.org/wiki/Q898814","display_name":"Oxidative stress","level":2,"score":0.4422999918460846},{"id":"https://openalex.org/C2776553924","wikidata":"https://www.wikidata.org/wiki/Q5270132","display_name":"Diabetic cardiomyopathy","level":4,"score":0.38359999656677246},{"id":"https://openalex.org/C2780248432","wikidata":"https://www.wikidata.org/wiki/Q1434206","display_name":"Fluorescein angiography","level":3,"score":0.36480000615119934},{"id":"https://openalex.org/C2779113765","wikidata":"https://www.wikidata.org/wiki/Q681562","display_name":"Electroretinography","level":3,"score":0.35679998993873596},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34450000524520874},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3151000142097473},{"id":"https://openalex.org/C2778313320","wikidata":"https://www.wikidata.org/wiki/Q550455","display_name":"Retinopathy","level":3,"score":0.30140000581741333},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.29089999198913574},{"id":"https://openalex.org/C2777474606","wikidata":"https://www.wikidata.org/wiki/Q7430070","display_name":"Scanning laser ophthalmoscopy","level":3,"score":0.27300000190734863}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11335854/v1","doi":"https://doi.org/10.21203/rs.3.rs-11335854/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11335854/v1","pdf_url":"https://www.researchsquare.com/article/rs-11335854/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11335854/v1","doi":"https://doi.org/10.21203/rs.3.rs-11335854/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11335854/v1","pdf_url":"https://www.researchsquare.com/article/rs-11335854/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9789000153541565}],"study_designs":[],"awards":[{"id":"https://openalex.org/G160694163","display_name":null,"funder_award_id":"22S31903000","funder_id":"https://openalex.org/F4320321885","funder_display_name":"Science and Technology Commission of Shanghai Municipality"},{"id":"https://openalex.org/G3539572497","display_name":null,"funder_award_id":"YG2022QN089","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G3830050664","display_name":null,"funder_award_id":"ynlc201909","funder_id":"https://openalex.org/F4320322999","funder_display_name":"Shanghai Jiao Tong University"},{"id":"https://openalex.org/G3958824726","display_name":null,"funder_award_id":"62175156","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"},{"id":"https://openalex.org/F4320321885","display_name":"Science and Technology Commission of Shanghai Municipality","ror":"https://ror.org/03kt66j61"},{"id":"https://openalex.org/F4320322999","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225339864.pdf","grobid_xml":"https://content.openalex.org/works/W7225339864.grobid-xml"},"referenced_works_count":16,"referenced_works":["https://openalex.org/W1997183854","https://openalex.org/W2138480916","https://openalex.org/W3046639829","https://openalex.org/W3112262219","https://openalex.org/W3194104601","https://openalex.org/W4206231713","https://openalex.org/W4221095162","https://openalex.org/W4307387789","https://openalex.org/W4367174230","https://openalex.org/W4379057947","https://openalex.org/W4386696954","https://openalex.org/W4389132381","https://openalex.org/W4392244956","https://openalex.org/W4392469283","https://openalex.org/W4401116156","https://openalex.org/W4403561170"],"related_works":["https://openalex.org/W4392244956","https://openalex.org/W4392048863","https://openalex.org/W4307387789","https://openalex.org/W3046591296","https://openalex.org/W4389097378","https://openalex.org/W7127174541","https://openalex.org/W4401116156","https://openalex.org/W4403474843","https://openalex.org/W4413157678","https://openalex.org/W3173453839"],"abstract_inverted_index":{"Abstract":[0],"Diabetic":[1],"retinopathy":[2],"(DR)":[3],"involves":[4],"early":[5,91],"neurovascular":[6],"and":[7,18,47,61,76],"metabolic":[8,98],"dysfunction.":[9],"We":[10],"evaluated":[11],"whether":[12],"longitudinal":[13,88],"optical":[14],"coherence":[15],"tomography":[16],"(OCT)":[17],"OCT":[19],"angiography":[20],"(OCTA)":[21],"can":[22],"provide":[23],"in":[24,32],"vivo":[25],"phenotypic":[26],"readouts":[27,89],"of":[28,90],"ferroptosis-related":[29,80,97],"retinal":[30,39,93],"injury":[31,94],"streptozotocin-induced":[33],"diabetic":[34,92],"rats.":[35],"Diabetes":[36],"caused":[37],"progressive":[38],"thinning,":[40],"reduced":[41,58],"capillary":[42],"plexus":[43],"vessel":[44],"area":[45],"density,":[46],"impaired":[48],"photopic":[49],"negative":[50],"responses,":[51],"accompanied":[52],"by":[53],"iron":[54],"accumulation,":[55],"lipid":[56],"peroxidation,":[57],"antioxidant":[59],"capacity,":[60],"altered":[62],"ferroptosis-associated":[63],"protein":[64],"expression.":[65],"Liproxstatin-1":[66],"partially":[67],"attenuated":[68],"these":[69],"abnormalities.":[70],"Exploratory":[71],"analyses":[72],"further":[73],"linked":[74],"OCTA":[75],"electrophysiological":[77],"phenotypes":[78],"with":[79,96],"measures.":[81],"These":[82],"findings":[83],"support":[84],"OCT/OCTA":[85],"as":[86],"noninvasive":[87],"associated":[95],"stress.":[99]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}