{"id":"https://openalex.org/W7225338689","doi":"https://doi.org/10.1111/pcmr.70134","title":"Females Display Greater Disease Severity in a Mouse Model of Vitiligo","display_name":"Females Display Greater Disease Severity in a Mouse Model of Vitiligo","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225338689","doi":"https://doi.org/10.1111/pcmr.70134","pmid":"https://pubmed.ncbi.nlm.nih.gov/42985814","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735204"},"language":"en","primary_location":{"id":"doi:10.1111/pcmr.70134","doi":"https://doi.org/10.1111/pcmr.70134","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcmr.70134","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcmr.70134","source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcmr.70134","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5119395196","display_name":"Kaitlyn O\u2019Donnell","orcid":"https://orcid.org/0009-0005-2205-6368","observed_orcids":["https://orcid.org/0009-0005-2205-6368"]},"institutions":[{"id":"https://openalex.org/I4394709130","display_name":"Indiana University School of Medicine","ror":"https://ror.org/02ets8c94","country_code":"US","type":"education","lineage":["https://openalex.org/I4394709130","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kaitlyn G. O'Donnell","raw_affiliation_strings":["Indiana University School of Medicine  Indianapolis Indiana USA"],"raw_orcid":"https://orcid.org/0009-0005-2205-6368","affiliations":[{"raw_affiliation_string":"Indiana University School of Medicine  Indianapolis Indiana USA","institution_ids":["https://openalex.org/I4394709130"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057253356","display_name":"Zhussipbek Mukhatayev","orcid":"https://orcid.org/0000-0002-5592-5727","observed_orcids":["https://orcid.org/0000-0002-5592-5727"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Zhussipbek Mukhatayev","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0000-0002-5592-5727","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137876151","display_name":"Hanin Abuzer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hanin Abuzer","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5003716674","display_name":"Rohan S. Shivde","orcid":"https://orcid.org/0000-0002-5777-0116","observed_orcids":["https://orcid.org/0000-0002-5777-0116"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rohan S. Shivde","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0000-0002-5777-0116","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079588934","display_name":"Sriram Saravanan Shanmugavelandy","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sriram Saravanan Shanmugavelandy","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160765168","display_name":"Octavio K. Bartos","orcid":"https://orcid.org/0009-0009-2468-2038","observed_orcids":["https://orcid.org/0009-0009-2468-2038"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Octavio K. Bartos","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0009-0009-2468-2038","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160735492","display_name":"Ellis Kang","orcid":"https://orcid.org/0009-0008-2869-3597","observed_orcids":["https://orcid.org/0009-0008-2869-3597"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ellis Kang","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0009-0008-2869-3597","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005759913","display_name":"Emilia Rae Dellacecca","orcid":"https://orcid.org/0000-0001-9031-2240","observed_orcids":["https://orcid.org/0000-0001-9031-2240"]},"institutions":[{"id":"https://openalex.org/I1330342723","display_name":"Mayo Clinic","ror":"https://ror.org/02qp3tb03","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1330342723"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Emilia R. Dellacecca","raw_affiliation_strings":["Mayo Clinic College of Medicine and Science, Mayo Clinic  Rochester Minnesota USA"],"raw_orcid":"https://orcid.org/0000-0001-9031-2240","affiliations":[{"raw_affiliation_string":"Mayo Clinic College of Medicine and Science, Mayo Clinic  Rochester Minnesota USA","institution_ids":["https://openalex.org/I1330342723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086095686","display_name":"Dinesh Jaishankar","orcid":"https://orcid.org/0000-0001-7906-176X","observed_orcids":["https://orcid.org/0000-0001-7906-176X"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Dinesh Jaishankar","raw_affiliation_strings":["Department of Surgery, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0000-0001-7906-176X","affiliations":[{"raw_affiliation_string":"Department of Surgery, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041954984","display_name":"Surya Pandey","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Surya Pandey","raw_affiliation_strings":["Department of Hematology and Oncology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Hematology and Oncology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112697375","display_name":"Hee Kap Kang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]},{"id":"https://openalex.org/I1294278766","display_name":"Lurie Children's Hospital","ror":"https://ror.org/03a6zw892","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1294278766"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Hee Kap Kang","raw_affiliation_strings":["Department of Pediatrics, Lurie Children's Hospital Northwestern University  Chicago Illinois USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatrics, Lurie Children's Hospital Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921","https://openalex.org/I1294278766"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034688662","display_name":"Ziyou Ren","orcid":"https://orcid.org/0000-0001-7127-4197","observed_orcids":["https://orcid.org/0000-0001-7127-4197"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Ziyou Ren","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0000-0001-7127-4197","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058458428","display_name":"I. Caroline Le Poole","orcid":"https://orcid.org/0000-0001-6853-4007","observed_orcids":["https://orcid.org/0000-0001-6853-4007"]},"institutions":[{"id":"https://openalex.org/I111979921","display_name":"Northwestern University","ror":"https://ror.org/000e0be47","country_code":"US","type":"education","lineage":["https://openalex.org/I111979921"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"I. Caroline Le Poole","raw_affiliation_strings":["Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA"],"raw_orcid":"https://orcid.org/0000-0001-6853-4007","affiliations":[{"raw_affiliation_string":"Department of Dermatology, Microbiology and Immunology, Feinberg School of Medicine Northwestern University  Chicago Illinois USA","institution_ids":["https://openalex.org/I111979921"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058458428"],"corresponding_institution_ids":["https://openalex.org/I111979921"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":{"value":5000,"currency":"USD","value_usd":5000},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.75979699,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"39","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11144","display_name":"melanin and skin pigmentation","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11167","display_name":"Hair Growth and Disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2708","display_name":"Dermatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/vitiligo","display_name":"vitiligo","score":1.0},{"id":"https://openalex.org/keywords/sex-differences","display_name":"sex differences","score":0.9929999709129333},{"id":"https://openalex.org/keywords/disease-severity","display_name":"disease severity","score":0.7440000176429749},{"id":"https://openalex.org/keywords/interferon-gamma","display_name":"interferon-gamma","score":0.6930000185966492},{"id":"https://openalex.org/keywords/melanocyte-destruction","display_name":"melanocyte destruction","score":0.703000009059906},{"id":"https://openalex.org/keywords/autoimmune-disease","display_name":"autoimmune disease","score":0.5870000123977661},{"id":"https://openalex.org/keywords/early-intervention","display_name":"early intervention","score":0.45899999141693115}],"concepts":[{"id":"https://openalex.org/C2779980618","wikidata":"https://www.wikidata.org/wiki/Q180152","display_name":"Vitiligo","level":2,"score":0.9697999954223633},{"id":"https://openalex.org/C2776972258","wikidata":"https://www.wikidata.org/wiki/Q3705665","display_name":"Depigmentation","level":2,"score":0.9502999782562256},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6420000195503235},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.569599986076355},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.5576000213623047},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.5372999906539917},{"id":"https://openalex.org/C2779075594","wikidata":"https://www.wikidata.org/wiki/Q8084905","display_name":"Autoimmune disease","level":3,"score":0.4893999993801117},{"id":"https://openalex.org/C2779179668","wikidata":"https://www.wikidata.org/wiki/Q7193408","display_name":"Pigmentation disorder","level":2,"score":0.358599990606308},{"id":"https://openalex.org/C16005928","wikidata":"https://www.wikidata.org/wiki/Q171171","display_name":"Dermatology","level":1,"score":0.32089999318122864},{"id":"https://openalex.org/C2780130043","wikidata":"https://www.wikidata.org/wiki/Q192360","display_name":"Autoimmunity","level":3,"score":0.30730000138282776},{"id":"https://openalex.org/C2779175014","wikidata":"https://www.wikidata.org/wiki/Q408570","display_name":"Methoxsalen","level":3,"score":0.27639999985694885},{"id":"https://openalex.org/C2780648854","wikidata":"https://www.wikidata.org/wiki/Q2745824","display_name":"Immunopathology","level":2,"score":0.2745000123977661},{"id":"https://openalex.org/C49039625","wikidata":"https://www.wikidata.org/wiki/Q84230","display_name":"Secretion","level":2,"score":0.263700008392334},{"id":"https://openalex.org/C2777702733","wikidata":"https://www.wikidata.org/wiki/Q1356761","display_name":"Immune tolerance","level":3,"score":0.26170000433921814},{"id":"https://openalex.org/C2992264114","wikidata":"https://www.wikidata.org/wiki/Q1394551","display_name":"Clinical disease","level":3,"score":0.260699987411499},{"id":"https://openalex.org/C2776291823","wikidata":"https://www.wikidata.org/wiki/Q1291366","display_name":"Hypopigmentation","level":2,"score":0.25290000438690186}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007371","descriptor_name":"Interferon-gamma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008544","descriptor_name":"Melanocytes","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D008810","descriptor_name":"Mice, Inbred C57BL","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012720","descriptor_name":"Severity of Illness Index","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013601","descriptor_name":"T-Lymphocytes","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":false},{"descriptor_ui":"D014820","descriptor_name":"Vitiligo","qualifier_ui":"Q000276","qualifier_name":"immunology","is_major_topic":true},{"descriptor_ui":"D014820","descriptor_name":"Vitiligo","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D018840","descriptor_name":"HSP70 Heat-Shock Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/pcmr.70134","doi":"https://doi.org/10.1111/pcmr.70134","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcmr.70134","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcmr.70134","source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735204","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735204/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735204/pdf/PCMR-39-0.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell Melanoma Res","raw_type":"Text"},{"id":"pmid:42985814","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42985814","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment cell & melanoma research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/pcmr.70134","doi":"https://doi.org/10.1111/pcmr.70134","is_oa":true,"landing_page_url":"https://doi.org/10.1111/pcmr.70134","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/pcmr.70134","source":{"id":"https://openalex.org/S179442820","display_name":"Pigment Cell & Melanoma Research","issn_l":"1755-1471","issn":["1755-1471","1755-148X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-c","doyens","jufo-2","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pigment Cell & Melanoma Research","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[{"id":"https://openalex.org/G322890519","display_name":null,"funder_award_id":"P30 AR075049","funder_id":"https://openalex.org/F4320309475","funder_display_name":"Northwestern University"}],"funders":[{"id":"https://openalex.org/F4320309475","display_name":"Northwestern University","ror":"https://ror.org/000e0be47"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225338689.pdf","grobid_xml":"https://content.openalex.org/works/W7225338689.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1521858627","https://openalex.org/W1543098232","https://openalex.org/W1563587206","https://openalex.org/W1646626736","https://openalex.org/W1991917553","https://openalex.org/W1999832688","https://openalex.org/W2016752509","https://openalex.org/W2019392325","https://openalex.org/W2024606840","https://openalex.org/W2035102795","https://openalex.org/W2065684908","https://openalex.org/W2067537386","https://openalex.org/W2069384112","https://openalex.org/W2114440834","https://openalex.org/W2119105870","https://openalex.org/W2119662171","https://openalex.org/W2146966558","https://openalex.org/W2148298487","https://openalex.org/W2159703967","https://openalex.org/W2161154771","https://openalex.org/W2168601768","https://openalex.org/W2170162789","https://openalex.org/W2293685166","https://openalex.org/W2311754459","https://openalex.org/W2338613830","https://openalex.org/W2527192536","https://openalex.org/W2756042030","https://openalex.org/W2780796457","https://openalex.org/W2783373090","https://openalex.org/W2915429179","https://openalex.org/W2980332453","https://openalex.org/W3002084169","https://openalex.org/W3110590410","https://openalex.org/W3113992584","https://openalex.org/W3199110510","https://openalex.org/W3199742729","https://openalex.org/W4210970334","https://openalex.org/W4309857360","https://openalex.org/W4401350033","https://openalex.org/W4405942468","https://openalex.org/W4407947855"],"related_works":["https://openalex.org/W1999832688","https://openalex.org/W2148298487","https://openalex.org/W102801842","https://openalex.org/W4252901523","https://openalex.org/W2097803930","https://openalex.org/W4388420705","https://openalex.org/W2901427531","https://openalex.org/W7171557534","https://openalex.org/W1563587206","https://openalex.org/W193074161"],"abstract_inverted_index":{"ABSTRACT":[0],"Vitiligo":[1],"is":[2],"an":[3],"autoimmune":[4],"disease":[5,31],"characterized":[6],"by":[7,88,135],"progressive":[8],"depigmentation":[9,50,111],"of":[10,18,67,81,94,104,154],"the":[11,78,145],"skin":[12],"due":[13],"to":[14,61,101,119,144],"T":[15,68,137],"cell\u2010mediated":[16],"destruction":[17],"melanocytes.":[19],"Disease":[20],"onset":[21],"varies":[22],"but":[23],"usually":[24],"initiates":[25],"during":[26],"adolescence.":[27],"Sex":[28],"differences":[29],"in":[30,49],"development":[32],"and":[33,51,65,72],"therapeutic":[34],"outcomes":[35],"have":[36],"not":[37],"been":[38],"explored.":[39],"We":[40],"previously":[41],"associated":[42,129],"stress":[43],"induced":[44],"HSP70i":[45,54,82],"with":[46,121,130],"immune":[47],"activation":[48,66],"showed":[52],"that":[53],"Q435A":[55,83],"can":[56],"tolerize":[57],"dendritic":[58],"cells":[59,138],"(DCs)":[60],"prevent":[62],"cutaneous":[63],"recruitment":[64],"cells.":[69],"Among":[70],"male":[71],"female":[73,140],"vitiligo\u2010prone":[74],"mice,":[75],"we":[76],"investigated":[77],"long\u2010term":[79],"efficacy":[80],"plasmid":[84],"DNA":[85],"treatment":[86,120,155],"introduced":[87],"biolistic":[89],"administration":[90],"at":[91,150],"varying":[92],"stages":[93],"vitiligo":[95],"development.":[96],"Mice":[97],"were":[98],"followed":[99],"up":[100],"46":[102],"weeks":[103],"age.":[105],"Female":[106],"mice":[107],"exhibited":[108],"1.89\u2010fold":[109],"greater":[110,161],"than":[112],"males":[113],"overall,":[114],"while":[115],"both":[116],"responded":[117],"proportionally":[118],"effects":[122],"lasting":[123],"throughout.":[124],"This":[125],"sex":[126],"difference":[127],"was":[128],"significantly":[131],"elevated":[132],"IFN\u2010\u03b3":[133],"secretion":[134],"melanocyte\u2010reactive":[136],"among":[139],"mice.":[141],"Humoral":[142],"responses":[143],"protein":[146],"remained":[147],"readily":[148],"detectable":[149],"end":[151],"point":[152],"regardless":[153],"interval.":[156],"These":[157],"findings":[158],"also":[159],"suggest":[160],"benefit":[162],"from":[163],"earlier":[164],"intervention.":[165]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}