{"id":"https://openalex.org/W7225337248","doi":"https://doi.org/10.3389/fcell.2026.1980797","title":"Integrative ferroptosis-related bioinformatics identifies PPAR\u03b3 as a therapeutic target of ursolic acid against inflammation and pathological osteogenesis in ankylosing spondylitis","display_name":"Integrative ferroptosis-related bioinformatics identifies PPAR\u03b3 as a therapeutic target of ursolic acid against inflammation and pathological osteogenesis in ankylosing spondylitis","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225337248","doi":"https://doi.org/10.3389/fcell.2026.1980797"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1980797","doi":"https://doi.org/10.3389/fcell.2026.1980797","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1980797","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1980797/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1980797/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160905802","display_name":"Ke Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ke Li","raw_affiliation_strings":["Qujing Hospital of Traditional Chinese Medicine","The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Qujing Hospital of Traditional Chinese Medicine","institution_ids":[]},{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160925296","display_name":"Xuqing Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuqing Ye","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160757937","display_name":"Houchun Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Houchun Wang","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100680306","display_name":"Liang Li","orcid":"https://orcid.org/0000-0002-0781-9735","observed_orcids":["https://orcid.org/0000-0002-0781-9735"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Li Liang","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090493327","display_name":"Rui Zeng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Rui Zeng","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160879696","display_name":"Zhibo Zhou","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhibo Zhou","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016502781","display_name":"Ziyi Huang","orcid":"https://orcid.org/0000-0003-2142-8244","observed_orcids":["https://orcid.org/0000-0003-2142-8244"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyi Huang","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101806438","display_name":"Zitong Chen","orcid":"https://orcid.org/0000-0003-3467-7311","observed_orcids":["https://orcid.org/0000-0003-3467-7311"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zitong Chen","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113204140","display_name":"Huiming Liang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huiming Liang","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5067438739","display_name":"Haifang Du","orcid":"https://orcid.org/0000-0002-5721-1779","observed_orcids":["https://orcid.org/0000-0002-5721-1779"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Haifang Du","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121586266","display_name":"Ziyun Shang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210105832","display_name":"First Affiliated Hospital of Guangzhou University of Chinese Medicine","ror":"https://ror.org/01mxpdw03","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105832"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziyun Shang","raw_affiliation_strings":["The First Affiliated Hospital of Guangzhou University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The First Affiliated Hospital of Guangzhou University of Chinese Medicine","institution_ids":["https://openalex.org/I4210105832"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100596803","display_name":"Mengyang Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210162181","display_name":"Luoyang Orthopedic-Traumatological Hospital of Henan Province","ror":"https://ror.org/05br7cm44","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210162181"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Mengyang Ma","raw_affiliation_strings":["Luoyang Orthopedic Hospital of Henan Province & Orthopedic Hospital of Henan Province"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Luoyang Orthopedic Hospital of Henan Province & Orthopedic Hospital of Henan Province","institution_ids":["https://openalex.org/I4210162181"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160796372","display_name":"Lu Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Lu Yang","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5058168687","display_name":"Yingyan Zhou","orcid":"https://orcid.org/0000-0003-2128-1625","observed_orcids":["https://orcid.org/0000-0003-2128-1625"]},"institutions":[{"id":"https://openalex.org/I117532281","display_name":"Guangzhou University of Chinese Medicine","ror":"https://ror.org/03qb7bg95","country_code":"CN","type":"education","lineage":["https://openalex.org/I117532281"]},{"id":"https://openalex.org/I4210105984","display_name":"Guangdong Provincial Hospital of Chinese Medicine","ror":"https://ror.org/01gb3y148","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210105984"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yingyan Zhou","raw_affiliation_strings":["The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"The Second Clinical Medical College, Guangzhou University of Chinese Medicine (Guangdong Provincial Hospital of Chinese Medicine)","institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5058168687","https://openalex.org/A5100596803","https://openalex.org/A5160796372"],"corresponding_institution_ids":["https://openalex.org/I117532281","https://openalex.org/I4210105984","https://openalex.org/I4210162181"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11092","display_name":"Spondyloarthritis Studies and Treatments","score":0.986299991607666,"subfield":{"id":"https://openalex.org/subfields/2745","display_name":"Rheumatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11297","display_name":"Ferroptosis and cancer prognosis","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.0017000000225380063,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ankylosing-spondylitis","display_name":"ankylosing spondylitis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ferroptosis","display_name":"ferroptosis","score":0.9950000047683716},{"id":"https://openalex.org/keywords/ursolic-acid","display_name":"ursolic acid","score":0.9879999756813049},{"id":"https://openalex.org/keywords/ppargamma","display_name":"PPAR\u03b3","score":0.9950000047683716},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.5870000123977661},{"id":"https://openalex.org/keywords/natural-product-screening","display_name":"natural product screening","score":0.5120000243186951},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tp53inp1","display_name":"TP53INP1","score":0.9850000143051147},{"id":"https://openalex.org/keywords/drug-repurposing","display_name":"drug repurposing","score":0.5950000286102295},{"id":"https://openalex.org/keywords/single-cell-transcriptomics","display_name":"single-cell transcriptomics","score":0.6389999985694885},{"id":"https://openalex.org/keywords/coexpression-network","display_name":"co-expression network","score":0.6940000057220459},{"id":"https://openalex.org/keywords/molecular-docking","display_name":"molecular docking","score":0.49900001287460327},{"id":"https://openalex.org/keywords/molecular-dynamics","display_name":"molecular dynamics","score":0.8240000009536743}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.6277999877929688},{"id":"https://openalex.org/C2777402515","wikidata":"https://www.wikidata.org/wiki/Q52849","display_name":"Ankylosing spondylitis","level":2,"score":0.5968000292778015},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5473999977111816},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.5037000179290771},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.49380001425743103},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.42899999022483826},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4221000075340271},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36489999294281006},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36149999499320984},{"id":"https://openalex.org/C130241916","wikidata":"https://www.wikidata.org/wiki/Q20970208","display_name":"Peroxisome proliferator-activated receptor gamma","level":4,"score":0.3528999984264374},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3440999984741211},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.33980000019073486},{"id":"https://openalex.org/C2779650986","wikidata":"https://www.wikidata.org/wiki/Q2165411","display_name":"Spondylitis","level":3,"score":0.3382999897003174},{"id":"https://openalex.org/C85265743","wikidata":"https://www.wikidata.org/wiki/Q885458","display_name":"Blot","level":3,"score":0.3310000002384186},{"id":"https://openalex.org/C2779513101","wikidata":"https://www.wikidata.org/wiki/Q416260","display_name":"Ursolic acid","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.30250000953674316},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28690001368522644},{"id":"https://openalex.org/C2778091532","wikidata":"https://www.wikidata.org/wiki/Q420574","display_name":"HLA-B27","level":4,"score":0.28040000796318054},{"id":"https://openalex.org/C2779396153","wikidata":"https://www.wikidata.org/wiki/Q901227","display_name":"Natural product","level":2,"score":0.2759999930858612},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.25679999589920044},{"id":"https://openalex.org/C156730664","wikidata":"https://www.wikidata.org/wiki/Q23308590","display_name":"Interleukin 23","level":4,"score":0.25130000710487366}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fcell.2026.1980797","doi":"https://doi.org/10.3389/fcell.2026.1980797","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1980797","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1980797/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:6eb61c84c2474ce6913fb7d2dc847e39","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/6eb61c84c2474ce6913fb7d2dc847e39","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1980797","doi":"https://doi.org/10.3389/fcell.2026.1980797","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1980797","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1980797/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225337248.pdf","grobid_xml":"https://content.openalex.org/works/W7225337248.grobid-xml"},"referenced_works_count":31,"referenced_works":["https://openalex.org/W1653739410","https://openalex.org/W1997183854","https://openalex.org/W1999758521","https://openalex.org/W2002156365","https://openalex.org/W2026088200","https://openalex.org/W2032459022","https://openalex.org/W2115348950","https://openalex.org/W2266314028","https://openalex.org/W2470283293","https://openalex.org/W2762087180","https://openalex.org/W2912331311","https://openalex.org/W2999063177","https://openalex.org/W3085488719","https://openalex.org/W3087134616","https://openalex.org/W3123922203","https://openalex.org/W3138796149","https://openalex.org/W3169346015","https://openalex.org/W4221108391","https://openalex.org/W4224219005","https://openalex.org/W4225324953","https://openalex.org/W4230650832","https://openalex.org/W4289133693","https://openalex.org/W4307091386","https://openalex.org/W4308803238","https://openalex.org/W4386135075","https://openalex.org/W4394847653","https://openalex.org/W4405427178","https://openalex.org/W4406616676","https://openalex.org/W4408536030","https://openalex.org/W4412441771","https://openalex.org/W4414201102"],"related_works":["https://openalex.org/W4386736988","https://openalex.org/W4386959685","https://openalex.org/W4394728222","https://openalex.org/W4308803238","https://openalex.org/W4289133693","https://openalex.org/W4408295778","https://openalex.org/W4409906979","https://openalex.org/W7213115452","https://openalex.org/W4293537731","https://openalex.org/W7169764409"],"abstract_inverted_index":{"Background":[0],"Ankylosing":[1],"spondylitis":[2],"(AS)":[3],"is":[4],"an":[5,182,341],"immune-mediated":[6],"inflammatory":[7,203,294],"disease":[8],"characterized":[9],"by":[10,378],"persistent":[11],"inflammation":[12],"and":[13,26,36,64,69,92,117,130,148,186,196,207,225,238,251,263,276,286,302,304,328,356,369,374],"aberrant":[14],"new":[15],"bone":[16,28,307],"formation.":[17],"Ferroptosis":[18],"has":[19],"increasingly":[20],"been":[21,113],"implicated":[22],"in":[23,34,55,181,187,309,367],"immune":[24,256],"dysregulation":[25],"pathological":[27,205,306],"remodeling;":[29],"however,":[30],"its":[31,37,144],"molecular":[32,53,140,265,277,354,365],"involvement":[33],"AS":[35,129,183,310],"potential":[38,282,394],"value":[39],"for":[40,123,397],"natural":[41,58,260,351],"product":[42,116,261,352],"discovery":[43],"remain":[44],"poorly":[45],"understood.":[46],"This":[47,338],"study":[48,339],"aimed":[49],"to":[50,78,102,138,165,201],"identify":[51],"ferroptosis-related":[52,223,345],"targets":[54],"AS,":[56,368],"screen":[57],"compounds":[59,125,135],"targeting":[60,387],"the":[61,104,108,131,167,170,247,297,321,332],"key":[62,132],"candidate,":[63],"validate":[65],"their":[66],"therapeutic":[67,174,395],"effects":[68,175,376],"underlying":[70],"mechanisms.":[71],"Methods":[72],"Bulk":[73],"RNA-seq":[74],"datasets":[75],"were":[76,100,120,136,163,178,199],"combined":[77],"perform":[79],"differential":[80],"expression":[81,253,298,318],"profiling,":[82],"ferroptosis":[83],"evaluation,":[84],"weighted":[85],"co-expression":[86,229],"network":[87],"construction,":[88],"functional":[89],"pathway":[90],"annotation,":[91],"machine-learning-driven":[93],"feature":[94],"screening.":[95],"Subsequently,":[96],"single-cell":[97],"transcriptomic":[98,212],"data":[99],"examined":[101,180],"map":[103],"cell-type-specific":[105],"localization":[106],"of":[107,169,176,191,299,335],"hub":[109,241],"genes":[110,216,226],"that":[111,386],"had":[112],"pinpointed.":[114],"Natural":[115],"compound\u2013target":[118],"databases":[119],"subsequently":[121,179],"searched":[122],"small-molecule":[124],"associated":[126],"with":[127,389],"both":[128],"target.":[133],"Candidate":[134],"subjected":[137],"batch":[139,264],"docking.":[141],"Based":[142],"on":[143],"predicted":[145],"binding":[146],"properties":[147],"biological":[149],"relevance,":[150],"Ursolic":[151],"acid":[152],"(UA)":[153],"was":[154,360],"selected":[155],"as":[156,240,269,362],"a":[157,270,281,363,393],"candidate":[158],"drug.":[159],"Molecular":[160,274],"dynamics":[161,278],"simulations":[162,279],"performed":[164],"evaluate":[166],"stability":[168],"UA\u2013PPAR\u03b3":[171],"complex.":[172],"The":[173],"UA":[177,268,285,291,315,370,390],"mouse":[184],"model":[185],"BMP-2/4-induced":[188],"osteogenic":[189,322,333],"differentiation":[190],"fibroblasts.":[192,336],"Histological":[193],"staining,":[194],"qRT-PCR,":[195],"western":[197],"blotting":[198],"used":[200],"assess":[202],"responses,":[204],"osteogenesis,":[206],"PPAR\u03b3-related":[208],"signaling.":[209],"Results":[210],"Integrated":[211],"analysis":[213,232],"identified":[214,234,267,361],"20":[215],"shared":[217],"among":[218,243],"AS-related":[219],"differentially":[220],"expressed":[221],"genes,":[222,224,242],"from":[227],"ferroptosis-associated":[228,364],"modules.":[230],"Machine-learning":[231],"further":[233],"PHF21A,":[235],"PPARG":[236,245],",":[237,290,314],"TP53INP1":[239],"which":[244],"showed":[246],"highest":[248],"predictive":[249],"contribution":[250],"distinct":[252],"patterns":[254],"across":[255],"cell":[257],"populations.":[258],"Database-based":[259],"screening":[262],"docking":[266,275],"promising":[271],"PPAR\u03b3-targeting":[272],"candidate.":[273],"supported":[280],"interaction":[283],"between":[284],"PPAR\u03b3.":[287],"In":[288,312],"vivo":[289],"markedly":[292],"alleviated":[293],"infiltration,":[295],"reduced":[296],"TNF-\u03b1,":[300],"IL-6,":[301],"IL-17,":[303],"attenuated":[305],"formation":[308],"mice.":[311],"vitro":[313],"increased":[316,379],"PPAR\u03b3":[317,359,380,388],"while":[319],"suppressing":[320],"markers":[323],"COL1A1,":[324],"ALP,":[325],"RUNX2,":[326],"OPN,":[327],"BMP-2,":[329],"thereby":[330],"inhibiting":[331],"transdifferentiation":[334],"Conclusion":[337],"established":[340],"integrated":[342],"strategy":[343,396],"combining":[344],"bioinformatics":[346],"analysis,":[347],"machine-learning-based":[348],"target":[349,366],"identification,":[350],"screening,":[353],"simulation,":[355],"experimental":[357],"validation.":[358],"exerted":[371],"concurrent":[372],"anti-inflammatory":[373],"anti-osteogenic":[375],"accompanied":[377],"protein":[381],"expression.":[382],"These":[383],"findings":[384],"suggest":[385],"might":[391],"be":[392],"AS.":[398]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
