{"id":"https://openalex.org/W7225335689","doi":"https://doi.org/10.3389/ffunb.2026.1900659","title":"Long-term serial subculture under microaerobic conditions enhances adhesion, reduces antifungal susceptibility, and attenuates virulence in Candida auris","display_name":"Long-term serial subculture under microaerobic conditions enhances adhesion, reduces antifungal susceptibility, and attenuates virulence in Candida auris","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225335689","doi":"https://doi.org/10.3389/ffunb.2026.1900659"},"language":"en","primary_location":{"id":"doi:10.3389/ffunb.2026.1900659","doi":"https://doi.org/10.3389/ffunb.2026.1900659","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ffunb.2026.1900659","pdf_url":"https://www.frontiersin.org/journals/fungal-biology/articles/10.3389/ffunb.2026.1900659/pdf","source":{"id":"https://openalex.org/S4210232538","display_name":"Frontiers in Fungal Biology","issn_l":"2673-6128","issn":["2673-6128"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Fungal Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/fungal-biology/articles/10.3389/ffunb.2026.1900659/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5072057653","display_name":"Ami Koizumi","orcid":"https://orcid.org/0009-0007-5228-1632","observed_orcids":["https://orcid.org/0009-0007-5228-1632"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ami Koizumi","raw_affiliation_strings":["Department of Diagnostic Testing and Technology Research, National Institute of Infectious Diseases, Japan Institute for Health Security","Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Diagnostic Testing and Technology Research, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110800635","display_name":"Sayoko Oiki","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sayoko Oiki","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113086884","display_name":"Amato Otani","orcid":"https://orcid.org/0009-0002-0191-8895","observed_orcids":["https://orcid.org/0009-0002-0191-8895"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Amato Otani","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044757311","display_name":"Takayuki Shinohara","orcid":"https://orcid.org/0000-0001-8804-0645","observed_orcids":["https://orcid.org/0000-0001-8804-0645"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takayuki Shinohara","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031346229","display_name":"Ken Miyazawa","orcid":"https://orcid.org/0000-0001-9211-1020","observed_orcids":["https://orcid.org/0000-0001-9211-1020"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ken Miyazawa","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084454121","display_name":"Keigo Ueno","orcid":"https://orcid.org/0000-0003-0671-0049","observed_orcids":["https://orcid.org/0000-0003-0671-0049"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Keigo Ueno","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159864934","display_name":"Ai Hirasawa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Ai Hirasawa","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014934812","display_name":"Hirotaka Kobayashi","orcid":"https://orcid.org/0009-0006-0615-7676","observed_orcids":["https://orcid.org/0009-0006-0615-7676"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Hirotaka Kobayashi","raw_affiliation_strings":["Department of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Infectious Disease Pathology, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086764205","display_name":"Masahiro Abe","orcid":"https://orcid.org/0000-0002-6355-716X","observed_orcids":["https://orcid.org/0000-0002-6355-716X"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Masahiro Abe","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5008416065","display_name":"Yoshitsugu Miyazaki","orcid":"https://orcid.org/0000-0001-8942-0869","observed_orcids":["https://orcid.org/0000-0001-8942-0869"]},"institutions":[{"id":"https://openalex.org/I4210086300","display_name":"National Institute of Infectious Diseases","ror":"https://ror.org/001ggbx22","country_code":"JP","type":"government","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4210086300","https://openalex.org/I4405286871"]},{"id":"https://openalex.org/I4405286871","display_name":"Japan Institute for Health Security","ror":"https://ror.org/03c8bq125","country_code":"JP","type":"facility","lineage":["https://openalex.org/I1333985979","https://openalex.org/I4405286871"]}],"countries":["JP"],"is_corresponding":true,"raw_author_name":"Yoshitsugu Miyazaki","raw_affiliation_strings":["Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Fungal Infection, National Institute of Infectious Diseases, Japan Institute for Health Security","institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5008416065","https://openalex.org/A5086764205"],"corresponding_institution_ids":["https://openalex.org/I4210086300","https://openalex.org/I4405286871"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"7","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10150","display_name":"Antifungal resistance and susceptibility","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10497","display_name":"Fungal and yeast genetics research","score":0.0007999999797903001,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11037","display_name":"Fungal Infections and Studies","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/candida-auris","display_name":"Candida auris","score":1.0},{"id":"https://openalex.org/keywords/microaerobic-conditions","display_name":"microaerobic conditions","score":0.8989999890327454},{"id":"https://openalex.org/keywords/serial-subculture","display_name":"serial subculture","score":0.8330000042915344},{"id":"https://openalex.org/keywords/oxygen-limitation","display_name":"oxygen limitation","score":0.593999981880188},{"id":"https://openalex.org/keywords/fungal-adhesion","display_name":"fungal adhesion","score":0.7990000247955322},{"id":"https://openalex.org/keywords/antifungal-susceptibility","display_name":"antifungal susceptibility","score":0.9409999847412109},{"id":"https://openalex.org/keywords/echinocandin-resistance","display_name":"echinocandin resistance","score":0.9399999976158142},{"id":"https://openalex.org/keywords/triazole-resistance","display_name":"triazole resistance","score":0.9950000047683716},{"id":"https://openalex.org/keywords/erg11","display_name":"ERG11","score":0.8500000238418579},{"id":"https://openalex.org/keywords/attenuated-virulence","display_name":"virulence attenuation","score":0.7459999918937683},{"id":"https://openalex.org/keywords/galleria-mellonella-infection-model","display_name":"Galleria mellonella infection model","score":0.8989999890327454},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.5320000052452087},{"id":"https://openalex.org/keywords/mrr1","display_name":"MRR1","score":0.7139999866485596},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.6710000038146973},{"id":"https://openalex.org/keywords/nosocomial-fungal-infections","display_name":"nosocomial fungal infections","score":0.5950000286102295}],"concepts":[{"id":"https://openalex.org/C2909786013","wikidata":"https://www.wikidata.org/wiki/Q26816853","display_name":"Candida auris","level":3,"score":0.9023000001907349},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.8575999736785889},{"id":"https://openalex.org/C60987743","wikidata":"https://www.wikidata.org/wiki/Q1460232","display_name":"Virulence","level":3,"score":0.8238999843597412},{"id":"https://openalex.org/C2779032433","wikidata":"https://www.wikidata.org/wiki/Q761648","display_name":"Galleria mellonella","level":4,"score":0.7947999835014343},{"id":"https://openalex.org/C132351222","wikidata":"https://www.wikidata.org/wiki/Q7454699","display_name":"Serial passage","level":3,"score":0.756600022315979},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7563999891281128},{"id":"https://openalex.org/C87863119","wikidata":"https://www.wikidata.org/wiki/Q842756","display_name":"Subculture (biology)","level":2,"score":0.7537000179290771},{"id":"https://openalex.org/C2776460866","wikidata":"https://www.wikidata.org/wiki/Q170065","display_name":"Pathogen","level":2,"score":0.6525999903678894},{"id":"https://openalex.org/C24527192","wikidata":"https://www.wikidata.org/wiki/Q17149729","display_name":"Human pathogen","level":3,"score":0.5365999937057495},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.46880000829696655},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4413999915122986},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.40880000591278076},{"id":"https://openalex.org/C2910135453","wikidata":"https://www.wikidata.org/wiki/Q3122802","display_name":"Fungal protein","level":4,"score":0.36329999566078186},{"id":"https://openalex.org/C2779443200","wikidata":"https://www.wikidata.org/wiki/Q144068","display_name":"Candida parapsilosis","level":3,"score":0.36250001192092896},{"id":"https://openalex.org/C2781011225","wikidata":"https://www.wikidata.org/wiki/Q7181400","display_name":"Phenotypic switching","level":4,"score":0.3467000126838684},{"id":"https://openalex.org/C2991737395","wikidata":"https://www.wikidata.org/wiki/Q578726","display_name":"Antifungal drug","level":3,"score":0.3407000005245209},{"id":"https://openalex.org/C2776927270","wikidata":"https://www.wikidata.org/wiki/Q815962","display_name":"Colonization","level":2,"score":0.3402000069618225},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.3312000036239624},{"id":"https://openalex.org/C2780917455","wikidata":"https://www.wikidata.org/wiki/Q310443","display_name":"Candida albicans","level":2,"score":0.3264000117778778},{"id":"https://openalex.org/C2778394675","wikidata":"https://www.wikidata.org/wiki/Q648056","display_name":"Fungi imperfecti","level":2,"score":0.321399986743927},{"id":"https://openalex.org/C2910751997","wikidata":"https://www.wikidata.org/wiki/Q3718510","display_name":"Echinocandins","level":5,"score":0.2969000041484833},{"id":"https://openalex.org/C3020434087","wikidata":"https://www.wikidata.org/wiki/Q835718","display_name":"Opportunistic pathogen","level":4,"score":0.2897000014781952},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C2780651595","wikidata":"https://www.wikidata.org/wiki/Q411478","display_name":"Fluconazole","level":3,"score":0.28139999508857727},{"id":"https://openalex.org/C58123911","wikidata":"https://www.wikidata.org/wiki/Q467410","display_name":"Biofilm","level":3,"score":0.2718999981880188},{"id":"https://openalex.org/C2775835631","wikidata":"https://www.wikidata.org/wiki/Q143138","display_name":"Candida tropicalis","level":3,"score":0.26899999380111694},{"id":"https://openalex.org/C2781090273","wikidata":"https://www.wikidata.org/wiki/Q1623405","display_name":"Virulence factor","level":4,"score":0.26739999651908875},{"id":"https://openalex.org/C2778566189","wikidata":"https://www.wikidata.org/wiki/Q101274","display_name":"Protozoa","level":2,"score":0.2524999976158142},{"id":"https://openalex.org/C2780530800","wikidata":"https://www.wikidata.org/wiki/Q7072921","display_name":"ORFS","level":5,"score":0.25200000405311584},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/ffunb.2026.1900659","doi":"https://doi.org/10.3389/ffunb.2026.1900659","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ffunb.2026.1900659","pdf_url":"https://www.frontiersin.org/journals/fungal-biology/articles/10.3389/ffunb.2026.1900659/pdf","source":{"id":"https://openalex.org/S4210232538","display_name":"Frontiers in Fungal Biology","issn_l":"2673-6128","issn":["2673-6128"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Fungal Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b2baaa3e14f2433f858b2e52c3243c3b","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b2baaa3e14f2433f858b2e52c3243c3b","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Fungal Biology, Vol 7 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/ffunb.2026.1900659","doi":"https://doi.org/10.3389/ffunb.2026.1900659","is_oa":true,"landing_page_url":"https://doi.org/10.3389/ffunb.2026.1900659","pdf_url":"https://www.frontiersin.org/journals/fungal-biology/articles/10.3389/ffunb.2026.1900659/pdf","source":{"id":"https://openalex.org/S4210232538","display_name":"Frontiers in Fungal Biology","issn_l":"2673-6128","issn":["2673-6128"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Fungal Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.6240000128746033,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311405","display_name":"Japan Agency for Medical Research and Development","ror":"https://ror.org/004rtk039"},{"id":"https://openalex.org/F4320334764","display_name":"Japan Society for the Promotion of Science","ror":"https://ror.org/00hhkn466"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225335689.pdf","grobid_xml":"https://content.openalex.org/works/W7225335689.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1966110095","https://openalex.org/W1975390013","https://openalex.org/W1987095367","https://openalex.org/W2024249465","https://openalex.org/W2107277218","https://openalex.org/W2112392590","https://openalex.org/W2130590948","https://openalex.org/W2521757275","https://openalex.org/W2536287248","https://openalex.org/W2538799985","https://openalex.org/W2547589532","https://openalex.org/W2616840010","https://openalex.org/W2793150370","https://openalex.org/W2799984788","https://openalex.org/W2886356978","https://openalex.org/W2890504745","https://openalex.org/W2996168925","https://openalex.org/W3021126375","https://openalex.org/W3025731814","https://openalex.org/W3048927596","https://openalex.org/W3107247576","https://openalex.org/W3174067014","https://openalex.org/W3213839595","https://openalex.org/W4210399946","https://openalex.org/W4221040485","https://openalex.org/W4324020291","https://openalex.org/W4324311089","https://openalex.org/W4367042962","https://openalex.org/W4387128705","https://openalex.org/W4390740012","https://openalex.org/W4400367578","https://openalex.org/W4401405450","https://openalex.org/W4404542595","https://openalex.org/W4405670661","https://openalex.org/W4410585568","https://openalex.org/W4410838519","https://openalex.org/W4411040283","https://openalex.org/W4412157108","https://openalex.org/W4412633162","https://openalex.org/W4413279951","https://openalex.org/W4413636624"],"related_works":["https://openalex.org/W3009864306","https://openalex.org/W3121426084","https://openalex.org/W4410722129","https://openalex.org/W4396770623","https://openalex.org/W7119466541","https://openalex.org/W7155397180","https://openalex.org/W4200150287","https://openalex.org/W4409224974","https://openalex.org/W4307133975","https://openalex.org/W7157894136"],"abstract_inverted_index":{"Candida":[0],"auris":[1,46,214],"is":[2],"a":[3,134],"multidrug-resistant":[4],"fungal":[5],"pathogen":[6,14],"associated":[7,175],"with":[8,72,106,176],"nosocomial":[9],"outbreaks":[10],"worldwide.":[11],"Although":[12],"this":[13,40],"may":[15],"encounter":[16],"oxygen-limited":[17],"environments":[18],"during":[19],"colonization":[20,239],"and":[21,61,79,85,126,130,179,188,235,240],"infection,":[22],"the":[23,170,218,229],"effects":[24],"of":[25,75,88,172,212,220],"prolonged":[26],"exposure":[27],"to":[28,58,119,124,227,238],"reduced":[29,122],"oxygen":[30,100],"availability":[31],"on":[32],"its":[33,63,158],"phenotypic":[34,140,210],"characteristics":[35,84,141],"remain":[36],"poorly":[37],"understood.":[38],"In":[39],"study,":[41],"we":[42],"serially":[43],"subcultured":[44],"C.":[45,213],"AR":[47],"0387":[48],"under":[49,97,111,147,198],"microaerobic":[50,92],"conditions":[51],"(5%":[52],"O":[53,103,200],"2":[54,104,201],")":[55],"for":[56],"up":[57],"40":[59],"passages,":[60],"examined":[62],"growth,":[64],"cellular":[65,86],"morphology,":[66],"adhesion,":[67,180],"antifungal":[68,128,221],"susceptibility,":[69],"virulence,":[70],"together":[71],"sequence":[73,151],"analysis":[74],"triazole":[76,127,177],"resistance-associated":[77],"genes":[78,174],"gene":[80],"expression":[81,171],"analysis.":[82],"Growth":[83],"morphology":[87],"strains":[89,115],"recovered":[90],"after":[91,144],"serial":[93,196],"subculture":[94,197],"were":[95,142,153,167],"altered":[96],"more":[98],"severe":[99],"limitation":[101],"(0.1%":[102],"),":[105],"no":[107],"clear":[108],"growth":[109],"advantage":[110],"these":[112,233],"conditions.":[113,149],"These":[114,139,191],"had":[116],"enhanced":[117],"adhesion":[118],"polypropylene":[120],"surfaces,":[121],"susceptibility":[123],"echinocandins":[125],"agents,":[129],"attenuated":[131],"virulence":[132],"in":[133,155,169,208,217,242],"Galleria":[135],"mellonella":[136],"infection":[137,241],"model.":[138],"maintained":[143],"subsequent":[145],"culture":[146],"aerobic":[148],"No":[150],"alterations":[152],"identified":[154],"ERG11":[156],",":[157,164,183,185,187,215],"1000-bp":[159],"upstream":[160],"region,":[161],"or":[162],"TAC1B":[163,182],"whereas":[165],"changes":[166,207,234],"observed":[168],"several":[173],"resistance":[178],"including":[181],"MRR1":[184],"ALS5":[186],"SCF1":[189],".":[190,244],"findings":[192],"suggest":[193],"that":[194],"long-term":[195],"5%":[199],"can":[202],"be":[203],"accompanied":[204],"by":[205],"persistent":[206],"multiple":[209],"traits":[211],"even":[216],"absence":[219],"selection.":[222],"Further":[223],"studies":[224],"are":[225],"required":[226],"determine":[228],"molecular":[230],"mechanisms":[231],"underlying":[232],"their":[236],"relevance":[237],"vivo":[243]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
