{"id":"https://openalex.org/W7225335681","doi":"https://doi.org/10.21203/rs.3.rs-11614966/v1","title":"Thermoring-driven allosteric gating coupling in TRPV2","display_name":"Thermoring-driven allosteric gating coupling in TRPV2","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225335681","doi":"https://doi.org/10.21203/rs.3.rs-11614966/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11614966/v1","doi":"https://doi.org/10.21203/rs.3.rs-11614966/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11614966/v1","pdf_url":"https://www.researchsquare.com/article/rs-11614966/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.researchsquare.com/article/rs-11614966/latest.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5122031417","display_name":"Guangyu Wang","orcid":"https://orcid.org/0000-0002-5581-6926","observed_orcids":["https://orcid.org/0000-0002-5581-6926"]},"institutions":[{"id":"https://openalex.org/I84218800","display_name":"University of California, Davis","ror":"https://ror.org/05rrcem69","country_code":"US","type":"education","lineage":["https://openalex.org/I84218800"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Guangyu Wang","raw_affiliation_strings":["University of California, Davis"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of California, Davis","institution_ids":["https://openalex.org/I84218800"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5122031417"],"corresponding_institution_ids":["https://openalex.org/I84218800"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11204","display_name":"Ion Channels and Receptors","score":0.9970999956130981,"subfield":{"id":"https://openalex.org/subfields/2809","display_name":"Sensory Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10044","display_name":"Protein Structure and Dynamics","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/trpv2","display_name":"TRPV2","score":0.9909999966621399},{"id":"https://openalex.org/keywords/allosteric-gating","display_name":"allosteric gating","score":0.8479999899864197},{"id":"https://openalex.org/keywords/thermosensitive-ion-channels","display_name":"thermosensitive ion channels","score":0.7429999709129333},{"id":"https://openalex.org/keywords/s4-s5-linker","display_name":"S4-S5 linker","score":0.7279999852180481}],"concepts":[{"id":"https://openalex.org/C166342909","wikidata":"https://www.wikidata.org/wiki/Q845326","display_name":"Allosteric regulation","level":3,"score":0.8331999778747559},{"id":"https://openalex.org/C99821215","wikidata":"https://www.wikidata.org/wiki/Q1136583","display_name":"Swap (finance)","level":2,"score":0.7475000023841858},{"id":"https://openalex.org/C194544171","wikidata":"https://www.wikidata.org/wiki/Q21105679","display_name":"Gating","level":2,"score":0.7307999730110168},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.6417999863624573},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5569000244140625},{"id":"https://openalex.org/C2780557392","wikidata":"https://www.wikidata.org/wiki/Q523796","display_name":"Linker","level":2,"score":0.5199999809265137},{"id":"https://openalex.org/C131584629","wikidata":"https://www.wikidata.org/wiki/Q4308705","display_name":"Coupling (piping)","level":2,"score":0.45159998536109924},{"id":"https://openalex.org/C2781338088","wikidata":"https://www.wikidata.org/wiki/Q903495","display_name":"Residue (chemistry)","level":2,"score":0.42730000615119934},{"id":"https://openalex.org/C204795200","wikidata":"https://www.wikidata.org/wiki/Q903282","display_name":"Symmetry breaking","level":2,"score":0.34880000352859497},{"id":"https://openalex.org/C155164980","wikidata":"https://www.wikidata.org/wiki/Q304043","display_name":"Transient receptor potential channel","level":3,"score":0.29910001158714294},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.2712000012397766},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.2687999904155731},{"id":"https://openalex.org/C2986219828","wikidata":"https://www.wikidata.org/wiki/Q1193095","display_name":"Coupling strength","level":2,"score":0.25380000472068787}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11614966/v1","doi":"https://doi.org/10.21203/rs.3.rs-11614966/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11614966/v1","pdf_url":"https://www.researchsquare.com/article/rs-11614966/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11614966/v1","doi":"https://doi.org/10.21203/rs.3.rs-11614966/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11614966/v1","pdf_url":"https://www.researchsquare.com/article/rs-11614966/latest.pdf","source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320306230","display_name":"American Heart Association","ror":"https://ror.org/013kjyp64"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225335681.pdf","grobid_xml":"https://content.openalex.org/works/W7225335681.grobid-xml"},"referenced_works_count":70,"referenced_works":["https://openalex.org/W1495409864","https://openalex.org/W1511198581","https://openalex.org/W1554059507","https://openalex.org/W1968827373","https://openalex.org/W2003380041","https://openalex.org/W2007572995","https://openalex.org/W2037651260","https://openalex.org/W2040222426","https://openalex.org/W2042968117","https://openalex.org/W2049682677","https://openalex.org/W2055971447","https://openalex.org/W2057154060","https://openalex.org/W2062753490","https://openalex.org/W2094955398","https://openalex.org/W2100241249","https://openalex.org/W2106960190","https://openalex.org/W2166903664","https://openalex.org/W2288312813","https://openalex.org/W2340643499","https://openalex.org/W2372195673","https://openalex.org/W2417513559","https://openalex.org/W2474419332","https://openalex.org/W2602180809","https://openalex.org/W2790336955","https://openalex.org/W2805565876","https://openalex.org/W2807983521","https://openalex.org/W2886463620","https://openalex.org/W2911398658","https://openalex.org/W2939042311","https://openalex.org/W2984139755","https://openalex.org/W3001763969","https://openalex.org/W3022823464","https://openalex.org/W3048084426","https://openalex.org/W3153270385","https://openalex.org/W3181088086","https://openalex.org/W3182194113","https://openalex.org/W3201537564","https://openalex.org/W4225149868","https://openalex.org/W4282913102","https://openalex.org/W4293385889","https://openalex.org/W4321100309","https://openalex.org/W4376138516","https://openalex.org/W4382451192","https://openalex.org/W4384938976","https://openalex.org/W4386303203","https://openalex.org/W4388221661","https://openalex.org/W4389426233","https://openalex.org/W4389916165","https://openalex.org/W4393186939","https://openalex.org/W4395665310","https://openalex.org/W4402068681","https://openalex.org/W4404024871","https://openalex.org/W4405338847","https://openalex.org/W4405896597","https://openalex.org/W4410606730","https://openalex.org/W4410747265","https://openalex.org/W4411196540","https://openalex.org/W4412457012","https://openalex.org/W4412622884","https://openalex.org/W4412772451","https://openalex.org/W4416137751","https://openalex.org/W4416843274","https://openalex.org/W4417325867","https://openalex.org/W7118346779","https://openalex.org/W7119991192","https://openalex.org/W7140718012","https://openalex.org/W7163985684","https://openalex.org/W7165377646","https://openalex.org/W7172310498","https://openalex.org/W7203837340"],"related_works":["https://openalex.org/W7163985684","https://openalex.org/W7161567217","https://openalex.org/W7172310498","https://openalex.org/W2990761140","https://openalex.org/W4387611670","https://openalex.org/W2394294586","https://openalex.org/W3201537564","https://openalex.org/W2172654939","https://openalex.org/W2968755537","https://openalex.org/W4416843274"],"abstract_inverted_index":{"Abstract":[0],"Allosteric":[1],"regulation":[2],"of":[3,16,40,98,128],"protein":[4],"activity":[5,166],"by":[6],"chemical":[7],"stimuli":[8,18],"has":[9],"been":[10],"extensively":[11],"investigated,":[12],"whereas":[13],"the":[14,37,56,66,71,77,83,89,96,99,107,116,126,129,144,150,158,169,179,198],"effects":[15],"physical":[17],"remain":[19],"comparatively":[20],"poorly":[21],"understood.":[22],"In":[23,65,114],"this":[24],"computational":[25],"study,":[26],"a":[27,51],"highly":[28],"sensitive":[29],"thermoring":[30],"energetic":[31],"model":[32],"was":[33],"employed":[34],"to":[35,197],"analyze":[36],"three-dimensional":[38],"structures":[39],"homotetrameric,":[41],"thermosensitive":[42],"transient":[43],"receptor":[44],"potential":[45],"vanilloid":[46],"2":[47],"(TRPV2)":[48],"channels":[49],"following":[50],"species-specific":[52],"residue":[53,118,151],"swap":[54,119,152],"near":[55,88],"central":[57,90],"lower":[58,91],"gate":[59],"in":[60,120,153],"rat":[61,67],"and":[62,86,105,133,160],"human":[63,121,154],"TRPV2.":[64],"TRPV2":[68,122,155],"triple":[69],"mutant,":[70],"swap-induced":[72],"symmetry":[73,189],"breaking":[74],"partially":[75],"disrupted":[76],"interfacial":[78,145,199],"swapping":[79,146,161,200],"\u03c0":[80,147,201],"bridges":[81,182],"between":[82],"S4-S5":[84],"linker":[85],"S5\u2019":[87],"gate.":[92],"It":[93],"also":[94],"altered":[95],"location":[97],"superficial":[100,130,180],"weakest":[101,131,159,181],"tertiary":[102],"noncovalent":[103],"bridge":[104,132],"shifted":[106],"corresponding":[108,135],"melting":[109,136],"threshold":[110,137],"for":[111,138,192],"heat":[112,139,186],"activation.":[113],"contrast,":[115],"equivalent":[117],"preserved":[123],"C4-fold":[124,188],"symmetry,":[125],"identity":[127],"its":[134],"activation,":[140],"as":[141,143,184],"well":[142],"bridges.":[148,202],"Notably,":[149],"simultaneously":[156],"weakened":[157],"bridges,":[162],"thereby":[163],"enhancing":[164],"heat-evoked":[165],"while":[167],"lowering":[168],"heat-activation":[170],"threshold.":[171],"Taken":[172],"together,":[173],"these":[174],"findings":[175],"suggest":[176],"that":[177],"when":[178],"function":[183],"putative":[185],"sensors,":[187],"is":[190],"essential":[191],"their":[193],"allosteric":[194],"gating":[195],"coupling":[196],"(202":[203],"words)":[204]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}