{"id":"https://openalex.org/W7225334684","doi":"https://doi.org/10.1007/s10439-026-04421-1","title":"Development of a Simplified Multi-Physics Computational Model of the Coronary Microcirculation","display_name":"Development of a Simplified Multi-Physics Computational Model of the Coronary Microcirculation","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225334684","doi":"https://doi.org/10.1007/s10439-026-04421-1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42989041"},"language":"en","primary_location":{"id":"doi:10.1007/s10439-026-04421-1","doi":"https://doi.org/10.1007/s10439-026-04421-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-026-04421-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04421-1.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04421-1.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5061525326","display_name":"Yuji Tomizawa","orcid":"https://orcid.org/0009-0007-6765-4884","observed_orcids":["https://orcid.org/0009-0007-6765-4884"]},"institutions":[{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yuji Tomizawa","raw_affiliation_strings":["Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5030555072","display_name":"Patricia E. McCallinhart","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patricia E. McCallinhart","raw_affiliation_strings":["Center for Cardiovascular Research and The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research and The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046429160","display_name":"Yukie Ueyama","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Yukie Ueyama","raw_affiliation_strings":["Center for Cardiovascular Research and The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research and The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5076776076","display_name":"Aaron J. Trask","orcid":"https://orcid.org/0000-0003-2236-0659","observed_orcids":["https://orcid.org/0000-0003-2236-0659"]},"institutions":[{"id":"https://openalex.org/I1314135232","display_name":"Nationwide Children's Hospital","ror":"https://ror.org/003rfsp33","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1314135232"]},{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I4405283103","display_name":"Abigail Wexner Research Institute","ror":"https://ror.org/010dtsm51","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Aaron J. Trask","raw_affiliation_strings":["Center for Cardiovascular Research and The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA","Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA","Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, OH, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Center for Cardiovascular Research and The Heart Center, The Abigail Wexner Research Institute, Nationwide Children's Hospital, Columbus, OH, USA","institution_ids":["https://openalex.org/I1314135232","https://openalex.org/I4405283103"]},{"raw_affiliation_string":"Department of Pediatrics, The Ohio State University College of Medicine, Columbus, OH, USA","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, OH, USA","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5010154615","display_name":"Samir N. Ghadiali","orcid":"https://orcid.org/0000-0002-6845-774X","observed_orcids":["https://orcid.org/0000-0002-6845-774X"]},"institutions":[{"id":"https://openalex.org/I2802841970","display_name":"The Ohio State University Wexner Medical Center","ror":"https://ror.org/00c01js51","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2802841970"]},{"id":"https://openalex.org/I52357470","display_name":"The Ohio State University","ror":"https://ror.org/00rs6vg23","country_code":"US","type":"education","lineage":["https://openalex.org/I52357470"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Samir N. Ghadiali","raw_affiliation_strings":["Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA. ghadiali.1@osu.edu","Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, OSU Wexner Medical Center, Columbus, OH, USA. ghadiali.1@osu.edu","Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, OH, USA. ghadiali.1@osu.edu"],"raw_orcid":"https://orcid.org/0000-0002-6845-774X","affiliations":[{"raw_affiliation_string":"Department of Biomedical Engineering, The Ohio State University, Columbus, OH, USA. ghadiali.1@osu.edu","institution_ids":["https://openalex.org/I52357470"]},{"raw_affiliation_string":"Division of Pulmonary, Critical Care, and Sleep Medicine, Department of Internal Medicine, OSU Wexner Medical Center, Columbus, OH, USA. ghadiali.1@osu.edu","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]},{"raw_affiliation_string":"Dorothy M. Davis Heart and Lung Research Institute, College of Medicine and Wexner Medical Center, The Ohio State University, Columbus, OH, USA. ghadiali.1@osu.edu","institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5010154615"],"corresponding_institution_ids":["https://openalex.org/I2802841970","https://openalex.org/I52357470"],"apc_list":{"value":4390,"currency":"USD","value_usd":4390},"apc_paid":{"value":4390,"currency":"USD","value_usd":4390},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11366","display_name":"Elasticity and Material Modeling","score":0.5297999978065491,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.25049999356269836,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10821","display_name":"Cardiovascular Function and Risk Factors","score":0.0997999981045723,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/coronary-blood-flow","display_name":"coronary blood flow","score":0.9390000104904175},{"id":"https://openalex.org/keywords/coronary-microcirculation","display_name":"coronary microcirculation","score":0.996999979019165},{"id":"https://openalex.org/keywords/vascular-smooth-muscle-cells","display_name":"vascular smooth muscle cells","score":0.7689999938011169},{"id":"https://openalex.org/keywords/myocardial-stiffness","display_name":"myocardial stiffness","score":0.8790000081062317},{"id":"https://openalex.org/keywords/vascular-remodeling","display_name":"vascular remodeling","score":0.5239999890327454},{"id":"https://openalex.org/keywords/type-2-diabetes","display_name":"type 2 diabetes","score":0.7680000066757202},{"id":"https://openalex.org/keywords/excitation-contraction-coupling","display_name":"excitation-contraction coupling","score":0.9200000166893005}],"concepts":[{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.7045999765396118},{"id":"https://openalex.org/C158846371","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Blood flow","level":2,"score":0.6967999935150146},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5802000164985657},{"id":"https://openalex.org/C12722491","wikidata":"https://www.wikidata.org/wiki/Q1632335","display_name":"Microcirculation","level":2,"score":0.536899983882904},{"id":"https://openalex.org/C57900726","wikidata":"https://www.wikidata.org/wiki/Q492905","display_name":"Diastole","level":3,"score":0.5336999893188477},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.4471000134944916},{"id":"https://openalex.org/C2776157398","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary circulation","level":3,"score":0.44190001487731934},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.42250001430511475},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.3944999873638153},{"id":"https://openalex.org/C178853913","wikidata":"https://www.wikidata.org/wiki/Q1642137","display_name":"Hemodynamics","level":2,"score":0.39160001277923584},{"id":"https://openalex.org/C2779372316","wikidata":"https://www.wikidata.org/wiki/Q569057","display_name":"Stiffness","level":2,"score":0.3785000145435333},{"id":"https://openalex.org/C2779395532","wikidata":"https://www.wikidata.org/wiki/Q7916469","display_name":"Vascular smooth muscle","level":3,"score":0.3598000109195709},{"id":"https://openalex.org/C99398487","wikidata":"https://www.wikidata.org/wiki/Q257319","display_name":"Cardiac cycle","level":2,"score":0.34209999442100525},{"id":"https://openalex.org/C2776449402","wikidata":"https://www.wikidata.org/wiki/Q7809658","display_name":"Tissue Doppler echocardiography","level":5,"score":0.3359000086784363},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.3127000033855438},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.30720001459121704},{"id":"https://openalex.org/C142757262","wikidata":"https://www.wikidata.org/wiki/Q76436","display_name":"Doppler effect","level":2,"score":0.296999990940094},{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.2969000041484833},{"id":"https://openalex.org/C2994477613","wikidata":"https://www.wikidata.org/wiki/Q497232","display_name":"Coronary vessel","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C2778996579","wikidata":"https://www.wikidata.org/wiki/Q10334846","display_name":"Cardiac muscle","level":2,"score":0.2903999984264374},{"id":"https://openalex.org/C2780829959","wikidata":"https://www.wikidata.org/wiki/Q30314111","display_name":"Diastolic function","level":4,"score":0.28760001063346863},{"id":"https://openalex.org/C38349280","wikidata":"https://www.wikidata.org/wiki/Q1434290","display_name":"Flow (mathematics)","level":2,"score":0.28700000047683716},{"id":"https://openalex.org/C2775850156","wikidata":"https://www.wikidata.org/wiki/Q4797538","display_name":"Arterial stiffness","level":3,"score":0.2793999910354614},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C197424946","wikidata":"https://www.wikidata.org/wiki/Q1165717","display_name":"Waveform","level":3,"score":0.2623000144958496},{"id":"https://openalex.org/C170700871","wikidata":"https://www.wikidata.org/wiki/Q193378","display_name":"Biomechanics","level":2,"score":0.2565000057220459},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.2531999945640564},{"id":"https://openalex.org/C109982973","wikidata":"https://www.wikidata.org/wiki/Q5297353","display_name":"Doppler imaging","level":4,"score":0.25220000743865967},{"id":"https://openalex.org/C166693061","wikidata":"https://www.wikidata.org/wiki/Q5462119","display_name":"Flow velocity","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s10439-026-04421-1","doi":"https://doi.org/10.1007/s10439-026-04421-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-026-04421-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04421-1.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},{"id":"pmid:42989041","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42989041","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of biomedical engineering","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1007/s10439-026-04421-1","doi":"https://doi.org/10.1007/s10439-026-04421-1","is_oa":true,"landing_page_url":"https://doi.org/10.1007/s10439-026-04421-1","pdf_url":"https://link.springer.com/content/pdf/10.1007/s10439-026-04421-1.pdf","source":{"id":"https://openalex.org/S141152059","display_name":"Annals of Biomedical Engineering","issn_l":"0090-6964","issn":["0090-6964","0191-5649","1573-9686"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-2","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Annals of Biomedical Engineering","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8048999905586243,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G1359438710","display_name":"Novel Non-Invasive Coronary Flow Patterning to Predict Early Coronary Microvascular Disease","funder_award_id":"R21EB026518","funder_id":"https://openalex.org/F4320337363","funder_display_name":"National Institute of Biomedical Imaging and Bioengineering"},{"id":"https://openalex.org/G9000895365","display_name":"The Role of Notch Signaling in Type 2 Diabetic Coronary Microvascular Disease","funder_award_id":"R01HL165124","funder_id":"https://openalex.org/F4320337338","funder_display_name":"National Heart, Lung, and Blood Institute"}],"funders":[{"id":"https://openalex.org/F4320306080","display_name":"Foundation for the National Institutes of Health","ror":"https://ror.org/00k86s890"},{"id":"https://openalex.org/F4320309374","display_name":"Ohio State University","ror":"https://ror.org/00rs6vg23"},{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320333165","display_name":"Research Institute, Nationwide Children's Hospital","ror":null},{"id":"https://openalex.org/F4320337338","display_name":"National Heart, Lung, and Blood Institute","ror":"https://ror.org/012pb6c26"},{"id":"https://openalex.org/F4320337363","display_name":"National Institute of Biomedical Imaging and Bioengineering","ror":"https://ror.org/00372qc85"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225334684.pdf","grobid_xml":"https://content.openalex.org/works/W7225334684.grobid-xml"},"referenced_works_count":68,"referenced_works":["https://openalex.org/W55869982","https://openalex.org/W187359130","https://openalex.org/W745610940","https://openalex.org/W1419099424","https://openalex.org/W1976396383","https://openalex.org/W1977643020","https://openalex.org/W1980615396","https://openalex.org/W1990181045","https://openalex.org/W1990850630","https://openalex.org/W2002939672","https://openalex.org/W2004553433","https://openalex.org/W2012475038","https://openalex.org/W2018574317","https://openalex.org/W2019095861","https://openalex.org/W2019557956","https://openalex.org/W2020665514","https://openalex.org/W2024180061","https://openalex.org/W2024200022","https://openalex.org/W2033110285","https://openalex.org/W2052514308","https://openalex.org/W2056319211","https://openalex.org/W2068385106","https://openalex.org/W2091874468","https://openalex.org/W2092571666","https://openalex.org/W2104701510","https://openalex.org/W2132826701","https://openalex.org/W2135965207","https://openalex.org/W2143421921","https://openalex.org/W2146623011","https://openalex.org/W2157482844","https://openalex.org/W2159066895","https://openalex.org/W2162834159","https://openalex.org/W2172080864","https://openalex.org/W2181589712","https://openalex.org/W2182355016","https://openalex.org/W2320435961","https://openalex.org/W2410518596","https://openalex.org/W2472500610","https://openalex.org/W2473992689","https://openalex.org/W2772533943","https://openalex.org/W2800981650","https://openalex.org/W2890690689","https://openalex.org/W2901892679","https://openalex.org/W2912614022","https://openalex.org/W2994149637","https://openalex.org/W2994230705","https://openalex.org/W3012427212","https://openalex.org/W3021454210","https://openalex.org/W3084645569","https://openalex.org/W3087051990","https://openalex.org/W3108409717","https://openalex.org/W3127589899","https://openalex.org/W3138531817","https://openalex.org/W3163741036","https://openalex.org/W3166242330","https://openalex.org/W4205305801","https://openalex.org/W4307870821","https://openalex.org/W4385144244","https://openalex.org/W4386865411","https://openalex.org/W4390535835","https://openalex.org/W4391447123","https://openalex.org/W4396553890","https://openalex.org/W4396669293","https://openalex.org/W4399457768","https://openalex.org/W4400588666","https://openalex.org/W4402294707","https://openalex.org/W4408557567","https://openalex.org/W4414797967"],"related_works":["https://openalex.org/W2163502236","https://openalex.org/W2911382608","https://openalex.org/W3104788220","https://openalex.org/W3016824826","https://openalex.org/W1979164759","https://openalex.org/W4400588666","https://openalex.org/W2130598429","https://openalex.org/W2155164189","https://openalex.org/W4410808128","https://openalex.org/W7222973594"],"abstract_inverted_index":{"Coronary":[0],"blood":[1,111],"flow":[2,112,215],"(CBF)":[3],"is":[4,31,94],"influenced":[5],"by":[6],"multiple":[7],"biophysical":[8,38,86,121,185],"factors,":[9],"including":[10],"vascular":[11,52,59],"function":[12],"(vasoconstriction/vasodilation),":[13],"structural":[14],"remodeling":[15,72],"(vascular":[16],"wall":[17,53,66],"thickening),":[18],"tissue":[19,107,204],"mechanical":[20,139],"properties":[21,190,217],"(stiffness),":[22],"cardiac":[23],"electrophysiology,":[24],"and":[25,73,88,109,113,141,162,196,201],"dynamic":[26,134],"extravascular":[27],"forces.":[28],"However,":[29,80],"it":[30],"difficult":[32],"to":[33,41,56,69,117,168,181,222,237],"experimentally":[34],"determine":[35],"how":[36,119,183,239],"these":[37,85],"factors":[39,87,122,186],"interact":[40],"regulate":[42,242],"CBF.":[43,79,124,211,243],"For":[44],"example,":[45],"during":[46],"type":[47],"2":[48],"diabetes":[49],"(T2D)":[50],"reduced":[51,57],"stiffness":[54,76,205],"due":[55,68],"coronary":[58,148],"smooth":[60],"muscle":[61],"cell":[62],"(VSMC)":[63],"stiffness,":[64],"increased":[65,74],"thickness":[67],"inward":[70],"hypertrophic":[71],"myocardial":[75,106,131,135,138,203,228],"may":[77],"alter":[78,187],"the":[81,142,147,188,192,207,214,225],"relative":[82],"importance":[83],"of":[84,105,144,191,210,218,227],"their":[89],"direct":[90],"effect":[91],"on":[92,224],"CBF":[93,154,193],"not":[95],"known.":[96],"Here,":[97],"we":[98],"developed":[99],"a":[100,234],"simplified":[101],"multi-physics":[102],"computational":[103,231],"model":[104,116,126],"deformation":[108],"intramyocardial":[110],"used":[114],"this":[115],"investigate":[118,182,238],"several":[120,184],"influence":[123],"This":[125,230],"accounts":[127],"for":[128],"excitation-contraction":[129],"coupling,":[130],"fiber":[132],"structure,":[133],"contraction,":[136],"passive":[137,202],"properties,":[140],"mechanics":[143],"VSMCs":[145,219],"in":[146,172],"microvascular":[149],"walls.":[150],"Baseline":[151],"models":[152],"yielded":[153],"velocity":[155,194],"waveforms":[156],"that":[157,165,199],"exhibited":[158],"peak":[159],"diastolic":[160],"velocities":[161],"waveform":[163],"morphologies":[164],"were":[166,179,206,220],"comparable":[167],"Doppler":[169],"echocardiography":[170],"measurements":[171],"normal":[173],"adult":[174],"humans.":[175],"Parameter":[176],"variation":[177],"studies":[178],"conducted":[180],"morphological":[189],"waveform,":[195],"results":[197],"indicate":[198],"VSMC":[200],"major":[208],"drivers":[209],"In":[212],"addition,":[213],"regulatory":[216],"found":[221],"depend":[223],"degree":[226],"stiffness.":[229],"framework":[232],"represents":[233],"new":[235],"way":[236],"coronary-cardiac":[240],"interactions":[241]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-06T00:00:00"}