{"id":"https://openalex.org/W7225333362","doi":"https://doi.org/10.1093/eurheartj/ehag878","title":"Atherosclerotic plaque healing: mechanisms and clinical relevance","display_name":"Atherosclerotic plaque healing: mechanisms and clinical relevance","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225333362","doi":"https://doi.org/10.1093/eurheartj/ehag878","pmid":"https://pubmed.ncbi.nlm.nih.gov/42986702"},"language":"en","primary_location":{"id":"doi:10.1093/eurheartj/ehag878","doi":"https://doi.org/10.1093/eurheartj/ehag878","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag878","pdf_url":"https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehag878/73133099/ehag878.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehag878/73133099/ehag878.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5087272055","display_name":"Angela Buonpane","orcid":"https://orcid.org/0000-0001-8438-1004","observed_orcids":["https://orcid.org/0000-0001-8438-1004"]},"institutions":[{"id":"https://openalex.org/I162290304","display_name":"Scuola Superiore Sant'Anna","ror":"https://ror.org/025602r80","country_code":"IT","type":"education","lineage":["https://openalex.org/I162290304"]},{"id":"https://openalex.org/I4210158339","display_name":"Fondazione Toscana Gabriele Monasterio","ror":"https://ror.org/058a2pj71","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210158339"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angela Buonpane","raw_affiliation_strings":["Cardiothoracic Department, Fondazione Toscana G. Monasterio, G. Pasquinucci Heart Hospital , Massa ,","Sant\u2019Anna School of Advanced Studies , Pisa ,"],"raw_orcid":"https://orcid.org/0000-0001-8438-1004","affiliations":[{"raw_affiliation_string":"Cardiothoracic Department, Fondazione Toscana G. Monasterio, G. Pasquinucci Heart Hospital , Massa ,","institution_ids":["https://openalex.org/I4210158339"]},{"raw_affiliation_string":"Sant\u2019Anna School of Advanced Studies , Pisa ,","institution_ids":["https://openalex.org/I162290304"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5037081057","display_name":"Alberto Ranieri De Caterina","orcid":"https://orcid.org/0000-0002-4470-4208","observed_orcids":["https://orcid.org/0000-0002-4470-4208"]},"institutions":[{"id":"https://openalex.org/I4210158339","display_name":"Fondazione Toscana Gabriele Monasterio","ror":"https://ror.org/058a2pj71","country_code":"IT","type":"other","lineage":["https://openalex.org/I4210155236","https://openalex.org/I4210158339"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Alberto R De Caterina","raw_affiliation_strings":["Cardiothoracic Department, Fondazione Toscana G. Monasterio, G. Pasquinucci Heart Hospital , Massa ,"],"raw_orcid":"https://orcid.org/0000-0002-4470-4208","affiliations":[{"raw_affiliation_string":"Cardiothoracic Department, Fondazione Toscana G. Monasterio, G. Pasquinucci Heart Hospital , Massa ,","institution_ids":["https://openalex.org/I4210158339"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078703572","display_name":"Italo Porto","orcid":"https://orcid.org/0000-0002-9854-5046","observed_orcids":["https://orcid.org/0000-0002-9854-5046"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Italo Porto","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa , Viale Benedetto XV, 6, 16132 Genoa ,","Interventional Cardiology Unit, Cardiothoracic and Vascular Department (DICATOV), IRCCS Ospedale Policlinico San Martino , Largo R. Benzi, 10, 16132 Genoa ,"],"raw_orcid":"https://orcid.org/0000-0002-9854-5046","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa , Viale Benedetto XV, 6, 16132 Genoa ,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Interventional Cardiology Unit, Cardiothoracic and Vascular Department (DICATOV), IRCCS Ospedale Policlinico San Martino , Largo R. Benzi, 10, 16132 Genoa ,","institution_ids":["https://openalex.org/I4210146472"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5031505042","display_name":"Filippo Crea","orcid":"https://orcid.org/0000-0002-9482-411X","observed_orcids":["https://orcid.org/0000-0002-9482-411X","https://orcid.org/0000-0001-9404-8846"]},"institutions":[{"id":"https://openalex.org/I2802557943","display_name":"Agostino Gemelli University Polyclinic","ror":"https://ror.org/00rg70c39","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I2802557943"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Filippo Crea","raw_affiliation_strings":["Center of Excellence for Cardiovascular Sciences, Isola Tiberina-Gemelli Isola Hospital , Via di Ponte Quattro Capi, 39, 00186 Rome ,"],"raw_orcid":"https://orcid.org/0000-0002-9482-411X","affiliations":[{"raw_affiliation_string":"Center of Excellence for Cardiovascular Sciences, Isola Tiberina-Gemelli Isola Hospital , Via di Ponte Quattro Capi, 39, 00186 Rome ,","institution_ids":["https://openalex.org/I2802557943"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065403268","display_name":"Rocco Vergallo","orcid":"https://orcid.org/0000-0001-5577-081X","observed_orcids":["https://orcid.org/0000-0001-5577-081X"]},"institutions":[{"id":"https://openalex.org/I4210146472","display_name":"Ospedale Policlinico San Martino","ror":"https://ror.org/04d7es448","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210146472","https://openalex.org/I4210153126","https://openalex.org/I4405264730"]},{"id":"https://openalex.org/I83816512","display_name":"University of Genoa","ror":"https://ror.org/0107c5v14","country_code":"IT","type":"education","lineage":["https://openalex.org/I83816512"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Rocco Vergallo","raw_affiliation_strings":["Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa , Viale Benedetto XV, 6, 16132 Genoa ,","Interventional Cardiology Unit, Cardiothoracic and Vascular Department (DICATOV), IRCCS Ospedale Policlinico San Martino , Largo R. Benzi, 10, 16132 Genoa ,"],"raw_orcid":"https://orcid.org/0000-0001-5577-081X","affiliations":[{"raw_affiliation_string":"Department of Internal Medicine and Medical Specialties (DiMI), University of Genoa , Viale Benedetto XV, 6, 16132 Genoa ,","institution_ids":["https://openalex.org/I83816512"]},{"raw_affiliation_string":"Interventional Cardiology Unit, Cardiothoracic and Vascular Department (DICATOV), IRCCS Ospedale Policlinico San Martino , Largo R. Benzi, 10, 16132 Genoa ,","institution_ids":["https://openalex.org/I4210146472"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5031505042","https://openalex.org/A5065403268"],"corresponding_institution_ids":["https://openalex.org/I2802557943","https://openalex.org/I4210146472","https://openalex.org/I83816512"],"apc_list":{"value":5240,"currency":"EUR","value_usd":5922},"apc_paid":{"value":5240,"currency":"EUR","value_usd":5922},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10193","display_name":"Coronary Interventions and Diagnostics","score":0.8788999915122986,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12955","display_name":"Atherosclerosis and Cardiovascular Diseases","score":0.094200000166893,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10816","display_name":"Cerebrovascular and Carotid Artery Diseases","score":0.00989999994635582,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/plaque-disruption","display_name":"plaque disruption","score":0.9070000052452087},{"id":"https://openalex.org/keywords/thrombus-lysis","display_name":"thrombus lysis","score":0.9509999752044678},{"id":"https://openalex.org/keywords/granulation-tissue-formation","display_name":"granulation tissue formation","score":0.8529999852180481},{"id":"https://openalex.org/keywords/re-endothelialization","display_name":"re-endothelialization","score":0.9980000257492065},{"id":"https://openalex.org/keywords/plaque-stabilization","display_name":"plaque stabilization","score":0.8180000185966492},{"id":"https://openalex.org/keywords/stable-coronary-artery-disease","display_name":"stable coronary artery disease","score":0.8080000281333923},{"id":"https://openalex.org/keywords/coronary-artery-disease","display_name":"coronary artery disease","score":0.7289999723434448},{"id":"https://openalex.org/keywords/optical-coherence-tomography","display_name":"optical coherence tomography","score":0.875},{"id":"https://openalex.org/keywords/intracoronary-imaging","display_name":"intracoronary imaging","score":0.9300000071525574},{"id":"https://openalex.org/keywords/luminal-narrowing","display_name":"luminal narrowing","score":0.7480000257492065},{"id":"https://openalex.org/keywords/plaque-progression","display_name":"plaque progression","score":0.3490000069141388}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9088000059127808},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.7268999814987183},{"id":"https://openalex.org/C2779179121","wikidata":"https://www.wikidata.org/wiki/Q559362","display_name":"Fibrous cap","level":2,"score":0.5996000170707703},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.5569000244140625},{"id":"https://openalex.org/C2781362458","wikidata":"https://www.wikidata.org/wiki/Q1588755","display_name":"Thrombus","level":2,"score":0.5302000045776367},{"id":"https://openalex.org/C2776055305","wikidata":"https://www.wikidata.org/wiki/Q1543255","display_name":"Granulation tissue","level":3,"score":0.5273000001907349},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5238000154495239},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.4844000041484833},{"id":"https://openalex.org/C2778710248","wikidata":"https://www.wikidata.org/wiki/Q17154669","display_name":"Vulnerable plaque","level":2,"score":0.4778999984264374},{"id":"https://openalex.org/C2776820930","wikidata":"https://www.wikidata.org/wiki/Q9655","display_name":"Artery","level":2,"score":0.43630000948905945},{"id":"https://openalex.org/C2778742706","wikidata":"https://www.wikidata.org/wiki/Q18361829","display_name":"Coronary arteries","level":3,"score":0.4047999978065491},{"id":"https://openalex.org/C2780269544","wikidata":"https://www.wikidata.org/wiki/Q1509074","display_name":"Wound healing","level":2,"score":0.39739999175071716},{"id":"https://openalex.org/C2778213512","wikidata":"https://www.wikidata.org/wiki/Q844935","display_name":"Coronary artery disease","level":2,"score":0.3456999957561493},{"id":"https://openalex.org/C2991716557","wikidata":"https://www.wikidata.org/wiki/Q12252367","display_name":"Coronary atherosclerosis","level":3,"score":0.30300000309944153},{"id":"https://openalex.org/C2780868729","wikidata":"https://www.wikidata.org/wiki/Q261327","display_name":"Thrombosis","level":2,"score":0.29989999532699585},{"id":"https://openalex.org/C2780394083","wikidata":"https://www.wikidata.org/wiki/Q539568","display_name":"Angiogenesis","level":2,"score":0.2906000018119812},{"id":"https://openalex.org/C2778818243","wikidata":"https://www.wikidata.org/wiki/Q899552","display_name":"Optical coherence tomography","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.27950000762939453},{"id":"https://openalex.org/C2777466421","wikidata":"https://www.wikidata.org/wiki/Q1266890","display_name":"Vascular disease","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C2776393769","wikidata":"https://www.wikidata.org/wiki/Q184559","display_name":"Arteriosclerosis","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.2542000114917755},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.2540999948978424}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1093/eurheartj/ehag878","doi":"https://doi.org/10.1093/eurheartj/ehag878","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag878","pdf_url":"https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehag878/73133099/ehag878.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},{"id":"pmid:42986702","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42986702","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European heart journal","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1093/eurheartj/ehag878","doi":"https://doi.org/10.1093/eurheartj/ehag878","is_oa":true,"landing_page_url":"https://doi.org/10.1093/eurheartj/ehag878","pdf_url":"https://academic.oup.com/eurheartj/advance-article-pdf/doi/10.1093/eurheartj/ehag878/73133099/ehag878.pdf","source":{"id":"https://openalex.org/S181568219","display_name":"European Heart Journal","issn_l":"0195-668X","issn":["0195-668X","1522-9645"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-a","doyens","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311648","host_organization_name":"Oxford University Press","host_organization_lineage":["https://openalex.org/P4310311648","https://openalex.org/P4310311647"],"host_organization_lineage_names":["Oxford University Press","University of Oxford"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"European Heart Journal","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9922999739646912}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225333362.pdf","grobid_xml":"https://content.openalex.org/works/W7225333362.grobid-xml"},"referenced_works_count":93,"referenced_works":["https://openalex.org/W16027210","https://openalex.org/W196835504","https://openalex.org/W2007206486","https://openalex.org/W2022113719","https://openalex.org/W2067722558","https://openalex.org/W2074721116","https://openalex.org/W2102785524","https://openalex.org/W2123660911","https://openalex.org/W2141470773","https://openalex.org/W2151749258","https://openalex.org/W2152889855","https://openalex.org/W2161682643","https://openalex.org/W2166910397","https://openalex.org/W2317358310","https://openalex.org/W2544068456","https://openalex.org/W2781670419","https://openalex.org/W2782720740","https://openalex.org/W2790498314","https://openalex.org/W2803450769","https://openalex.org/W2810645356","https://openalex.org/W2888909234","https://openalex.org/W2899366946","https://openalex.org/W2907012814","https://openalex.org/W2909165994","https://openalex.org/W2913638136","https://openalex.org/W2921932327","https://openalex.org/W2942937269","https://openalex.org/W2945926178","https://openalex.org/W2978122541","https://openalex.org/W2980651239","https://openalex.org/W2987695377","https://openalex.org/W2991295858","https://openalex.org/W2996059902","https://openalex.org/W3016877130","https://openalex.org/W3018329629","https://openalex.org/W3024065863","https://openalex.org/W3045984961","https://openalex.org/W3080801838","https://openalex.org/W3081049904","https://openalex.org/W3083688820","https://openalex.org/W3087509451","https://openalex.org/W3089707047","https://openalex.org/W3092783089","https://openalex.org/W3111359688","https://openalex.org/W3135691734","https://openalex.org/W3143875167","https://openalex.org/W3159411238","https://openalex.org/W3160247188","https://openalex.org/W3161896957","https://openalex.org/W3203044708","https://openalex.org/W3215971779","https://openalex.org/W4200046072","https://openalex.org/W4205954362","https://openalex.org/W4220775671","https://openalex.org/W4220854669","https://openalex.org/W4224082333","https://openalex.org/W4294990711","https://openalex.org/W4308019509","https://openalex.org/W4308367583","https://openalex.org/W4319945287","https://openalex.org/W4323036992","https://openalex.org/W4323050211","https://openalex.org/W4324357631","https://openalex.org/W4376127227","https://openalex.org/W4376613819","https://openalex.org/W4382501609","https://openalex.org/W4385330322","https://openalex.org/W4386019925","https://openalex.org/W4386153206","https://openalex.org/W4388539935","https://openalex.org/W4392488662","https://openalex.org/W4394579663","https://openalex.org/W4394993437","https://openalex.org/W4399069634","https://openalex.org/W4399298187","https://openalex.org/W4400046883","https://openalex.org/W4401728155","https://openalex.org/W4402064302","https://openalex.org/W4402349582","https://openalex.org/W4403673118","https://openalex.org/W4405194915","https://openalex.org/W4405236334","https://openalex.org/W4405330484","https://openalex.org/W4406314344","https://openalex.org/W4407964861","https://openalex.org/W4409133212","https://openalex.org/W4410157118","https://openalex.org/W4416528928","https://openalex.org/W7123541519","https://openalex.org/W7125365459","https://openalex.org/W7134241490","https://openalex.org/W7148313485","https://openalex.org/W7156949305"],"related_works":["https://openalex.org/W4412522324","https://openalex.org/W3080801838","https://openalex.org/W4311750301","https://openalex.org/W2918517514","https://openalex.org/W2956265415","https://openalex.org/W3082079558","https://openalex.org/W4366602771","https://openalex.org/W3203044708","https://openalex.org/W4312817651","https://openalex.org/W1972401634"],"abstract_inverted_index":{"Atherosclerotic":[0],"plaque":[1,11,52,67,122,143,152,194],"healing":[2,53,68,140],"is":[3],"a":[4,71],"dynamic":[5],"biological":[6],"mechanism":[7],"that":[8,139,204],"occurrs":[9],"after":[10],"disruption":[12,153],"and":[13,37,49,57,182,196,200],"represents":[14],"an":[15,175],"endogenous":[16,31],"reparative":[17],"response":[18],"within":[19],"the":[20,40,61,94,118,137,146,166,179,191],"atherosclerotic":[21],"lesion.":[22],"This":[23,172],"process":[24],"unfolds":[25],"through":[26],"three":[27],"partially":[28],"overlapping":[29],"phases:":[30],"thrombus":[32],"lysis,":[33],"granulation":[34],"tissue":[35],"formation,":[36],"re-endothelialization.":[38],"Through":[39],"coordinated":[41],"interaction":[42],"of":[43,60,80,93,98,105,117,121,151,169,178,184],"circulating":[44],"cells,":[45],"vascular":[46],"wall":[47],"components,":[48],"soluble":[50],"mediators,":[51],"promotes":[54],"fibrous":[55],"repair":[56,156],"structural":[58],"stabilization":[59],"disrupted":[62],"plaque.":[63],"For":[64],"many":[65],"years,":[66],"remained":[69],"primarily":[70],"histopathological":[72],"observation":[73],"described":[74],"in":[75,90,130,187,207],"post-mortem":[76],"studies.":[77],"The":[78],"advent":[79],"high-resolution":[81],"intracoronary":[82,199],"imaging,":[83],"particularly":[84],"optical":[85],"coherence":[86],"tomography,":[87],"has":[88],"enabled":[89],"vivo":[91,208],"visualization":[92],"characteristic":[95],"layered":[96],"morphology":[97],"healed":[99,185],"plaques,":[100],"providing":[101],"direct":[102],"clinical":[103,119,180],"confirmation":[104],"these":[106],"early":[107],"pathological":[108],"findings.":[109],"These":[110],"observations":[111],"have":[112],"significantly":[113],"improved":[114],"our":[115],"understanding":[116],"significance":[120,181],"healing.":[123],"Healed":[124],"plaques":[125,186],"are":[126],"more":[127],"frequently":[128],"observed":[129],"patients":[131],"with":[132],"chronic":[133],"coronary":[134,170,188],"syndromes,":[135],"supporting":[136],"concept":[138],"contributes":[141],"to":[142,159,165],"stabilization.":[144],"At":[145],"same":[147],"time,":[148],"recurrent":[149],"cycles":[150],"followed":[154],"by":[155],"may":[157],"lead":[158],"progressive":[160],"luminal":[161],"narrowing,":[162],"thereby":[163],"contributing":[164],"long-term":[167],"progression":[168],"atherosclerosis.":[171],"review":[173],"provided":[174],"updated":[176],"overview":[177],"implications":[183],"artery":[189],"disease,":[190],"mechanisms":[192],"underlying":[193],"healing,":[195],"examines":[197],"emerging":[198],"non-invasive":[201],"imaging":[202],"modalities":[203],"allow":[205],"their":[206],"identification.":[209]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}