{"id":"https://openalex.org/W7225332883","doi":"https://doi.org/10.3389/fimmu.2026.1897445","title":"Iron promotes M1 polarization of decidual macrophages during parturition via increased TfR1 and TLR4 expression","display_name":"Iron promotes M1 polarization of decidual macrophages during parturition via increased TfR1 and TLR4 expression","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225332883","doi":"https://doi.org/10.3389/fimmu.2026.1897445"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1897445","doi":"https://doi.org/10.3389/fimmu.2026.1897445","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1897445","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1897445/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1897445/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077947470","display_name":"Xiaoying Wang","orcid":"https://orcid.org/0000-0002-1008-9155","observed_orcids":["https://orcid.org/0000-0002-1008-9155","https://orcid.org/0009-0001-0470-2507"]},"institutions":[{"id":"https://openalex.org/I4210122309","display_name":"Fourth Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/02s7c9e98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122309"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaoying Wang","raw_affiliation_strings":["Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210122309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5044133879","display_name":"Wenjia Lan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210156501","display_name":"First Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/05vy2sc54","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210156501"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenjia Lan","raw_affiliation_strings":["Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Clinical Laboratory, The First Affiliated Hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210156501"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109379745","display_name":"Limin Song","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122309","display_name":"Fourth Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/02s7c9e98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122309"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Limin Song","raw_affiliation_strings":["Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210122309"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160981538","display_name":"Xuemei Piao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210122309","display_name":"Fourth Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/02s7c9e98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122309"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xuemei Piao","raw_affiliation_strings":["Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210122309"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5065209768","display_name":"Yan Cai","orcid":"https://orcid.org/0000-0002-7269-7375","observed_orcids":["https://orcid.org/0000-0002-7269-7375"]},"institutions":[{"id":"https://openalex.org/I4210122309","display_name":"Fourth Affiliated Hospital of Harbin Medical University","ror":"https://ror.org/02s7c9e98","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210122309"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yan Cai","raw_affiliation_strings":["Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Obstetrics, The Fourth Affiliated Hospital of Harbin Medical University","institution_ids":["https://openalex.org/I4210122309"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5065209768"],"corresponding_institution_ids":["https://openalex.org/I4210122309"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.6909000277519226,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10452","display_name":"Iron Metabolism and Disorders","score":0.17219999432563782,"subfield":{"id":"https://openalex.org/subfields/2720","display_name":"Hematology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11313","display_name":"Immune cells in cancer","score":0.053599998354911804,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/iron-availability","display_name":"iron availability","score":0.6520000100135803},{"id":"https://openalex.org/keywords/m1-macrophage-polarization","display_name":"M1 macrophage polarization","score":0.9110000133514404},{"id":"https://openalex.org/keywords/childbirth","display_name":"childbirth","score":0.8970000147819519},{"id":"https://openalex.org/keywords/term-labor","display_name":"term labor","score":0.8090000152587891},{"id":"https://openalex.org/keywords/transferrin-receptor-1","display_name":"transferrin receptor 1","score":0.9950000047683716},{"id":"https://openalex.org/keywords/tlr4","display_name":"TLR4","score":0.996999979019165},{"id":"https://openalex.org/keywords/myd88-nf-kappab-signaling","display_name":"MyD88/NF-\u03baB signaling","score":0.9829999804496765},{"id":"https://openalex.org/keywords/maternal-fetal-interface","display_name":"maternal-fetal interface","score":0.8389999866485596},{"id":"https://openalex.org/keywords/dietary-iron-supplementation","display_name":"dietary iron supplementation","score":0.7799999713897705},{"id":"https://openalex.org/keywords/ferric-ammonium-citrate","display_name":"ferric ammonium citrate","score":0.9350000023841858},{"id":"https://openalex.org/keywords/deferoxamine","display_name":"deferoxamine","score":0.996999979019165},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.4690000116825104},{"id":"https://openalex.org/keywords/cd68","display_name":"CD68","score":0.6029999852180481},{"id":"https://openalex.org/keywords/cd86","display_name":"CD86","score":0.902999997138977},{"id":"https://openalex.org/keywords/cd206","display_name":"CD206","score":0.9990000128746033}],"concepts":[{"id":"https://openalex.org/C32264632","wikidata":"https://www.wikidata.org/wiki/Q1134983","display_name":"Transferrin receptor","level":3,"score":0.7610999941825867},{"id":"https://openalex.org/C2776682551","wikidata":"https://www.wikidata.org/wiki/Q21072584","display_name":"Macrophage polarization","level":4,"score":0.7534999847412109},{"id":"https://openalex.org/C2776070231","wikidata":"https://www.wikidata.org/wiki/Q14914098","display_name":"TLR4","level":3,"score":0.6775000095367432},{"id":"https://openalex.org/C2779244956","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"Macrophage","level":3,"score":0.6589999794960022},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.5831999778747559},{"id":"https://openalex.org/C2776710925","wikidata":"https://www.wikidata.org/wiki/Q24777245","display_name":"Ferroportin","level":4,"score":0.5809999704360962},{"id":"https://openalex.org/C2775858924","wikidata":"https://www.wikidata.org/wiki/Q18034009","display_name":"CD163","level":4,"score":0.5672000050544739},{"id":"https://openalex.org/C2776460901","wikidata":"https://www.wikidata.org/wiki/Q21109693","display_name":"CD68","level":3,"score":0.5127000212669373},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.49790000915527344},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.46399998664855957},{"id":"https://openalex.org/C2910375186","wikidata":"https://www.wikidata.org/wiki/Q184204","display_name":"M2 Macrophage","level":4,"score":0.46380001306533813},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.4636000096797943},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.4553999900817871},{"id":"https://openalex.org/C2781107390","wikidata":"https://www.wikidata.org/wiki/Q5249153","display_name":"Decidual cells","level":5,"score":0.45210000872612},{"id":"https://openalex.org/C2776672577","wikidata":"https://www.wikidata.org/wiki/Q419618","display_name":"Deferoxamine","level":2,"score":0.3700000047683716},{"id":"https://openalex.org/C2780197806","wikidata":"https://www.wikidata.org/wiki/Q2531387","display_name":"Decidua","level":5,"score":0.35839998722076416},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.3517000079154968},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3239000141620636},{"id":"https://openalex.org/C16685009","wikidata":"https://www.wikidata.org/wiki/Q335057","display_name":"Andrology","level":1,"score":0.31470000743865967},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.31380000710487366},{"id":"https://openalex.org/C22814914","wikidata":"https://www.wikidata.org/wiki/Q410473","display_name":"Transferrin","level":2,"score":0.30720001459121704},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.30559998750686646},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.3003000020980835},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.2985999882221222},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.29170000553131104},{"id":"https://openalex.org/C2776953305","wikidata":"https://www.wikidata.org/wiki/Q1212935","display_name":"Placenta","level":4,"score":0.28859999775886536},{"id":"https://openalex.org/C50442881","wikidata":"https://www.wikidata.org/wiki/Q426626","display_name":"Macrophage colony-stimulating factor","level":4,"score":0.287200003862381},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.27889999747276306},{"id":"https://openalex.org/C187316574","wikidata":"https://www.wikidata.org/wiki/Q423698","display_name":"Interleukin 10","level":3,"score":0.27570000290870667},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2743000090122223},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.271699994802475},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.25920000672340393},{"id":"https://openalex.org/C2780534640","wikidata":"https://www.wikidata.org/wiki/Q3233795","display_name":"Ferric","level":2,"score":0.2587999999523163},{"id":"https://openalex.org/C11988809","wikidata":"https://www.wikidata.org/wiki/Q412889","display_name":"Interleukin 6","level":3,"score":0.25209999084472656}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1897445","doi":"https://doi.org/10.3389/fimmu.2026.1897445","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1897445","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1897445/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:f187b2c488c64195b3f610be4e1a1cdb","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/f187b2c488c64195b3f610be4e1a1cdb","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1897445","doi":"https://doi.org/10.3389/fimmu.2026.1897445","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1897445","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1897445/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225332883.pdf","grobid_xml":"https://content.openalex.org/works/W7225332883.grobid-xml"},"referenced_works_count":15,"referenced_works":["https://openalex.org/W1996613264","https://openalex.org/W2057724677","https://openalex.org/W2071987245","https://openalex.org/W2165892104","https://openalex.org/W2999536522","https://openalex.org/W3091956488","https://openalex.org/W3121129246","https://openalex.org/W3214157627","https://openalex.org/W4407071862","https://openalex.org/W4408147299","https://openalex.org/W4409690326","https://openalex.org/W4411420793","https://openalex.org/W4412170483","https://openalex.org/W4415697874","https://openalex.org/W7140845323"],"related_works":["https://openalex.org/W2072116531","https://openalex.org/W4411575980","https://openalex.org/W2804763780","https://openalex.org/W2792465177","https://openalex.org/W2165347529","https://openalex.org/W7167684913","https://openalex.org/W610500836","https://openalex.org/W2167399827","https://openalex.org/W2588576443","https://openalex.org/W2196312800"],"abstract_inverted_index":{"Introduction":[0],"Decidual":[1],"macrophages":[2],"participate":[3],"in":[4,75,194,200],"the":[5,12,23,34,49,103,262,311,322,332],"inflammatory":[6,20,216,233,240,300],"processes":[7],"associated":[8,182],"with":[9,142,183,251],"parturition.":[10],"However,":[11],"potential":[13,50,137,253,312],"relationship":[14,104,255],"between":[15,36,105,256,314],"iron":[16,37,82,95,106,123,152,179,269,294,315],"availability":[17,295,316],"and":[18,39,46,72,87,89,111,125,130,159,171,190,215,232,258,277,289,317],"macrophage":[19,41,84,109,165,188,213,239,275,299],"regulation":[21],"at":[22,68,114,321],"maternal\u2013fetal":[24,323],"interface":[25],"remains":[26],"incompletely":[27],"understood.":[28],"This":[29],"study":[30],"aimed":[31],"to":[32,47,101,134,298,330],"investigate":[33,135],"association":[35],"status":[38],"decidual":[40,63,108,146,195,268],"phenotypes":[42,214],"during":[43,284,338],"term":[44,69,73,285],"labor":[45,70,76,115],"explore":[48],"involvement":[51],"of":[52,128,186,273,335],"transferrin":[53],"receptor":[54,57],"1":[55],"(TfR1)/Toll-like":[56],"4":[58],"(TLR4)-associated":[59],"signaling.":[60,305],"Methods":[61],"Human":[62],"tissues":[64,147],"obtained":[65],"from":[66],"women":[67],"(TL)":[71],"not":[74],"(TNL)":[77],"were":[78,132,181,281],"analyzed":[79],"for":[80],"total":[81,151],"content,":[83,153,270],"phenotypic":[85],"markers,":[86,276],"TfR1":[88,129,170,225,245,257],"TLR4":[90,131,172,228,236],"expression.":[91,173,246],"A":[92],"graded":[93],"dietary":[94,178],"supplementation":[96],"mouse":[97],"model":[98],"was":[99],"used":[100],"examine":[102],"availability,":[107],"phenotypes,":[110],"TfR1/TLR4":[112,192,279],"expression":[113,185,193,272,280],"onset.":[116],"In":[117,174,204],"vitro":[118,205],"experiments":[119,291],"using":[120],"RAW264.7":[121],"macrophages,":[122],"manipulation,":[124],"siRNA-mediated":[126],"knockdown":[127,226,237],"performed":[133],"their":[136],"regulatory":[138,254],"relationships.":[139],"Results":[140],"Compared":[141],"TNL":[143],"tissues,":[144,196],"TL":[145],"exhibited":[148],"significantly":[149,243],"higher":[150],"increased":[154,191],"CD68":[155,161],"+":[156,158,162,164],"CD86":[157],"decreased":[160],"CD206":[163],"populations,":[166],"accompanied":[167],"by":[168],"enhanced":[169,211,271],"pregnant":[175],"mice,":[176],"increasing":[177],"concentrations":[180],"greater":[184],"M1-associated":[187,212,274],"markers":[189],"without":[197,242],"significant":[198],"changes":[199],"maternal":[201],"hematological":[202],"parameters.":[203],",":[206],"ferric":[207],"ammonium":[208],"citrate":[209],"(FAC)":[210],"cytokine":[217],"expression,":[218,229],"whereas":[219],"deferoxamine":[220],"(DFO)":[221],"attenuated":[222,238],"these":[223],"responses.":[224,234],"reduced":[227],"MyD88/NF-\u03baB-associated":[230],"signaling,":[231],"Conversely,":[235],"activation":[241],"altering":[244],"These":[247,306],"findings":[248,307],"are":[249,328],"consistent":[250],"a":[252],"TLR4-associated":[259],"signaling":[260],"under":[261],"experimental":[263],"conditions":[264],"examined.":[265],"Discussion":[266],"Increased":[267],"elevated":[278],"observed":[282],"concomitantly":[283],"labor.":[286,340],"Complementary":[287],"animal":[288],"cell":[290],"suggest":[292],"that":[293],"may":[296],"contribute":[297],"regulation,":[301],"potentially":[302],"involving":[303],"TfR1/TLR4/MyD88/NF-\u03baB-associated":[304],"provide":[308],"insights":[309],"into":[310],"interplay":[313],"innate":[318],"immune":[319],"responses":[320],"interface,":[324],"although":[325],"further":[326],"studies":[327],"needed":[329],"establish":[331],"physiological":[333],"relevance":[334],"this":[336],"mechanism":[337],"human":[339]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}