{"id":"https://openalex.org/W7225329616","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","title":"577 Biopsy-associated tumor regression in late relapsed DLBCL after tandem CD20-CD19 CAR-T cell therapy","display_name":"577 Biopsy-associated tumor regression in late relapsed DLBCL after tandem CD20-CD19 CAR-T cell therapy","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225329616","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0577"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0577","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A649.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A649.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036472187","display_name":"Kevin M. Christmas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Kevin M Christmas","raw_affiliation_strings":["Miltenyi Biomedicine, Boston, MA, USA","Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miltenyi Biomedicine, Boston, MA, USA","institution_ids":[]},{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033267586","display_name":"Mrs. Madhavi Nallewar","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Madhavi Nallewar","raw_affiliation_strings":["Miltenyi Biomedicine, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Miltenyi Biomedicine, Boston, MA, USA","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5010753718","display_name":"Levanto Gershon Schachter","orcid":"https://orcid.org/0000-0002-4680-7411","observed_orcids":["https://orcid.org/0000-0002-4680-7411"]},"institutions":[{"id":"https://openalex.org/I161318765","display_name":"University of California, Los Angeles","ror":"https://ror.org/046rm7j60","country_code":"US","type":"education","lineage":["https://openalex.org/I161318765"]},{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Levanto G Schachter","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR, USA","UCLA, Los Angeles, CA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]},{"raw_affiliation_string":"UCLA, Los Angeles, CA, USA","institution_ids":["https://openalex.org/I161318765"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5082092102","display_name":"Richard Thomas Maziarz","orcid":"https://orcid.org/0000-0002-8184-7099","observed_orcids":["https://orcid.org/0000-0002-8184-7099"]},"institutions":[{"id":"https://openalex.org/I165690674","display_name":"Oregon Health & Science University","ror":"https://ror.org/009avj582","country_code":"US","type":"education","lineage":["https://openalex.org/I165690674"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Richard T Maziarz","raw_affiliation_strings":["Oregon Health & Science University, Portland, OR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Oregon Health & Science University, Portland, OR, USA","institution_ids":["https://openalex.org/I165690674"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A649","last_page":"A649"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11491","display_name":"CAR-T cell therapy research","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10185","display_name":"Lymphoma Diagnosis and Treatment","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2734","display_name":"Pathology and Forensic Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/diffuse-large-b-cell-lymphoma","display_name":"diffuse large B-cell lymphoma","score":0.906000018119812},{"id":"https://openalex.org/keywords/relapsed-refractory-lymphoma","display_name":"relapsed/refractory lymphoma","score":0.9520000219345093},{"id":"https://openalex.org/keywords/car-t-cell-therapy","display_name":"CAR T-cell therapy","score":0.8730000257492065},{"id":"https://openalex.org/keywords/core-needle-biopsy","display_name":"core needle biopsy","score":0.6779999732971191},{"id":"https://openalex.org/keywords/complete-metabolic-response","display_name":"complete metabolic response","score":0.7379999756813049},{"id":"https://openalex.org/keywords/salvage-radiotherapy","display_name":"salvage radiotherapy","score":0.5090000033378601},{"id":"https://openalex.org/keywords/immune-reconstitution","display_name":"immune reconstitution","score":0.6140000224113464},{"id":"https://openalex.org/keywords/germinal-center-b-cell-dlbcl","display_name":"germinal center B-cell DLBCL","score":0.6629999876022339}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9126999974250793},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.5220999717712402},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.48890000581741333},{"id":"https://openalex.org/C2780775027","wikidata":"https://www.wikidata.org/wiki/Q17141389","display_name":"Salvage therapy","level":3,"score":0.46889999508857727},{"id":"https://openalex.org/C2779338263","wikidata":"https://www.wikidata.org/wiki/Q208414","display_name":"Lymphoma","level":2,"score":0.45339998602867126},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.4242999851703644},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.41929998993873596},{"id":"https://openalex.org/C196166836","wikidata":"https://www.wikidata.org/wiki/Q902926","display_name":"Immunophenotyping","level":3,"score":0.4115000069141388},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.38109999895095825},{"id":"https://openalex.org/C126838900","wikidata":"https://www.wikidata.org/wiki/Q77604","display_name":"Radiology","level":1,"score":0.3718000054359436},{"id":"https://openalex.org/C3019914693","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Core biopsy","level":4,"score":0.35920000076293945},{"id":"https://openalex.org/C2780653079","wikidata":"https://www.wikidata.org/wiki/Q412323","display_name":"Rituximab","level":3,"score":0.34700000286102295},{"id":"https://openalex.org/C18031839","wikidata":"https://www.wikidata.org/wiki/Q5009796","display_name":"CD20","level":3,"score":0.335099995136261},{"id":"https://openalex.org/C2778559949","wikidata":"https://www.wikidata.org/wiki/Q2626074","display_name":"Diffuse large B-cell lymphoma","level":3,"score":0.31690001487731934},{"id":"https://openalex.org/C509974204","wikidata":"https://www.wikidata.org/wiki/Q180507","display_name":"Radiation therapy","level":2,"score":0.3154999911785126},{"id":"https://openalex.org/C2776755627","wikidata":"https://www.wikidata.org/wiki/Q408524","display_name":"Cyclophosphamide","level":3,"score":0.2994000017642975},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.28679999709129333},{"id":"https://openalex.org/C2778720950","wikidata":"https://www.wikidata.org/wiki/Q424972","display_name":"Prednisone","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C3019096185","wikidata":"https://www.wikidata.org/wiki/Q1340863","display_name":"Complete response","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.27149999141693115},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.27129998803138733},{"id":"https://openalex.org/C2911194787","wikidata":"https://www.wikidata.org/wiki/Q5099363","display_name":"CAR T-cell therapy","level":5,"score":0.2662000060081482},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.26269999146461487},{"id":"https://openalex.org/C2779675984","wikidata":"https://www.wikidata.org/wiki/Q23671272","display_name":"Venetoclax","level":4,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0577","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A649.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0577","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0577","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A649.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":1.0,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":false},"content_urls":{"pdf":"https://content.openalex.org/works/W7225329616.pdf"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3175073311","https://openalex.org/W4324130422","https://openalex.org/W4214870439","https://openalex.org/W3208806702","https://openalex.org/W4380077847","https://openalex.org/W7138887442","https://openalex.org/W4411102870","https://openalex.org/W2792332511","https://openalex.org/W4308687186","https://openalex.org/W4401362405"],"abstract_inverted_index":{"Background":[0],"CAR":[1,38,70,352,363,389],"T-cell":[2],"therapy":[3,27,178],"revolutionized":[4],"relapsed/refractory":[5],"(r/r)":[6],"diffuse":[7],"large":[8],"B-cell":[9,218],"lymphoma":[10],"(DLBCL)":[11],"treatment,":[12],"yet":[13],"40\u201350%":[14],"of":[15,55,67,161,187,258,270,304,348,361,375,382,387],"patients":[16],"progress.":[17],"Clinical":[18],"responses":[19,378],"can":[20,45],"be":[21,46],"delayed,":[22],"such":[23],"that":[24,132],"standard-of-care":[25],"salvage":[26,177,259,383],"is":[28,53,98],"administered":[29,114],"before":[30],"immunological":[31],"maximum":[32],"benefit,":[33],"generally":[34],"seen":[35],"early":[36],"after":[37,65,92],"T":[39,71,324,353,364,390],"therapy.":[40,384],"Isolated":[41],"late":[42,322],"solitary":[43],"relapse":[44],"challenging":[47],"regarding":[48],"optimal":[49],"management.":[50],"A":[51,73],"case":[52,311,371],"presented":[54],"complete":[56],"metabolic":[57],"response":[58,202],"following":[59],"core":[60,167],"needle":[61,168],"biopsy":[62,169,213],">18":[63],"months":[64,199,250],"infusion":[66],"tandem":[68],"CD20-CD19":[69],"therapy.Methods":[72],"59-year-old":[74],"female":[75],"with":[76,109,159,300,379],"r/r":[77],"DLBCL":[78,219],"(IPI:":[79],"stage":[80],"4;":[81],"high":[82],"tumor":[83,317],"volume)":[84],"received":[85],"zamtocabtagene":[86],"autoleucel":[87],"(zamto-cel)":[88],"in":[89,267,320],"third":[90],"line":[91],"failing":[93],"R-CHOP/R-ICE":[94],"(":[95],"NCT04792489).":[96],"Zamto-cel":[97],"manufactured":[99],"using":[100],"CliniMACS":[101],"Prodigy\u00ae":[102],"(Miltenyi":[103],"Biotec),":[104],"a":[105,116,152,185,264,313],"closed,":[106],"automated":[107],"system":[108],"14-day":[110],"vein-to-vein":[111],"time":[112],"and":[113,197,231,246,278,341],"as":[115],"fresh":[117],"formulation.":[118],"Lymphodepletion":[119],"chemotherapy":[120],"was":[121,142,192,223,276],"initiated":[122],"during":[123],"the":[124,256,268,282,321,373],"manufacturing":[125],"process.":[126],"Day":[127],"30":[128],"evaluation":[129],"revealed":[130,240],"CMR":[131,285],"persisted":[133],"through":[134],"year":[135,238],"1":[136,239],"when":[137],"an":[138],"isolated":[139],"retrocaval":[140],"signal":[141],"observed":[143],"at":[144,171,194,207,237,307],"month":[145,172,211,280,308],"14":[146],"(Deauville":[147,163,286],"4/X;":[148],"SUVmax:":[149,165],"5.6)":[150],"suggesting":[151],"sanctuary":[153],"relapse.":[154],"Participant":[155],"followed":[156],"expectantly,":[157],"but":[158],"evidence":[160,303],"progression,":[162],"5;":[164],"16.8)":[166],"performed":[170,193],"19":[173],"confirmed":[174,214,316],"progression.":[175],"Subsequent":[176],"deferred":[179],"due":[180],"to":[181,200,255,367],"patient":[182,298],"preference,":[183],"creating":[184],"window":[186],"observation.":[188],"Serial":[189],"PET/CT":[190],"imaging":[191,205,262],"21,":[195],"25":[196],"36":[198],"assess":[201],"kinetics,":[203],"CT":[204],"obtained":[206],"48":[208],"months.Results":[209],"At":[210],"19,":[212],"recurrent":[215],"germinal":[216],"center":[217],"(Ki-67":[220],"80%).":[221],"Immunophenotype":[222],"CD20":[224],"+,":[225],"variable":[226],"CD19,":[227],"CD10+,":[228],"CD79a+,":[229],"BCL6+,":[230],"BCL2+":[232],"expression.":[233],"Immune":[234],"reconstitution":[235,357],"studies":[236],"total":[241],"CD3:":[242],"562/uL,":[243],"CD4:":[244],"358/uL":[245],"B-cell:":[247],"73/uL.":[248],"Two":[249],"post-biopsy":[251],"(month":[252],"21),":[253],"prior":[254],"onset":[257],"XRT,":[260],"PET":[261],"demonstrated":[263],"38%":[265],"decrease":[266],"sum":[269],"product":[271],"diameters":[272],"(SPD).":[273],"Continued":[274],"observation":[275],"elected":[277],"by":[279],"25,":[281],"participant":[283],"achieved":[284],"1\u20132)":[287],"across":[288],"all":[289],"sites":[290],"without":[291],"chemotherapy,":[292],"radiation,":[293],"or":[294,328],"other":[295],"immunotherapies.":[296],"The":[297],"remains":[299],"no":[301],"clinical":[302,368],"active":[305],"disease":[306],"48.Conclusions":[309],"This":[310,370],"demonstrates":[312],"rare":[314],"biopsy-induced,":[315],"site":[318],"regression":[319],"post-CAR":[323],"setting.":[325],"No":[326],"local":[327],"systemic":[329],"therapies":[330],"were":[331],"administered.":[332],"Localized":[333],"tissue":[334],"injury,":[335],"via":[336],"damage-associated":[337],"molecular":[338],"patterns":[339],"(DAMPs)":[340],"pro-inflammatory":[342],"cytokines,":[343],"may":[344,392],"trigger":[345],"delayed":[346,388],"reactivation":[347,391],"exhausted,":[349],"previously":[350],"trafficked":[351],"cells.":[354],"Late-stage":[355],"immune":[356],"and/or":[358],"functional":[359],"activation":[360],"residual":[362],"cells":[365],"contributed":[366],"response.":[369],"highlights":[372],"possibility":[374],"preempting":[376],"spontaneous":[377],"immediate":[380],"application":[381],"Identifying":[385],"signals":[386],"eliminate":[393],"need":[394],"for":[395],"subsequent":[396],"treatments.":[397]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}