{"id":"https://openalex.org/W7225329487","doi":"https://doi.org/10.3389/fphar.2026.1928236","title":"Neurological adverse events associated with immune checkpoint inhibitors: a pharmacovigilance study based on the FAERS and JADER databases","display_name":"Neurological adverse events associated with immune checkpoint inhibitors: a pharmacovigilance study based on the FAERS and JADER databases","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225329487","doi":"https://doi.org/10.3389/fphar.2026.1928236"},"language":"en","primary_location":{"id":"doi:10.3389/fphar.2026.1928236","doi":"https://doi.org/10.3389/fphar.2026.1928236","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1928236","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928236/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928236/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124439738","display_name":"Huilin Luo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huilin Luo","raw_affiliation_strings":["Department of Anesthesiology, Guangxi Medical University Cancer Hospital","Guangxi Clinical Research Center for Anesthesiology","Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Guangxi Medical University Cancer Hospital","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Guangxi Clinical Research Center for Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","institution_ids":[]},{"raw_affiliation_string":"Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160578929","display_name":"Xie Xianlong","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xianlong Xie","raw_affiliation_strings":["Department of Anesthesiology, Guangxi Medical University Cancer Hospital","Guangxi Clinical Research Center for Anesthesiology","Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Guangxi Medical University Cancer Hospital","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Guangxi Clinical Research Center for Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","institution_ids":[]},{"raw_affiliation_string":"Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114122461","display_name":"Shiran Qin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210115919","display_name":"The People's Hospital of Guangxi Zhuang Autonomous Region","ror":"https://ror.org/02aa8kj12","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210115919"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiran Qin","raw_affiliation_strings":["Department of Pharmacy, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacy, The People\u2019s Hospital of Guangxi Zhuang Autonomous Region","institution_ids":["https://openalex.org/I4210115919"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033857582","display_name":"Linghui Pan","orcid":"https://orcid.org/0000-0002-3379-6549","observed_orcids":["https://orcid.org/0000-0002-3379-6549"]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Linghui Pan","raw_affiliation_strings":["Department of Anesthesiology, Guangxi Medical University Cancer Hospital","Guangxi Clinical Research Center for Anesthesiology","Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Guangxi Medical University Cancer Hospital","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Guangxi Clinical Research Center for Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","institution_ids":[]},{"raw_affiliation_string":"Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5158683742","display_name":"Liu Ye","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I160354086","display_name":"Guangxi Medical University","ror":"https://ror.org/03dveyr97","country_code":"CN","type":"education","lineage":["https://openalex.org/I160354086"]},{"id":"https://openalex.org/I4210155683","display_name":"Tumor Hospital of Guangxi Medical University","ror":"https://ror.org/051mn8706","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210155683"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Liu Ye","raw_affiliation_strings":["Department of Anesthesiology, Guangxi Medical University Cancer Hospital","Guangxi Clinical Research Center for Anesthesiology","Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Guangxi Medical University Cancer Hospital","institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"]},{"raw_affiliation_string":"Guangxi Clinical Research Center for Anesthesiology","institution_ids":[]},{"raw_affiliation_string":"Guangxi Engineering Research Center for Tissue & Organ Injury and Repair Medicine","institution_ids":[]},{"raw_affiliation_string":"Guangxi Health Commission Key Laboratory of Basic Science and Prevention of Perioperative Organ Disfunction","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5033857582","https://openalex.org/A5158683742"],"corresponding_institution_ids":["https://openalex.org/I160354086","https://openalex.org/I4210155683"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11943","display_name":"Pharmacovigilance and Adverse Drug Reactions","score":0.7939000129699707,"subfield":{"id":"https://openalex.org/subfields/3005","display_name":"Toxicology"},"field":{"id":"https://openalex.org/fields/30","display_name":"Pharmacology, Toxicology and Pharmaceutics"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.20260000228881836,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11235","display_name":"Statistical Methods in Clinical Trials","score":0.00019999999494757503,"subfield":{"id":"https://openalex.org/subfields/2613","display_name":"Statistics and Probability"},"field":{"id":"https://openalex.org/fields/26","display_name":"Mathematics"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.9800000190734863},{"id":"https://openalex.org/keywords/neurological-adverse-events","display_name":"neurological adverse events","score":0.996999979019165},{"id":"https://openalex.org/keywords/myasthenia-gravis","display_name":"myasthenia gravis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/encephalitis","display_name":"encephalitis","score":0.8859999775886536},{"id":"https://openalex.org/keywords/immune-mediated-myositis","display_name":"immune-mediated myositis","score":0.9800000190734863},{"id":"https://openalex.org/keywords/pd-1-inhibitors","display_name":"PD-1 inhibitors","score":0.847000002861023},{"id":"https://openalex.org/keywords/pd-l1-inhibitors","display_name":"PD-L1 inhibitors","score":0.9980000257492065},{"id":"https://openalex.org/keywords/ctla-4-inhibitors","display_name":"CTLA-4 inhibitors","score":0.9599999785423279},{"id":"https://openalex.org/keywords/cemiplimab","display_name":"cemiplimab","score":0.8769999742507935},{"id":"https://openalex.org/keywords/time-to-onset","display_name":"time to onset","score":0.6610000133514404},{"id":"https://openalex.org/keywords/adverse-drug-reaction-reporting","display_name":"adverse drug reaction reporting","score":0.47600001096725464},{"id":"https://openalex.org/keywords/drug-safety-signals","display_name":"drug safety signals","score":0.503000020980835},{"id":"https://openalex.org/keywords/immunotherapy-adverse-events","display_name":"immunotherapy adverse events","score":0.5529999732971191},{"id":"https://openalex.org/keywords/fda-adverse-event-reporting-system","display_name":"FDA Adverse Event Reporting System","score":0.7099999785423279},{"id":"https://openalex.org/keywords/jader","display_name":"JADER","score":0.8450000286102295},{"id":"https://openalex.org/keywords/disproportionality-analysis","display_name":"disproportionality analysis","score":0.5899999737739563}],"concepts":[{"id":"https://openalex.org/C57658597","wikidata":"https://www.wikidata.org/wiki/Q1550789","display_name":"Pharmacovigilance","level":3,"score":0.9150000214576721},{"id":"https://openalex.org/C2777105317","wikidata":"https://www.wikidata.org/wiki/Q4686710","display_name":"Adverse Event Reporting System","level":3,"score":0.8037999868392944},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8021000027656555},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.7190999984741211},{"id":"https://openalex.org/C199475168","wikidata":"https://www.wikidata.org/wiki/Q1539689","display_name":"MedDRA","level":4,"score":0.6351000070571899},{"id":"https://openalex.org/C156957248","wikidata":"https://www.wikidata.org/wiki/Q1862216","display_name":"Odds ratio","level":2,"score":0.6337000131607056},{"id":"https://openalex.org/C151956035","wikidata":"https://www.wikidata.org/wiki/Q1132755","display_name":"Logistic regression","level":2,"score":0.5210999846458435},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.47530001401901245},{"id":"https://openalex.org/C44249647","wikidata":"https://www.wikidata.org/wiki/Q208498","display_name":"Confidence interval","level":2,"score":0.4618000090122223},{"id":"https://openalex.org/C77088390","wikidata":"https://www.wikidata.org/wiki/Q8513","display_name":"Database","level":1,"score":0.40130001306533813},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.37770000100135803},{"id":"https://openalex.org/C2778105408","wikidata":"https://www.wikidata.org/wiki/Q8285","display_name":"Myasthenia gravis","level":2,"score":0.35339999198913574},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.31529998779296875},{"id":"https://openalex.org/C2781433595","wikidata":"https://www.wikidata.org/wiki/Q2459042","display_name":"Ipilimumab","level":4,"score":0.3046000003814697},{"id":"https://openalex.org/C143095724","wikidata":"https://www.wikidata.org/wiki/Q515895","display_name":"Odds","level":3,"score":0.2863999903202057},{"id":"https://openalex.org/C67761136","wikidata":"https://www.wikidata.org/wiki/Q2105849","display_name":"Post-hoc analysis","level":2,"score":0.2786000072956085},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fphar.2026.1928236","doi":"https://doi.org/10.3389/fphar.2026.1928236","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1928236","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928236/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:d04e28b011c14009952a30d06677b341","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/d04e28b011c14009952a30d06677b341","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Pharmacology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fphar.2026.1928236","doi":"https://doi.org/10.3389/fphar.2026.1928236","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fphar.2026.1928236","pdf_url":"https://www.frontiersin.org/journals/pharmacology/articles/10.3389/fphar.2026.1928236/pdf","source":{"id":"https://openalex.org/S132108250","display_name":"Frontiers in Pharmacology","issn_l":"1663-9812","issn":["1663-9812"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Pharmacology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[{"id":"https://openalex.org/F4320313613","display_name":"Natural Science Foundation of Guangxi Zhuang Autonomous Region","ror":null}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225329487.pdf","grobid_xml":"https://content.openalex.org/works/W7225329487.grobid-xml"},"referenced_works_count":41,"referenced_works":["https://openalex.org/W1528517702","https://openalex.org/W1988100739","https://openalex.org/W2015487160","https://openalex.org/W2064716383","https://openalex.org/W2074289946","https://openalex.org/W2096721022","https://openalex.org/W2107516065","https://openalex.org/W2113514677","https://openalex.org/W2532352313","https://openalex.org/W2736166064","https://openalex.org/W2783137027","https://openalex.org/W2786816161","https://openalex.org/W2791483720","https://openalex.org/W2887577080","https://openalex.org/W2899240190","https://openalex.org/W2902131045","https://openalex.org/W2921962307","https://openalex.org/W2956028371","https://openalex.org/W2995674745","https://openalex.org/W3109803741","https://openalex.org/W3132809852","https://openalex.org/W3134562413","https://openalex.org/W3173954641","https://openalex.org/W3184368361","https://openalex.org/W4224264528","https://openalex.org/W4288041492","https://openalex.org/W4386369601","https://openalex.org/W4388130338","https://openalex.org/W4389657646","https://openalex.org/W4394806058","https://openalex.org/W4400788053","https://openalex.org/W4403292765","https://openalex.org/W4409391283","https://openalex.org/W4412856372","https://openalex.org/W4414376285","https://openalex.org/W4414444267","https://openalex.org/W4417036159","https://openalex.org/W7119857288","https://openalex.org/W7128444120","https://openalex.org/W7140512638","https://openalex.org/W7160059031"],"related_works":["https://openalex.org/W2970138558","https://openalex.org/W4412856372","https://openalex.org/W4389460401","https://openalex.org/W3120804503","https://openalex.org/W7140512638","https://openalex.org/W7204457059","https://openalex.org/W2947945944","https://openalex.org/W3082287626","https://openalex.org/W4220988176","https://openalex.org/W7169870311"],"abstract_inverted_index":{"Background":[0],"Neurological":[1],"adverse":[2],"events":[3],"(NAEs)":[4],"have":[5],"been":[6],"reported":[7],"during":[8],"immune":[9],"checkpoint":[10],"inhibitor":[11],"(ICI)":[12],"therapy,":[13],"but":[14],"their":[15],"reporting":[16,83,221,234,304],"spectrum":[17],"and":[18,23,46,90,94,102,125,141,162,175,198,213,259,273,282,294,296,317,319,330],"onset":[19,298],"patterns":[20,182,270,299],"across":[21,136,143,271,300],"drugs":[22,272],"pharmacovigilance":[24,33],"databases":[25],"remain":[26],"incompletely":[27],"characterized.":[28],"Methods":[29],"We":[30],"conducted":[31],"a":[32,151],"study":[34],"of":[35,113,208],"seven":[36,156],"ICIs":[37,157,166],"using":[38,62,99],"the":[39,47,169],"FDA":[40],"Adverse":[41,49],"Event":[42,51],"Reporting":[43],"System":[44],"(FAERS)":[45],"Japanese":[48],"Drug":[50],"Report":[52],"(JADER)":[53],"database.":[54],"Primary":[55],"drug\u2013preferred":[56],"term":[57],"(PT)":[58],"signals":[59],"were":[60,84,108,202,216],"evaluated":[61],"whole-database":[63],"disproportionality":[64,152],"analyses.":[65,104],"An":[66],"exploratory":[67],"FAERS":[68,87,124,140,160,258,292],"analysis":[69,118],"compared":[70],"PD-L1":[71,212,237],"with":[72,81,192,204,218,267,324],"PD-1":[73,225,239],"inhibitors":[74],"within":[75],"study-defined":[76],"tumor-indicator":[77],"strata.":[78],"Factors":[79],"associated":[80,203,217],"NAE":[82,121,209],"assessed":[85],"in":[86,139,146,158,168,240,257,265,322],"by":[88],"univariate":[89],"multivariable":[91],"logistic":[92],"regression,":[93],"time-to-onset":[95],"(TTO)":[96],"was":[97],"summarized":[98,109],"descriptive":[100,316],"statistics":[101],"Weibull":[103,269],"JADER":[105,170],"cemiplimab":[106],"data":[107],"descriptively":[110],"only":[111],"because":[112],"sparse":[114],"reporting.":[115],"Results":[116],"The":[117,129,227,302],"included":[119,167,188,246],"3,915":[120],"reports":[122,161,191,278,293],"from":[123,127,252,260],"2,929":[126],"JADER.":[128,147],"heatmaps":[130],"displayed":[131],"111":[132],"positive":[133],"drug\u2013PT":[134],"pairs":[135],"31":[137],"PTs":[138,145],"49":[142],"16":[144,253,261],"Myasthenia":[148],"gravis":[149,233],"showed":[150,230,279],"signal":[153,171],"for":[154,163,236],"all":[155,164],"non-Japanese":[159,291],"six":[165],"analysis;":[172],"encephalitis-related":[173],"terms":[174],"immune-mediated":[176],"myositis":[177],"also":[178],"recurred,":[179],"although":[180],"drug-specific":[181],"varied.":[183],"In":[184],"FAERS,":[185],"complete-case":[186],"regression":[187],"111,879":[189],"ICI-related":[190],"2,887":[193],"NAEs.":[194],"Age":[195],"\u226565":[196],"years":[197],"ICI":[199],"combination":[200],"therapy":[201],"higher":[205],"adjusted":[206,220],"odds":[207,222,235],"reporting,":[210],"whereas":[211],"CTLA-4":[214],"monotherapy":[215],"lower":[219,231],"relative":[223],"to":[224,254,262],"monotherapy.":[226],"stratified":[228],"comparison":[229],"myasthenia":[232],"than":[238],"both":[241],"strata;":[242],"encephalitis":[243],"confidence":[244],"intervals":[245],"1.":[247],"Drug-level":[248],"median":[249],"TTOs":[250],"ranged":[251],"43":[255],"days":[256,264],"32":[263],"JADER,":[266,295],"heterogeneous":[268,297],"databases.":[274],"Conclusion":[275],"ICI-associated":[276],"neurological":[277],"recurring":[280],"neuromuscular":[281],"central":[283],"nervous":[284],"system":[285],"signals,":[286],"partial":[287],"qualitative":[288],"concordance":[289],"between":[290],"drugs.":[301],"observed":[303],"associations":[305],"do":[306],"not":[307],"establish":[308],"comparative":[309],"clinical":[310],"safety.":[311],"Overall,":[312],"these":[313],"findings":[314],"are":[315],"hypothesis-generating":[318],"warrant":[320],"confirmation":[321],"studies":[323],"exposure":[325],"denominators,":[326],"clinically":[327],"adjudicated":[328],"diagnoses,":[329],"longitudinal":[331],"follow-up.":[332]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}