{"id":"https://openalex.org/W7225329339","doi":"https://doi.org/10.6084/m9.figshare.34922501","title":"Plain language summary: comparing ivonescimab plus chemotherapy with placebo plus chemotherapy in people with advanced EGFR-mutated non\u2013small cell lung cancer (NSCLC) whose disease worsened on EGFR-TKI treatment in the HARMONi study","display_name":"Plain language summary: comparing ivonescimab plus chemotherapy with placebo plus chemotherapy in people with advanced EGFR-mutated non\u2013small cell lung cancer (NSCLC) whose disease worsened on EGFR-TKI treatment in the HARMONi study","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225329339","doi":"https://doi.org/10.6084/m9.figshare.34922501"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.34922501","doi":"https://doi.org/10.6084/m9.figshare.34922501","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922501","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},"volume":null,"type":"other","is_traditional":false,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34922501","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5007462622","display_name":"Xiuning Le","orcid":"https://orcid.org/0000-0002-8554-1185","observed_orcids":["https://orcid.org/0000-0002-8554-1185","https://orcid.org/0009-0003-5164-3567"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiuning Le","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033247793","display_name":"Antonio Passaro","orcid":"https://orcid.org/0000-0002-7575-3870","observed_orcids":["https://orcid.org/0000-0002-7575-3870"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Passaro","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160781638","display_name":"Yuanyuan Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuanyuan Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160885581","display_name":"Yan Huang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yan Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160962433","display_name":"Janessa Laskin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Janessa Laskin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5055964030","display_name":"Delvys Rodr\u00edguez\u2010Abreu","orcid":"https://orcid.org/0000-0003-0506-1366","observed_orcids":["https://orcid.org/0000-0003-0506-1366"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Delvys Rodriguez-Abreu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158562740","display_name":"Antonio Calles","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Antonio Calles","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5157712311","display_name":"Lyudmila Bazhenova","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Lyudmila Bazhenova","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160784328","display_name":"Giuseppe Lo Russo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Giuseppe Lo Russo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160954914","display_name":"Natasha B. Leighl","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Natasha B. Leighl","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122012297","display_name":"Federico Cappuzzo","orcid":"https://orcid.org/0000-0002-6295-6767","observed_orcids":["https://orcid.org/0000-0002-6295-6767"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Federico Cappuzzo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084513212","display_name":"Nicolas Girard","orcid":"https://orcid.org/0000-0002-7636-6688","observed_orcids":["https://orcid.org/0000-0002-7636-6688"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Nicolas Girard","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5048231332","display_name":"Sanjay Popat","orcid":"https://orcid.org/0000-0003-2087-4963","observed_orcids":["https://orcid.org/0000-0003-2087-4963"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Sanjay Popat","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160751647","display_name":"Wenfeng Fang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Wenfeng Fang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160920640","display_name":"Yongzhong Luo","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yongzhong Luo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5122247142","display_name":"Zhiyong He","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiyong He","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160754220","display_name":"Hui Zhao","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hui Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160916827","display_name":"Mingjun Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Mingjun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102201896","display_name":"Qibin Song","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Qibin Song","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033151800","display_name":"Hongyun Zhao","orcid":"https://orcid.org/0000-0002-1251-3888","observed_orcids":["https://orcid.org/0000-0002-1251-3888","https://orcid.org/0009-0004-1986-827X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hongyun Zhao","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022346721","display_name":"Haidar El Darsa","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Haidar El Darsa","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5047402540","display_name":"I. Monnet","orcid":"https://orcid.org/0000-0003-3279-9569","observed_orcids":["https://orcid.org/0000-0003-3279-9569"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Isabelle Monnet","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160864856","display_name":"Manuel Cobo Dols","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Manuel Cobo Dols","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110838557","display_name":"Rosario Garc\u00eda Campelo","orcid":"https://orcid.org/0000-0002-5067-7533","observed_orcids":["https://orcid.org/0000-0002-5067-7533"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Rosario Garc\u00eda Campelo","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160916950","display_name":"Robert Jotte","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Robert Jotte","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5029460219","display_name":"David Berz","orcid":"https://orcid.org/0000-0001-8368-4601","observed_orcids":["https://orcid.org/0000-0001-8368-4601"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"David Berz","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133236287","display_name":" Alexander Spira","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexander Spira","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110499066","display_name":"Maurice P\u00e9rol","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Maurice P\u00e9rol","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160917111","display_name":"Misako Nagasaka","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Misako Nagasaka","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160942655","display_name":"Howard West","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Howard West","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000671978","display_name":"Jianling Li","orcid":"https://orcid.org/0000-0002-3427-3109","observed_orcids":["https://orcid.org/0000-0002-3427-3109"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jianling Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015774745","display_name":"Fong Clow","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fong Clow","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5137803412","display_name":"Amy C. Moore","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Amy C. Moore","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129547595","display_name":"Jonathan Goldman","orcid":"https://orcid.org/0000-0002-4925-8243","observed_orcids":["https://orcid.org/0000-0002-4925-8243"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jonathan Goldman","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160787501","display_name":"Zhang Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhang Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12334","display_name":"Lung Cancer Research Studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/ivonescimab","display_name":"ivonescimab","score":0.9850000143051147},{"id":"https://openalex.org/keywords/egfr-mutant-non-small-cell-lung-cancer","display_name":"EGFR-mutant non-small cell lung cancer","score":0.9539999961853027},{"id":"https://openalex.org/keywords/egfr-tki-resistance","display_name":"EGFR tyrosine kinase inhibitor resistance","score":0.9100000262260437},{"id":"https://openalex.org/keywords/anti-vegf-antibody","display_name":"anti-VEGF antibody","score":0.49900001287460327},{"id":"https://openalex.org/keywords/chemotherapy","display_name":"chemotherapy","score":0.3779999911785126},{"id":"https://openalex.org/keywords/progression-free-survival","display_name":"progression-free survival","score":0.9769999980926514},{"id":"https://openalex.org/keywords/overall-survival","display_name":"overall survival","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-related-adverse-events","display_name":"treatment-related adverse events","score":0.8230000138282776},{"id":"https://openalex.org/keywords/immune-checkpoint-inhibitors","display_name":"immune checkpoint inhibitors","score":0.5099999904632568},{"id":"https://openalex.org/keywords/angiogenesis-inhibition","display_name":"angiogenesis inhibition","score":0.5479999780654907},{"id":"https://openalex.org/keywords/metastatic-lung-cancer","display_name":"metastatic lung cancer","score":0.6320000290870667},{"id":"https://openalex.org/keywords/egfr-mutation","display_name":"EGFR mutation","score":0.5519999861717224},{"id":"https://openalex.org/keywords/treatment-efficacy-and-safety","display_name":"treatment efficacy and safety","score":0.3499999940395355}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8835999965667725},{"id":"https://openalex.org/C2776694085","wikidata":"https://www.wikidata.org/wiki/Q974135","display_name":"Chemotherapy","level":2,"score":0.8184000253677368},{"id":"https://openalex.org/C27081682","wikidata":"https://www.wikidata.org/wiki/Q269829","display_name":"Placebo","level":3,"score":0.675599992275238},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.6514000296592712},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.6294999718666077},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.49810001254081726},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4323999881744385},{"id":"https://openalex.org/C2778336483","wikidata":"https://www.wikidata.org/wiki/Q5090632","display_name":"Chemotherapy regimen","level":3,"score":0.3968999981880188},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.3653999865055084},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.30709999799728394},{"id":"https://openalex.org/C2776907518","wikidata":"https://www.wikidata.org/wiki/Q1734165","display_name":"Performance status","level":3,"score":0.3070000112056732},{"id":"https://openalex.org/C2778822529","wikidata":"https://www.wikidata.org/wiki/Q1951525","display_name":"Progressive disease","level":3,"score":0.28459998965263367},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.2547999918460846},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.25110000371932983}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.34922501","doi":"https://doi.org/10.6084/m9.figshare.34922501","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922501","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},{"id":"doi:10.6084/m9.figshare.34922501.v1","doi":"https://doi.org/10.6084/m9.figshare.34922501.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922501.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34922501","doi":"https://doi.org/10.6084/m9.figshare.34922501","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922501","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"Other"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7204086740","https://openalex.org/W4415871411","https://openalex.org/W7137991713","https://openalex.org/W4400037508","https://openalex.org/W7163340438","https://openalex.org/W7225103758","https://openalex.org/W4415520617","https://openalex.org/W4399201775","https://openalex.org/W4414219678","https://openalex.org/W7138040194"],"abstract_inverted_index":{"What":[0,101,286],"is":[1,6,61],"this":[2,180],"summary":[3],"about?":[4],"HARMONi":[5,92],"a":[7,10,62,307,343],"study":[8,37],"of":[9,65,83,155,190,198,209,217,310,346,364],"new":[11,63,84],"treatment":[12,52,67,259,350,368],"for":[13],"people":[14],"with":[15,24,53,97,131,136,139,164,172,236,320,328],"advanced":[16,294],"or":[17,119,152,194,213,263,314,366],"metastatic":[18],"non\u2013small":[19],"cell":[20,244],"lung":[21],"cancer":[22,47,66,116,311],"(NSCLC)":[23],"an":[25,54],"activating":[26],"mutation":[27],"in":[28,40,242,252,257,306,342,348],"the":[29,70,81,103,153,288,333,361],"epidermal":[30],"growth":[31],"factor":[32],"receptor":[33],"(EGFR)":[34],"gene.":[35],"The":[36,124,148],"included":[38,240],"participants":[39,157,192,211,256,268,292,347],"Asia,":[41],"Europe,":[42],"and":[43,74,188,207,250,274],"North":[44],"America":[45],"whose":[46,293],"had":[48,226,261,296],"gotten":[49,297],"worse":[50,118,298,313],"after":[51,159,299],"EGFR":[55],"tyrosine":[56],"kinase":[57],"inhibitor":[58],"(EGFR-TKI).":[59],"Ivonescimab":[60],"type":[64],"that":[68,87],"helps":[69],"immune":[71],"system":[72],"recognize":[73],"attack":[75],"tumor":[76],"cells.":[77],"It":[78],"also":[79],"blocks":[80],"formation":[82],"blood":[85,243],"vessels":[86],"tumors":[88],"need":[89],"to":[90,230],"grow.":[91],"compared":[93,135,171,319],"ivonescimab":[94,109,132,165,204,237,271,302,329],"plus":[95,99,110,133,141,166,174,205,224,238,272,279,303,322,330],"chemotherapy":[96,111,134,167,175,206,225,239,273,280,304],"placebo":[98,140,173,223,278,321],"chemotherapy.":[100,142,323],"were":[102,107,202,221],"results?":[104],"Participants":[105],"who":[106,201,220,269,276],"given":[108,203,222],"lived":[112,158],"longer":[113,163,327],"without":[114,358],"their":[115,231],"getting":[117,312],"spreading":[120,315],"(called":[121],"progression-free":[122,126],"survival).":[123],"median":[125,149],"survival":[127,325],"was":[128,145,162,182,326,335],"6.8":[129],"months":[130,138],"4.4":[137],"This":[143],"difference":[144,181,334],"statistically":[146,184,337],"significant.":[147,185,338],"overall":[150],"survival,":[151],"amount":[154],"time":[156],"starting":[160],"treatment,":[161,301],"(median,":[168,176],"16.8":[169],"months)":[170],"14.0":[177],"months);":[178],"however,":[179,332],"not":[183,336],"Two":[186],"hundred":[187],"seven":[189],"218":[191,210],"(95%,":[193],"about":[195,214],"9":[196,215],"out":[197,216],"every":[199,218],"10)":[200,219],"203":[208],"(93%,":[212],"side":[227,234,265,284,353],"effects":[228,235,340,354],"related":[229],"treatment.":[232],"Common":[233],"changes":[241,251],"levels,":[245],"nausea,":[246],"decreased":[247],"appetite,":[248],"vomiting,":[249],"liver":[253],"enzymes.":[254],"Some":[255],"each":[258],"group":[260],"severe":[262],"serious":[264],"effects.":[266,285],"Four":[267],"received":[270,277],"five":[275],"died":[281],"from":[282],"treatment-related":[283],"do":[287],"results":[289],"mean?":[290],"For":[291],"NSCLC":[295],"EGFR-TKI":[300],"resulted":[305],"reduced":[308],"risk":[309],"by":[316],"nearly":[317],"half,":[318],"Overall":[324],"chemotherapy;":[331],"Side":[339],"occurred":[341],"similar":[344],"proportion":[345],"both":[349],"groups.":[351],"Most":[352],"could":[355],"be":[356],"managed":[357],"significantly":[359],"impacting":[360],"participants\u2019":[362],"quality":[363],"life":[365],"requiring":[367],"discontinuation.":[369],"Clinical":[370],"trial":[371],"number:":[372],"NCT06396065":[373]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-06T00:00:00"}
