{"id":"https://openalex.org/W7225329279","doi":"https://doi.org/10.3389/fimmu.2026.1998081","title":"Compartmental immune responses and biomarker discordance after neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer","display_name":"Compartmental immune responses and biomarker discordance after neoadjuvant chemoimmunotherapy in resectable non-small cell lung cancer","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225329279","doi":"https://doi.org/10.3389/fimmu.2026.1998081"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1998081","doi":"https://doi.org/10.3389/fimmu.2026.1998081","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1998081","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1998081/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1998081/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5147165137","display_name":"Songchen Han","orcid":"https://orcid.org/0009-0003-4185-0108","observed_orcids":["https://orcid.org/0009-0003-4185-0108"]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Songchen Han","raw_affiliation_strings":["Department of Thoracic Surgery, Gansu Provincial Hospital","The Third Clinical Medical College of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Gansu Provincial Hospital","institution_ids":["https://openalex.org/I4210114785"]},{"raw_affiliation_string":"The Third Clinical Medical College of Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160889762","display_name":"Ying Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ying Ma","raw_affiliation_strings":["Department of Radiology, Gansu Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Radiology, Gansu Provincial Hospital","institution_ids":["https://openalex.org/I4210114785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124992084","display_name":"Zhenjun Li","orcid":"https://orcid.org/0009-0001-3414-1384","observed_orcids":["https://orcid.org/0009-0001-3414-1384"]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhenjun Li","raw_affiliation_strings":["Department of Pathology, Gansu Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Gansu Provincial Hospital","institution_ids":["https://openalex.org/I4210114785"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5123087428","display_name":"WenLong Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210092839","display_name":"Gansu University of Traditional Chinese Medicine","ror":"https://ror.org/00g741v42","country_code":"CN","type":"education","lineage":["https://openalex.org/I4210092839"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Wenlong Chen","raw_affiliation_strings":["First Clinical Medical College, Gansu University of Chinese Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"First Clinical Medical College, Gansu University of Chinese Medicine","institution_ids":["https://openalex.org/I4210092839"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5127804733","display_name":"Zhihui Xue","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhihui Xue","raw_affiliation_strings":["Department of Internal Medicine, Sunan County People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Internal Medicine, Sunan County People\u2019s Hospital","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5115592258","display_name":"Yunjiu Gou","orcid":"https://orcid.org/0000-0002-6105-0082","observed_orcids":["https://orcid.org/0000-0002-6105-0082","https://orcid.org/0000-0002-3431-4169"]},"institutions":[{"id":"https://openalex.org/I4210114785","display_name":"Gansu Provincial Hospital","ror":"https://ror.org/02axars19","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210114785"]},{"id":"https://openalex.org/I76214153","display_name":"Lanzhou University","ror":"https://ror.org/01mkqqe32","country_code":"CN","type":"education","lineage":["https://openalex.org/I76214153"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yunjiu Gou","raw_affiliation_strings":["Department of Thoracic Surgery, Gansu Provincial Hospital","The Third Clinical Medical College of Lanzhou University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thoracic Surgery, Gansu Provincial Hospital","institution_ids":["https://openalex.org/I4210114785"]},{"raw_affiliation_string":"The Third Clinical Medical College of Lanzhou University","institution_ids":["https://openalex.org/I76214153"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5115592258"],"corresponding_institution_ids":["https://openalex.org/I4210114785","https://openalex.org/I76214153"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10202","display_name":"Lung Cancer Diagnosis and Treatment","score":0.8916000127792358,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.04349999874830246,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10417","display_name":"Lung Cancer Treatments and Mutations","score":0.027300000190734863,"subfield":{"id":"https://openalex.org/subfields/2740","display_name":"Pulmonary and Respiratory Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neoadjuvant-immunochemotherapy","display_name":"neoadjuvant chemoimmunotherapy","score":0.9440000057220459},{"id":"https://openalex.org/keywords/non-small-cell-lung-cancer","display_name":"non-small cell lung cancer","score":0.8989999890327454},{"id":"https://openalex.org/keywords/resectable-lung-cancer","display_name":"resectable lung cancer","score":0.7739999890327454},{"id":"https://openalex.org/keywords/biomarker-discordance","display_name":"biomarker discordance","score":0.7990000247955322},{"id":"https://openalex.org/keywords/circulating-tumor-dna","display_name":"circulating tumor DNA","score":0.8100000023841858},{"id":"https://openalex.org/keywords/tumor-regression","display_name":"tumor regression","score":0.47999998927116394},{"id":"https://openalex.org/keywords/lymph-node-response","display_name":"lymph node response","score":0.7139999866485596},{"id":"https://openalex.org/keywords/regional-lymph-nodes","display_name":"regional lymph nodes","score":0.5669999718666077},{"id":"https://openalex.org/keywords/residual-disease","display_name":"residual disease","score":0.4350000023841858},{"id":"https://openalex.org/keywords/postoperative-pathology","display_name":"postoperative pathology","score":0.5109999775886536},{"id":"https://openalex.org/keywords/treatment-adaptation","display_name":"treatment adaptation","score":0.3310000002384186}],"concepts":[{"id":"https://openalex.org/C2780790343","wikidata":"https://www.wikidata.org/wiki/Q5090610","display_name":"Chemoimmunotherapy","level":4,"score":0.8571000099182129},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.714900016784668},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.555899977684021},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.5346999764442444},{"id":"https://openalex.org/C2777306565","wikidata":"https://www.wikidata.org/wiki/Q15917291","display_name":"Tumour heterogeneity","level":3,"score":0.47369998693466187},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.46790000796318054},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.39070001244544983},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.3822000026702881},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.36800000071525574},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34850001335144043},{"id":"https://openalex.org/C2780283643","wikidata":"https://www.wikidata.org/wiki/Q2110267","display_name":"Primary tumor","level":4,"score":0.34700000286102295},{"id":"https://openalex.org/C2776256026","wikidata":"https://www.wikidata.org/wiki/Q47912","display_name":"Lung cancer","level":2,"score":0.34060001373291016},{"id":"https://openalex.org/C520017518","wikidata":"https://www.wikidata.org/wiki/Q178934","display_name":"Occult","level":3,"score":0.33239999413490295},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.3321000039577484},{"id":"https://openalex.org/C181152851","wikidata":"https://www.wikidata.org/wiki/Q712604","display_name":"Lymphatic system","level":2,"score":0.3043999969959259},{"id":"https://openalex.org/C2778292576","wikidata":"https://www.wikidata.org/wiki/Q6991934","display_name":"Neoadjuvant therapy","level":4,"score":0.30399999022483826},{"id":"https://openalex.org/C83330619","wikidata":"https://www.wikidata.org/wiki/Q21124872","display_name":"NODAL","level":2,"score":0.30090001225471497},{"id":"https://openalex.org/C146357865","wikidata":"https://www.wikidata.org/wiki/Q1123245","display_name":"Stage (stratigraphy)","level":2,"score":0.2976999878883362},{"id":"https://openalex.org/C2779529041","wikidata":"https://www.wikidata.org/wiki/Q22349364","display_name":"Liquid biopsy","level":3,"score":0.2939999997615814},{"id":"https://openalex.org/C45664433","wikidata":"https://www.wikidata.org/wiki/Q17029420","display_name":"Imaging biomarker","level":3,"score":0.2937999963760376},{"id":"https://openalex.org/C2780849966","wikidata":"https://www.wikidata.org/wiki/Q170758","display_name":"Lymph node","level":2,"score":0.2937999963760376},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.28610000014305115},{"id":"https://openalex.org/C2780108502","wikidata":"https://www.wikidata.org/wiki/Q4915018","display_name":"Biological response modifiers","level":3,"score":0.2777999937534332},{"id":"https://openalex.org/C2776512019","wikidata":"https://www.wikidata.org/wiki/Q1816418","display_name":"Efferent","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C2779823535","wikidata":"https://www.wikidata.org/wiki/Q6865356","display_name":"Minimal residual disease","level":3,"score":0.2721000015735626},{"id":"https://openalex.org/C61238886","wikidata":"https://www.wikidata.org/wiki/Q5121689","display_name":"Circulating tumor cell","level":4,"score":0.2689000070095062},{"id":"https://openalex.org/C2775934546","wikidata":"https://www.wikidata.org/wiki/Q179991","display_name":"Biopsy","level":2,"score":0.2671000063419342},{"id":"https://openalex.org/C3018877446","wikidata":"https://www.wikidata.org/wiki/Q1421432","display_name":"Disease monitoring","level":3,"score":0.2612999975681305},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2565999925136566},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.251800000667572}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1998081","doi":"https://doi.org/10.3389/fimmu.2026.1998081","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1998081","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1998081/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:9bb0dcb1b25a4bc998b5a6535fd95252","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9bb0dcb1b25a4bc998b5a6535fd95252","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1998081","doi":"https://doi.org/10.3389/fimmu.2026.1998081","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1998081","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1998081/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225329279.pdf","grobid_xml":"https://content.openalex.org/works/W7225329279.grobid-xml"},"referenced_works_count":73,"referenced_works":["https://openalex.org/W1988160404","https://openalex.org/W2264008678","https://openalex.org/W2561075927","https://openalex.org/W2608738563","https://openalex.org/W2997606923","https://openalex.org/W3003197494","https://openalex.org/W3109756956","https://openalex.org/W3186781833","https://openalex.org/W3189520376","https://openalex.org/W3195215840","https://openalex.org/W3195537958","https://openalex.org/W4214512176","https://openalex.org/W4223502512","https://openalex.org/W4285740574","https://openalex.org/W4297497362","https://openalex.org/W4309610019","https://openalex.org/W4365484830","https://openalex.org/W4366275948","https://openalex.org/W4379209546","https://openalex.org/W4382363420","https://openalex.org/W4384664746","https://openalex.org/W4386640941","https://openalex.org/W4387542351","https://openalex.org/W4387643017","https://openalex.org/W4387879971","https://openalex.org/W4388033556","https://openalex.org/W4390908539","https://openalex.org/W4391798209","https://openalex.org/W4396915845","https://openalex.org/W4397000064","https://openalex.org/W4398202966","https://openalex.org/W4399142336","https://openalex.org/W4399474716","https://openalex.org/W4399929133","https://openalex.org/W4402389357","https://openalex.org/W4403040533","https://openalex.org/W4403118500","https://openalex.org/W4403411790","https://openalex.org/W4403466590","https://openalex.org/W4404289843","https://openalex.org/W4404581119","https://openalex.org/W4409258866","https://openalex.org/W4410351770","https://openalex.org/W4410475710","https://openalex.org/W4410821864","https://openalex.org/W4410943999","https://openalex.org/W4411115547","https://openalex.org/W4411281753","https://openalex.org/W4413480512","https://openalex.org/W4414946498","https://openalex.org/W4415915319","https://openalex.org/W4416918324","https://openalex.org/W7118603690","https://openalex.org/W7119035400","https://openalex.org/W7124315299","https://openalex.org/W7127075453","https://openalex.org/W7127626412","https://openalex.org/W7131834791","https://openalex.org/W7134922616","https://openalex.org/W7160055731","https://openalex.org/W7160824819","https://openalex.org/W7163346337","https://openalex.org/W7165169550","https://openalex.org/W7165838347","https://openalex.org/W7166534240","https://openalex.org/W7166745171","https://openalex.org/W7167606305","https://openalex.org/W7168151907","https://openalex.org/W7168385920","https://openalex.org/W7168386901","https://openalex.org/W7202276680","https://openalex.org/W7203953659","https://openalex.org/W7204588740"],"related_works":["https://openalex.org/W7223179575","https://openalex.org/W4388085254","https://openalex.org/W7213463455","https://openalex.org/W4387542351","https://openalex.org/W4394690326","https://openalex.org/W7124296984","https://openalex.org/W4411032732","https://openalex.org/W7212154953","https://openalex.org/W7127626412","https://openalex.org/W4391798209"],"abstract_inverted_index":{"Neoadjuvant":[0],"chemoimmunotherapy":[1],"can":[2,33,95,153,191],"produce":[3],"uneven":[4],"responses":[5],"across":[6],"the":[7,86,204,224,229],"primary":[8,69,112],"tumour,":[9],"regional":[10],"lymph":[11],"nodes,":[12],"and":[13,22,52,60,70,74,77,82,91,113,161,178],"occult":[14],"systemic":[15],"disease.":[16],"Pathology,":[17],"circulating":[18,87],"tumour":[19,100],"DNA":[20],"(ctDNA),":[21],"imaging":[23,97,144],"capture":[24],"different":[25],"consequences":[26],"of":[27,128],"this":[28],"response,":[29,125],"so":[30],"their":[31],"disagreement":[32],"contain":[34],"clinically":[35],"relevant":[36],"biological":[37,216],"information.":[38,119],"This":[39],"structured":[40],"narrative":[41],"review":[42,152],"examines":[43],"same-patient":[44],"evidence":[45,200],"in":[46],"resectable":[47],"non-small":[48],"cell":[49],"lung":[50],"cancer":[51],"interprets":[53],"discordance":[54,209],"through":[55],"anatomical":[56],"compartment,":[57],"sampling":[58],"time,":[59],"local":[61],"immune":[62,72],"context.":[63],"Paired":[64],"tissue":[65,93,129,156],"studies":[66],"show":[67],"distinct":[68],"nodal":[71,114,174],"ecologies":[73],"response-associated":[75],"lymphoid":[76],"myeloid":[78],"programmes.":[79],"Spatial":[80],"clonality":[81],"unequal":[83],"shedding":[84],"shape":[85],"signal,":[88],"while":[89,172],"inflammatory":[90],"reparative":[92],"changes":[94],"sustain":[96],"abnormalities":[98],"after":[99],"regression.":[101],"These":[102],"observations":[103],"inform":[104],"four":[105],"proposed":[106],"principles":[107],"for":[108,138],"multidisciplinary":[109],"interpretation.":[110],"Separate":[111],"reporting":[115],"preserves":[116],"compartment-specific":[117],"response":[118],"Presurgical":[120],"ctDNA":[121],"clearance":[122],"indicates":[123],"molecular":[124,133,180],"not":[126],"proof":[127],"eradication.":[130],"Confirmed":[131],"postoperative":[132,164],"conversion":[134],"provides":[135],"a":[136,193,220],"rationale":[137],"reassessing":[139],"current":[140],"disease":[141,167],"status.":[142],"For":[143],"conflicts":[145],"that":[146,201],"could":[147],"alter":[148],"curative-intent":[149],"management,":[150],"lesion-level":[151],"identify":[154,187],"when":[155],"confirmation":[157],"would":[158],"be":[159],"feasible":[160],"decision-changing.":[162],"A":[163],"pathology\u2013molecular":[165],"residual":[166],"matrix":[168],"organises":[169],"research":[170],"questions":[171],"preserving":[173],"findings,":[175],"unresolved":[176],"lesions,":[177],"serial":[179],"trajectory.":[181],"The":[182],"immediate":[183],"contribution":[184],"is":[185,210],"to":[186,222],"which":[188],"additional":[189],"observation":[190],"resolve":[192],"consequential":[194],"conflict;":[195],"treatment":[196],"adaptation":[197],"then":[198],"requires":[199],"acting":[202],"on":[203],"result":[205],"benefits":[206],"patients.":[207],"Biomarker":[208],"therefore":[211],"an":[212],"interpretive":[213],"problem":[214],"with":[215],"content,":[217],"rather":[218],"than":[219],"reason":[221],"let":[223],"most":[225],"favourable":[226],"test":[227],"define":[228],"entire":[230],"response.":[231]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}