{"id":"https://openalex.org/W7225329173","doi":"https://doi.org/10.3389/fonc.2026.1946947","title":"STING signaling opposes AXL to regulate interferon responses in dedifferentiated human melanoma","display_name":"STING signaling opposes AXL to regulate interferon responses in dedifferentiated human melanoma","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225329173","doi":"https://doi.org/10.3389/fonc.2026.1946947"},"language":"en","primary_location":{"id":"doi:10.3389/fonc.2026.1946947","doi":"https://doi.org/10.3389/fonc.2026.1946947","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1946947","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1946947/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1946947/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018905791","display_name":"Carl A. Shirley","orcid":"https://orcid.org/0009-0009-4398-404X","observed_orcids":["https://orcid.org/0009-0009-4398-404X"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Carl A. Shirley","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073073926","display_name":"Michael B. Wolfe","orcid":"https://orcid.org/0000-0002-0276-0551","observed_orcids":["https://orcid.org/0000-0002-0276-0551"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Michael B. Wolfe","raw_affiliation_strings":["Carbone Comprehensive Cancer Center, University of Wisconsin-Madison","Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Comprehensive Cancer Center, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160822709","display_name":"Karla B. Anaya-Aldrete","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Karla B. Anaya-Aldrete","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5089062097","display_name":"Minakshi Nihal","orcid":"https://orcid.org/0000-0002-9295-3946","observed_orcids":["https://orcid.org/0000-0002-9295-3946"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210141342","display_name":"William S. Middleton Memorial Veterans Hospital","ror":"https://ror.org/037xafn82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210141342"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Minakshi Nihal","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin","William S. Middleton Memorial Veterans Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]},{"raw_affiliation_string":"William S. Middleton Memorial Veterans Hospital","institution_ids":["https://openalex.org/I4210141342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041944784","display_name":"Gagan Chhabra","orcid":"https://orcid.org/0000-0001-5205-7218","observed_orcids":["https://orcid.org/0000-0001-5205-7218"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gagan Chhabra","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036323056","display_name":"Sean J. McIlwain","orcid":"https://orcid.org/0000-0002-3820-8400","observed_orcids":["https://orcid.org/0000-0002-3820-8400"]},"institutions":[{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210103341","display_name":"University of Wisconsin Carbone Cancer Center","ror":"https://ror.org/01e4byj08","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I135310074","https://openalex.org/I2799905417","https://openalex.org/I4210103341","https://openalex.org/I4210132596"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sean J. McIlwain","raw_affiliation_strings":["Carbone Comprehensive Cancer Center, University of Wisconsin-Madison","Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Carbone Comprehensive Cancer Center, University of Wisconsin-Madison","institution_ids":["https://openalex.org/I135310074","https://openalex.org/I4210103341"]},{"raw_affiliation_string":"Department of Biostatistics and Medical Informatics, School of Medicine and Public Health, University of Wisconsin","institution_ids":["https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5094224980","display_name":"Julia M. Krien","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Julia M. Krien","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025592530","display_name":"Mary Ann Ndiaye","orcid":"https://orcid.org/0000-0002-5254-1840","observed_orcids":["https://orcid.org/0000-0002-5254-1840"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mary A. Ndiaye","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045348217","display_name":"Nihal Ahmad","orcid":"https://orcid.org/0000-0002-4239-9887","observed_orcids":["https://orcid.org/0000-0002-4239-9887"]},"institutions":[{"id":"https://openalex.org/I1304256225","display_name":"University of Wisconsin System","ror":"https://ror.org/03ydkyb10","country_code":"US","type":"education","lineage":["https://openalex.org/I1304256225"]},{"id":"https://openalex.org/I135310074","display_name":"University of Wisconsin\u2013Madison","ror":"https://ror.org/01y2jtd41","country_code":"US","type":"education","lineage":["https://openalex.org/I135310074"]},{"id":"https://openalex.org/I4210141342","display_name":"William S. Middleton Memorial Veterans Hospital","ror":"https://ror.org/037xafn82","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1322918889","https://openalex.org/I2799886695","https://openalex.org/I4210115976","https://openalex.org/I4210141342"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nihal Ahmad","raw_affiliation_strings":["Department of Dermatology, University of Wisconsin","William S. Middleton Memorial Veterans Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Dermatology, University of Wisconsin","institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074"]},{"raw_affiliation_string":"William S. Middleton Memorial Veterans Hospital","institution_ids":["https://openalex.org/I4210141342"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5045348217"],"corresponding_institution_ids":["https://openalex.org/I1304256225","https://openalex.org/I135310074","https://openalex.org/I4210141342"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"16","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11668","display_name":"interferon and immune responses","score":0.9789999723434448,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.014100000262260437,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10580","display_name":"Immunotherapy and Immune Responses","score":0.0019000000320374966,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sting-signaling","display_name":"STING signaling","score":0.9150000214576721},{"id":"https://openalex.org/keywords/axl-receptor-tyrosine-kinase","display_name":"AXL receptor tyrosine kinase","score":0.9769999980926514},{"id":"https://openalex.org/keywords/interferon-response","display_name":"interferon response","score":0.8029999732971191},{"id":"https://openalex.org/keywords/type-i-interferon","display_name":"type I interferon","score":0.9580000042915344},{"id":"https://openalex.org/keywords/immunotherapy-resistance","display_name":"immunotherapy resistance","score":0.7749999761581421},{"id":"https://openalex.org/keywords/innate-immune-evasion","display_name":"innate immune evasion","score":0.7139999866485596}],"concepts":[{"id":"https://openalex.org/C2779300339","wikidata":"https://www.wikidata.org/wiki/Q7617409","display_name":"Sting","level":2,"score":0.8294000029563904},{"id":"https://openalex.org/C2776178377","wikidata":"https://www.wikidata.org/wiki/Q188269","display_name":"Interferon","level":2,"score":0.8091999888420105},{"id":"https://openalex.org/C2777349159","wikidata":"https://www.wikidata.org/wiki/Q18055374","display_name":"Stimulator of interferon genes","level":4,"score":0.7555000185966492},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.6917999982833862},{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6825000047683716},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.5717999935150146},{"id":"https://openalex.org/C101544691","wikidata":"https://www.wikidata.org/wiki/Q420511","display_name":"Receptor tyrosine kinase","level":3,"score":0.5252000093460083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4880000054836273},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.4749999940395355},{"id":"https://openalex.org/C42362537","wikidata":"https://www.wikidata.org/wiki/Q87099740","display_name":"Tyrosine kinase","level":3,"score":0.4163999855518341},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3869999945163727},{"id":"https://openalex.org/C2778278966","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Interferon type I","level":3,"score":0.36309999227523804},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.3492000102996826},{"id":"https://openalex.org/C2909179924","wikidata":"https://www.wikidata.org/wiki/Q6046488","display_name":"Alpha interferon","level":3,"score":0.3472000062465668},{"id":"https://openalex.org/C2778820342","wikidata":"https://www.wikidata.org/wiki/Q906415","display_name":"Tyrosine-kinase inhibitor","level":3,"score":0.33559998869895935},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.3197000026702881},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.31869998574256897},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.3183000087738037},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.30379998683929443},{"id":"https://openalex.org/C184235292","wikidata":"https://www.wikidata.org/wiki/Q421851","display_name":"Kinase","level":2,"score":0.29829999804496765},{"id":"https://openalex.org/C2780851360","wikidata":"https://www.wikidata.org/wiki/Q21686041","display_name":"Immune checkpoint","level":4,"score":0.2815999984741211},{"id":"https://openalex.org/C2781228144","wikidata":"https://www.wikidata.org/wiki/Q6046441","display_name":"Interferon alfa","level":4,"score":0.2768000066280365},{"id":"https://openalex.org/C2778690821","wikidata":"https://www.wikidata.org/wiki/Q212354","display_name":"Cytokine","level":2,"score":0.2732999920845032},{"id":"https://openalex.org/C189014844","wikidata":"https://www.wikidata.org/wiki/Q189118","display_name":"Cell type","level":3,"score":0.26600000262260437},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2648000121116638},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C2776165026","wikidata":"https://www.wikidata.org/wiki/Q188017","display_name":"Tyrosine","level":2,"score":0.2574999928474426},{"id":"https://openalex.org/C5364575","wikidata":"https://www.wikidata.org/wiki/Q17836543","display_name":"AXL receptor tyrosine kinase","level":5,"score":0.2535000145435333},{"id":"https://openalex.org/C117705580","wikidata":"https://www.wikidata.org/wiki/Q18027494","display_name":"IRF8","level":4,"score":0.2524000108242035}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fonc.2026.1946947","doi":"https://doi.org/10.3389/fonc.2026.1946947","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1946947","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1946947/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:448bbcfeff814a7a8d6813646a2b98ab","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/448bbcfeff814a7a8d6813646a2b98ab","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Oncology, Vol 16 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fonc.2026.1946947","doi":"https://doi.org/10.3389/fonc.2026.1946947","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fonc.2026.1946947","pdf_url":"https://www.frontiersin.org/journals/oncology/articles/10.3389/fonc.2026.1946947/pdf","source":{"id":"https://openalex.org/S2596394214","display_name":"Frontiers in Oncology","issn_l":"2234-943X","issn":["2234-943X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Oncology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225329173.pdf","grobid_xml":"https://content.openalex.org/works/W7225329173.grobid-xml"},"referenced_works_count":78,"referenced_works":["https://openalex.org/W1969717303","https://openalex.org/W2043398720","https://openalex.org/W2052005627","https://openalex.org/W2055450519","https://openalex.org/W2093970050","https://openalex.org/W2127956110","https://openalex.org/W2130410032","https://openalex.org/W2136059817","https://openalex.org/W2148482462","https://openalex.org/W2153767355","https://openalex.org/W2190545194","https://openalex.org/W2312073547","https://openalex.org/W2332292689","https://openalex.org/W2465860350","https://openalex.org/W2522313999","https://openalex.org/W2525369565","https://openalex.org/W2563663251","https://openalex.org/W2587048937","https://openalex.org/W2613983133","https://openalex.org/W2736476343","https://openalex.org/W2758315173","https://openalex.org/W2782124401","https://openalex.org/W2783053138","https://openalex.org/W2783667606","https://openalex.org/W2791483720","https://openalex.org/W2797906965","https://openalex.org/W2808419418","https://openalex.org/W2904139947","https://openalex.org/W2936119023","https://openalex.org/W2944727022","https://openalex.org/W2946864592","https://openalex.org/W2949375297","https://openalex.org/W2956987968","https://openalex.org/W2970843395","https://openalex.org/W2984472267","https://openalex.org/W3043703771","https://openalex.org/W3046191976","https://openalex.org/W3047821845","https://openalex.org/W3088246260","https://openalex.org/W3113132520","https://openalex.org/W3152326806","https://openalex.org/W3157357317","https://openalex.org/W3157834930","https://openalex.org/W3158287089","https://openalex.org/W3177071586","https://openalex.org/W3192823395","https://openalex.org/W3198426699","https://openalex.org/W3203575974","https://openalex.org/W3203846814","https://openalex.org/W3211078038","https://openalex.org/W3211966976","https://openalex.org/W4200019954","https://openalex.org/W4220752565","https://openalex.org/W4224237090","https://openalex.org/W4282983929","https://openalex.org/W4315784559","https://openalex.org/W4321491890","https://openalex.org/W4324325031","https://openalex.org/W4327857219","https://openalex.org/W4353087862","https://openalex.org/W4361282386","https://openalex.org/W4361299044","https://openalex.org/W4378745672","https://openalex.org/W4381481431","https://openalex.org/W4383821992","https://openalex.org/W4389371330","https://openalex.org/W4390589556","https://openalex.org/W4390639255","https://openalex.org/W4391508523","https://openalex.org/W4391818823","https://openalex.org/W4393059250","https://openalex.org/W4396943617","https://openalex.org/W4402755359","https://openalex.org/W4404595681","https://openalex.org/W4405506472","https://openalex.org/W4406679886","https://openalex.org/W4406731688","https://openalex.org/W4408290575"],"related_works":["https://openalex.org/W4406299098","https://openalex.org/W2970843395","https://openalex.org/W4405903754","https://openalex.org/W3082820499","https://openalex.org/W4282959150","https://openalex.org/W4409636103","https://openalex.org/W3152326806","https://openalex.org/W4353087862","https://openalex.org/W4406180867","https://openalex.org/W4282559953"],"abstract_inverted_index":{"Introduction":[0],"Cancer":[1],"cells":[2,148],"can":[3],"evade":[4],"interferon":[5,44,74,167,202,210],"(IFN)":[6],"signaling":[7,14,104],"pressures":[8],"by":[9],"suppressing":[10],"intrinsic":[11],"innate":[12],"immune":[13,169],"pathways":[15],"or":[16],"dedifferentiating,":[17],"giving":[18],"rise":[19],"to":[20,28,68,98,209],"immunotherapy-resistant":[21],"cell":[22,179],"states.":[23],"Therapeutic":[24],"strategies":[25],"specifically":[26],"tailored":[27],"account":[29],"for":[30,159,166,191],"and":[31,60,73,95,126,153,168,181,193,201,204],"eliminate":[32],"such":[33],"states":[34],"remain":[35],"limited.":[36],"Methods":[37],"Here,":[38],"we":[39],"genetically":[40],"reintroduced":[41],"stimulator":[42],"of":[43,92,107,112,139,176,183,198],"genes":[45,200],"(STING)":[46],"in":[47,76,132,195,212],"dedifferentiated":[48,133],"STING-deficient":[49],"melanoma":[50,113,135,143,178],"cells,":[51],"used":[52],"AXL":[53,115,154,194],"receptor":[54],"tyrosine":[55],"kinase":[56],"(AXL)":[57],"small-molecule":[58,116],"inhibition,":[59],"analyzed":[61],"publicly":[62,140],"available":[63,141],"single-cell":[64,184],"RNA-sequencing":[65],"(scRNA-seq)":[66],"datasets":[67],"examine":[69],"connections":[70],"between":[71],"dedifferentiation":[72,214],"responses":[75],"human":[77,134,142,177],"melanoma.":[78],"Results":[79],"We":[80],"found":[81],"that":[82],"STING":[83,103,120,151,192],"reintroduction":[84],"induced":[85],"type":[86,100,128],"I":[87],"IFN":[88,130],"signaling,":[89],"increased":[90],"expression":[91,106,125],"antigen-presentation":[93,123],"genes,":[94],"enhanced":[96],"sensitivity":[97,131,203,211],"exogenous":[99],"II":[101,129],"IFN.":[102],"silenced":[105],"AXL,":[108],"a":[109],"key":[110],"marker":[111],"dedifferentiation.":[114],"inhibition":[117],"partially":[118],"phenocopied":[119],"reintroduction,":[121],"potentiating":[122],"gene":[124],"enhancing":[127],"cells.":[136],"Consistently,":[137],"analysis":[138,182],"scRNA-Seq":[144],"data":[145],"revealed":[146],"tumor":[147],"with":[149],"concomitant":[150],"loss":[152],"gain":[155],"are":[156],"positively":[157],"enriched":[158,165],"melanocyte":[160],"stem-cell-like":[161],"signatures,":[162],"while":[163],"negatively":[164],"activation":[170],"signatures.":[171],"Discussion":[172],"Together,":[173],"through":[174],"manipulation":[175],"lines":[180],"states,":[185],"our":[186],"results":[187],"support":[188],"opposing":[189],"roles":[190],"the":[196,213],"regulation":[197],"antigen-presenting":[199],"more":[205],"broadly":[206],"implicate":[207],"changes":[208],"process.":[215]},"counts_by_year":[],"updated_date":"2026-11-10T11:39:43.021295","created_date":"2026-11-06T00:00:00"}