{"id":"https://openalex.org/W7225328800","doi":"https://doi.org/10.20944/preprints202611.0459.v1","title":"Integrative Transcriptomics Deconstructs the H-P-M Axis: A Multi-Level Coordinated Regulatory Network Mediated by an \u201cInterface-Relay-Hub\u201d Architecture","display_name":"Integrative Transcriptomics Deconstructs the H-P-M Axis: A Multi-Level Coordinated Regulatory Network Mediated by an \u201cInterface-Relay-Hub\u201d Architecture","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225328800","doi":"https://doi.org/10.20944/preprints202611.0459.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202611.0459.v1","doi":"https://doi.org/10.20944/preprints202611.0459.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0459.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202611.0459.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124909144","display_name":"Chaoyun Yang","orcid":"https://orcid.org/0000-0001-6190-7958","observed_orcids":["https://orcid.org/0000-0001-6190-7958"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Chaoyun Yang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160932283","display_name":"Xiaofang Feng","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaofang Feng","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101566351","display_name":"Zhiqiang Hu","orcid":"https://orcid.org/0000-0002-8878-270X","observed_orcids":["https://orcid.org/0000-0002-8878-270X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zhiqiang Hu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5042130366","display_name":"Yunxia Qi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yunxia Qi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160807725","display_name":"Jun Li","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jun Li","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084622505","display_name":"\u9ec3\u589e\u6587","orcid":"https://orcid.org/0000-0002-7223-4047","observed_orcids":["https://orcid.org/0000-0002-7223-4047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Zengwen Huang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160822452","display_name":"Jiankui Wang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Jiankui Wang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160875235","display_name":"Ran Guan","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Ran Guan","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160822452","https://openalex.org/A5160875235"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10594","display_name":"Genetic and phenotypic traits in livestock","score":0.8633000254631042,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10748","display_name":"Growth Hormone and Insulin-like Growth Factors","score":0.08070000261068344,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13354","display_name":"Genetics and Physical Performance","score":0.007699999958276749,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sheep-growth-performance","display_name":"sheep growth","score":0.5080000162124634},{"id":"https://openalex.org/keywords/hypothalamus","display_name":"hypothalamus","score":0.7889999747276306},{"id":"https://openalex.org/keywords/pituitary-gland","display_name":"pituitary gland","score":0.8859999775886536},{"id":"https://openalex.org/keywords/longissimus-muscle","display_name":"longissimus dorsi","score":0.9520000219345093},{"id":"https://openalex.org/keywords/differentially-expressed-genes","display_name":"differentially expressed genes","score":0.8130000233650208},{"id":"https://openalex.org/keywords/regulatory-networks","display_name":"regulatory networks","score":0.5759999752044678},{"id":"https://openalex.org/keywords/hub-genes","display_name":"hub genes","score":0.7059999704360962},{"id":"https://openalex.org/keywords/neuropeptide-y","display_name":"neuropeptide Y","score":0.8579999804496765},{"id":"https://openalex.org/keywords/skeletal-muscle-growth","display_name":"skeletal muscle growth","score":0.7450000047683716},{"id":"https://openalex.org/keywords/livestock-genetic-improvement","display_name":"livestock genetic improvement","score":0.6499999761581421}],"concepts":[{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.7210999727249146},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.6345999836921692},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6179999709129333},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.5995000004768372},{"id":"https://openalex.org/C67339327","wikidata":"https://www.wikidata.org/wiki/Q1502576","display_name":"Gene regulatory network","level":4,"score":0.5199999809265137},{"id":"https://openalex.org/C33498276","wikidata":"https://www.wikidata.org/wiki/Q2138797","display_name":"Regulator gene","level":4,"score":0.4250999987125397},{"id":"https://openalex.org/C26517878","wikidata":"https://www.wikidata.org/wiki/Q228039","display_name":"Key (lock)","level":2,"score":0.40400001406669617},{"id":"https://openalex.org/C69991583","wikidata":"https://www.wikidata.org/wiki/Q1423575","display_name":"Candidate gene","level":3,"score":0.3555000126361847},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.34040001034736633},{"id":"https://openalex.org/C21592294","wikidata":"https://www.wikidata.org/wiki/Q3238407","display_name":"Regulatory sequence","level":4,"score":0.33079999685287476},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.28450000286102295},{"id":"https://openalex.org/C123657996","wikidata":"https://www.wikidata.org/wiki/Q12271","display_name":"Architecture","level":2,"score":0.2782999873161316},{"id":"https://openalex.org/C2776207758","wikidata":"https://www.wikidata.org/wiki/Q5303302","display_name":"Downstream (manufacturing)","level":2,"score":0.2727000117301941},{"id":"https://openalex.org/C9287583","wikidata":"https://www.wikidata.org/wiki/Q5532883","display_name":"Genetic architecture","level":4,"score":0.271699994802475},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.27129998803138733},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.2581999897956848},{"id":"https://openalex.org/C107397762","wikidata":"https://www.wikidata.org/wiki/Q2542347","display_name":"RNA-Seq","level":5,"score":0.2529999911785126}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202611.0459.v1","doi":"https://doi.org/10.20944/preprints202611.0459.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0459.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202611.0459.v1","doi":"https://doi.org/10.20944/preprints202611.0459.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0459.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3045326167","https://openalex.org/W2943732054","https://openalex.org/W4403779315","https://openalex.org/W2521693023","https://openalex.org/W1530557214","https://openalex.org/W3185278794","https://openalex.org/W4392949892","https://openalex.org/W7119506051","https://openalex.org/W4415932695","https://openalex.org/W2086120282"],"abstract_inverted_index":{"The":[0],"molecular":[1,126],"architecture":[2],"of":[3,17,39,84,103,116],"the":[4,18,85,114],"growth-regulating":[5],"hypothalamus-pituitary-muscle":[6],"(H-P-M)":[7],"axis":[8],"is":[9],"poorly":[10],"understood.":[11],"We":[12],"performed":[13],"integrative":[14],"transcriptomic":[15],"analysis":[16],"hypothalamus,":[19],"pituitary,":[20],"and":[21,67,96,123],"longissimus":[22],"dorsi":[23],"muscle":[24,121],"from":[25],"Liangshan":[26],"black":[27],"sheep":[28],"with":[29,101],"superior":[30],"growth":[31,122],"performance":[32],"to":[33],"dissect":[34],"this":[35],"regulatory":[36,53,82],"network.":[37],"Analysis":[38],"3,422":[40],"differentially":[41],"expressed":[42],"genes":[43,98,106],"(DEGs)":[44],"identified":[45],"across":[46],"pairwise":[47],"tissue":[48],"comparisons":[49],"revealed":[50],"a":[51,80],"three-tiered":[52],"architecture:":[54],"(1)":[55],"tissue-specific":[56],"interfaces":[57],"defining":[58],"spatial":[59],"hierarchy,":[60],"(2)":[61],"relay":[62],"modules":[63],"for":[64,128],"temporal":[65],"dynamics,":[66],"(3)":[68],"shared":[69],"core":[70],"hubs":[71],"(131":[72],"genes)":[73],"establishing":[74],"neuro-endocrine-muscle":[75],"integration.":[76],"This":[77],"study":[78],"provides":[79],"multi-level":[81],"map":[83],"H-P-M":[86],"axis,":[87],"identifying":[88],"key":[89],"pathways":[90],"such":[91],"as":[92],"pituitary":[93],"calcium":[94],"signaling":[95],"hub":[97],"(e.g.,":[99],"NPY),":[100],"12":[102],"14":[104],"candidate":[105],"validated":[107],"by":[108],"quantitative":[109],"PCR.":[110],"These":[111],"findings":[112],"deepen":[113],"understanding":[115],"neuroendocrine":[117],"control":[118],"over":[119],"skeletal":[120],"offer":[124],"novel":[125],"targets":[127],"genetic":[129],"improvement":[130],"in":[131],"livestock.":[132]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}
