{"id":"https://openalex.org/W7225327041","doi":"https://doi.org/10.64898/2026.11.04.764182","title":"Age-specific pediatric templates improve EEG source-reconstructed biomarkers in children","display_name":"Age-specific pediatric templates improve EEG source-reconstructed biomarkers in children","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225327041","doi":"https://doi.org/10.64898/2026.11.04.764182"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.764182","doi":"https://doi.org/10.64898/2026.11.04.764182","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764182","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.764182.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.764182.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160971253","display_name":"Marit van den Berg","orcid":"https://orcid.org/0009-0000-6423-5659","observed_orcids":["https://orcid.org/0009-0000-6423-5659"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marit van den Berg","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":"https://orcid.org/0009-0000-6423-5659","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160248651","display_name":"Tina Ganjipour","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Tina Ganjipour","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022253459","display_name":"Marina Diachenko","orcid":"https://orcid.org/0000-0002-6578-4913","observed_orcids":["https://orcid.org/0000-0002-6578-4913"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Marina Diachenko","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":"https://orcid.org/0000-0002-6578-4913","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115835935","display_name":"Maria Candellero","orcid":"https://orcid.org/0009-0006-7946-2823","observed_orcids":["https://orcid.org/0009-0006-7946-2823"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Maria Candellero","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":"https://orcid.org/0009-0006-7946-2823","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5056188201","display_name":"Huibert D. Mansvelder","orcid":"https://orcid.org/0000-0003-1365-5340","observed_orcids":["https://orcid.org/0000-0003-1365-5340"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Huibert D. Mansvelder","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":"https://orcid.org/0000-0003-1365-5340","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017660150","display_name":"Hilgo Bruining","orcid":"https://orcid.org/0000-0003-0660-1969","observed_orcids":["https://orcid.org/0000-0003-0660-1969"]},"institutions":[{"id":"https://openalex.org/I4210151833","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I4210151833"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Hilgo Bruining","raw_affiliation_strings":["Amsterdam Universitair Medisch Centrum"],"raw_orcid":"https://orcid.org/0000-0003-0660-1969","affiliations":[{"raw_affiliation_string":"Amsterdam Universitair Medisch Centrum","institution_ids":["https://openalex.org/I4210151833"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065337520","display_name":"Arthur-Ervin Avr\u0103miea","orcid":"https://orcid.org/0000-0002-0826-8269","observed_orcids":["https://orcid.org/0000-0002-0826-8269"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Arthur-Ervin Avramiea","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":"https://orcid.org/0000-0002-0826-8269","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017644047","display_name":"Klaus Linkenkaer\u2010Hansen","orcid":"https://orcid.org/0000-0003-2140-9780","observed_orcids":["https://orcid.org/0000-0003-2140-9780"]},"institutions":[{"id":"https://openalex.org/I865915315","display_name":"Vrije Universiteit Amsterdam","ror":"https://ror.org/008xxew50","country_code":"NL","type":"education","lineage":["https://openalex.org/I865915315"]}],"countries":["NL"],"is_corresponding":true,"raw_author_name":"Klaus Linkenkaer-Hansen","raw_affiliation_strings":["Vrije Universiteit Amsterdam;"],"raw_orcid":"https://orcid.org/0000-0003-2140-9780","affiliations":[{"raw_affiliation_string":"Vrije Universiteit Amsterdam;","institution_ids":["https://openalex.org/I865915315"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5017644047"],"corresponding_institution_ids":["https://openalex.org/I865915315"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10429","display_name":"EEG and Brain-Computer Interfaces","score":0.9409000277519226,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10581","display_name":"Neural dynamics and brain function","score":0.041999999433755875,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10241","display_name":"Functional Brain Connectivity Studies","score":0.0044999998062849045,"subfield":{"id":"https://openalex.org/subfields/2805","display_name":"Cognitive Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/eeg-source-reconstruction","display_name":"EEG source reconstruction","score":0.9779999852180481},{"id":"https://openalex.org/keywords/anatomical-head-model","display_name":"anatomical head model","score":0.8289999961853027},{"id":"https://openalex.org/keywords/eeg-biomarkers","display_name":"EEG biomarkers","score":0.7459999918937683},{"id":"https://openalex.org/keywords/children-and-adolescents","display_name":"children and adolescents","score":0.6990000009536743},{"id":"https://openalex.org/keywords/developmental-changes","display_name":"developmental changes","score":0.4490000009536743},{"id":"https://openalex.org/keywords/long-range-temporal-correlations","display_name":"long-range temporal correlations","score":0.7720000147819519},{"id":"https://openalex.org/keywords/detrended-fluctuation-analysis","display_name":"detrended fluctuation analysis","score":0.9049999713897705}],"concepts":[{"id":"https://openalex.org/C522805319","wikidata":"https://www.wikidata.org/wiki/Q179965","display_name":"Electroencephalography","level":2,"score":0.7649000287055969},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6671000123023987},{"id":"https://openalex.org/C82714645","wikidata":"https://www.wikidata.org/wiki/Q438331","display_name":"Template","level":2,"score":0.5270000100135803},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.4715999960899353},{"id":"https://openalex.org/C143409427","wikidata":"https://www.wikidata.org/wiki/Q161238","display_name":"Magnetic resonance imaging","level":2,"score":0.4611000120639801},{"id":"https://openalex.org/C2781082017","wikidata":"https://www.wikidata.org/wiki/Q7268925","display_name":"Quantitative electroencephalography","level":3,"score":0.38690000772476196},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.3702999949455261},{"id":"https://openalex.org/C120843803","wikidata":"https://www.wikidata.org/wiki/Q4955807","display_name":"Brain activity and meditation","level":3,"score":0.3474999964237213},{"id":"https://openalex.org/C2779226451","wikidata":"https://www.wikidata.org/wiki/Q903809","display_name":"Functional magnetic resonance imaging","level":2,"score":0.33230000734329224},{"id":"https://openalex.org/C548259974","wikidata":"https://www.wikidata.org/wiki/Q569965","display_name":"Audiology","level":1,"score":0.3264000117778778},{"id":"https://openalex.org/C45664433","wikidata":"https://www.wikidata.org/wiki/Q17029420","display_name":"Imaging biomarker","level":3,"score":0.31610000133514404},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.30149999260902405},{"id":"https://openalex.org/C50231774","wikidata":"https://www.wikidata.org/wiki/Q639842","display_name":"Brain mapping","level":2,"score":0.290800005197525},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.28760001063346863}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.764182","doi":"https://doi.org/10.64898/2026.11.04.764182","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764182","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.764182.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.764182","doi":"https://doi.org/10.64898/2026.11.04.764182","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.764182","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.764182.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9537000060081482,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320319101","display_name":"Amsterdam University Medical Centers","ror":"https://ror.org/05grdyy37"},{"id":"https://openalex.org/F4320321800","display_name":"Nederlandse Organisatie voor Wetenschappelijk Onderzoek","ror":"https://ror.org/04jsz6e67"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225327041.pdf","grobid_xml":"https://content.openalex.org/works/W7225327041.grobid-xml"},"referenced_works_count":43,"referenced_works":["https://openalex.org/W74848703","https://openalex.org/W1493718371","https://openalex.org/W2001419531","https://openalex.org/W2001428189","https://openalex.org/W2003520203","https://openalex.org/W2020745232","https://openalex.org/W2027386628","https://openalex.org/W2048029629","https://openalex.org/W2055132316","https://openalex.org/W2067724039","https://openalex.org/W2079987516","https://openalex.org/W2095064393","https://openalex.org/W2110065044","https://openalex.org/W2116210000","https://openalex.org/W2130863149","https://openalex.org/W2135595031","https://openalex.org/W2137958317","https://openalex.org/W2139852582","https://openalex.org/W2141403362","https://openalex.org/W2148582387","https://openalex.org/W2169918686","https://openalex.org/W2327037637","https://openalex.org/W2771414833","https://openalex.org/W2780601052","https://openalex.org/W2948800812","https://openalex.org/W2950120067","https://openalex.org/W2951617899","https://openalex.org/W3033819379","https://openalex.org/W3083932917","https://openalex.org/W3092044683","https://openalex.org/W3105641049","https://openalex.org/W3114823596","https://openalex.org/W3173556047","https://openalex.org/W3201700449","https://openalex.org/W4241074797","https://openalex.org/W4280537606","https://openalex.org/W4295750005","https://openalex.org/W4304845748","https://openalex.org/W4319968601","https://openalex.org/W4378782211","https://openalex.org/W4402911697","https://openalex.org/W4403235413","https://openalex.org/W4416960401"],"related_works":["https://openalex.org/W3035960832","https://openalex.org/W2066321227","https://openalex.org/W2126984007","https://openalex.org/W7214926634","https://openalex.org/W7202085246","https://openalex.org/W7160335086","https://openalex.org/W1265769531","https://openalex.org/W4282922830","https://openalex.org/W3193725856","https://openalex.org/W4378782211"],"abstract_inverted_index":{"EEG":[0,57,136,208],"source":[1],"reconstruction":[2,84],"requires":[3],"an":[4,115],"anatomical":[5,44,110],"head":[6],"model,":[7],"ideally":[8],"constructed":[9],"from":[10,93,119],"individual":[11,82,113,166,197,206],"magnetic":[12],"resonance":[13],"imaging":[14],"(MRI)":[15],"scans.":[16],"In":[17],"developmental":[18,171],"studies":[19],"of":[20,226],"children":[21,78],"and":[22,79,128,140,155,173,228],"adolescents,":[23,80],"however,":[24],"MRIs":[25],"are":[26],"rarely":[27],"available.":[28],"Researchers":[29],"therefore":[30],"routinely":[31],"rely":[32],"on":[33,52],"adult":[34,53,130,184,215],"templates,":[35],"such":[36],"as":[37,85],"the":[38,86,129,183,214,231],"FreeSurfer":[39],"average":[40],"(fsaverage),":[41],"despite":[42],"substantial":[43],"changes":[45],"throughout":[46],"development.":[47],"How":[48],"much":[49],"this":[50,238],"reliance":[51],"models":[54],"biases":[55],"downstream":[56],"biomarkers":[58,76,137,168,220],"remains":[59],"unclear.":[60],"Here,":[61],"we":[62,107],"investigated":[63],"whether":[64],"age-specific":[65,116,202],"pediatric":[66,117,203],"templates":[67,161,204],"offer":[68],"a":[69,120],"better":[70],"alternative":[71],"to":[72,101,222,237],"fsaverage":[73,131],"for":[74,187],"EEG-derived":[75],"in":[77,138,169,190],"using":[81],"MRI-based":[83,167,207],"reference.":[87],"We":[88,133,193],"analyzed":[89],"eyes-closed":[90],"resting-state":[91],"EEGs":[92],"384":[94],"Healthy":[95],"Brain":[96],"Network":[97],"participants":[98],"aged":[99],"5.5":[100],"17.5":[102],"years.":[103],"For":[104],"each":[105],"participant,":[106],"tested":[108],"three":[109],"models:":[111],"their":[112],"MRI,":[114],"template":[118,216],"series":[121],"spanning":[122],"ages":[123],"6-17":[124],"at":[125,234],"one-year":[126],"intervals,":[127],"template.":[132],"compared":[134],"four":[135,219],"childhood":[139],"adolescence:":[141],"absolute":[142,188],"power,":[143,145],"relative":[144],"long-range":[146],"temporal":[147],"correlations":[148],"quantified":[149],"with":[150,165,177],"detrended":[151],"fluctuation":[152],"analysis":[153],"(DFA),":[154],"functional":[156],"excitation-inhibition":[157],"(fE/I)":[158],"ratio.":[159],"Pediatric":[160],"agreed":[162],"more":[163,211],"closely":[164,212],"both":[170],"groups":[172],"had":[174],"fewer":[175],"parcels":[176],"significantly":[178],"different":[179],"biomarker":[180,209],"values":[181,210],"than":[182,213],"template,":[185],"except":[186],"power":[189],"older":[191],"adolescents.":[192],"conclude":[194],"that":[195],"when":[196],"MRI":[198],"is":[199],"not":[200],"available,":[201],"match":[205],"across":[217],"all":[218],"up":[221,236],"approximately":[223],"12":[224],"years":[225],"age":[227],"should":[229],"be":[230],"preferred":[232],"choice":[233],"least":[235],"age.":[239]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}