{"id":"https://openalex.org/W7225326912","doi":"https://doi.org/10.1126/science.aej1120","title":"Obesity management medications: The way forward","display_name":"Obesity management medications: The way forward","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225326912","doi":"https://doi.org/10.1126/science.aej1120","pmid":"https://pubmed.ncbi.nlm.nih.gov/42986954"},"language":"en","primary_location":{"id":"doi:10.1126/science.aej1120","doi":"https://doi.org/10.1126/science.aej1120","is_oa":true,"landing_page_url":"https://doi.org/10.1126/science.aej1120","pdf_url":"https://www.science.org/doi/pdf/10.1126/science.aej1120?download=true","source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":true,"oa_status":"bronze","oa_url":"https://www.science.org/doi/pdf/10.1126/science.aej1120?download=true","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5073471236","display_name":"Matthias Bl\u00fcher","orcid":"https://orcid.org/0000-0003-0208-2065","observed_orcids":["https://orcid.org/0000-0003-0208-2065"]},"institutions":[{"id":"https://openalex.org/I3018134672","display_name":"Helmholtz Munich","ror":"https://ror.org/00cfam450","country_code":"DE","type":"facility","lineage":["https://openalex.org/I1305996414","https://openalex.org/I3018134672"]},{"id":"https://openalex.org/I4210125843","display_name":"University Hospital Leipzig","ror":"https://ror.org/028hv5492","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210125843"]},{"id":"https://openalex.org/I926574661","display_name":"Leipzig University","ror":"https://ror.org/03s7gtk40","country_code":"DE","type":"education","lineage":["https://openalex.org/I926574661"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Matthias Bl\u00fcher","raw_affiliation_strings":["Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany","Leipzig Center of Metabolism (LeiCeM), University of Leipzig, Leipzig, Germany","Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany"],"raw_orcid":"https://orcid.org/0000-0003-0208-2065","affiliations":[{"raw_affiliation_string":"Helmholtz Institute for Metabolic, Obesity and Vascular Research (HI-MAG) of the Helmholtz Zentrum M\u00fcnchen at the University of Leipzig and University Hospital Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I926574661"]},{"raw_affiliation_string":"Leipzig Center of Metabolism (LeiCeM), University of Leipzig, Leipzig, Germany","institution_ids":["https://openalex.org/I926574661"]},{"raw_affiliation_string":"Medical Department III\u2014Endocrinology, Nephrology, Rheumatology, University of Leipzig Medical Center, Leipzig, Germany","institution_ids":["https://openalex.org/I4210125843","https://openalex.org/I926574661"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5073471236"],"corresponding_institution_ids":["https://openalex.org/I3018134672","https://openalex.org/I4210125843","https://openalex.org/I926574661"],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"394","issue":"6824","first_page":"626","last_page":"632"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12539","display_name":"Pharmacology and Obesity Treatment","score":0.9994999766349792,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10489","display_name":"Regulation of Appetite and Obesity","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10569","display_name":"Bariatric Surgery and Outcomes","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/obesity","display_name":"obesity","score":0.7540000081062317},{"id":"https://openalex.org/keywords/anti-obesity-drugs","display_name":"anti-obesity drugs","score":0.8759999871253967},{"id":"https://openalex.org/keywords/drug-therapy","display_name":"pharmacotherapy","score":0.7760000228881836},{"id":"https://openalex.org/keywords/bariatric-surgery","display_name":"bariatric surgery","score":0.9520000219345093},{"id":"https://openalex.org/keywords/food-intake-regulation","display_name":"food intake regulation","score":0.7919999957084656},{"id":"https://openalex.org/keywords/energy-expenditure","display_name":"energy expenditure","score":0.996999979019165},{"id":"https://openalex.org/keywords/weight-loss","display_name":"weight loss","score":0.7730000019073486},{"id":"https://openalex.org/keywords/treatment-adherence","display_name":"medication adherence","score":0.6579999923706055},{"id":"https://openalex.org/keywords/adverse-drug-reactions","display_name":"adverse drug reactions","score":0.7120000123977661},{"id":"https://openalex.org/keywords/treatment-response-heterogeneity","display_name":"treatment response heterogeneity","score":0.7400000095367432}],"concepts":[{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.7997999787330627},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.638700008392334},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.5849999785423279},{"id":"https://openalex.org/C2988147884","wikidata":"https://www.wikidata.org/wiki/Q5377024","display_name":"Energy expenditure","level":2,"score":0.5616000294685364},{"id":"https://openalex.org/C2779952866","wikidata":"https://www.wikidata.org/wiki/Q6746705","display_name":"Management of obesity","level":4,"score":0.5314000248908997},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.48840001225471497},{"id":"https://openalex.org/C544821477","wikidata":"https://www.wikidata.org/wiki/Q718113","display_name":"Weight loss","level":3,"score":0.435699999332428},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.4187000095844269},{"id":"https://openalex.org/C2987552334","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic disease","level":2,"score":0.40869998931884766},{"id":"https://openalex.org/C34320749","wikidata":"https://www.wikidata.org/wiki/Q17087302","display_name":"Weight management","level":4,"score":0.38999998569488525},{"id":"https://openalex.org/C2780600951","wikidata":"https://www.wikidata.org/wiki/Q383126","display_name":"Chronic condition","level":3,"score":0.33000001311302185},{"id":"https://openalex.org/C99454951","wikidata":"https://www.wikidata.org/wiki/Q932068","display_name":"Environmental health","level":1,"score":0.32120001316070557},{"id":"https://openalex.org/C74909509","wikidata":"https://www.wikidata.org/wiki/Q10387","display_name":"Gerontology","level":1,"score":0.31279999017715454},{"id":"https://openalex.org/C147583825","wikidata":"https://www.wikidata.org/wiki/Q620876","display_name":"Body weight","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C3018685816","wikidata":"https://www.wikidata.org/wiki/Q213449","display_name":"Food intake","level":2,"score":0.3021000027656555},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.29010000824928284},{"id":"https://openalex.org/C3019806175","wikidata":"https://www.wikidata.org/wiki/Q11974939","display_name":"Health professionals","level":3,"score":0.2849999964237213},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.28459998965263367},{"id":"https://openalex.org/C2991848491","wikidata":"https://www.wikidata.org/wiki/Q2351083","display_name":"Metabolic disease","level":2,"score":0.27489998936653137},{"id":"https://openalex.org/C64903051","wikidata":"https://www.wikidata.org/wiki/Q2198549","display_name":"Drug development","level":3,"score":0.2687999904155731},{"id":"https://openalex.org/C112930515","wikidata":"https://www.wikidata.org/wiki/Q4389547","display_name":"Risk analysis (engineering)","level":1,"score":0.26820001006126404},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.2635999917984009},{"id":"https://openalex.org/C2992518758","wikidata":"https://www.wikidata.org/wiki/Q193583","display_name":"Fat accumulation","level":3,"score":0.25290000438690186}],"mesh":[{"descriptor_ui":"D000076722","descriptor_name":"Drug Development","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D000097789","descriptor_name":"Glucagon-Like Peptide-1 Receptor Agonists","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D000273","descriptor_name":"Adipose Tissue","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":false},{"descriptor_ui":"D004734","descriptor_name":"Energy Metabolism","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000188","qualifier_name":"drug therapy","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D015431","descriptor_name":"Weight Loss","qualifier_ui":"Q000187","qualifier_name":"drug effects","is_major_topic":false},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000009","qualifier_name":"adverse effects","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000494","qualifier_name":"pharmacology","is_major_topic":true},{"descriptor_ui":"D019440","descriptor_name":"Anti-Obesity Agents","qualifier_ui":"Q000627","qualifier_name":"therapeutic use","is_major_topic":true}],"locations_count":2,"locations":[{"id":"doi:10.1126/science.aej1120","doi":"https://doi.org/10.1126/science.aej1120","is_oa":true,"landing_page_url":"https://doi.org/10.1126/science.aej1120","pdf_url":"https://www.science.org/doi/pdf/10.1126/science.aej1120?download=true","source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},{"id":"pmid:42986954","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42986954","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science (New York, N.Y.)","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1126/science.aej1120","doi":"https://doi.org/10.1126/science.aej1120","is_oa":true,"landing_page_url":"https://doi.org/10.1126/science.aej1120","pdf_url":"https://www.science.org/doi/pdf/10.1126/science.aej1120?download=true","source":{"id":"https://openalex.org/S3880285","display_name":"Science","issn_l":"0036-8075","issn":["0036-8075","0193-4511","1095-9203"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-class-a","anvur-scientific","cwts-core","dongbi-a","doyens","erih-plus","jufo-3","ki-jl-3","medline","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310315823","host_organization_name":"American Association for the Advancement of Science","host_organization_lineage":["https://openalex.org/P4310315823"],"host_organization_lineage_names":["American Association for the Advancement of Science"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Science","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320325298","display_name":"Universit\u00e4t Leipzig","ror":"https://ror.org/03s7gtk40"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225326912.pdf","grobid_xml":"https://content.openalex.org/works/W7225326912.grobid-xml"},"referenced_works_count":52,"referenced_works":["https://openalex.org/W2008411184","https://openalex.org/W2039153962","https://openalex.org/W2080128749","https://openalex.org/W2095327289","https://openalex.org/W2106650290","https://openalex.org/W2142170772","https://openalex.org/W2319361543","https://openalex.org/W2493912138","https://openalex.org/W2895833672","https://openalex.org/W2917520831","https://openalex.org/W2996821007","https://openalex.org/W3009496837","https://openalex.org/W3032939189","https://openalex.org/W3092759212","https://openalex.org/W3127371223","https://openalex.org/W3217337816","https://openalex.org/W4281934192","https://openalex.org/W4293102675","https://openalex.org/W4297021616","https://openalex.org/W4306166132","https://openalex.org/W4388592674","https://openalex.org/W4393535636","https://openalex.org/W4393854150","https://openalex.org/W4399682057","https://openalex.org/W4400362563","https://openalex.org/W4404144873","https://openalex.org/W4404310616","https://openalex.org/W4404858081","https://openalex.org/W4405133548","https://openalex.org/W4406352787","https://openalex.org/W4408051488","https://openalex.org/W4409253167","https://openalex.org/W4411542117","https://openalex.org/W4414222945","https://openalex.org/W4414708467","https://openalex.org/W7120163088","https://openalex.org/W7124314989","https://openalex.org/W7133195341","https://openalex.org/W7136817436","https://openalex.org/W7137854865","https://openalex.org/W7141094182","https://openalex.org/W7151833440","https://openalex.org/W7154695117","https://openalex.org/W7158790410","https://openalex.org/W7160957545","https://openalex.org/W7161030652","https://openalex.org/W7161942986","https://openalex.org/W7164559829","https://openalex.org/W7165632856","https://openalex.org/W7167674005","https://openalex.org/W7167681602","https://openalex.org/W7214802080"],"related_works":["https://openalex.org/W7212016427","https://openalex.org/W2038797955","https://openalex.org/W4403860527","https://openalex.org/W3196669338","https://openalex.org/W2792527993","https://openalex.org/W4312325758","https://openalex.org/W4395468533","https://openalex.org/W2951092893","https://openalex.org/W4404880528","https://openalex.org/W2002044479"],"abstract_inverted_index":{"Obesity":[0],"is":[1],"now":[2],"widely":[3],"recognized":[4],"as":[5],"a":[6],"chronic":[7],"progressive":[8],"condition.":[9],"The":[10],"altered":[11],"biological":[12],"mechanisms":[13],"that":[14,39,75],"cause":[15],"obesity":[16,32,40],"frequently":[17],"require":[18],"long-term":[19,93],"treatment,":[20],"including":[21],"pharmacotherapies":[22],"or":[23],"bariatric":[24],"surgery.":[25],"In":[26],"recent":[27],"decades,":[28],"the":[29,52,67,71,102,109,116],"pathophysiology":[30],"of":[31,54,73,78,104,111,118],"has":[33],"been":[34],"understood":[35],"to":[36,66,70,114],"an":[37],"extent":[38],"management":[41],"medication":[42],"(OMM)":[43],"discovery":[44],"could":[45],"be":[46],"rationally":[47],"pursued.":[48],"Advances":[49],"in":[50],"defining":[51],"regulation":[53],"food":[55],"intake":[56],"and":[57,82,97,107],"energy":[58],"expenditure":[59],"by":[60],"molecular":[61],"communication":[62],"from":[63],"peripheral":[64],"organs":[65],"brain":[68],"led":[69],"development":[72,110],"OMMs":[74,106],"appear":[76],"capable":[77],"safely":[79],"achieving":[80],"scalable":[81],"sustained":[83],"body":[84],"weight":[85],"loss.":[86],"However,":[87],"side":[88],"effects,":[89],"heterogeneous":[90],"treatment":[91],"responses,":[92],"metabolic":[94],"adaptations,":[95],"adherence,":[96],"other":[98],"factors":[99],"may":[100],"limit":[101],"use":[103],"existing":[105],"justify":[108],"additional":[112],"medications":[113],"improve":[115],"health":[117],"people":[119],"living":[120],"with":[121],"obesity.":[122]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-06T00:00:00"}
