{"id":"https://openalex.org/W7225325530","doi":"https://doi.org/10.64898/2026.11.03.26367187","title":"Memory Self-Awareness Phenotypes are Associated with Alzheimer\u2019s Disease Biomarker Burden and Clinical Progression in Amnestic Mild Cognitive Impairment","display_name":"Memory Self-Awareness Phenotypes are Associated with Alzheimer\u2019s Disease Biomarker Burden and Clinical Progression in Amnestic Mild Cognitive Impairment","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225325530","doi":"https://doi.org/10.64898/2026.11.03.26367187"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.03.26367187","doi":"https://doi.org/10.64898/2026.11.03.26367187","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.26367187","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.03.26367187.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.03.26367187.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5126033330","display_name":"Nicholas Enbar-Salo","orcid":"https://orcid.org/0009-0005-1001-8479","observed_orcids":["https://orcid.org/0009-0005-1001-8479"]},"institutions":[{"id":"https://openalex.org/I135474949","display_name":"Bowdoin College","ror":"https://ror.org/03gh96r95","country_code":"US","type":"education","lineage":["https://openalex.org/I135474949"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Nicholas Enbar-Salo","raw_affiliation_strings":["Department of Computer Science and Mathematics, Bowdoin College, Brunswick, ME, USA","Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":"https://orcid.org/0009-0005-1001-8479","affiliations":[{"raw_affiliation_string":"Department of Computer Science and Mathematics, Bowdoin College, Brunswick, ME, USA","institution_ids":["https://openalex.org/I135474949"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5078594672","display_name":"Phebe Palmer","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Phebe Palmer","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008450759","display_name":"Catherine E. Munro","orcid":"https://orcid.org/0000-0002-8707-1826","observed_orcids":["https://orcid.org/0000-0002-8707-1826"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Catherine Munro","raw_affiliation_strings":["Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5020465769","display_name":"Mark A. Dubbelman","orcid":"https://orcid.org/0000-0002-5708-4925","observed_orcids":["https://orcid.org/0000-0002-5708-4925"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Mark Dubbelman","raw_affiliation_strings":["Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074005748","display_name":"Anna Aaronson","orcid":"https://orcid.org/0000-0002-5231-9684","observed_orcids":["https://orcid.org/0000-0002-5231-9684"]},"institutions":[{"id":"https://openalex.org/I111088046","display_name":"Boston University","ror":"https://ror.org/05qwgg493","country_code":"US","type":"education","lineage":["https://openalex.org/I111088046"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Anna Aaronson","raw_affiliation_strings":["Department of Behavioral Neuroscience, Boston University CTE Center, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Behavioral Neuroscience, Boston University CTE Center, Boston, MA, USA","institution_ids":["https://openalex.org/I111088046"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079745650","display_name":"Rachel L. Nosheny","orcid":"https://orcid.org/0000-0003-4995-8319","observed_orcids":["https://orcid.org/0000-0003-4995-8319"]},"institutions":[{"id":"https://openalex.org/I180670191","display_name":"University of California, San Francisco","ror":"https://ror.org/043mz5j54","country_code":"US","type":"education","lineage":["https://openalex.org/I180670191"]},{"id":"https://openalex.org/I4210166254","display_name":"Northern California Institute for Research and Education","ror":"https://ror.org/05p48p517","country_code":"US","type":"nonprofit","lineage":["https://openalex.org/I4210166254"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Rachel Nosheny","raw_affiliation_strings":["Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA","Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA","Northern California Institute for Research and Education (NCIRE), San Francisco, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Psychiatry and Behavioral Sciences, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Department of Radiology and Biomedical Imaging, University of California, San Francisco, USA","institution_ids":["https://openalex.org/I180670191"]},{"raw_affiliation_string":"Northern California Institute for Research and Education (NCIRE), San Francisco, USA","institution_ids":["https://openalex.org/I4210166254"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046541908","display_name":"Jennifer R. Gatchel","orcid":"https://orcid.org/0000-0002-3892-9742","observed_orcids":["https://orcid.org/0000-0002-3892-9742"]},"institutions":[{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I2801148111","display_name":"McLean Hospital","ror":"https://ror.org/01kta7d96","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I2801148111"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jennifer Gatchel","raw_affiliation_strings":["Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]},{"raw_affiliation_string":"Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I2801148111"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064793425","display_name":"Gad A. Marshall","orcid":"https://orcid.org/0000-0002-9096-2355","observed_orcids":["https://orcid.org/0000-0002-9096-2355"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Gad A. Marshall","raw_affiliation_strings":["Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057415951","display_name":"Patrizia Vannini","orcid":"https://orcid.org/0000-0002-9425-1059","observed_orcids":["https://orcid.org/0000-0002-9425-1059"]},"institutions":[{"id":"https://openalex.org/I1283280774","display_name":"Brigham and Women's Hospital","ror":"https://ror.org/04b6nzv94","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I121934306","https://openalex.org/I1283280774","https://openalex.org/I48633490"]},{"id":"https://openalex.org/I136199984","display_name":"Harvard University","ror":"https://ror.org/03vek6s52","country_code":"US","type":"education","lineage":["https://openalex.org/I136199984"]},{"id":"https://openalex.org/I4210087915","display_name":"Massachusetts General Hospital","ror":"https://ror.org/002pd6e78","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I4210087915","https://openalex.org/I48633490"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Patrizia Vannini","raw_affiliation_strings":["Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Brigham and Women\u2019s Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I1283280774","https://openalex.org/I136199984"]},{"raw_affiliation_string":"Department of Neurology, Massachusetts General Hospital, Harvard Medical School, Boston, MA, USA","institution_ids":["https://openalex.org/I136199984","https://openalex.org/I4210087915"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5146660230","display_name":"Alzheimer\u2019s Disease Neuroimaging Initiative","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"the Alzheimer\u2019s Disease Neuroimaging Initiative","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":8,"corresponding_author_ids":["https://openalex.org/A5126033330"],"corresponding_institution_ids":["https://openalex.org/I135474949","https://openalex.org/I136199984","https://openalex.org/I4210087915"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10009","display_name":"Dementia and Cognitive Impairment Research","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10086","display_name":"Alzheimer's disease research and treatments","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T13077","display_name":"Cancer-related cognitive impairment studies","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/amnestic-mild-cognitive-impairment","display_name":"amnestic mild cognitive impairment","score":0.9750000238418579},{"id":"https://openalex.org/keywords/alzheimer-s-disease","display_name":"Alzheimer's disease","score":0.9440000057220459},{"id":"https://openalex.org/keywords/prodromal-alzheimer-s-disease","display_name":"prodromal Alzheimer's disease","score":0.8930000066757202},{"id":"https://openalex.org/keywords/memory-phenotype","display_name":"memory phenotype","score":0.4569999873638153},{"id":"https://openalex.org/keywords/amyloid-beta","display_name":"amyloid-beta","score":0.6919999718666077},{"id":"https://openalex.org/keywords/phosphorylated-tau","display_name":"phosphorylated tau","score":0.9660000205039978},{"id":"https://openalex.org/keywords/amyloid-pet","display_name":"amyloid PET","score":0.9359999895095825},{"id":"https://openalex.org/keywords/clinical-progression","display_name":"clinical progression","score":0.7390000224113464},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.75},{"id":"https://openalex.org/keywords/cerebrospinal-fluid-biomarkers","display_name":"cerebrospinal fluid biomarkers","score":0.7789999842643738}],"concepts":[{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.6567000150680542},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.6467999815940857},{"id":"https://openalex.org/C2781197716","wikidata":"https://www.wikidata.org/wiki/Q864574","display_name":"Biomarker","level":2,"score":0.6134999990463257},{"id":"https://openalex.org/C2984915365","wikidata":"https://www.wikidata.org/wiki/Q5141203","display_name":"Cognitive impairment","level":3,"score":0.6086999773979187},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5874000191688538},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.553600013256073},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.5472000241279602},{"id":"https://openalex.org/C3018842126","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Memory impairment","level":3,"score":0.5062999725341797},{"id":"https://openalex.org/C502032728","wikidata":"https://www.wikidata.org/wiki/Q11081","display_name":"Alzheimer's disease","level":3,"score":0.5005000233650208},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.4957999885082245},{"id":"https://openalex.org/C169900460","wikidata":"https://www.wikidata.org/wiki/Q2200417","display_name":"Cognition","level":2,"score":0.4855000078678131},{"id":"https://openalex.org/C2776656118","wikidata":"https://www.wikidata.org/wiki/Q6815713","display_name":"Memory clinic","level":4,"score":0.4415999948978424},{"id":"https://openalex.org/C88576662","wikidata":"https://www.wikidata.org/wiki/Q18646","display_name":"Episodic memory","level":3,"score":0.38029998540878296},{"id":"https://openalex.org/C2910528735","wikidata":"https://www.wikidata.org/wiki/Q1140331","display_name":"Prodromal Stage","level":4,"score":0.37130001187324524},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3531999886035919},{"id":"https://openalex.org/C2984863031","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Cognitive decline","level":4,"score":0.32499998807907104},{"id":"https://openalex.org/C2778615406","wikidata":"https://www.wikidata.org/wiki/Q11072","display_name":"Amnesia","level":2,"score":0.3239000141620636},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3077000081539154},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.3061000108718872},{"id":"https://openalex.org/C58693492","wikidata":"https://www.wikidata.org/wiki/Q551875","display_name":"Neuroimaging","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2757999897003174},{"id":"https://openalex.org/C2779483572","wikidata":"https://www.wikidata.org/wiki/Q83030","display_name":"Dementia","level":3,"score":0.2712000012397766},{"id":"https://openalex.org/C3020404979","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk stratification","level":2,"score":0.25929999351501465},{"id":"https://openalex.org/C2779407169","wikidata":"https://www.wikidata.org/wiki/Q3072083","display_name":"Memory disorder","level":5,"score":0.258899986743927},{"id":"https://openalex.org/C185711340","wikidata":"https://www.wikidata.org/wiki/Q5347381","display_name":"Effects of sleep deprivation on cognitive performance","level":3,"score":0.25189998745918274},{"id":"https://openalex.org/C70410870","wikidata":"https://www.wikidata.org/wiki/Q199906","display_name":"Clinical psychology","level":1,"score":0.2506999969482422}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.03.26367187","doi":"https://doi.org/10.64898/2026.11.03.26367187","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.26367187","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.03.26367187.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.03.26367187","doi":"https://doi.org/10.64898/2026.11.03.26367187","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.03.26367187","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.03.26367187.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225325530.pdf","grobid_xml":"https://content.openalex.org/works/W7225325530.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W171474986","https://openalex.org/W201461438","https://openalex.org/W1578299474","https://openalex.org/W1626555178","https://openalex.org/W1702095876","https://openalex.org/W1967642097","https://openalex.org/W1971988258","https://openalex.org/W1988085205","https://openalex.org/W1997417397","https://openalex.org/W2006084264","https://openalex.org/W2028680001","https://openalex.org/W2032044128","https://openalex.org/W2033285138","https://openalex.org/W2047266653","https://openalex.org/W2051224630","https://openalex.org/W2052742260","https://openalex.org/W2056854151","https://openalex.org/W2071985231","https://openalex.org/W2077841286","https://openalex.org/W2093825948","https://openalex.org/W2096716068","https://openalex.org/W2115300091","https://openalex.org/W2116294124","https://openalex.org/W2132766843","https://openalex.org/W2138878035","https://openalex.org/W2152038045","https://openalex.org/W2161603871","https://openalex.org/W2167720733","https://openalex.org/W2170417569","https://openalex.org/W2592358437","https://openalex.org/W2605127394","https://openalex.org/W2619223814","https://openalex.org/W2946720770","https://openalex.org/W3004676831","https://openalex.org/W3028295829","https://openalex.org/W3108007701","https://openalex.org/W3175989095","https://openalex.org/W3207675371","https://openalex.org/W4366728513","https://openalex.org/W4366983676","https://openalex.org/W4392514918","https://openalex.org/W4399181094","https://openalex.org/W4406030172","https://openalex.org/W4416198899","https://openalex.org/W4416455941","https://openalex.org/W7117258239"],"related_works":["https://openalex.org/W2746955433","https://openalex.org/W2605127394","https://openalex.org/W2990056118","https://openalex.org/W4390201441","https://openalex.org/W2803076616","https://openalex.org/W4366983676","https://openalex.org/W2435534205","https://openalex.org/W4390193590","https://openalex.org/W2532672725","https://openalex.org/W2959668659"],"abstract_inverted_index":{"STRUCTURED":[0],"ABSTRACT":[1],"Background":[2],"Altered":[3],"memory":[4,32,41,131],"self-awareness":[5,33,132],"is":[6],"common":[7],"in":[8,146],"mild":[9],"cognitive":[10],"impairment":[11],"(MCI),":[12],"but":[13],"its":[14],"relationship":[15],"to":[16],"Alzheimer\u2019s":[17],"disease":[18],"(AD)":[19],"pathology":[20],"and":[21,50,55,66,73,83,90,95,135,141],"progression":[22,75,105],"remains":[23],"unclear.":[24],"Methods":[25],"Using":[26],"590":[27],"amnestic":[28],"MCI":[29,140],"ADNI":[30],"participants,":[31],"was":[34,76,101],"derived":[35],"from":[36],"participant\u2013informant":[37],"discrepancies":[38],"on":[39],"the":[40,44,114],"subdomain":[42],"of":[43,130],"Everyday":[45],"Cognition":[46],"questionnaire.":[47],"Heightened":[48],"awareness":[49],"unawareness":[51],"subscores":[52],"were":[53,71],"calculated,":[54],"k-means":[56],"clustering":[57],"identified":[58],"four":[59],"phenotypes.":[60],"Associations":[61],"with":[62,103],"cerebrospinal":[63],"fluid":[64],"(CSF)":[65],"positron":[67],"emission":[68],"tomography":[69],"(PET)":[70],"examined,":[72],"clinical":[74],"assessed":[77],"using":[78],"Cox":[79],"models.":[80],"Results":[81],"Aware":[82],"Unaware":[84,99],"groups":[85],"showed":[86,118],"lower":[87],"CSF":[88,92],"amyloid-\u03b2,":[89],"higher":[91],"phosphorylated":[93],"tau":[94],"PET":[96],"amyloid.":[97],"The":[98],"phenotype":[100,117],"associated":[102],"increased":[104],"risk":[106,120,144],"(hazard":[107,121],"ratio":[108,122],"2.41,":[109],"95%":[110,124],"CI":[111,125],"1.48\u20133.92),":[112],"whereas":[113],"Worried":[115],"Well":[116],"reduced":[119],"0.58,":[123],"0.34\u20130.99).":[126],"Conclusions":[127],"Multidimensional":[128],"assessment":[129],"identifies":[133],"biologically":[134],"prognostically":[136],"distinct":[137],"subgroups":[138],"within":[139],"may":[142],"improve":[143],"stratification":[145],"prodromal":[147],"AD.":[148]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-06T00:00:00"}