{"id":"https://openalex.org/W7225325503","doi":"https://doi.org/10.1186/s12915-026-02784-4","title":"Chronic pain-like responses revealed by allodynia and hyperalgesia in the ant Lasius niger","display_name":"Chronic pain-like responses revealed by allodynia and hyperalgesia in the ant Lasius niger","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225325503","doi":"https://doi.org/10.1186/s12915-026-02784-4"},"language":"en","primary_location":{"id":"doi:10.1186/s12915-026-02784-4","doi":"https://doi.org/10.1186/s12915-026-02784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-026-02784-4","pdf_url":null,"source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12915-026-02784-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106838898","display_name":"Moana Vorjans","orcid":"https://orcid.org/0009-0007-1415-5432","observed_orcids":["https://orcid.org/0009-0007-1415-5432"]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Moana Vorjans","raw_affiliation_strings":["Animal Cognition and Ecology Laboratory, Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, Berlin, 14195, Germany","Animal Comparative Economics Laboratory, Faculty of Biology and Preclinical Medicine, University of Regensburg, Regensburg, 93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Cognition and Ecology Laboratory, Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, Berlin, 14195, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Animal Comparative Economics Laboratory, Faculty of Biology and Preclinical Medicine, University of Regensburg, Regensburg, 93053, Germany","institution_ids":["https://openalex.org/I60668342"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026740392","display_name":"Meghan Barrett","orcid":"https://orcid.org/0000-0002-1270-4983","observed_orcids":["https://orcid.org/0000-0002-1270-4983","https://orcid.org/0000-0003-3486-0204"]},"institutions":[{"id":"https://openalex.org/I4388446366","display_name":"Indiana University Indianapolis","ror":"https://ror.org/03eftgw80","country_code":"US","type":"education","lineage":["https://openalex.org/I4388446366","https://openalex.org/I592451"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Meghan Barrett","raw_affiliation_strings":["Department of Biology, Indiana University Indianapolis, Indianapolis, IN, 46202, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Indiana University Indianapolis, Indianapolis, IN, 46202, USA","institution_ids":["https://openalex.org/I4388446366"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160866266","display_name":"Tomer Joseph Czaczkes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I60668342","display_name":"University of Regensburg","ror":"https://ror.org/01eezs655","country_code":"DE","type":"education","lineage":["https://openalex.org/I60668342"]},{"id":"https://openalex.org/I75951250","display_name":"Freie Universit\u00e4t Berlin","ror":"https://ror.org/046ak2485","country_code":"DE","type":"education","lineage":["https://openalex.org/I75951250"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Tomer Joseph Czaczkes","raw_affiliation_strings":["Animal Cognition and Ecology Laboratory, Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, Berlin, 14195, Germany","Animal Comparative Economics Laboratory, Faculty of Biology and Preclinical Medicine, University of Regensburg, Regensburg, 93053, Germany"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Animal Cognition and Ecology Laboratory, Department of Biology, Chemistry, Pharmacy, Freie Universit\u00e4t Berlin, Berlin, 14195, Germany","institution_ids":["https://openalex.org/I75951250"]},{"raw_affiliation_string":"Animal Comparative Economics Laboratory, Faculty of Biology and Preclinical Medicine, University of Regensburg, Regensburg, 93053, Germany","institution_ids":["https://openalex.org/I60668342"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5106838898"],"corresponding_institution_ids":["https://openalex.org/I60668342","https://openalex.org/I75951250"],"apc_list":{"value":3690,"currency":"USD","value_usd":3690},"apc_paid":{"value":3690,"currency":"USD","value_usd":3690},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10423","display_name":"Neurobiology and Insect Physiology Research","score":0.8140000104904175,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10196","display_name":"Pain Mechanisms and Treatments","score":0.17479999363422394,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10702","display_name":"Insect and Arachnid Ecology and Behavior","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/allodynia","display_name":"allodynia","score":0.9309999942779541},{"id":"https://openalex.org/keywords/hyperalgesia","display_name":"hyperalgesia","score":1.0},{"id":"https://openalex.org/keywords/chronic-pain","display_name":"chronic pain","score":0.6150000095367432},{"id":"https://openalex.org/keywords/nociception","display_name":"nociception","score":0.8019999861717224},{"id":"https://openalex.org/keywords/lasius-niger","display_name":"Lasius niger","score":0.7799999713897705},{"id":"https://openalex.org/keywords/burns","display_name":"burns","score":0.7369999885559082},{"id":"https://openalex.org/keywords/pain-sensitization","display_name":"pain sensitization","score":0.7039999961853027},{"id":"https://openalex.org/keywords/locomotor-behaviour","display_name":"locomotor behaviour","score":0.6349999904632568}],"concepts":[{"id":"https://openalex.org/C2777883359","wikidata":"https://www.wikidata.org/wiki/Q1888634","display_name":"Allodynia","level":5,"score":0.8949999809265137},{"id":"https://openalex.org/C2779245659","wikidata":"https://www.wikidata.org/wiki/Q1633866","display_name":"Hyperalgesia","level":4,"score":0.8009999990463257},{"id":"https://openalex.org/C2776217527","wikidata":"https://www.wikidata.org/wiki/Q944828","display_name":"Sensitization","level":2,"score":0.7138000130653381},{"id":"https://openalex.org/C15490471","wikidata":"https://www.wikidata.org/wiki/Q2734305","display_name":"Nociception","level":3,"score":0.6194000244140625},{"id":"https://openalex.org/C2776111856","wikidata":"https://www.wikidata.org/wiki/Q1157048","display_name":"Lasius","level":3,"score":0.5949000120162964},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4415000081062317},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.38690000772476196},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.3582000136375427},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3352999985218048},{"id":"https://openalex.org/C46762472","wikidata":"https://www.wikidata.org/wiki/Q178648","display_name":"Peripheral","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C2776378700","wikidata":"https://www.wikidata.org/wiki/Q3030775","display_name":"Distraction","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3237999975681305},{"id":"https://openalex.org/C2780196728","wikidata":"https://www.wikidata.org/wiki/Q1413166","display_name":"Scratching","level":2,"score":0.32249999046325684},{"id":"https://openalex.org/C2781118164","wikidata":"https://www.wikidata.org/wiki/Q1088113","display_name":"Chronic pain","level":2,"score":0.3158999979496002},{"id":"https://openalex.org/C2777107010","wikidata":"https://www.wikidata.org/wiki/Q2798704","display_name":"Neuropathic pain","level":2,"score":0.31209999322891235},{"id":"https://openalex.org/C2780723003","wikidata":"https://www.wikidata.org/wiki/Q2917928","display_name":"Licking","level":2,"score":0.29510000348091125},{"id":"https://openalex.org/C140530291","wikidata":"https://www.wikidata.org/wiki/Q1225063","display_name":"Dorsum","level":2,"score":0.289900004863739},{"id":"https://openalex.org/C2776204877","wikidata":"https://www.wikidata.org/wiki/Q477415","display_name":"Amputation","level":2,"score":0.2754000127315521},{"id":"https://openalex.org/C81077568","wikidata":"https://www.wikidata.org/wiki/Q5397078","display_name":"Escape response","level":2,"score":0.27399998903274536},{"id":"https://openalex.org/C172659308","wikidata":"https://www.wikidata.org/wiki/Q412542","display_name":"Nociceptor","level":4,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12915-026-02784-4","doi":"https://doi.org/10.1186/s12915-026-02784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-026-02784-4","pdf_url":null,"source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12915-026-02784-4","doi":"https://doi.org/10.1186/s12915-026-02784-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12915-026-02784-4","pdf_url":null,"source":{"id":"https://openalex.org/S25903957","display_name":"BMC Biology","issn_l":"1741-7007","issn":["1741-7007"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.5683000087738037,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320324521","display_name":"Freie Universit\u00e4t Berlin","ror":null}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W3174577232","https://openalex.org/W288230236","https://openalex.org/W2085474248","https://openalex.org/W1968822414","https://openalex.org/W2521699409","https://openalex.org/W1847833199","https://openalex.org/W1990986143","https://openalex.org/W2115767608","https://openalex.org/W2136477585","https://openalex.org/W2080076872"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Allodynia":[2],"(pain":[3],"in":[4,26,38,61,132,151,219,226,245],"response":[5,171],"to":[6,14,93,108,140,232,242],"normally":[7,113],"non-noxious":[8,114],"stimuli)":[9,16],"and":[10,46,58,76,96,100,137,148,154,164,193,210],"hyperalgesia":[11,47,161],"(increased":[12],"sensitivity":[13],"painful":[15],"are":[17],"well-established":[18],"indicators":[19],"of":[20,51,102,130,191,196],"pain":[21],"sensitization":[22,203],"after":[23],"tissue":[24],"damage":[25],"vertebrates.":[27],"These":[28,199],"phenomena":[29],"may":[30,239],"also":[31],"offer":[32],"valuable":[33],"insights":[34],"into":[35],"nociceptive":[36],"processing":[37,218],"invertebrates.":[39],"We":[40,125],"assessed":[41],"behavioural":[42],"evidence":[43,190,195,214],"for":[44,160,215],"allodynia":[45,95,192],"following":[48],"two":[49],"types":[50],"peripheral":[52],"injury":[53,208,224],"(tarsus":[54],"amputation":[55],"or":[56,117,235],"burning)":[57],"sham":[59],"treatment":[60,230],"black":[62],"garden":[63],"ants":[64,133,153,167,186],"(":[65],"Lasius":[66],"niger":[67],",":[68],"Hymenoptera:":[69],"Formicidae).":[70],"At":[71],"20":[72],"min,":[73],"24":[74],"h,":[75],"96":[77,183],"h":[78],"post-anaesthesia,":[79],"a":[80,169,222],"ramping":[81],"hot":[82],"plate":[83],"assay":[84],"with":[85,134,143,212],"sublethal,":[86],"but":[87,180],"increasingly":[88],"noxious,":[89],"temperatures":[90,115,122,175],"was":[91,146,162],"used":[92],"assess":[94],"hyperalgesia.":[97,197],"Locomotor":[98],"speed":[99],"proportion":[101],"time":[103,157,178],"spent":[104],"moving":[105],"were":[106],"quantified":[107],"detect":[109],"increased":[110],"responsiveness":[111,131],"at":[112,120,155,173,176,182],"(allodynia)":[116],"exaggerated":[118],"responses":[119],"higher":[121,174],"(hyperalgesia).":[123],"Results":[124],"observed":[126],"an":[127],"earlier":[128,177],"onset":[129],"tarsus":[135],"amputations":[136],"burns":[138],"compared":[139],"controls,":[141],"consistent":[142,150,189],"allodynia,":[144],"which":[145],"stronger":[147],"more":[149],"tarsus-amputated":[152],"later":[156],"points.":[158],"Evidence":[159],"limited":[163],"time-dependent:":[165],"amputated":[166],"showed":[168,187],"steeper":[170],"increase":[172],"points,":[179],"not":[181],"h.":[184],"Burn-treated":[185],"less":[188],"no":[194],"Conclusions":[198],"findings":[200],"suggest":[201],"that":[202],"extends":[204],"beyond":[205],"the":[206,228,236],"acute":[207],"phase":[209],"align":[211],"broader":[213],"chronic,":[216],"pain-like":[217],"insects.":[220],"As":[221],"new":[223],"model":[225],"insects,":[227],"burn":[229],"needs":[231],"be":[233,240],"refined,":[234],"underlying":[237],"mechanisms":[238],"different":[241],"those":[243],"involved":[244],"classic,":[246],"amputation-induced":[247],"sensitization.":[248]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}