{"id":"https://openalex.org/W7225325434","doi":"https://doi.org/10.26036/cnp0008195","title":"Untargeted Metabolomics Analysis of Cerebrospinal Fluid in Patients with Acute Cervical Traumatic Spinal Cord Injury","display_name":"Untargeted Metabolomics Analysis of Cerebrospinal Fluid in Patients with Acute Cervical Traumatic Spinal Cord Injury","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225325434","doi":"https://doi.org/10.26036/cnp0008195"},"language":"en","primary_location":{"id":"doi:10.26036/cnp0008195","doi":"https://doi.org/10.26036/cnp0008195","is_oa":true,"landing_page_url":"https://doi.org/10.26036/cnp0008195","pdf_url":null,"source":{"id":"https://openalex.org/S7407050933","display_name":"China National GeneBank DataBase","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149137","host_organization_name":"China National GeneBank","host_organization_lineage":["https://openalex.org/I4210149137"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.26036/cnp0008195","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160912698","display_name":"\u848b\u6587\u5eb7(Wenkang Jiang)","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"\u848b\u6587\u5eb7(Wenkang Jiang)","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5160912698"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10925","display_name":"Spinal Cord Injury Research","score":0.9634000062942505,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10836","display_name":"Metabolomics and Mass Spectrometry Studies","score":0.030700000002980232,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10706","display_name":"Traumatic Brain Injury and Neurovascular Disturbances","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/traumatic-spinal-cord-injury","display_name":"traumatic spinal cord injury","score":0.9810000061988831},{"id":"https://openalex.org/keywords/cervical-spinal-cord-injury","display_name":"cervical spinal cord injury","score":0.9509999752044678},{"id":"https://openalex.org/keywords/cerebrospinal-fluid","display_name":"cerebrospinal fluid","score":0.9330000281333923},{"id":"https://openalex.org/keywords/untargeted-metabolomics","display_name":"untargeted metabolomics","score":0.9210000038146973},{"id":"https://openalex.org/keywords/idiopathic-normal-pressure-hydrocephalus","display_name":"idiopathic normal pressure hydrocephalus","score":0.8970000147819519},{"id":"https://openalex.org/keywords/biomarkers","display_name":"biomarkers","score":0.5299999713897705},{"id":"https://openalex.org/keywords/acute-spinal-cord-injury","display_name":"acute spinal cord injury","score":0.5009999871253967}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.911300003528595},{"id":"https://openalex.org/C2778334475","wikidata":"https://www.wikidata.org/wiki/Q1415275","display_name":"Spinal cord injury","level":3,"score":0.6342999935150146},{"id":"https://openalex.org/C2779651940","wikidata":"https://www.wikidata.org/wiki/Q54196","display_name":"Cerebrospinal fluid","level":2,"score":0.5939000248908997},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.5655999779701233},{"id":"https://openalex.org/C44575665","wikidata":"https://www.wikidata.org/wiki/Q1293405","display_name":"Lumbar","level":2,"score":0.5508000254631042},{"id":"https://openalex.org/C2781017439","wikidata":"https://www.wikidata.org/wiki/Q1995526","display_name":"Traumatic brain injury","level":2,"score":0.5371000170707703},{"id":"https://openalex.org/C2779480328","wikidata":"https://www.wikidata.org/wiki/Q1183684","display_name":"Decompression","level":2,"score":0.5117999911308289},{"id":"https://openalex.org/C2780775167","wikidata":"https://www.wikidata.org/wiki/Q9606","display_name":"Spinal cord","level":2,"score":0.47839999198913574},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.45329999923706055},{"id":"https://openalex.org/C10162356","wikidata":"https://www.wikidata.org/wiki/Q1135939","display_name":"Pathophysiology","level":2,"score":0.44530001282691956},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.44020000100135803},{"id":"https://openalex.org/C2780066322","wikidata":"https://www.wikidata.org/wiki/Q719444","display_name":"Lumbar puncture","level":3,"score":0.4381999969482422},{"id":"https://openalex.org/C2779281540","wikidata":"https://www.wikidata.org/wiki/Q5062122","display_name":"Central nervous system disease","level":2,"score":0.32580000162124634},{"id":"https://openalex.org/C2779632786","wikidata":"https://www.wikidata.org/wiki/Q920297","display_name":"Cord","level":2,"score":0.26440000534057617},{"id":"https://openalex.org/C2777597760","wikidata":"https://www.wikidata.org/wiki/Q1049655","display_name":"Paraplegia","level":3,"score":0.2590000033378601},{"id":"https://openalex.org/C2780724011","wikidata":"https://www.wikidata.org/wiki/Q1295316","display_name":"Emergency department","level":2,"score":0.25119999051094055}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.26036/cnp0008195","doi":"https://doi.org/10.26036/cnp0008195","is_oa":true,"landing_page_url":"https://doi.org/10.26036/cnp0008195","pdf_url":null,"source":{"id":"https://openalex.org/S7407050933","display_name":"China National GeneBank DataBase","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149137","host_organization_name":"China National GeneBank","host_organization_lineage":["https://openalex.org/I4210149137"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"}],"best_oa_location":{"id":"doi:10.26036/cnp0008195","doi":"https://doi.org/10.26036/cnp0008195","is_oa":true,"landing_page_url":"https://doi.org/10.26036/cnp0008195","pdf_url":null,"source":{"id":"https://openalex.org/S7407050933","display_name":"China National GeneBank DataBase","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210149137","host_organization_name":"China National GeneBank","host_organization_lineage":["https://openalex.org/I4210149137"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"article-journal"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.979200005531311}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7225123785","https://openalex.org/W2564254866","https://openalex.org/W3197138136","https://openalex.org/W4405982173","https://openalex.org/W4291291897","https://openalex.org/W3005129989","https://openalex.org/W1997431718","https://openalex.org/W4382458474","https://openalex.org/W4387455430","https://openalex.org/W4377289449"],"abstract_inverted_index":{"Traumatic":[0],"spinal":[1,58],"cord":[2,59],"injury":[3,60],"(TSCI)":[4],"is":[5],"a":[6,32,57,72],"destructive":[7],"neurological":[8],"disorder":[9],"whose":[10],"complex":[11],"underlying":[12,26],"mechanisms":[13,25],"remain":[14],"incompletely":[15],"elucidated.":[16],"To":[17],"gain":[18],"deeper":[19],"insights":[20],"into":[21,168],"the":[22,45,127,140,207],"central":[23],"pathophysiological":[24],"TSCI,":[27,70],"this":[28],"study":[29,52],"prospectively":[30],"recruited":[31],"consecutive":[33],"cohort":[34],"of":[35,47,54,93,122,130],"10":[36],"participants":[37],"between":[38],"February":[39],"2023":[40],"and":[41,71,136,139,147,172,206],"August":[42],"2024":[43],"at":[44,152,158,174],"Department":[46],"Neurosurgery,":[48],"Zhongda":[49,131],"Hospital.":[50],"The":[51,162],"consisted":[53],"two":[55],"groups:":[56],"group":[61,74],"(SCI":[62],"group,":[63,76],"n=5)":[64,77],"comprising":[65,78],"patients":[66,79],"with":[67,81,202],"acute":[68],"cervical":[69],"control":[73],"(CON":[75],"diagnosed":[80],"idiopathic":[82],"normal":[83],"pressure":[84],"hydrocephalus":[85],"(iNPH).":[86],"For":[87,108],"SCI":[88],"patients,":[89,110],"approximately":[90],"4":[91,159],"ml":[92],"CSF":[94,134],"was":[95,114],"collected":[96,115],"via":[97],"lumbar":[98,119],"puncture":[99],"immediately":[100,148],"following":[101],"emergency":[102],"decompression":[103],"surgery":[104],"under":[105],"general":[106],"anesthesia.":[107],"CON":[109],"an":[111,183,189],"equivalent":[112],"volume":[113],"during":[116],"routine":[117,135],"diagnostic":[118],"puncture.":[120],"Half":[121],"samples":[123],"were":[124,143,165,200],"sent":[125],"to":[126,214],"Clinical":[128],"Laboratory":[129],"Hospital":[132],"for":[133,155,178],"biochemical":[137],"tests,":[138],"rest":[141],"half":[142],"kept":[144],"on":[145,188],"ice":[146],"processed":[149],"by":[150],"centrifugation":[151],"3,000":[153],"rpm":[154],"15":[156],"minutes":[157],"Degree":[160,176],"Celsius.":[161],"resulting":[163],"supernatants":[164],"carefully":[166],"aliquoted":[167],"sterile":[169],"cryotubes,":[170],"labeled,":[171],"stored":[173],"-80":[175],"Celsius":[177],"further":[179],"analysis.":[180],"We":[181],"utilized":[182],"untargeted":[184],"metabolomics":[185],"approach":[186],"based":[187],"ultra":[190],"performance":[191],"liquid":[192],"chromatography-Tandem":[193],"mass":[194],"spectrometry":[195],"(UPLC-MS/MS)":[196],"system,":[197],"all":[198],"experiments":[199],"performed":[201],"three":[203],"technical":[204],"replicates,":[205],"results":[208],"are":[209],"reported":[210],"as":[211],"mean":[212],"values":[213],"ensure":[215],"data":[216],"reliability.":[217]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}
