{"id":"https://openalex.org/W7225324856","doi":"https://doi.org/10.3389/fmedt.2026.1996526","title":"Engineering Osmo-DESs through computational screening and thermophysical validation for pharmaceutical technologies","display_name":"Engineering Osmo-DESs through computational screening and thermophysical validation for pharmaceutical technologies","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225324856","doi":"https://doi.org/10.3389/fmedt.2026.1996526"},"language":"en","primary_location":{"id":"doi:10.3389/fmedt.2026.1996526","doi":"https://doi.org/10.3389/fmedt.2026.1996526","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmedt.2026.1996526","pdf_url":"https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2026.1996526/pdf","source":{"id":"https://openalex.org/S4210239291","display_name":"Frontiers in Medical Technology","issn_l":"2673-3129","issn":["2673-3129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medical Technology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2026.1996526/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5015272181","display_name":"Priyanka Yadav","orcid":"https://orcid.org/0009-0001-9853-219X","observed_orcids":["https://orcid.org/0009-0001-9853-219X","https://orcid.org/0000-0002-2562-2020"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Priyanka Yadav","raw_affiliation_strings":["Department of Mechanical Engineering, University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5081585912","display_name":"Akshat Satyanarayan Mallya","orcid":"https://orcid.org/0000-0002-9833-584X","observed_orcids":["https://orcid.org/0000-0002-9833-584X"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Akshat S. Mallya","raw_affiliation_strings":["Department of Mechanical Engineering, University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160780574","display_name":"Elyssa Meixner","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Elyssa Meixner","raw_affiliation_strings":["Department of Mechanical Engineering, University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5044001134","display_name":"Allison Hubel","orcid":"https://orcid.org/0000-0001-5856-0500","observed_orcids":["https://orcid.org/0000-0001-5856-0500"]},"institutions":[{"id":"https://openalex.org/I130238516","display_name":"University of Minnesota","ror":"https://ror.org/017zqws13","country_code":"US","type":"education","lineage":["https://openalex.org/I130238516"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Allison Hubel","raw_affiliation_strings":["Department of Mechanical Engineering, University of Minnesota Twin Cities"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Mechanical Engineering, University of Minnesota Twin Cities","institution_ids":["https://openalex.org/I130238516"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5044001134"],"corresponding_institution_ids":["https://openalex.org/I130238516"],"apc_list":{"value":1950,"currency":"CHF","value_usd":2353},"apc_paid":{"value":1950,"currency":"CHF","value_usd":2353},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"8","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10480","display_name":"Ionic liquids properties and applications","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10402","display_name":"Phase Equilibria and Thermodynamics","score":0.0006000000284984708,"subfield":{"id":"https://openalex.org/subfields/1606","display_name":"Physical and Theoretical Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10474","display_name":"Material Dynamics and Properties","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2505","display_name":"Materials Chemistry"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/thermophysical-properties","display_name":"thermophysical properties","score":0.699999988079071},{"id":"https://openalex.org/keywords/melting-point","display_name":"melting point","score":0.8199999928474426},{"id":"https://openalex.org/keywords/glass-transition-temperature","display_name":"glass transition temperature","score":0.9890000224113464},{"id":"https://openalex.org/keywords/ph","display_name":"pH","score":0.531000018119812},{"id":"https://openalex.org/keywords/hydrogen-bond-network","display_name":"hydrogen bond network","score":0.8539999723434448},{"id":"https://openalex.org/keywords/amino-acids","display_name":"amino acids","score":0.7350000143051147},{"id":"https://openalex.org/keywords/sugar","display_name":"sugar","score":0.4050000011920929},{"id":"https://openalex.org/keywords/polyols","display_name":"sugar alcohols","score":0.9879999756813049},{"id":"https://openalex.org/keywords/trimethylamine-n-oxide","display_name":"trimethylamine N-oxide","score":0.8640000224113464},{"id":"https://openalex.org/keywords/betaine","display_name":"betaine","score":0.7580000162124634},{"id":"https://openalex.org/keywords/taurine","display_name":"taurine","score":0.800000011920929},{"id":"https://openalex.org/keywords/urea","display_name":"urea","score":0.9639999866485596},{"id":"https://openalex.org/keywords/cosmo-rs-screening","display_name":"COSMO-RS screening","score":0.7770000100135803},{"id":"https://openalex.org/keywords/green-solvents","display_name":"green solvents","score":0.5870000123977661}],"concepts":[{"id":"https://openalex.org/C18168003","wikidata":"https://www.wikidata.org/wiki/Q628595","display_name":"Eutectic system","level":3,"score":0.7202000021934509},{"id":"https://openalex.org/C39519442","wikidata":"https://www.wikidata.org/wiki/Q904893","display_name":"Differential scanning calorimetry","level":2,"score":0.6557999849319458},{"id":"https://openalex.org/C97355855","wikidata":"https://www.wikidata.org/wiki/Q11473","display_name":"Thermodynamics","level":1,"score":0.6093000173568726},{"id":"https://openalex.org/C36591836","wikidata":"https://www.wikidata.org/wiki/Q125264","display_name":"Mole fraction","level":2,"score":0.5993000268936157},{"id":"https://openalex.org/C122865956","wikidata":"https://www.wikidata.org/wiki/Q825643","display_name":"Glass transition","level":3,"score":0.5181000232696533},{"id":"https://openalex.org/C129564387","wikidata":"https://www.wikidata.org/wiki/Q484790","display_name":"Enthalpy of fusion","level":3,"score":0.4747999906539917},{"id":"https://openalex.org/C2985276288","wikidata":"https://www.wikidata.org/wiki/Q16873139","display_name":"Melting temperature","level":2,"score":0.4645000100135803},{"id":"https://openalex.org/C13530604","wikidata":"https://www.wikidata.org/wiki/Q15318","display_name":"Melting point","level":2,"score":0.45170000195503235},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4404999911785126},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.41659998893737793},{"id":"https://openalex.org/C3288061","wikidata":"https://www.wikidata.org/wiki/Q161064","display_name":"Enthalpy","level":2,"score":0.41260001063346863},{"id":"https://openalex.org/C112964491","wikidata":"https://www.wikidata.org/wiki/Q213659","display_name":"Supercooling","level":2,"score":0.4002000093460083},{"id":"https://openalex.org/C2780365088","wikidata":"https://www.wikidata.org/wiki/Q48318","display_name":"Urea","level":2,"score":0.38339999318122864},{"id":"https://openalex.org/C44280652","wikidata":"https://www.wikidata.org/wiki/Q104837","display_name":"Phase (matter)","level":2,"score":0.3734000027179718},{"id":"https://openalex.org/C97346530","wikidata":"https://www.wikidata.org/wiki/Q487005","display_name":"Thermal conductivity","level":2,"score":0.37299999594688416},{"id":"https://openalex.org/C129446986","wikidata":"https://www.wikidata.org/wiki/Q542419","display_name":"Thermal analysis","level":3,"score":0.35899999737739563},{"id":"https://openalex.org/C149288129","wikidata":"https://www.wikidata.org/wiki/Q185357","display_name":"Phase transition","level":2,"score":0.3321000039577484},{"id":"https://openalex.org/C64452783","wikidata":"https://www.wikidata.org/wiki/Q1524945","display_name":"Ternary operation","level":2,"score":0.3292999863624573},{"id":"https://openalex.org/C149629883","wikidata":"https://www.wikidata.org/wiki/Q660926","display_name":"Fraction (chemistry)","level":2,"score":0.31520000100135803},{"id":"https://openalex.org/C42360764","wikidata":"https://www.wikidata.org/wiki/Q83588","display_name":"Chemical engineering","level":1,"score":0.31380000710487366},{"id":"https://openalex.org/C116628846","wikidata":"https://www.wikidata.org/wiki/Q899138","display_name":"Mass fraction","level":2,"score":0.3098999857902527},{"id":"https://openalex.org/C60205243","wikidata":"https://www.wikidata.org/wiki/Q179388","display_name":"Heat capacity","level":2,"score":0.30889999866485596},{"id":"https://openalex.org/C202270520","wikidata":"https://www.wikidata.org/wiki/Q634314","display_name":"Calorimetry","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C21582691","wikidata":"https://www.wikidata.org/wiki/Q3705725","display_name":"Melting-point depression","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C113196181","wikidata":"https://www.wikidata.org/wiki/Q485223","display_name":"Analytical Chemistry (journal)","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C110884469","wikidata":"https://www.wikidata.org/wiki/Q906367","display_name":"Miscibility","level":3,"score":0.28780001401901245},{"id":"https://openalex.org/C180512476","wikidata":"https://www.wikidata.org/wiki/Q465149","display_name":"Freezing-point depression","level":3,"score":0.28529998660087585},{"id":"https://openalex.org/C58024561","wikidata":"https://www.wikidata.org/wiki/Q207721","display_name":"Latent heat","level":2,"score":0.28519999980926514},{"id":"https://openalex.org/C204530211","wikidata":"https://www.wikidata.org/wiki/Q752823","display_name":"Thermal","level":2,"score":0.28139999508857727},{"id":"https://openalex.org/C85906118","wikidata":"https://www.wikidata.org/wiki/Q186693","display_name":"Phase diagram","level":3,"score":0.2727999985218048},{"id":"https://openalex.org/C59593255","wikidata":"https://www.wikidata.org/wiki/Q901663","display_name":"Molecular dynamics","level":2,"score":0.2605000138282776},{"id":"https://openalex.org/C2776836360","wikidata":"https://www.wikidata.org/wiki/Q2741084","display_name":"Rhodanine","level":2,"score":0.2563000023365021}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fmedt.2026.1996526","doi":"https://doi.org/10.3389/fmedt.2026.1996526","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmedt.2026.1996526","pdf_url":"https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2026.1996526/pdf","source":{"id":"https://openalex.org/S4210239291","display_name":"Frontiers in Medical Technology","issn_l":"2673-3129","issn":["2673-3129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medical Technology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:db00a4220b6b4bebb157da245c4e2dde","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/db00a4220b6b4bebb157da245c4e2dde","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Medical Technology, Vol 8 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fmedt.2026.1996526","doi":"https://doi.org/10.3389/fmedt.2026.1996526","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fmedt.2026.1996526","pdf_url":"https://www.frontiersin.org/journals/medical-technology/articles/10.3389/fmedt.2026.1996526/pdf","source":{"id":"https://openalex.org/S4210239291","display_name":"Frontiers in Medical Technology","issn_l":"2673-3129","issn":["2673-3129"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Medical Technology","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320332161","display_name":"National Institutes of Health","ror":"https://ror.org/01cwqze88"},{"id":"https://openalex.org/F4320332180","display_name":"Defense Advanced Research Projects Agency","ror":"https://ror.org/02caytj08"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225324856.pdf","grobid_xml":"https://content.openalex.org/works/W7225324856.grobid-xml"},"referenced_works_count":59,"referenced_works":["https://openalex.org/W1582009577","https://openalex.org/W1793341005","https://openalex.org/W2006708449","https://openalex.org/W2065820312","https://openalex.org/W2073328513","https://openalex.org/W2088642458","https://openalex.org/W2116888800","https://openalex.org/W2140852334","https://openalex.org/W2162651138","https://openalex.org/W2319128214","https://openalex.org/W2545134791","https://openalex.org/W2550679877","https://openalex.org/W2552453670","https://openalex.org/W2610973917","https://openalex.org/W2811114989","https://openalex.org/W2945520314","https://openalex.org/W2949044617","https://openalex.org/W2980442648","https://openalex.org/W3005855205","https://openalex.org/W3012424941","https://openalex.org/W3012979290","https://openalex.org/W3030698984","https://openalex.org/W3032999684","https://openalex.org/W3110668392","https://openalex.org/W3111003051","https://openalex.org/W3190308129","https://openalex.org/W4210979461","https://openalex.org/W4280557059","https://openalex.org/W4281678662","https://openalex.org/W4282940522","https://openalex.org/W4283767374","https://openalex.org/W4285271069","https://openalex.org/W4285394117","https://openalex.org/W4287356902","https://openalex.org/W4293774345","https://openalex.org/W4309656466","https://openalex.org/W4310169426","https://openalex.org/W4310290796","https://openalex.org/W4366424572","https://openalex.org/W4380763210","https://openalex.org/W4382753140","https://openalex.org/W4387407947","https://openalex.org/W4391027010","https://openalex.org/W4400654796","https://openalex.org/W4403649618","https://openalex.org/W4404264822","https://openalex.org/W4406038915","https://openalex.org/W4407406397","https://openalex.org/W4408624903","https://openalex.org/W4412984206","https://openalex.org/W4413860047","https://openalex.org/W4413977700","https://openalex.org/W4415899751","https://openalex.org/W4416126203","https://openalex.org/W4417460507","https://openalex.org/W7117291402","https://openalex.org/W7161552760","https://openalex.org/W7167437644","https://openalex.org/W7204438335"],"related_works":["https://openalex.org/W4410279520","https://openalex.org/W2937393885","https://openalex.org/W2763434263","https://openalex.org/W4413860047","https://openalex.org/W2999773875","https://openalex.org/W4407023653","https://openalex.org/W4404367604","https://openalex.org/W3194048879","https://openalex.org/W4416925981","https://openalex.org/W6995697277"],"abstract_inverted_index":{"Osmolyte-based":[0],"Deep":[1],"Eutectic":[2],"Solvents":[3],"(Osmo-DESs)":[4],"inspired":[5],"by":[6,134],"biological":[7],"systems":[8],"are":[9,175],"emerging":[10],"as":[11,101,155,303],"sustainable,":[12,282],"biocompatible":[13],"alternatives":[14],"to":[15,50,88],"conventional":[16],"solvents":[17],"for":[18,286,309],"biomedical":[19],"and":[20,45,47,66,77,94,120,149,157,167,189,196,242,299,312,317],"pharmaceutical":[21],"applications.":[22],"In":[23],"this":[24,275],"study,":[25],"we":[26,80],"systematically":[27],"investigate":[28],"the":[29,52,211,218,234,262,278,297],"thermophysical":[30,98],"properties":[31,99],"of":[32,61,115,162,165,183,193,223,231,250,258,265,281,289,301],"multi-component":[33,126],"Osmo-DESs":[34,127,284,302],"based":[35,152],"on":[36],"naturally":[37],"occurring":[38],"metabolites,":[39],"including":[40,91,186,291],"amino-acids,":[41],"sugars,":[42,190],"sugar":[43,187],"alcohols,":[44],"urea":[46,243],"trimethylamine":[48],"N-oxide":[49],"mimic":[51],"complex":[53],"intracellular":[54],"environments":[55,264],"found":[56],"in":[57,145,315],"nature.":[58],"Using":[59],"combinations":[60,201],"osmolytes,":[62],"COSMO-RS":[63],"computational":[64,270],"screening":[65],"experimental":[67,273],"validation":[68],"employing":[69],"polarized":[70],"optical":[71],"microscopy,":[72],"Differential":[73],"Scanning":[74],"Calorimetry":[75],"(DSC),":[76],"pH":[78,197,204],"measurements":[79],"explore":[81],"how":[82],"increasing":[83],"compositional":[84],"complexity,":[85],"from":[86],"binary":[87,212],"multicomponent":[89,235],"mixtures,":[90,96],"three-,":[92],"four-,":[93],"six-component":[95],"influences":[97],"such":[100,154],"melting":[102,116,163,221,248],"temperature":[103,109,222,249],"(T":[104,110],"m":[105,118],"),":[106,112,119],"glass":[107],"transition":[108],"g":[111],"latent":[113],"enthalpy":[114],"(\u0394H":[117],"pH.":[121],"Our":[122,294],"results":[123],"demonstrate":[124],"that":[125],"exhibit":[128],"highly":[129],"tunable":[130],"thermal":[131,195],"behaviour":[132],"governed":[133],"intricate":[135],"hydrogen-bond":[136],"networks,":[137],"with":[138,177,199,272],"water":[139,172,228,255],"fraction":[140,230,257],"playing":[141],"a":[142,227,245,254,287],"pivotal":[143],"role":[144],"modulating":[146],"phase":[147],"transitions":[148],"stability.":[150],"Amino-acid":[151],"Osmo-DESs,":[153,214],"Proline:Betaine":[156],"Proline:Sarcosine,":[158],"show":[159],"significant":[160],"depression":[161],"temperatures":[164],"\u221230.09\u00b0C":[166],"\u221228.93\u00b0C":[168],"respectively":[169],"at":[170,206,226,253],"low":[171],"mole":[173,229,256],"fractions,":[174],"consistent":[176],"strong":[178],"eutectic":[179],"interactions.":[180],"The":[181],"addition":[182],"further":[184],"components,":[185],"alcohols":[188],"enables":[191],"fine-tuning":[192],"both":[194],"properties,":[198],"certain":[200],"maintaining":[202],"alkaline":[203],"even":[205],"high":[207],"hydration":[208],"levels.":[209],"Among":[210],"TMAO-based":[213],"TMAO:":[215],"Gua":[216],"exhibited":[217],"lowest":[219],"peak":[220,247],"\u221246.13":[224],"\u00b0C":[225,252],"0.71,":[232],"whereas":[233],"bio-inspired":[236],"T-Osmo-DESs":[237],"containing":[238],"TMAO,":[239],"betaine,":[240],"taurine,":[241],"reached":[244],"minimum":[246],"\u221243.78":[251],"0.61,":[259],"closely":[260],"mimicking":[261],"protective":[263],"living":[266],"cells.":[267],"By":[268],"bridging":[269],"predictions":[271],"insights,":[274],"work":[276],"advances":[277],"rational":[279],"design":[280],"green":[283],"tailored":[285],"variety":[288],"applications":[290],"biomolecular":[292],"stabilization.":[293],"findings":[295],"highlight":[296],"versatility":[298],"promise":[300],"next-generation":[304],"solvents,":[305],"offering":[306],"new":[307],"opportunities":[308],"environmentally":[310],"friendly":[311],"application-specific":[313],"solutions":[314],"biotechnology":[316],"medicine.":[318]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
