{"id":"https://openalex.org/W7225324594","doi":"https://doi.org/10.1021/acs.inorgchem.6c04436","title":"Redox Behavior of Heme Embedded in Mycobacterium tuberculosis Bacterioferritin Protein Shell: Impact of Axial Ligands and Non-heme Iron","display_name":"Redox Behavior of Heme Embedded in Mycobacterium tuberculosis Bacterioferritin Protein Shell: Impact of Axial Ligands and Non-heme Iron","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225324594","doi":"https://doi.org/10.1021/acs.inorgchem.6c04436"},"language":"en","primary_location":{"id":"doi:10.1021/acs.inorgchem.6c04436","doi":"https://doi.org/10.1021/acs.inorgchem.6c04436","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.inorgchem.6c04436","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5026567723","display_name":"S. Mallik","orcid":"https://orcid.org/0000-0003-2483-1047","observed_orcids":["https://orcid.org/0000-0003-2483-1047"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Swagatika Mallik","raw_affiliation_strings":["National Institute of Technology , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2483-1047","affiliations":[{"raw_affiliation_string":"National Institute of Technology , , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5106355271","display_name":"Gargee Bhattacharyya","orcid":"https://orcid.org/0000-0002-8890-2521","observed_orcids":["https://orcid.org/0000-0002-8890-2521"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Gargee Bhattacharyya","raw_affiliation_strings":["National Institute of Technology , , , ,"],"raw_orcid":"https://orcid.org/0000-0002-8890-2521","affiliations":[{"raw_affiliation_string":"National Institute of Technology , , , ,","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160828563","display_name":"Sara Tanibayashi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I180941496","display_name":"University of Hyogo","ror":"https://ror.org/0151bmh98","country_code":"JP","type":"education","lineage":["https://openalex.org/I180941496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Sara Tanibayashi","raw_affiliation_strings":["University of Hyogo , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hyogo , , ,","institution_ids":["https://openalex.org/I180941496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5028952753","display_name":"Rei Tohda","orcid":"https://orcid.org/0000-0001-5644-1399","observed_orcids":["https://orcid.org/0000-0001-5644-1399"]},"institutions":[{"id":"https://openalex.org/I180941496","display_name":"University of Hyogo","ror":"https://ror.org/0151bmh98","country_code":"JP","type":"education","lineage":["https://openalex.org/I180941496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Rei Tohda","raw_affiliation_strings":["University of Hyogo , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Hyogo , , ,","institution_ids":["https://openalex.org/I180941496"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015255703","display_name":"Takehiko Tosha","orcid":"https://orcid.org/0000-0002-8971-0759","observed_orcids":["https://orcid.org/0000-0002-8971-0759"]},"institutions":[{"id":"https://openalex.org/I180941496","display_name":"University of Hyogo","ror":"https://ror.org/0151bmh98","country_code":"JP","type":"education","lineage":["https://openalex.org/I180941496"]}],"countries":["JP"],"is_corresponding":false,"raw_author_name":"Takehiko Tosha","raw_affiliation_strings":["University of Hyogo , , ,"],"raw_orcid":"https://orcid.org/0000-0002-8971-0759","affiliations":[{"raw_affiliation_string":"University of Hyogo , , ,","institution_ids":["https://openalex.org/I180941496"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5045489228","display_name":"Rabindra Kumar Behera","orcid":"https://orcid.org/0000-0003-2849-3292","observed_orcids":["https://orcid.org/0000-0003-2849-3292"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Rabindra K. Behera","raw_affiliation_strings":["National Institute of Technology , , , ,"],"raw_orcid":"https://orcid.org/0000-0003-2849-3292","affiliations":[{"raw_affiliation_string":"National Institute of Technology , , , ,","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5045489228"],"corresponding_institution_ids":[],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.427700012922287,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T12094","display_name":"Hemoglobin structure and function","score":0.427700012922287,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.35109999775886536,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11626","display_name":"Metalloenzymes and iron-sulfur proteins","score":0.1096000000834465,"subfield":{"id":"https://openalex.org/subfields/1303","display_name":"Biochemistry"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/bacterioferritin","display_name":"bacterioferritin","score":0.949999988079071},{"id":"https://openalex.org/keywords/mycobacterium-tuberculosis","display_name":"Mycobacterium tuberculosis","score":0.9350000023841858},{"id":"https://openalex.org/keywords/heme","display_name":"heme","score":0.7149999737739563},{"id":"https://openalex.org/keywords/axial-ligands","display_name":"axial ligands","score":0.7110000252723694},{"id":"https://openalex.org/keywords/non-heme-iron","display_name":"non-heme iron","score":0.949999988079071},{"id":"https://openalex.org/keywords/redox-potential","display_name":"redox potential","score":0.7820000052452087},{"id":"https://openalex.org/keywords/electron-transfer","display_name":"electron transfer","score":0.6840000152587891},{"id":"https://openalex.org/keywords/iron-acquisition","display_name":"iron acquisition","score":0.4860000014305115},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.5590000152587891},{"id":"https://openalex.org/keywords/crystal-structure","display_name":"crystal structure","score":0.33500000834465027}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.926800012588501},{"id":"https://openalex.org/C2776217839","wikidata":"https://www.wikidata.org/wiki/Q189621","display_name":"Heme","level":3,"score":0.8985999822616577},{"id":"https://openalex.org/C55904794","wikidata":"https://www.wikidata.org/wiki/Q82682","display_name":"Redox","level":2,"score":0.7721999883651733},{"id":"https://openalex.org/C20705724","wikidata":"https://www.wikidata.org/wiki/Q902628","display_name":"Hemeprotein","level":4,"score":0.5072000026702881},{"id":"https://openalex.org/C2777975735","wikidata":"https://www.wikidata.org/wiki/Q130971","display_name":"Mycobacterium tuberculosis","level":3,"score":0.44440001249313354},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.4399999976158142},{"id":"https://openalex.org/C2778319317","wikidata":"https://www.wikidata.org/wiki/Q22327449","display_name":"Ferritin","level":2,"score":0.4284999966621399},{"id":"https://openalex.org/C17165728","wikidata":"https://www.wikidata.org/wiki/Q423350","display_name":"Metalloprotein","level":3,"score":0.4180999994277954},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3896999955177307},{"id":"https://openalex.org/C523546767","wikidata":"https://www.wikidata.org/wiki/Q10876","display_name":"Bacteria","level":2,"score":0.374099999666214},{"id":"https://openalex.org/C2778921574","wikidata":"https://www.wikidata.org/wiki/Q2012217","display_name":"One-electron reduction","level":4,"score":0.3492000102996826},{"id":"https://openalex.org/C2779268744","wikidata":"https://www.wikidata.org/wiki/Q407479","display_name":"Oxidoreductase","level":3,"score":0.34790000319480896},{"id":"https://openalex.org/C2778917026","wikidata":"https://www.wikidata.org/wiki/Q43041","display_name":"Hemoglobin","level":2,"score":0.3172000050544739},{"id":"https://openalex.org/C8010536","wikidata":"https://www.wikidata.org/wiki/Q160398","display_name":"Crystallography","level":1,"score":0.2935999929904938},{"id":"https://openalex.org/C75473681","wikidata":"https://www.wikidata.org/wiki/Q188651","display_name":"Photochemistry","level":1,"score":0.2702000141143799},{"id":"https://openalex.org/C29311851","wikidata":"https://www.wikidata.org/wiki/Q408223","display_name":"Cytochrome c","level":3,"score":0.2700999975204468},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.26989999413490295},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.2637999951839447},{"id":"https://openalex.org/C148898269","wikidata":"https://www.wikidata.org/wiki/Q1108792","display_name":"Kinetics","level":2,"score":0.26260000467300415},{"id":"https://openalex.org/C111335779","wikidata":"https://www.wikidata.org/wiki/Q3454686","display_name":"Reduction (mathematics)","level":2,"score":0.257099986076355}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.inorgchem.6c04436","doi":"https://doi.org/10.1021/acs.inorgchem.6c04436","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.inorgchem.6c04436","pdf_url":null,"source":{"id":"https://openalex.org/S171072222","display_name":"Inorganic Chemistry","issn_l":"0020-1669","issn":["0020-1669","1520-510X"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","jufo-2","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Inorganic Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.428600013256073,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320719","display_name":"Department of Science and Technology, Ministry of Science and Technology, India","ror":"https://ror.org/0101xrq71"},{"id":"https://openalex.org/F4320320767","display_name":"University Grants Commission","ror":"https://ror.org/04p800546"},{"id":"https://openalex.org/F4320334771","display_name":"Science and Engineering Research Board","ror":"https://ror.org/03ffdsr55"}],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":96,"referenced_works":["https://openalex.org/W1555806273","https://openalex.org/W1568912715","https://openalex.org/W1693967370","https://openalex.org/W1837972849","https://openalex.org/W1963692701","https://openalex.org/W1965970124","https://openalex.org/W1972433518","https://openalex.org/W1973009377","https://openalex.org/W1978594401","https://openalex.org/W1986584436","https://openalex.org/W1986787983","https://openalex.org/W1993798891","https://openalex.org/W1998628577","https://openalex.org/W2001134683","https://openalex.org/W2005380695","https://openalex.org/W2010896393","https://openalex.org/W2015943325","https://openalex.org/W2016509950","https://openalex.org/W2023691021","https://openalex.org/W2026182346","https://openalex.org/W2029689644","https://openalex.org/W2030881324","https://openalex.org/W2034746991","https://openalex.org/W2044678473","https://openalex.org/W2046761749","https://openalex.org/W2051464752","https://openalex.org/W2055252335","https://openalex.org/W2055300232","https://openalex.org/W2055820030","https://openalex.org/W2066697471","https://openalex.org/W2066731465","https://openalex.org/W2069099129","https://openalex.org/W2078748328","https://openalex.org/W2079598803","https://openalex.org/W2082795475","https://openalex.org/W2086567353","https://openalex.org/W2087244548","https://openalex.org/W2088197208","https://openalex.org/W2089438702","https://openalex.org/W2101871052","https://openalex.org/W2103065556","https://openalex.org/W2109745203","https://openalex.org/W2113850335","https://openalex.org/W2120951232","https://openalex.org/W2128385833","https://openalex.org/W2136909852","https://openalex.org/W2144081223","https://openalex.org/W2153839710","https://openalex.org/W2154197653","https://openalex.org/W2163341755","https://openalex.org/W2165293275","https://openalex.org/W2176126080","https://openalex.org/W2180229411","https://openalex.org/W2317873538","https://openalex.org/W2331937820","https://openalex.org/W2346243518","https://openalex.org/W2442400681","https://openalex.org/W2509947845","https://openalex.org/W2532713663","https://openalex.org/W2569572906","https://openalex.org/W2580415908","https://openalex.org/W2587215353","https://openalex.org/W2771322609","https://openalex.org/W2783855936","https://openalex.org/W2792911458","https://openalex.org/W2802749931","https://openalex.org/W2902430687","https://openalex.org/W2914589637","https://openalex.org/W2922073842","https://openalex.org/W2930836551","https://openalex.org/W2934147889","https://openalex.org/W2994932491","https://openalex.org/W3009168386","https://openalex.org/W3092359591","https://openalex.org/W3121551002","https://openalex.org/W3130331088","https://openalex.org/W3136838882","https://openalex.org/W3187189392","https://openalex.org/W3211041358","https://openalex.org/W4206667778","https://openalex.org/W4214631023","https://openalex.org/W4214656813","https://openalex.org/W4223599230","https://openalex.org/W4254829130","https://openalex.org/W4280573617","https://openalex.org/W4308178919","https://openalex.org/W4311823853","https://openalex.org/W4380319120","https://openalex.org/W4382051702","https://openalex.org/W4392154275","https://openalex.org/W4395075870","https://openalex.org/W4401364626","https://openalex.org/W4406618550","https://openalex.org/W4411411017","https://openalex.org/W4415146910","https://openalex.org/W4417184842"],"related_works":["https://openalex.org/W3211041358","https://openalex.org/W2165293275","https://openalex.org/W4392169829","https://openalex.org/W1968784716","https://openalex.org/W2025768624","https://openalex.org/W7215094441","https://openalex.org/W2148982058","https://openalex.org/W3162253243","https://openalex.org/W2051338042","https://openalex.org/W2082795475"],"abstract_inverted_index":{"Abstract":[0],"While":[1],"higher":[2],"organisms":[3],"synthesize":[4],"only":[5],"heme-free":[6,19],"ferritin,":[7],"pathogenic":[8],"bacteria":[9,30],"such":[10],"as":[11,97],"Mycobacterium":[12],"tuberculosis":[13],"(Mtb)":[14],"express":[15],"both":[16],"heme-bound":[17,41],"and":[18,31,36,69,89,109,115,128,183,200],"analogues.":[20],"The":[21],"synthesis":[22],"of":[23,26,34,50,71,95,107,117,122,132,151,172],"multiple":[24],"types":[25],"ferritin":[27],"in":[28,40,53,81,103,134,156,197],"these":[29],"the":[32,47,66,93,162,170,178,186,204],"roles":[33],"heme(s)":[35],"conserved":[37],"axial":[38,123],"Met52":[39,124,147],"bacterioferritin":[42,54,136,189],"remain":[43],"a":[44],"mystery.":[45],"Though":[46],"redox":[48,79],"chemistry":[49],"heme":[51,72,87,96,113,126,133,182],"embedded":[52],"seems":[55],"crucial,":[56],"reports":[57],"on":[58],"its":[59,78],"reduction":[60,67,73,88,114,129],"potential":[61,68],"(Em,7)":[62],"are":[63],"scarce.":[64],"Here,":[65],"kinetics":[70],"were":[74],"obtained":[75],"to":[76,139,177,191,202],"understand":[77],"behavior":[80],"detail.":[82],"A":[83],"transient":[84,118],"profile":[85],"for":[86,165],"subsequent":[90],"reoxidation":[91],"suggests":[92],"role":[94],"an":[98],"intrinsic":[99],"electron":[100,173],"relay":[101],"station":[102],"Mtb":[104,192],"bacterioferritin.":[105],"Presence":[106],"O2":[108],"non-heme":[110,152],"iron":[111,205],"impacts":[112],"detection":[116],"reduced-heme":[119],"species.":[120],"Substitution":[121],"affects":[125],"binding":[127],"kinetics.":[130],"Em,7":[131],"wild-type":[135],"was":[137],"found":[138],"be":[140],"unusually":[141],"negative,":[142],"which":[143],"further":[144],"decreased":[145],"upon":[146],"substitution":[148],"or":[149],"incorporation":[150],"iron.":[153],"These":[154],"findings,":[155],"conjunction":[157],"with":[158],"crystallographic":[159],"analyses,":[160],"explain":[161,185],"natural":[163],"preference":[164],"Met52.":[166],"This":[167],"work":[168],"establishes":[169],"direction":[171],"flow":[174],"from":[175],"reductants":[176],"mineral":[179],"core":[180],"via":[181],"may":[184],"advantages":[187],"that":[188],"provides":[190],"under":[193],"limited":[194],"iron/O2":[195],"levels":[196],"human":[198],"macrophages":[199],"lungs":[201],"meet":[203],"requirements.":[206]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}