{"id":"https://openalex.org/W7225324126","doi":"https://doi.org/10.20944/preprints202611.0588.v1","title":"KIR Alleles and Their Correlation with Longevity: A Perspective on the Immunogenetics of Aging","display_name":"KIR Alleles and Their Correlation with Longevity: A Perspective on the Immunogenetics of Aging","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225324126","doi":"https://doi.org/10.20944/preprints202611.0588.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202611.0588.v1","doi":"https://doi.org/10.20944/preprints202611.0588.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0588.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202611.0588.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5069322423","display_name":"Radu Alexandru Truica","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Radu-Alexandru Truic\u0103","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5022316240","display_name":"Adriana T\u0103l\u0103ngescu","orcid":"https://orcid.org/0009-0002-9721-5915","observed_orcids":["https://orcid.org/0009-0002-9721-5915"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Adriana T\u0103l\u0103ngescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035620025","display_name":"Ion M\u0103run\u021belu","orcid":"https://orcid.org/0000-0002-4284-8654","observed_orcids":["https://orcid.org/0000-0002-4284-8654"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ion M\u0103run\u021belu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5113104466","display_name":"Alexandra Elena Constantinescu","orcid":"https://orcid.org/0000-0001-8565-7965","observed_orcids":["https://orcid.org/0000-0001-8565-7965"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Alexandra Elena Constantinescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5029178083","display_name":"Ileana Constantinescu","orcid":"https://orcid.org/0000-0002-3404-7240","observed_orcids":["https://orcid.org/0000-0002-3404-7240"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ileana Constantinescu","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11020","display_name":"Immune Cell Function and Interaction","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10261","display_name":"Genetic Associations and Epidemiology","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11510","display_name":"Reproductive System and Pregnancy","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/killer-cell-immunoglobulin-like-receptors","display_name":"killer cell immunoglobulin-like receptors","score":0.9300000071525574},{"id":"https://openalex.org/keywords/longevity","display_name":"longevity","score":0.656000018119812},{"id":"https://openalex.org/keywords/aging","display_name":"aging","score":0.6759999990463257},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.9229999780654907},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8600000143051147},{"id":"https://openalex.org/keywords/kir-polymorphism","display_name":"KIR polymorphism","score":0.7300000190734863},{"id":"https://openalex.org/keywords/kir2dl3","display_name":"KIR2DL3","score":0.8050000071525574},{"id":"https://openalex.org/keywords/kir2ds2","display_name":"KIR2DS2","score":0.9929999709129333},{"id":"https://openalex.org/keywords/kir3dl1","display_name":"KIR3DL1","score":0.9980000257492065},{"id":"https://openalex.org/keywords/immunosurveillance","display_name":"immune surveillance","score":0.5920000076293945},{"id":"https://openalex.org/keywords/genetic-diversity","display_name":"genetic diversity","score":0.6140000224113464},{"id":"https://openalex.org/keywords/disease-susceptibility","display_name":"disease susceptibility","score":0.503000020980835}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.7838000059127808},{"id":"https://openalex.org/C180754005","wikidata":"https://www.wikidata.org/wiki/Q80726","display_name":"Allele","level":3,"score":0.7659000158309937},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.6211000084877014},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.512499988079071},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.4562000036239624},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.42910000681877136},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4147999882698059},{"id":"https://openalex.org/C84597430","wikidata":"https://www.wikidata.org/wiki/Q106227","display_name":"Locus (genetics)","level":3,"score":0.4113999903202057},{"id":"https://openalex.org/C68873052","wikidata":"https://www.wikidata.org/wiki/Q349856","display_name":"Genetic variation","level":3,"score":0.4002000093460083},{"id":"https://openalex.org/C1547928","wikidata":"https://www.wikidata.org/wiki/Q1660177","display_name":"Immunogenetics","level":3,"score":0.38179999589920044},{"id":"https://openalex.org/C81977670","wikidata":"https://www.wikidata.org/wiki/Q585259","display_name":"Genetic diversity","level":3,"score":0.36880001425743103},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.3675999939441681},{"id":"https://openalex.org/C500499127","wikidata":"https://www.wikidata.org/wiki/Q332154","display_name":"Ageing","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C188280979","wikidata":"https://www.wikidata.org/wiki/Q911125","display_name":"Human leukocyte antigen","level":3,"score":0.34119999408721924},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.32829999923706055},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C172777353","wikidata":"https://www.wikidata.org/wiki/Q1374271","display_name":"Genetic variability","level":4,"score":0.2567000091075897},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.25290000438690186},{"id":"https://openalex.org/C186413461","wikidata":"https://www.wikidata.org/wiki/Q744727","display_name":"Genetic association","level":5,"score":0.25130000710487366}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202611.0588.v1","doi":"https://doi.org/10.20944/preprints202611.0588.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0588.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202611.0588.v1","doi":"https://doi.org/10.20944/preprints202611.0588.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0588.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8371999859809875,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[{"display_name":"Observational Study","id":"https://openalex.org/study-designs/observational-study"}],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W1986822630","https://openalex.org/W7213932685","https://openalex.org/W2082326009","https://openalex.org/W2084887572","https://openalex.org/W4390615935","https://openalex.org/W2018684816","https://openalex.org/W2101308462","https://openalex.org/W45326318","https://openalex.org/W1544840263","https://openalex.org/W2788224475"],"abstract_inverted_index":{"Exceptional":[0],"longevity":[1,206],"is":[2,89],"a":[3,62,115,155],"multifactorial":[4],"phenomenon":[5],"in":[6,50,65,114,120,135,195],"which":[7],"optimal":[8],"immune":[9,51,67],"system":[10],"function":[11],"plays":[12],"an":[13,92],"essential":[14],"role.":[15],"KIR":[16,45,112,138,152,193],"receptors":[17],"(Killer-cell":[18],"Immunoglobulin-like":[19],"Receptors),":[20],"expressed":[21],"on":[22,28],"Natural":[23],"Killer":[24],"(NK)":[25],"cells":[26,60,79,88],"and":[27,75,96,132,184,207,222,229],"subpopulations":[29],"of":[30,37,43,77,84,94,111,117,151,158,192,215],"CD8+":[31],"T":[32],"lymphocytes,":[33],"represent":[34],"key":[35],"modula-tors":[36],"innate":[38],"immunity.":[39],"The":[40,81,160,186],"extensive":[41],"polymorphism":[42],"the":[44,66,70,73,85,102,109,121,167,189],"locus":[46],"generates":[47],"interindividual":[48],"variability":[49],"surveillance":[52],"capacity,":[53],"with":[54,154,169,212],"possible":[55],"implications":[56,134,225],"for":[57,148,226],"aging.":[58],"NK":[59,78],"play":[61],"pivotal":[63],"role":[64],"response.":[68],"During":[69],"ageing":[71],"process,":[72],"activity":[74,83],"number":[76,214],"varies.":[80],"cytolytic":[82],"natural":[86],"killer":[87],"controlled":[90],"by":[91],"array":[93],"activating":[95],"inhibitory":[97],"cell":[98],"surface":[99],"receptors,":[100],"including":[101],"KIRs.The":[103],"present":[104],"study":[105,187],"aims":[106],"to":[107,205,219],"explore":[108],"frequency":[110],"alleles":[113,153,171,194,200],"cohort":[116],"86":[118],"individuals":[119],"65-90":[122],"age":[123],"bracket":[124],"from":[125],"Romania,":[126],"providing":[127],"inisghts":[128],"into":[129],"genetic":[130,190],"diversity":[131,165,191],"potential":[133],"longevity.":[136,185],"High-resolution":[137],"typing":[139],"was":[140],"performed":[141],"using":[142],"next-generation":[143],"sequencing":[144],"(NGS)":[145],"technology,":[146],"allowing":[147],"pre-cise":[149],"identification":[150],"high":[156],"degree":[157],"accuracy.":[159],"results":[161],"reveal":[162],"significant":[163],"ge-netic":[164],"within":[166],"cohort,":[168],"prevalent":[170,199],"such":[172],"as":[173],"KIR2DL3*0020103,":[174],"KIR2DL3*0020101,":[175],"KIR2DS2*0010124,":[176],"KIR2DS2*0010115":[177],"or":[178],"KIR3DL1*0050101,":[179],"potentially":[180],"influencing":[181],"disease":[182,208],"susceptibility":[183],"reveals":[188],"elderly":[196],"Romanians,":[197],"highlighting":[198],"that":[201],"could":[202],"be":[203],"linked":[204],"resistance.":[209],"Further":[210],"studies":[211],"larger":[213],"samples":[216],"are":[217],"needed":[218],"confirm":[220],"findings":[221],"uncover":[223],"their":[224],"healthy":[227],"aging":[228],"healthcare.":[230]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}
