{"id":"https://openalex.org/W7225323314","doi":"https://doi.org/10.3389/fimmu.2026.1901751","title":"RANKL blockade attenuates MASH by remodeling the hepatic immune microenvironment","display_name":"RANKL blockade attenuates MASH by remodeling the hepatic immune microenvironment","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225323314","doi":"https://doi.org/10.3389/fimmu.2026.1901751"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1901751","doi":"https://doi.org/10.3389/fimmu.2026.1901751","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1901751","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1901751/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1901751/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101766074","display_name":"Junxue Wang","orcid":"https://orcid.org/0000-0003-0748-7504","observed_orcids":["https://orcid.org/0000-0003-0748-7504"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junxue Wang","raw_affiliation_strings":["Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160906992","display_name":"Ningjia Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ningjia Yang","raw_affiliation_strings":["Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160928052","display_name":"Huixia Li","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104602","display_name":"Shanghai Second People's Hospital","ror":"https://ror.org/00yb8k233","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104602"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Huixia Li","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Second People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Second People\u2019s Hospital","institution_ids":["https://openalex.org/I4210104602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5016485089","display_name":"Sijia Dan","orcid":"https://orcid.org/0000-0002-3962-9522","observed_orcids":["https://orcid.org/0000-0002-3962-9522"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Sijia Dan","raw_affiliation_strings":["Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai JiaoTong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Key Laboratory of Cell Differentiation and Apoptosis of Chinese Ministry of Education, Shanghai JiaoTong University School of Medicine","institution_ids":["https://openalex.org/I183067930"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160793523","display_name":"Hui Guo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104602","display_name":"Shanghai Second People's Hospital","ror":"https://ror.org/00yb8k233","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104602"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hui Guo","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Second People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Second People\u2019s Hospital","institution_ids":["https://openalex.org/I4210104602"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5068858012","display_name":"Kexi Zha","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210104602","display_name":"Shanghai Second People's Hospital","ror":"https://ror.org/00yb8k233","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210104602"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Kexi Zha","raw_affiliation_strings":["Department of Endocrinology and Metabolism, Shanghai Second People\u2019s Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Endocrinology and Metabolism, Shanghai Second People\u2019s Hospital","institution_ids":["https://openalex.org/I4210104602"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5000831507","display_name":"Fangzhen Xia","orcid":"https://orcid.org/0000-0002-1069-0418","observed_orcids":["https://orcid.org/0000-0002-1069-0418","https://orcid.org/0000-0001-6055-7466"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210097066","display_name":"Shanghai Ninth People's Hospital","ror":"https://ror.org/010826a91","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210097066"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Fangzhen Xia","raw_affiliation_strings":["Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Institute and Department of Endocrinology and Metabolism, Shanghai Ninth People\u2019s Hospital, Shanghai JiaoTong University School of Medicine","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5000831507","https://openalex.org/A5068858012"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210097066","https://openalex.org/I4210104602"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10351","display_name":"Liver Disease Diagnosis and Treatment","score":0.9922000169754028,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.00559999980032444,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11834","display_name":"Liver Diseases and Immunity","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rankl-blockade","display_name":"RANKL blockade","score":0.9160000085830688},{"id":"https://openalex.org/keywords/non-alcoholic-steatohepatitis","display_name":"nonalcoholic steatohepatitis","score":0.996999979019165},{"id":"https://openalex.org/keywords/hepatic-immune-microenvironment","display_name":"hepatic immune microenvironment","score":0.9039999842643738},{"id":"https://openalex.org/keywords/rank-rankl-opg-axis","display_name":"RANK/RANKL/OPG axis","score":0.9290000200271606},{"id":"https://openalex.org/keywords/choline-deficient-high-fat-diet","display_name":"choline-deficient high-fat diet","score":0.9169999957084656},{"id":"https://openalex.org/keywords/liver-macrophages","display_name":"hepatic macrophages","score":0.8659999966621399},{"id":"https://openalex.org/keywords/kupffer-cells","display_name":"Kupffer cells","score":0.9269999861717224},{"id":"https://openalex.org/keywords/m1-like-macrophages","display_name":"M1-like macrophages","score":0.765999972820282},{"id":"https://openalex.org/keywords/natural-killer-cells","display_name":"natural killer cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/nkt-like-cells","display_name":"NKT-like cells","score":0.8109999895095825},{"id":"https://openalex.org/keywords/gamma-delta-t-cells","display_name":"\u03b3\u03b4 T cells","score":0.8849999904632568},{"id":"https://openalex.org/keywords/liver-fibrosis","display_name":"liver fibrosis","score":0.8119999766349792},{"id":"https://openalex.org/keywords/hepatic-steatosis","display_name":"hepatic steatosis","score":0.9369999766349792},{"id":"https://openalex.org/keywords/glucose-tolerance","display_name":"glucose tolerance","score":0.6549999713897705}],"concepts":[{"id":"https://openalex.org/C2779428903","wikidata":"https://www.wikidata.org/wiki/Q418934","display_name":"RANKL","level":4,"score":0.8447999954223633},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.7150999903678894},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5667999982833862},{"id":"https://openalex.org/C2778468042","wikidata":"https://www.wikidata.org/wiki/Q273976","display_name":"Blockade","level":3,"score":0.544700026512146},{"id":"https://openalex.org/C2779478299","wikidata":"https://www.wikidata.org/wiki/Q2335423","display_name":"Steatohepatitis","level":4,"score":0.474700003862381},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.4207000136375427},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.40790000557899475},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.3862999975681305},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.37310001254081726},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.37229999899864197},{"id":"https://openalex.org/C2781101188","wikidata":"https://www.wikidata.org/wiki/Q5009846","display_name":"CD86","level":4,"score":0.36649999022483826},{"id":"https://openalex.org/C4733338","wikidata":"https://www.wikidata.org/wiki/Q2792936","display_name":"Lipid metabolism","level":2,"score":0.35760000348091125},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3424000144004822},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.3337000012397766},{"id":"https://openalex.org/C193419808","wikidata":"https://www.wikidata.org/wiki/Q1645075","display_name":"Acquired immune system","level":3,"score":0.32910001277923584},{"id":"https://openalex.org/C159654299","wikidata":"https://www.wikidata.org/wiki/Q79460","display_name":"Antibody","level":2,"score":0.3222000002861023},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.30880001187324524},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.30399999022483826},{"id":"https://openalex.org/C2778772119","wikidata":"https://www.wikidata.org/wiki/Q6058862","display_name":"Fatty liver","level":3,"score":0.3034999966621399},{"id":"https://openalex.org/C171779818","wikidata":"https://www.wikidata.org/wiki/Q3799301","display_name":"Integrin alpha M","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.27730000019073486},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.27129998803138733},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.2711000144481659}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1901751","doi":"https://doi.org/10.3389/fimmu.2026.1901751","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1901751","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1901751/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:9bdfc4d218dd463da385a273fc0d7ced","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9bdfc4d218dd463da385a273fc0d7ced","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1901751","doi":"https://doi.org/10.3389/fimmu.2026.1901751","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1901751","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1901751/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G8083799459","display_name":null,"funder_award_id":"82470901","funder_id":"https://openalex.org/F4320321001","funder_display_name":"National Natural Science Foundation of China"}],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225323314.pdf","grobid_xml":"https://content.openalex.org/works/W7225323314.grobid-xml"},"referenced_works_count":64,"referenced_works":["https://openalex.org/W1586986973","https://openalex.org/W1966126902","https://openalex.org/W1967758223","https://openalex.org/W1985592156","https://openalex.org/W2000532842","https://openalex.org/W2011725731","https://openalex.org/W2028680175","https://openalex.org/W2028694920","https://openalex.org/W2032905332","https://openalex.org/W2033957878","https://openalex.org/W2044250052","https://openalex.org/W2055142018","https://openalex.org/W2057445384","https://openalex.org/W2066749771","https://openalex.org/W2084579743","https://openalex.org/W2093415475","https://openalex.org/W2102817784","https://openalex.org/W2130812234","https://openalex.org/W2158332324","https://openalex.org/W2233172544","https://openalex.org/W2550046752","https://openalex.org/W2585046292","https://openalex.org/W2604947595","https://openalex.org/W2609637087","https://openalex.org/W2769501542","https://openalex.org/W2783965560","https://openalex.org/W2810423511","https://openalex.org/W2886710836","https://openalex.org/W2902419609","https://openalex.org/W2904711730","https://openalex.org/W2924084550","https://openalex.org/W2968872536","https://openalex.org/W2980820618","https://openalex.org/W3009902673","https://openalex.org/W3023775962","https://openalex.org/W3028975783","https://openalex.org/W3032168802","https://openalex.org/W3036581248","https://openalex.org/W3084059564","https://openalex.org/W3097776824","https://openalex.org/W3163863100","https://openalex.org/W3206948891","https://openalex.org/W3214276446","https://openalex.org/W4280638090","https://openalex.org/W4282554753","https://openalex.org/W4313648807","https://openalex.org/W4319459347","https://openalex.org/W4378717316","https://openalex.org/W4388452323","https://openalex.org/W4389262245","https://openalex.org/W4391542175","https://openalex.org/W4391545890","https://openalex.org/W4393204273","https://openalex.org/W4394714984","https://openalex.org/W4395468660","https://openalex.org/W4404353519","https://openalex.org/W4404816270","https://openalex.org/W4408416697","https://openalex.org/W4409277469","https://openalex.org/W4410085891","https://openalex.org/W4410742615","https://openalex.org/W4411873897","https://openalex.org/W4416083516","https://openalex.org/W7130421569"],"related_works":["https://openalex.org/W2987992648","https://openalex.org/W4410733649","https://openalex.org/W4412823255","https://openalex.org/W3028975783","https://openalex.org/W7128526157","https://openalex.org/W4404166923","https://openalex.org/W7163339383","https://openalex.org/W7160187754","https://openalex.org/W4401887677","https://openalex.org/W4416931126"],"abstract_inverted_index":{"Objective":[0],"Metabolic":[1,113],"dysfunction-associated":[2],"steatohepatitis":[3],"(MASH)":[4],"is":[5,15,33],"a":[6,34,75,85,281,286],"leading":[7],"cause":[8],"of":[9,28,37,71,78,195,261,292],"chronic":[10,19],"liver":[11,115],"disease":[12],"worldwide":[13],"and":[14,21,68,96,117,130,161,187,218,234,277],"largely":[16],"driven":[17],"by":[18,135,144,175],"inflammation":[20],"hepatic":[22,158,197,251],"immune":[23,131,185,198],"dysregulation.":[24],"The":[25],"receptor":[26],"activator":[27],"nuclear":[29],"factor-\u03baB":[30],"ligand":[31],"(RANKL)":[32],"master":[35],"regulator":[36],"bone":[38],"metabolism":[39],"with":[40,99,258],"emerging":[41],"immunomodulatory":[42],"functions.":[43],"Although":[44],"growing":[45],"evidence":[46],"links":[47],"the":[48,66,100,196],"RANK-RANKL-OPG":[49],"axis":[50],"to":[51,93],"MASH":[52,58,95,149,172,275],"pathophysiology,":[53],"whether":[54],"RANKL":[55,72,152,176,247,272,279],"blockade":[56,73,153,248,273],"attenuates":[57],"development":[59,276],"remains":[60],"unclear.":[61],"This":[62],"study":[63],"therefore":[64],"investigated":[65],"effects":[67],"underlying":[69],"mechanisms":[70],"in":[74,171,182,295],"mouse":[76],"model":[77],"MASH.":[79],"Methods":[80],"Male":[81],"mice":[82],"were":[83,97,120,133,169,180],"fed":[84],"choline-deficient":[86],"high-fat":[87],"diet":[88],"(CDHFD)":[89],"for":[90,289],"16":[91],"weeks":[92],"induce":[94],"treated":[98],"RANKL-neutralizing":[101],"antibody":[102],"IK22/5":[103,200],"(1,":[104],"4,":[105],"or":[106,109],"8":[107],"mg/kg)":[108],"an":[110],"IgG":[111],"control.":[112],"parameters,":[114],"histology,":[116],"biochemical":[118],"markers":[119],"assessed.":[121],"Hepatic":[122],"immune-cell":[123],"infiltration":[124],"was":[125],"analyzed":[126],"using":[127,147],"CIBERSORT-based":[128],"deconvolution,":[129],"populations":[132],"characterized":[134],"flow":[136],"cytometry.":[137],"Transcriptomic":[138,163],"profiling":[139,191],"identified":[140,165],"RANKL-regulated":[141],"genes,":[142],"followed":[143],"cross-species":[145],"analysis":[146,164],"human":[148],"datasets.":[150],"Results":[151],"dose-responsively":[154],"improved":[155],"glucose":[156],"tolerance,":[157],"steatosis,":[159],"inflammation,":[160],"fibrosis.":[162],"48":[166],"genes":[167,179],"that":[168,246,271],"dysregulated":[170],"but":[173],"reversed":[174],"blockade;":[177],"these":[178,268],"enriched":[181],"lipid":[183],"metabolism,":[184],"regulation,":[186],"fibrosis":[188],"pathways.":[189],"Immune":[190],"revealed":[192],"broad":[193],"remodeling":[194],"microenvironment:":[199],"reduced":[201,250],"CD11b":[202,236],"high":[203],"F4/80":[204,238,254],"+":[205,209,215,220,222,239,241,253,255],"monocyte-derived":[206],"macrophages,":[207,211,256],"CD86":[208],"M1-like":[210],"CD3":[212,219],"-":[213,224,226],"NK1.1":[214,221],"NK":[216],"cells,":[217,228],"CD4":[223],"CD8":[225],"NKT-like":[227],"while":[229],"increasing":[230],"\u03b3\u03b4":[231],"T":[232],"cells":[233],"preserving":[235],"int":[237],"Tim4":[240],"Kupffer":[242],"cells.":[243],"Immunofluorescence":[244],"showed":[245],"significantly":[249],"CD74":[252],"together":[257],"decreased":[259],"expression":[260],"other":[262],"lipid-associated":[263],"macrophage":[264],"markers.":[265],"Conclusions":[266],"Overall,":[267],"findings":[269],"indicate":[270],"attenuated":[274],"support":[278],"as":[280],"potential":[282],"immune\u2013metabolic":[283],"regulator,":[284],"providing":[285],"preclinical":[287],"rationale":[288],"further":[290],"evaluation":[291],"RANKL-targeted":[293],"strategies":[294],"clinically":[296],"relevant":[297],"models.":[298]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}
