{"id":"https://openalex.org/W7225323238","doi":"https://doi.org/10.3389/fimmu.2026.1993731","title":"A machine learning-assisted hypoxia-associated prognostic model reveals PFKP-mediated glycolytic regulation in uveal melanoma","display_name":"A machine learning-assisted hypoxia-associated prognostic model reveals PFKP-mediated glycolytic regulation in uveal melanoma","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225323238","doi":"https://doi.org/10.3389/fimmu.2026.1993731"},"language":"en","primary_location":{"id":"doi:10.3389/fimmu.2026.1993731","doi":"https://doi.org/10.3389/fimmu.2026.1993731","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1993731","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1993731/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1993731/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5090001971","display_name":"Kunxia Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kunxia Lin","raw_affiliation_strings":["Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5124720108","display_name":"Yi Cui","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yi Cui","raw_affiliation_strings":["Department of Ophthalmology, Fujian Medical University Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Fujian Medical University Union Hospital","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5102701884","display_name":"Yuzhe Jiang","orcid":"https://orcid.org/0009-0003-9029-8364","observed_orcids":["https://orcid.org/0009-0003-9029-8364"]},"institutions":[{"id":"https://openalex.org/I4210163933","display_name":"Union Hospital","ror":"https://ror.org/055gkcy74","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210163933"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuzhe Jiang","raw_affiliation_strings":["Department of Ophthalmology, Fujian Medical University Union Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Fujian Medical University Union Hospital","institution_ids":["https://openalex.org/I4210163933"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158858904","display_name":"Mi Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mi Zheng","raw_affiliation_strings":["Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160815452","display_name":"Yuyang Yang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyang Yang","raw_affiliation_strings":["Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160791580","display_name":"Jing Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jing Chen","raw_affiliation_strings":["Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5121078247","display_name":"Wenjie Wu","orcid":"https://orcid.org/0009-0007-0122-6406","observed_orcids":["https://orcid.org/0009-0007-0122-6406"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenjie Wu","raw_affiliation_strings":["Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5100727235","display_name":"Nuo Xu","orcid":"https://orcid.org/0000-0001-6920-6048","observed_orcids":["https://orcid.org/0000-0001-6920-6048"]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Nuo Xu","raw_affiliation_strings":["Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Ophthalmology, Shengli Clinical Medical College of Fujian Medical University, Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5100727235","https://openalex.org/A5121078247"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I80947539"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11328","display_name":"Ocular Oncology and Treatments","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11194","display_name":"Ocular Diseases and Beh\u00e7et\u2019s Syndrome","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2731","display_name":"Ophthalmology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/uveal-melanoma","display_name":"uveal melanoma","score":1.0},{"id":"https://openalex.org/keywords/hypoxia","display_name":"hypoxia","score":0.8550000190734863},{"id":"https://openalex.org/keywords/prognostic-model","display_name":"prognostic model","score":0.902999997138977},{"id":"https://openalex.org/keywords/pfkp","display_name":"PFKP","score":0.968999981880188},{"id":"https://openalex.org/keywords/eno3","display_name":"ENO3","score":0.8980000019073486},{"id":"https://openalex.org/keywords/foxo3","display_name":"FOXO3","score":0.996999979019165},{"id":"https://openalex.org/keywords/glycolysis","display_name":"glycolysis","score":0.8949999809265137},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7760000228881836},{"id":"https://openalex.org/keywords/immune-evasion","display_name":"immune evasion","score":0.8199999928474426},{"id":"https://openalex.org/keywords/immune-checkpoint-genes","display_name":"immune checkpoint genes","score":0.8029999732971191},{"id":"https://openalex.org/keywords/cd8-t-cell-infiltration","display_name":"CD8+ T cell infiltration","score":0.9470000267028809},{"id":"https://openalex.org/keywords/metastasis-free-survival","display_name":"metastasis-free survival","score":0.7879999876022339},{"id":"https://openalex.org/keywords/risk-signature","display_name":"risk signature","score":0.43700000643730164},{"id":"https://openalex.org/keywords/tumor-metabolism","display_name":"cancer metabolism","score":0.43799999356269836},{"id":"https://openalex.org/keywords/protein-protein-interaction-network","display_name":"protein-protein interaction network","score":0.597000002861023},{"id":"https://openalex.org/keywords/tumor-purity","display_name":"tumor purity","score":0.4869999885559082}],"concepts":[{"id":"https://openalex.org/C2777658100","wikidata":"https://www.wikidata.org/wiki/Q180614","display_name":"Melanoma","level":2,"score":0.6545000076293945},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.6057000160217285},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.6001999974250793},{"id":"https://openalex.org/C2776107976","wikidata":"https://www.wikidata.org/wiki/Q1786433","display_name":"Tumor microenvironment","level":3,"score":0.5795999765396118},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5655999779701233},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5216000080108643},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.4458000063896179},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.42410001158714294},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.4133000075817108},{"id":"https://openalex.org/C63363279","wikidata":"https://www.wikidata.org/wiki/Q5133848","display_name":"Clinical significance","level":2,"score":0.3806999921798706},{"id":"https://openalex.org/C72563966","wikidata":"https://www.wikidata.org/wiki/Q1303415","display_name":"Cohort","level":2,"score":0.3601999878883362},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3555999994277954},{"id":"https://openalex.org/C2779694297","wikidata":"https://www.wikidata.org/wiki/Q2888953","display_name":"Bioconductor","level":3,"score":0.34940001368522644},{"id":"https://openalex.org/C168003608","wikidata":"https://www.wikidata.org/wiki/Q21101484","display_name":"FOXO3","level":4,"score":0.3411000072956085},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3269999921321869},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.2978000044822693},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.2867000102996826},{"id":"https://openalex.org/C2779256057","wikidata":"https://www.wikidata.org/wiki/Q16909647","display_name":"Tumor progression","level":3,"score":0.27619999647140503},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27489998936653137},{"id":"https://openalex.org/C2777701055","wikidata":"https://www.wikidata.org/wiki/Q1427096","display_name":"Immunotherapy","level":3,"score":0.271699994802475},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.26330000162124634}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fimmu.2026.1993731","doi":"https://doi.org/10.3389/fimmu.2026.1993731","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1993731","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1993731/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:a8904f39127e4217bf6816f77552b399","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/a8904f39127e4217bf6816f77552b399","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Immunology, Vol 17 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fimmu.2026.1993731","doi":"https://doi.org/10.3389/fimmu.2026.1993731","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fimmu.2026.1993731","pdf_url":"https://www.frontiersin.org/journals/immunology/articles/10.3389/fimmu.2026.1993731/pdf","source":{"id":"https://openalex.org/S2595292759","display_name":"Frontiers in Immunology","issn_l":"1664-3224","issn":["1664-3224"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","ki-jl-1","medline","norway-1","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Immunology","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.98580002784729}],"study_designs":[],"awards":[{"id":"https://openalex.org/G3183701041","display_name":null,"funder_award_id":"2025J01069","funder_id":"https://openalex.org/F4320321878","funder_display_name":"Natural Science Foundation of Fujian Province"}],"funders":[{"id":"https://openalex.org/F4320321878","display_name":"Natural Science Foundation of Fujian Province","ror":null},{"id":"https://openalex.org/F4320328318","display_name":"Fujian Provincial Health Commission","ror":"https://ror.org/0136mc929"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225323238.pdf","grobid_xml":"https://content.openalex.org/works/W7225323238.grobid-xml"},"referenced_works_count":57,"referenced_works":["https://openalex.org/W1779367761","https://openalex.org/W1965801346","https://openalex.org/W1979211126","https://openalex.org/W2006128086","https://openalex.org/W2017525816","https://openalex.org/W2032388524","https://openalex.org/W2039656279","https://openalex.org/W2043115106","https://openalex.org/W2045065861","https://openalex.org/W2052825782","https://openalex.org/W2058197007","https://openalex.org/W2060878129","https://openalex.org/W2078434983","https://openalex.org/W2078979790","https://openalex.org/W2117004913","https://openalex.org/W2125096092","https://openalex.org/W2125190989","https://openalex.org/W2157076315","https://openalex.org/W2295598076","https://openalex.org/W2562162676","https://openalex.org/W2605362070","https://openalex.org/W2745658163","https://openalex.org/W2763548994","https://openalex.org/W2796207838","https://openalex.org/W2954318102","https://openalex.org/W3001381700","https://openalex.org/W3002671583","https://openalex.org/W3013214564","https://openalex.org/W3083849833","https://openalex.org/W3096103413","https://openalex.org/W3111889155","https://openalex.org/W3133076643","https://openalex.org/W3161436245","https://openalex.org/W3170573239","https://openalex.org/W3171069383","https://openalex.org/W3194168008","https://openalex.org/W3199915153","https://openalex.org/W3205040251","https://openalex.org/W3208779213","https://openalex.org/W4206773095","https://openalex.org/W4282983858","https://openalex.org/W4291900992","https://openalex.org/W4297229391","https://openalex.org/W4377044021","https://openalex.org/W4392056928","https://openalex.org/W4393505419","https://openalex.org/W4400961898","https://openalex.org/W4402614870","https://openalex.org/W4403272087","https://openalex.org/W4409663348","https://openalex.org/W4413883366","https://openalex.org/W4413898967","https://openalex.org/W4416156884","https://openalex.org/W7163152460","https://openalex.org/W7168144956","https://openalex.org/W7170091587","https://openalex.org/W7171371784"],"related_works":["https://openalex.org/W4286587529","https://openalex.org/W4291900992","https://openalex.org/W4282983858","https://openalex.org/W4297229391","https://openalex.org/W3127698625","https://openalex.org/W4396575350","https://openalex.org/W3199706860","https://openalex.org/W3199915153","https://openalex.org/W4226065246","https://openalex.org/W4391062298"],"abstract_inverted_index":{"Purpose":[0],"Uveal":[1],"melanoma":[2],"(UM)":[3],"is":[4],"a":[5,34,216,316,343],"highly":[6,63],"aggressive":[7],"intraocular":[8],"malignancy":[9],"with":[10,46,156,235,282,349],"strong":[11],"metastatic":[12],"propensity":[13],"and":[14,25,40,51,73,88,105,143,159,165,175,187,196,208,245,250,264,270,287,300,305,324,338],"poor":[15],"response":[16],"to":[17,32,112],"immunotherapy.":[18],"Hypoxia":[19],"profoundly":[20],"reshapes":[21],"the":[22,97,114,121,126,135,183,211,226,256,327],"tumor":[23,268,308],"microenvironment":[24,145],"drives":[26],"immune":[27,144,157,263,274,288],"evasion.":[28],"This":[29],"study":[30],"aimed":[31],"develop":[33],"machine":[35,79],"learning-assisted":[36],"hypoxia-related":[37,65,318],"prognostic":[38,115,118,213,319,329],"model":[39,122,220],"identify":[41],"relevant":[42,345],"metabolic":[43],"candidates":[44,104],"associated":[45,234,281,348],"UM":[47,56,296,350],"progression.":[48,351],"Methods":[49],"RNA-sequencing":[50],"clinical":[52,136],"data":[53],"from":[54,60],"80":[55],"patients":[57],"were":[58,67,100,147,198,233,253],"obtained":[59],"TCGA.":[61],"Thirty":[62],"connected":[64],"genes":[66],"prioritized":[68],"through":[69,162],"protein-protein":[70],"interaction":[71],"analysis":[72],"evaluated":[74,107,124,224],"using":[75,130],"five":[76,98,192,336],"complementary":[77],"survival-based":[78],"learning":[80],"approaches:":[81],"LASSO-Cox,":[82],"CoxBoost,":[83],"random":[84],"survival":[85,132,238],"forest,":[86],"XGBoost-Cox,":[87],"Survival-SVM.":[89],"Genes":[90],"supported":[91,189,199,333],"by":[92,108,190,200,334],"at":[93],"least":[94],"three":[95],"of":[96,120,273],"methods":[99],"defined":[101],"as":[102,134,177,210,342],"core":[103,178],"further":[106,151,223],"multivariable":[109],"Cox":[110,204],"regression":[111,205],"construct":[113],"model.":[116],"The":[117],"relevance":[119],"was":[123,150,188,222,279],"in":[125,163,166,225,239,243,255,303,310],"dependent":[127],"GSE22138":[128,228],"cohort":[129],"metastasis-free":[131],"(MFS)":[133],"endpoint.":[137],"Survival":[138],"analysis,":[139],"ROC,":[140],"PCA,":[141],"GSEA,":[142],"analyses":[146],"performed.":[148],"PFKP":[149,181,209,277,293,325],"examined":[152],"for":[153,321],"its":[154],"associations":[155],"features":[158],"experimentally":[160],"validated":[161],"vitro":[164,304],"vivo":[167,311],"assays.":[168],"Results":[169],"Multi-algorithm":[170],"consensus":[171],"identified":[172],"PFKP,":[173,332],"ENO3,":[174],"FOXO3":[176,197],"candidate":[179,347],"genes.":[180,276],"showed":[182],"strongest":[184],"cross-model":[185],"consistency":[186],"all":[191,335],"methods,":[193],"whereas":[194],"ENO3":[195,207,323],"four":[201],"methods.":[202],"Multivariable":[203],"retained":[206],"final":[212,328],"genes,":[214],"yielding":[215],"parsimonious":[217],"two-gene":[218],"risk":[219,231],"that":[221],"independent":[227],"cohort.":[229],"Higher":[230],"scores":[232],"worse":[236],"overall":[237],"TCGA-UM,":[240],"shorter":[241],"MFS":[242],"GSE22138,":[244],"more":[246],"advanced":[247],"disease.":[248],"Hypoxia-":[249],"glycolysis-related":[251,346],"pathways":[252],"enriched":[254],"high-risk":[257],"group,":[258],"which":[259],"also":[260],"exhibited":[261],"higher":[262],"stromal":[265],"scores,":[266],"lower":[267],"purity,":[269],"increased":[271],"expression":[272,278],"checkpoint":[275],"positively":[280],"CD8":[283],"+":[284],"T-cell":[285],"infiltration":[286],"checkpoint-related":[289],"gene":[290],"expression.":[291],"Functionally,":[292],"knockdown":[294],"reduced":[295],"cell":[297],"proliferation,":[298],"migration,":[299],"glycolytic":[301],"activity":[302],"suppressed":[306],"xenograft":[307],"growth":[309],".":[312],"Conclusion":[313],"We":[314],"established":[315],"cross-algorithm":[317],"framework":[320],"UM.":[322],"constituted":[326],"signature,":[330],"while":[331],"algorithms":[337],"experimental":[339],"validation,":[340],"emerged":[341],"functionally":[344]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}
