{"id":"https://openalex.org/W7225322770","doi":"https://doi.org/10.1021/acscatal.6c07711","title":"Bioinformatic-Guided Discovery of O -Dealkylation Activity in Cytochrome P450 Monooxygenases","display_name":"Bioinformatic-Guided Discovery of O -Dealkylation Activity in Cytochrome P450 Monooxygenases","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225322770","doi":"https://doi.org/10.1021/acscatal.6c07711"},"language":"en","primary_location":{"id":"doi:10.1021/acscatal.6c07711","doi":"https://doi.org/10.1021/acscatal.6c07711","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscatal.6c07711","pdf_url":"https://pubs.acs.org/accacs/article-pdf/doi/10.1021/acscatal.6c07711/69097655/cs-2026-07711m.pdf","source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"hybrid","oa_url":"https://pubs.acs.org/accacs/article-pdf/doi/10.1021/acscatal.6c07711/69097655/cs-2026-07711m.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5106064211","display_name":"Lina A. Csechala","orcid":"https://orcid.org/0009-0004-8037-6469","observed_orcids":["https://orcid.org/0009-0004-8037-6469"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Lina A. Csechala","raw_affiliation_strings":["University of Greifswald , , Felix-Hausdorff-Str. 4 , ,"],"raw_orcid":"https://orcid.org/0009-0004-8037-6469","affiliations":[{"raw_affiliation_string":"University of Greifswald , , Felix-Hausdorff-Str. 4 , ,","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079315294","display_name":"Verena Scheibelreiter","orcid":"https://orcid.org/0000-0002-8236-9658","observed_orcids":["https://orcid.org/0000-0002-8236-9658"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Verena Scheibelreiter","raw_affiliation_strings":["TU Wien , , Getreidemarkt 9 , ,"],"raw_orcid":"https://orcid.org/0000-0002-8236-9658","affiliations":[{"raw_affiliation_string":"TU Wien , , Getreidemarkt 9 , ,","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5062183980","display_name":"Ina Menyes","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Ina Menyes","raw_affiliation_strings":["University of Greifswald , , Felix-Hausdorff-Str. 4 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Greifswald , , Felix-Hausdorff-Str. 4 , ,","institution_ids":["https://openalex.org/I36522303"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5119739689","display_name":"Maximilian Wutscher","orcid":"https://orcid.org/0009-0006-5200-2018","observed_orcids":["https://orcid.org/0009-0006-5200-2018"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Maximilian Wutscher","raw_affiliation_strings":["TU Wien , , Getreidemarkt 9 , ,"],"raw_orcid":"https://orcid.org/0009-0006-5200-2018","affiliations":[{"raw_affiliation_string":"TU Wien , , Getreidemarkt 9 , ,","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007748962","display_name":"Florian Rudroff","orcid":"https://orcid.org/0000-0002-6680-8200","observed_orcids":["https://orcid.org/0000-0002-6680-8200"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":true,"raw_author_name":"Florian Rudroff","raw_affiliation_strings":["TU Wien , , Getreidemarkt 9 , ,"],"raw_orcid":"https://orcid.org/0000-0002-6680-8200","affiliations":[{"raw_affiliation_string":"TU Wien , , Getreidemarkt 9 , ,","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018581138","display_name":"Christian Stanetty","orcid":"https://orcid.org/0000-0001-7692-6932","observed_orcids":["https://orcid.org/0000-0001-7692-6932"]},"institutions":[{"id":"https://openalex.org/I145847075","display_name":"TU Wien","ror":"https://ror.org/04d836q62","country_code":"AT","type":"education","lineage":["https://openalex.org/I145847075"]}],"countries":["AT"],"is_corresponding":false,"raw_author_name":"Christian Stanetty","raw_affiliation_strings":["TU Wien , , Getreidemarkt 9 , ,"],"raw_orcid":"https://orcid.org/0000-0001-7692-6932","affiliations":[{"raw_affiliation_string":"TU Wien , , Getreidemarkt 9 , ,","institution_ids":["https://openalex.org/I145847075"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084945746","display_name":"Thomas Bayer","orcid":"https://orcid.org/0000-0002-0656-3280","observed_orcids":["https://orcid.org/0000-0002-0656-3280"]},"institutions":[{"id":"https://openalex.org/I118564535","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05","country_code":"CH","type":"education","lineage":["https://openalex.org/I118564535"]}],"countries":["CH"],"is_corresponding":false,"raw_author_name":"Thomas Bayer","raw_affiliation_strings":["University of Bern , , Freiestrasse 3 , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Bern , , Freiestrasse 3 , ,","institution_ids":["https://openalex.org/I118564535"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5031181844","display_name":"Uwe T. Bornscheuer","orcid":"https://orcid.org/0000-0003-0685-2696","observed_orcids":["https://orcid.org/0000-0003-0685-2696"]},"institutions":[{"id":"https://openalex.org/I36522303","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15","country_code":"DE","type":"education","lineage":["https://openalex.org/I36522303"]}],"countries":["DE"],"is_corresponding":true,"raw_author_name":"Uwe T. Bornscheuer","raw_affiliation_strings":["University of Greifswald , , Felix-Hausdorff-Str. 4 , ,"],"raw_orcid":"https://orcid.org/0000-0003-0685-2696","affiliations":[{"raw_affiliation_string":"University of Greifswald , , Felix-Hausdorff-Str. 4 , ,","institution_ids":["https://openalex.org/I36522303"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5007748962","https://openalex.org/A5031181844"],"corresponding_institution_ids":["https://openalex.org/I145847075","https://openalex.org/I36522303"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":{"value":4500,"currency":"USD","value_usd":4500},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10404","display_name":"Enzyme Catalysis and Immobilization","score":0.9984999895095825,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11747","display_name":"Metal-Catalyzed Oxygenation Mechanisms","score":0.000699999975040555,"subfield":{"id":"https://openalex.org/subfields/1604","display_name":"Inorganic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11617","display_name":"Enzyme Production and Characterization","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/o-dealkylation","display_name":"O-dealkylation","score":0.9660000205039978},{"id":"https://openalex.org/keywords/cytochrome-p450-monooxygenases","display_name":"cytochrome P450 monooxygenase","score":0.9559999704360962},{"id":"https://openalex.org/keywords/alkyl-ethers","display_name":"alkyl ethers","score":0.7699999809265137},{"id":"https://openalex.org/keywords/sequence-similarity-networks","display_name":"sequence similarity networks","score":0.8709999918937683},{"id":"https://openalex.org/keywords/regioselectivity","display_name":"regioselectivity","score":0.9480000138282776},{"id":"https://openalex.org/keywords/veratryl-alcohol","display_name":"veratryl alcohol","score":0.8600000143051147},{"id":"https://openalex.org/keywords/biocatalyst-discovery","display_name":"biocatalyst discovery","score":0.6340000033378601}],"concepts":[{"id":"https://openalex.org/C13002179","wikidata":"https://www.wikidata.org/wiki/Q6901821","display_name":"Monooxygenase","level":4,"score":0.7684000134468079},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.7630000114440918},{"id":"https://openalex.org/C59759590","wikidata":"https://www.wikidata.org/wiki/Q2275927","display_name":"Regioselectivity","level":3,"score":0.6827999949455261},{"id":"https://openalex.org/C2780263894","wikidata":"https://www.wikidata.org/wiki/Q335268","display_name":"Alkyl","level":2,"score":0.5877000093460083},{"id":"https://openalex.org/C191503008","wikidata":"https://www.wikidata.org/wiki/Q16007026","display_name":"Biocatalysis","level":4,"score":0.5637000203132629},{"id":"https://openalex.org/C201194858","wikidata":"https://www.wikidata.org/wiki/Q898238","display_name":"Steric effects","level":2,"score":0.525600016117096},{"id":"https://openalex.org/C526171541","wikidata":"https://www.wikidata.org/wiki/Q407693","display_name":"Cytochrome P450","level":3,"score":0.5242999792098999},{"id":"https://openalex.org/C2777289219","wikidata":"https://www.wikidata.org/wiki/Q7632154","display_name":"Substrate (aquarium)","level":2,"score":0.4959999918937683},{"id":"https://openalex.org/C21951064","wikidata":"https://www.wikidata.org/wiki/Q899212","display_name":"Combinatorial chemistry","level":1,"score":0.4690000116825104},{"id":"https://openalex.org/C181199279","wikidata":"https://www.wikidata.org/wiki/Q8047","display_name":"Enzyme","level":2,"score":0.46000000834465027},{"id":"https://openalex.org/C178790620","wikidata":"https://www.wikidata.org/wiki/Q11351","display_name":"Organic chemistry","level":1,"score":0.39500001072883606},{"id":"https://openalex.org/C2778112365","wikidata":"https://www.wikidata.org/wiki/Q3511065","display_name":"Sequence (biology)","level":2,"score":0.3671000003814697},{"id":"https://openalex.org/C161790260","wikidata":"https://www.wikidata.org/wiki/Q82264","display_name":"Catalysis","level":2,"score":0.3571999967098236},{"id":"https://openalex.org/C71240020","wikidata":"https://www.wikidata.org/wiki/Q186011","display_name":"Stereochemistry","level":1,"score":0.3443000018596649},{"id":"https://openalex.org/C41183919","wikidata":"https://www.wikidata.org/wiki/Q423026","display_name":"Active site","level":3,"score":0.3440000116825104},{"id":"https://openalex.org/C535685238","wikidata":"https://www.wikidata.org/wiki/Q1153832","display_name":"Organic synthesis","level":3,"score":0.33329999446868896},{"id":"https://openalex.org/C69118441","wikidata":"https://www.wikidata.org/wiki/Q2941663","display_name":"Enzyme catalysis","level":3,"score":0.31279999017715454},{"id":"https://openalex.org/C2991944050","wikidata":"https://www.wikidata.org/wiki/Q36534","display_name":"Reaction conditions","level":3,"score":0.30649998784065247},{"id":"https://openalex.org/C2781109383","wikidata":"https://www.wikidata.org/wiki/Q898497","display_name":"Hydroxylation","level":3,"score":0.3028999865055084},{"id":"https://openalex.org/C2994592520","wikidata":"https://www.wikidata.org/wiki/Q5090496","display_name":"Substrate specificity","level":3,"score":0.2980000078678131},{"id":"https://openalex.org/C2776910235","wikidata":"https://www.wikidata.org/wiki/Q18574","display_name":"Reactivity (psychology)","level":3,"score":0.28690001368522644},{"id":"https://openalex.org/C2781066024","wikidata":"https://www.wikidata.org/wiki/Q156","display_name":"Alcohol","level":2,"score":0.2824999988079071},{"id":"https://openalex.org/C2777977315","wikidata":"https://www.wikidata.org/wiki/Q7243056","display_name":"Primary (astronomy)","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C27881333","wikidata":"https://www.wikidata.org/wiki/Q864895","display_name":"Biotransformation","level":3,"score":0.2799000144004822},{"id":"https://openalex.org/C2780768313","wikidata":"https://www.wikidata.org/wiki/Q408068","display_name":"Cytochrome","level":3,"score":0.27889999747276306},{"id":"https://openalex.org/C114373084","wikidata":"https://www.wikidata.org/wiki/Q273499","display_name":"Chemical synthesis","level":3,"score":0.2782000005245209},{"id":"https://openalex.org/C190667039","wikidata":"https://www.wikidata.org/wiki/Q3738104","display_name":"Chemoselectivity","level":3,"score":0.273499995470047},{"id":"https://openalex.org/C58548122","wikidata":"https://www.wikidata.org/wiki/Q838390","display_name":"Cascade reaction","level":3,"score":0.2705000042915344}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acscatal.6c07711","doi":"https://doi.org/10.1021/acscatal.6c07711","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscatal.6c07711","pdf_url":"https://pubs.acs.org/accacs/article-pdf/doi/10.1021/acscatal.6c07711/69097655/cs-2026-07711m.pdf","source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1021/acscatal.6c07711","doi":"https://doi.org/10.1021/acscatal.6c07711","is_oa":true,"landing_page_url":"https://doi.org/10.1021/acscatal.6c07711","pdf_url":"https://pubs.acs.org/accacs/article-pdf/doi/10.1021/acscatal.6c07711/69097655/cs-2026-07711m.pdf","source":{"id":"https://openalex.org/S37391459","display_name":"ACS Catalysis","issn_l":"2155-5435","issn":["2155-5435"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-a","jufo-3","ki-jl-2","norway-2","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"ACS Catalysis","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320309616","display_name":"Technische Universitat Wien","ror":"https://ror.org/04d836q62"},{"id":"https://openalex.org/F4320310992","display_name":"University of Bern","ror":"https://ror.org/02k7v4d05"},{"id":"https://openalex.org/F4320320879","display_name":"Deutsche Forschungsgemeinschaft","ror":"https://ror.org/018mejw64"},{"id":"https://openalex.org/F4320320933","display_name":"Rijksuniversiteit Groningen","ror":"https://ror.org/012p63287"},{"id":"https://openalex.org/F4320321181","display_name":"Austrian Science Fund","ror":"https://ror.org/013tf3c58"},{"id":"https://openalex.org/F4320322839","display_name":"Technische Universit\u00e4t Wien","ror":"https://ror.org/04d836q62"},{"id":"https://openalex.org/F4320326656","display_name":"Department of Biotechnology, Government of West Bengal","ror":"https://ror.org/03k93wc57"},{"id":"https://openalex.org/F4320330128","display_name":"Universit\u00e4t Greifswald","ror":"https://ror.org/00r1edq15"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225322770.pdf","grobid_xml":"https://content.openalex.org/works/W7225322770.grobid-xml"},"referenced_works_count":69,"referenced_works":["https://openalex.org/W1495151627","https://openalex.org/W1554763469","https://openalex.org/W1566080486","https://openalex.org/W1571241687","https://openalex.org/W1951469402","https://openalex.org/W1969609483","https://openalex.org/W1970057367","https://openalex.org/W1970256241","https://openalex.org/W1987370810","https://openalex.org/W1990200436","https://openalex.org/W1990324427","https://openalex.org/W2017843489","https://openalex.org/W2024718601","https://openalex.org/W2028046413","https://openalex.org/W2028859755","https://openalex.org/W2036716674","https://openalex.org/W2039103245","https://openalex.org/W2048084736","https://openalex.org/W2055542085","https://openalex.org/W2063519382","https://openalex.org/W2086046888","https://openalex.org/W2106195907","https://openalex.org/W2113561798","https://openalex.org/W2123323249","https://openalex.org/W2134967712","https://openalex.org/W2140615337","https://openalex.org/W2147469677","https://openalex.org/W2153877336","https://openalex.org/W2158285772","https://openalex.org/W2158737588","https://openalex.org/W2159675211","https://openalex.org/W2159818299","https://openalex.org/W2163089754","https://openalex.org/W2291747082","https://openalex.org/W2405270468","https://openalex.org/W2500841323","https://openalex.org/W2572705855","https://openalex.org/W2608022098","https://openalex.org/W2751743037","https://openalex.org/W2793743030","https://openalex.org/W2914012452","https://openalex.org/W2951666587","https://openalex.org/W2976704092","https://openalex.org/W3005375818","https://openalex.org/W3012521310","https://openalex.org/W3089122619","https://openalex.org/W3166176468","https://openalex.org/W3177261807","https://openalex.org/W3189763370","https://openalex.org/W4206117801","https://openalex.org/W4220749138","https://openalex.org/W4238420766","https://openalex.org/W4244771042","https://openalex.org/W4306762966","https://openalex.org/W4320486716","https://openalex.org/W4321207605","https://openalex.org/W4324304712","https://openalex.org/W4388266089","https://openalex.org/W4388936967","https://openalex.org/W4390062537","https://openalex.org/W4396721167","https://openalex.org/W4402668948","https://openalex.org/W4403499989","https://openalex.org/W4404531735","https://openalex.org/W4405443211","https://openalex.org/W4407581009","https://openalex.org/W4409519400","https://openalex.org/W4414134644","https://openalex.org/W4414538163"],"related_works":["https://openalex.org/W6890011257","https://openalex.org/W6965274892","https://openalex.org/W7119538929","https://openalex.org/W7123259281","https://openalex.org/W4414538163","https://openalex.org/W593045638","https://openalex.org/W7129272765","https://openalex.org/W2067661637","https://openalex.org/W1994744663","https://openalex.org/W2101646238"],"abstract_inverted_index":{"Abstract":[0],"The":[1],"O-dealkylation":[2,42,64],"of":[3,8,80,103,143,149,156,176,183,191],"alkyl":[4,10,177],"ethers\u2014or":[5],"the":[6,40,67,101,113,140,157,169,173,181,189,194],"removal":[7,175],"small":[9],"protecting":[11],"groups":[12],"(PGs)\u2014remains":[13],"a":[14,51],"significant":[15,83],"challenge":[16],"in":[17,72],"organic":[18],"synthesis.":[19],"While":[20,96],"traditional":[21],"chemical":[22],"methods":[23],"require":[24],"harsh":[25],"reaction":[26],"conditions":[27],"and":[28,98,105,108,126,159,179],"lack":[29],"sufficient":[30],"selectivity,":[31],"biocatalytic":[32],"approaches":[33,187],"represent":[34],"valuable":[35],"alternatives.":[36],"However,":[37],"enzymes":[38],"facilitating":[39],"desired":[41,195],"reactions":[43,148],"are":[44],"scarce.":[45],"In":[46,123],"this":[47],"work,":[48],"we":[49],"applied":[50],"sequence":[52,69],"similarity":[53],"network":[54],"(SSN)-guided":[55],"approach":[56],"to":[57,154],"identify":[58],"cytochrome":[59],"P450":[60],"monooxygenases":[61],"(CYPs)":[62],"with":[63,193],"activity":[65,84],"within":[66],"growing":[68],"diversity":[70],"found":[71],"public":[73],"databases.":[74],"We":[75],"investigated":[76],"six":[77],"CYPs,":[78],"three":[79,150],"which":[81],"exhibited":[82,128],"toward":[85],"structurally":[86],"diverse":[87],"ethers":[88],"bearing":[89],"methyl,":[90],"ethyl,":[91],"propyl,":[92],"or":[93],"allyl":[94],"groups.":[95],"P450ThcB":[97,125,138],"P450Terp":[99,127],"enabled":[100,139],"deprotection":[102,142],"aromatic":[104],"aliphatic":[106],"primary":[107],"secondary":[109],"ethers,":[110],"P450Sca2-mut":[111],"complemented":[112],"substrate":[114],"scope":[115],"by":[116],"effectively":[117],"deprotecting":[118],"sterically":[119],"demanding":[120],"tertiary":[121],"ethers.":[122,136],"particular,":[124],"high":[129],"regioselectivity,":[130],"preferentially":[131],"cleaving":[132],"phenolic":[133],"over":[134],"benzylic":[135],"Furthermore,":[137],"regioselective":[141],"veratryl":[144],"alcohol.":[145],"Preparative":[146],"scale":[147],"substrates":[151],"yielded":[152],"up":[153],"74%":[155],"isolated":[158],"(regioselectively)":[160],"cleaved":[161],"alcohol":[162],"product.":[163],"Together,":[164],"these":[165],"findings":[166],"substantially":[167],"expand":[168],"enzymatic":[170],"toolbox":[171],"for":[172,188],"selective":[174],"PGs":[178],"highlight":[180],"suitability":[182],"SSN-guided":[184],"database":[185],"mining":[186],"identification":[190],"biocatalysts":[192],"function.":[196]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}