{"id":"https://openalex.org/W7225322762","doi":"https://doi.org/10.1186/s13073-026-01826-4","title":"Decoding neuroendocrine tumors: a cross-site multiomic approach unveils clinically relevant molecular subtypes","display_name":"Decoding neuroendocrine tumors: a cross-site multiomic approach unveils clinically relevant molecular subtypes","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225322762","doi":"https://doi.org/10.1186/s13073-026-01826-4"},"language":"en","primary_location":{"id":"doi:10.1186/s13073-026-01826-4","doi":"https://doi.org/10.1186/s13073-026-01826-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13073-026-01826-4","pdf_url":null,"source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s13073-026-01826-4","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5033946433","display_name":"Carlos Carretero-Puche","orcid":"https://orcid.org/0000-0003-0474-8668","observed_orcids":["https://orcid.org/0000-0003-0474-8668"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Carlos Carretero-Puche","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5103130275","display_name":"Beatriz Ant\u00f3n-Pascual","orcid":"https://orcid.org/0000-0001-9237-8614","observed_orcids":["https://orcid.org/0000-0001-9237-8614"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Anton-Pascual","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]},{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059043999","display_name":"Alberto Lens\u2010Pardo","orcid":"https://orcid.org/0000-0002-0394-9081","observed_orcids":["https://orcid.org/0000-0002-0394-9081"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alberto Lens-Pardo","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5053487646","display_name":"Gonzalo Gom\u00e9z-L\u00f3pez","orcid":"https://orcid.org/0000-0002-4146-0551","observed_orcids":["https://orcid.org/0000-0002-4146-0551"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Gonzalo Gomez-Lopez","raw_affiliation_strings":["Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045911159","display_name":"Marcos Rubio\u2010Fern\u00e1ndez","orcid":"https://orcid.org/0000-0001-6210-9966","observed_orcids":["https://orcid.org/0000-0001-6210-9966"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marcos Rubio-Fernandez","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5015839602","display_name":"Beatriz Rubio-Cuesta","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Beatriz Rubio-Cuesta","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111407371","display_name":"Marta Benavent","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Marta Benavent","raw_affiliation_strings":["Medical Oncology Department, Hospital Universitario Virgen del Roc\u00edo, IBIS, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Virgen del Roc\u00edo, IBIS, Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021070087","display_name":"Lourdes Gomez\u2010Izquierdo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210133602","display_name":"Instituto de Biomedicina de Sevilla","ror":"https://ror.org/031zwx660","country_code":"ES","type":"facility","lineage":["https://openalex.org/I134820265","https://openalex.org/I158283456","https://openalex.org/I4210133602","https://openalex.org/I79238269","https://openalex.org/I918821925"]},{"id":"https://openalex.org/I4210153139","display_name":"Hospital Universitario Virgen del Roc\u00edo","ror":"https://ror.org/04vfhnm78","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210153139"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Lourdes Gomez-Izquierdo","raw_affiliation_strings":["Pathology Department, Hospital Universitario Virgen del Roc\u00edo, IBIS, Sevilla, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Universitario Virgen del Roc\u00edo, IBIS, Sevilla, Spain","institution_ids":["https://openalex.org/I4210133602","https://openalex.org/I4210153139"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5045108507","display_name":"Paula Jim\u00e9nez\u2010Fonseca","orcid":"https://orcid.org/0000-0003-4592-3813","observed_orcids":["https://orcid.org/0000-0003-4592-3813"]},"institutions":[{"id":"https://openalex.org/I4210133994","display_name":"Hospital Universitario Central de Asturias","ror":"https://ror.org/03v85ar63","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210133994","https://openalex.org/I4405258403"]},{"id":"https://openalex.org/I4210166274","display_name":"Instituto de Investigaci\u00f3n Sanitaria del Principado de Asturias","ror":"https://ror.org/05xzb7x97","country_code":"ES","type":"facility","lineage":["https://openalex.org/I2800212897","https://openalex.org/I4210166274"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Jimenez-Fonseca","raw_affiliation_strings":["Medical Oncology Department, Hospital Universitario Central de Asturias, ISPA, Oviedo, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Central de Asturias, ISPA, Oviedo, Spain","institution_ids":["https://openalex.org/I4210133994","https://openalex.org/I4210166274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027710328","display_name":"Ana Teijo","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Ana Teijo","raw_affiliation_strings":["Pathology Department, Hospital Universitario Doce de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084262225","display_name":"Yolanda Rodriguez-Gil","orcid":"https://orcid.org/0000-0002-4811-5486","observed_orcids":["https://orcid.org/0000-0002-4811-5486"]},"institutions":[{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Yolanda Rodriguez-Gil","raw_affiliation_strings":["Pathology Department, Hospital Universitario Doce de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Pathology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017233833","display_name":"Cristian Perna","orcid":"https://orcid.org/0000-0001-8566-1198","observed_orcids":["https://orcid.org/0000-0001-8566-1198"]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Cristian Perna","raw_affiliation_strings":["Department of Pathology, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, Universidad de Alcal\u00e1, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, Universidad de Alcal\u00e1, Madrid, Spain","institution_ids":["https://openalex.org/I189268942","https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5074199720","display_name":"Alejandra Caminoa","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I189268942","display_name":"Universidad de Alcal\u00e1","ror":"https://ror.org/04pmn0e78","country_code":"ES","type":"education","lineage":["https://openalex.org/I189268942"]},{"id":"https://openalex.org/I4210127475","display_name":"Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria","ror":"https://ror.org/03fftr154","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210127475"]},{"id":"https://openalex.org/I4210161852","display_name":"Hospital Universitario Ram\u00f3n y Cajal","ror":"https://ror.org/050eq1942","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210139293","https://openalex.org/I4210161852"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Alejandra Caminoa","raw_affiliation_strings":["Department of Pathology, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, Universidad de Alcal\u00e1, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pathology, Hospital Universitario Ram\u00f3n y Cajal, Instituto Ram\u00f3n y Cajal de Investigaci\u00f3n Sanitaria, Universidad de Alcal\u00e1, Madrid, Spain","institution_ids":["https://openalex.org/I189268942","https://openalex.org/I4210127475","https://openalex.org/I4210161852"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5025178554","display_name":"Paula Espinosa-Olarte","orcid":"https://orcid.org/0000-0002-5545-6764","observed_orcids":["https://orcid.org/0000-0002-5545-6764"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Paula Espinosa-Olarte","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]},{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021860279","display_name":"Anna La Salvia","orcid":"https://orcid.org/0000-0002-5020-8657","observed_orcids":["https://orcid.org/0000-0002-5020-8657"]},"institutions":[{"id":"https://openalex.org/I27897274","display_name":"Istituto Superiore di Sanit\u00e0","ror":"https://ror.org/02hssy432","country_code":"IT","type":"government","lineage":["https://openalex.org/I27897274"]},{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES","IT"],"is_corresponding":false,"raw_author_name":"Anna La Salvia","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","National Center for Drug Research and Evaluation, National Institute of Health (Istituto Superiore di Sanit\u00e0, ISS), Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]},{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]},{"raw_affiliation_string":"National Center for Drug Research and Evaluation, National Institute of Health (Istituto Superiore di Sanit\u00e0, ISS), Rome, Italy","institution_ids":["https://openalex.org/I27897274"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014473319","display_name":"David G\u00f3mez-S\u00e1nchez","orcid":"https://orcid.org/0000-0002-5170-1590","observed_orcids":["https://orcid.org/0000-0002-5170-1590"]},"institutions":[{"id":"https://openalex.org/I1334819555","display_name":"Memorial Sloan Kettering Cancer Center","ror":"https://ror.org/02yrq0923","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1334819555"]},{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES","US"],"is_corresponding":false,"raw_author_name":"David Gomez-Sanchez","raw_affiliation_strings":["Department of Surgery, Colorectal Service & Department of Epidemiology and Biostatistics, Computational Oncology Service, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, United States","H12O-CNIO Lung Cancer Clinical Research Unit, Health Research Institute Hospital 12 de Octubre (Imas12) & Spanish National Cancer Research Center (CNIO), Computational Oncology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Surgery, Colorectal Service & Department of Epidemiology and Biostatistics, Computational Oncology Service, Memorial Sloan Kettering Cancer Center (MSKCC), New York, NY, United States","institution_ids":["https://openalex.org/I1334819555"]},{"raw_affiliation_string":"H12O-CNIO Lung Cancer Clinical Research Unit, Health Research Institute Hospital 12 de Octubre (Imas12) & Spanish National Cancer Research Center (CNIO), Computational Oncology Group, Spanish National Cancer Research Center (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084843262","display_name":"Mar\u00eda Jos\u00e9 Jim\u00e9nez\u2010Santos","orcid":"https://orcid.org/0000-0002-1430-3067","observed_orcids":["https://orcid.org/0000-0002-1430-3067"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Maria Jose Jimenez-Santos","raw_affiliation_strings":["Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5073610195","display_name":"Santiago Garc\u00eda\u2010Mart\u00edn","orcid":"https://orcid.org/0000-0002-4540-9446","observed_orcids":["https://orcid.org/0000-0002-4540-9446"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Santiago Garcia-Martin","raw_affiliation_strings":["Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5021759168","display_name":"Benjamin Gibert","orcid":"https://orcid.org/0000-0002-5295-3124","observed_orcids":["https://orcid.org/0000-0002-5295-3124"]},"institutions":[{"id":"https://openalex.org/I100532134","display_name":"Lyon 1 Universit\u00e9","ror":"https://ror.org/029brtt94","country_code":"FR","type":"education","lineage":["https://openalex.org/I100532134","https://openalex.org/I203339264"]},{"id":"https://openalex.org/I1294671590","display_name":"Centre National de la Recherche Scientifique","ror":"https://ror.org/02feahw73","country_code":"FR","type":"government","lineage":["https://openalex.org/I1294671590"]},{"id":"https://openalex.org/I154526488","display_name":"Inserm","ror":"https://ror.org/02vjkv261","country_code":"FR","type":"government","lineage":["https://openalex.org/I154526488"]},{"id":"https://openalex.org/I4210105738","display_name":"Centre L\u00e9on B\u00e9rard","ror":"https://ror.org/01cmnjq37","country_code":"FR","type":"nonprofit","lineage":["https://openalex.org/I4210105738"]},{"id":"https://openalex.org/I4210125048","display_name":"Centre de Recherche en Canc\u00e9rologie de Lyon","ror":"https://ror.org/02mgw3155","country_code":"FR","type":"facility","lineage":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I203339264","https://openalex.org/I4210096427","https://openalex.org/I4210105738","https://openalex.org/I4210125048"]}],"countries":["FR"],"is_corresponding":false,"raw_author_name":"Benjamin Gibert","raw_affiliation_strings":["Gastroenterology and Technologies for Health (Universit\u00e9 Claude Bernard Lyon 1, INSERM U1052, CNRS UMR5286, Centre L\u00e9on B\u00e9rard), Cancer Research Center of Lyon, Lyon, France"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gastroenterology and Technologies for Health (Universit\u00e9 Claude Bernard Lyon 1, INSERM U1052, CNRS UMR5286, Centre L\u00e9on B\u00e9rard), Cancer Research Center of Lyon, Lyon, France","institution_ids":["https://openalex.org/I100532134","https://openalex.org/I1294671590","https://openalex.org/I154526488","https://openalex.org/I4210105738","https://openalex.org/I4210125048"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5059545146","display_name":"Mercedes Robledo","orcid":"https://orcid.org/0000-0001-6256-5902","observed_orcids":["https://orcid.org/0000-0001-6256-5902"]},"institutions":[{"id":"https://openalex.org/I2801357902","display_name":"Instituto de Salud Carlos III","ror":"https://ror.org/00ca2c886","country_code":"ES","type":"nonprofit","lineage":["https://openalex.org/I2801357902","https://openalex.org/I4387152914"]},{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]},{"id":"https://openalex.org/I4210111366","display_name":"Centre for Biomedical Network Research on Rare Diseases","ror":"https://ror.org/01ygm5w19","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210111366"]}],"countries":["ES"],"is_corresponding":false,"raw_author_name":"Mercedes Robledo","raw_affiliation_strings":["Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain","Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Investigaci\u00f3n Biom\u00e9dica en Red de Enfermedades Raras (CIBERER), Institute of Health Carlos III (ISCIII), Madrid, Spain","institution_ids":["https://openalex.org/I2801357902","https://openalex.org/I4210111366"]},{"raw_affiliation_string":"Hereditary Endocrine Cancer Group, Human Cancer Genetics Program, Spanish National Cancer Research Center (CNIO), Madrid, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027004121","display_name":"F\u00e1tima Al\u2010Shahrour","orcid":"https://orcid.org/0000-0003-2373-769X","observed_orcids":["https://orcid.org/0000-0003-2373-769X"]},"institutions":[{"id":"https://openalex.org/I4210089594","display_name":"Spanish National Cancer Research Centre","ror":"https://ror.org/00bvhmc43","country_code":"ES","type":"facility","lineage":["https://openalex.org/I4210089594"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Fatima Al-Shahrour","raw_affiliation_strings":["Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Bioinformatics Unit, Spanish National Cancer Research Center (CNIO), C/ Melchor Fern\u00e1ndez Almagro, 3, Madrid, 28029, Spain","institution_ids":["https://openalex.org/I4210089594"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064621937","display_name":"Beatriz Soldevilla","orcid":"https://orcid.org/0000-0002-1118-1316","observed_orcids":["https://orcid.org/0000-0002-1118-1316"]},"institutions":[{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Beatriz Soldevilla","raw_affiliation_strings":["Molecular Mechanisms of Neuroendocrine Tumors and New Approaches in Precision Medicine, Centro de Oncolog\u00eda Experimental, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Av. de C\u00f3rdoba s/n, Madrid, 28041, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Molecular Mechanisms of Neuroendocrine Tumors and New Approaches in Precision Medicine, Centro de Oncolog\u00eda Experimental, Instituto de Investigaci\u00f3n Hospital 12 de Octubre (imas12), Av. de C\u00f3rdoba s/n, Madrid, 28041, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5048223620","display_name":"Rocio Garc\u00eda\u2010Carbonero","orcid":"https://orcid.org/0000-0002-3342-397X","observed_orcids":["https://orcid.org/0000-0002-3342-397X"]},"institutions":[{"id":"https://openalex.org/I121748325","display_name":"Universidad Complutense de Madrid","ror":"https://ror.org/02p0gd045","country_code":"ES","type":"education","lineage":["https://openalex.org/I121748325"]},{"id":"https://openalex.org/I4210086614","display_name":"Research Institute Hospital 12 de Octubre","ror":"https://ror.org/002x1sg85","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210086614"]},{"id":"https://openalex.org/I4210101691","display_name":"Hospital Universitario 12 De Octubre","ror":"https://ror.org/00qyh5r35","country_code":"ES","type":"healthcare","lineage":["https://openalex.org/I4210101691","https://openalex.org/I4210139293"]}],"countries":["ES"],"is_corresponding":true,"raw_author_name":"Rocio Garcia-Carbonero","raw_affiliation_strings":["Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","Facultad de Medicina, Departamento de Medicina, Universidad Complutense de Madrid, Madrid, Spain","Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Centro de Oncolog\u00eda Experimental, Grupo de Investigaci\u00f3n en Tumores Gastrointestinales y Neuroendocrinos, Instituto de Investigaci\u00f3n Sanitaria Hospital 12 de Octubre (imas12), CNIO, Madrid, Spain","institution_ids":["https://openalex.org/I4210086614","https://openalex.org/I4210101691"]},{"raw_affiliation_string":"Facultad de Medicina, Departamento de Medicina, Universidad Complutense de Madrid, Madrid, Spain","institution_ids":["https://openalex.org/I121748325"]},{"raw_affiliation_string":"Medical Oncology Department, Hospital Universitario Doce de Octubre, Madrid, Spain","institution_ids":["https://openalex.org/I4210101691"]}]}],"institutions":[],"countries_distinct_count":4,"institutions_distinct_count":20,"corresponding_author_ids":["https://openalex.org/A5027004121","https://openalex.org/A5048223620","https://openalex.org/A5064621937"],"corresponding_institution_ids":["https://openalex.org/I121748325","https://openalex.org/I4210086614","https://openalex.org/I4210089594","https://openalex.org/I4210101691"],"apc_list":{"value":5290,"currency":"USD","value_usd":5290},"apc_paid":{"value":5290,"currency":"USD","value_usd":5290},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10754","display_name":"Neuroendocrine Tumor Research Advances","score":0.9976000189781189,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.0003000000142492354,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10183","display_name":"Breast Cancer Treatment Studies","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/neuroendocrine-tumors","display_name":"neuroendocrine tumors","score":1.0},{"id":"https://openalex.org/keywords/molecular-subtypes","display_name":"molecular subtypes","score":0.972000002861023},{"id":"https://openalex.org/keywords/dna-methylation","display_name":"DNA methylation","score":0.925000011920929},{"id":"https://openalex.org/keywords/gene-expression","display_name":"gene expression","score":0.9240000247955322},{"id":"https://openalex.org/keywords/consensus-clustering","display_name":"consensus clustering","score":0.5860000252723694},{"id":"https://openalex.org/keywords/prognostic-factors","display_name":"prognostic factors","score":0.7269999980926514},{"id":"https://openalex.org/keywords/immunophenotype","display_name":"immunophenotype","score":0.7670000195503235},{"id":"https://openalex.org/keywords/dna-hypermethylation","display_name":"DNA hypermethylation","score":0.8840000033378601},{"id":"https://openalex.org/keywords/neuroendocrine-differentiation","display_name":"neuroendocrine differentiation","score":0.8289999961853027},{"id":"https://openalex.org/keywords/survival","display_name":"survival","score":0.382999986410141},{"id":"https://openalex.org/keywords/lung-neuroendocrine-tumors","display_name":"lung neuroendocrine tumors","score":0.7689999938011169},{"id":"https://openalex.org/keywords/small-intestinal-neuroendocrine-tumors","display_name":"small bowel neuroendocrine tumors","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pancreatic-neuroendocrine-tumors","display_name":"pancreatic neuroendocrine tumors","score":0.9779999852180481},{"id":"https://openalex.org/keywords/colorectal-neuroendocrine-tumors","display_name":"colorectal neuroendocrine tumors","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2779066768","wikidata":"https://www.wikidata.org/wiki/Q1981276","display_name":"Neuroendocrine tumors","level":2,"score":0.602400004863739},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.5389000177383423},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4896000027656555},{"id":"https://openalex.org/C190727270","wikidata":"https://www.wikidata.org/wiki/Q874745","display_name":"DNA methylation","level":4,"score":0.4537000060081482},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.423799991607666},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.4020000100135803},{"id":"https://openalex.org/C73555534","wikidata":"https://www.wikidata.org/wiki/Q622825","display_name":"Cluster analysis","level":2,"score":0.3675000071525574},{"id":"https://openalex.org/C143998085","wikidata":"https://www.wikidata.org/wiki/Q162555","display_name":"Oncology","level":1,"score":0.36230000853538513},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.3549000024795532},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.3528999984264374},{"id":"https://openalex.org/C63479239","wikidata":"https://www.wikidata.org/wiki/Q7353546","display_name":"Robustness (evolution)","level":3,"score":0.351500004529953},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.3382999897003174},{"id":"https://openalex.org/C2781187634","wikidata":"https://www.wikidata.org/wiki/Q20969980","display_name":"KRAS","level":4,"score":0.33469998836517334},{"id":"https://openalex.org/C10515644","wikidata":"https://www.wikidata.org/wiki/Q543310","display_name":"Survival analysis","level":2,"score":0.3271999955177307},{"id":"https://openalex.org/C207886595","wikidata":"https://www.wikidata.org/wiki/Q1456138","display_name":"Pathological","level":2,"score":0.3190999925136566},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.3172000050544739},{"id":"https://openalex.org/C186767784","wikidata":"https://www.wikidata.org/wiki/Q5162841","display_name":"Consensus clustering","level":5,"score":0.3140999972820282},{"id":"https://openalex.org/C120821319","wikidata":"https://www.wikidata.org/wiki/Q1501491","display_name":"Copy-number variation","level":4,"score":0.2935999929904938},{"id":"https://openalex.org/C152662350","wikidata":"https://www.wikidata.org/wiki/Q815297","display_name":"Systems biology","level":2,"score":0.29179999232292175},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.28859999775886536},{"id":"https://openalex.org/C47042493","wikidata":"https://www.wikidata.org/wiki/Q265799","display_name":"Human genetics","level":3,"score":0.2833999991416931},{"id":"https://openalex.org/C18431079","wikidata":"https://www.wikidata.org/wiki/Q1502169","display_name":"Gene expression profiling","level":4,"score":0.27649998664855957},{"id":"https://openalex.org/C163763905","wikidata":"https://www.wikidata.org/wiki/Q17075943","display_name":"Precision medicine","level":2,"score":0.27320000529289246},{"id":"https://openalex.org/C204315192","wikidata":"https://www.wikidata.org/wiki/Q210506","display_name":"Molecular genetics","level":3,"score":0.27160000801086426},{"id":"https://openalex.org/C194409129","wikidata":"https://www.wikidata.org/wiki/Q103824","display_name":"Hematology","level":2,"score":0.2655999958515167},{"id":"https://openalex.org/C74092355","wikidata":"https://www.wikidata.org/wiki/Q1056943","display_name":"Molecular pathology","level":3,"score":0.25780001282691956}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s13073-026-01826-4","doi":"https://doi.org/10.1186/s13073-026-01826-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13073-026-01826-4","pdf_url":null,"source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s13073-026-01826-4","doi":"https://doi.org/10.1186/s13073-026-01826-4","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s13073-026-01826-4","pdf_url":null,"source":{"id":"https://openalex.org/S149201819","display_name":"Genome Medicine","issn_l":"1756-994X","issn":["1756-994X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-3","ki-jl-2","medline","norway-1","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Genome Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9391000270843506,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4282944349","https://openalex.org/W4353101377","https://openalex.org/W2980806329","https://openalex.org/W4408383644","https://openalex.org/W7204243257","https://openalex.org/W4403379651","https://openalex.org/W2173461168","https://openalex.org/W4383311920","https://openalex.org/W4211093337","https://openalex.org/W4403203743"],"abstract_inverted_index":{"Neuroendocrine":[0],"tumors":[1],"(NETs)":[2],"comprise":[3],"a":[4,102,160,266],"heterogeneous":[5],"family":[6],"of":[7,9,34,52,96,139,179,218,247,254,275],"malignancies":[8],"wide":[10],"anatomic":[11],"distribution":[12],"but":[13],"shared":[14],"clinical":[15,58],"and":[16,47,54,64,74,87,121,143,164,169,181,195,222,236,260,271],"molecular":[17,50,112,122,155],"features.":[18],"Although":[19],"tissue-specific":[20],"biology":[21],"has":[22],"been":[23],"well":[24],"characterized":[25,116,186],"for":[26,204,231,268],"some":[27],"common":[28,261],"primary":[29,219],"sites,":[30],"comprehensive":[31],"analyses":[32],"capable":[33],"defining":[35],"biologically":[36,93],"meaningful,":[37],"site-independent":[38],"subtypes":[39,51,156],"are":[40],"lacking.":[41],"This":[42,250],"study":[43],"aimed":[44],"to":[45,55,69,100],"identify":[46],"validate":[48],"cross-site":[49,252],"NETs":[53,145,255],"evaluate":[56],"their":[57],"relevance.":[59],"Multi-omic":[60],"factor":[61],"analysis":[62],"(MOFA)":[63],"unsupervised":[65,109],"clustering":[66,105],"were":[67,98,216],"used":[68],"integrate":[70],"tumor":[71,220,237],"gene":[72],"expression":[73],"DNA":[75,189],"methylation":[76],"data":[77],"from":[78,107],"194":[79],"patients":[80],"with":[81,124,146,177],"lung,":[82,140],"stomach,":[83],"pancreas,":[84],"small":[85,141],"intestine,":[86,142],"colorectal":[88],"NETs.":[89],"Latent":[90],"factors":[91],"representing":[92],"meaningful":[94],"sources":[95],"variation":[97],"leveraged":[99],"generate":[101],"robust":[103],"consensus":[104],"derived":[106],"eight":[108],"algorithms.":[110],"Each":[111],"subtype":[113],"was":[114,133,165,185],"comprehensively":[115],"by":[117,187],"integrating":[118],"clinical,":[119],"pathological":[120],"features":[123],"survival":[125],"through":[126],"multivariable":[127,228],"Cox":[128],"proportional":[129],"hazards":[130],"models.":[131],"Validation":[132,239],"performed":[134],"in":[135,167,192,227,240],"independent":[136,217,224],"external":[137,242],"cohorts":[138],"pancreatic":[144],"publicly":[147],"available":[148],"multi-omic":[149],"datasets.":[150],"We":[151],"identified":[152],"three":[153],"distinct":[154],"(NS1\u20133).":[157],"NS1":[158],"exhibited":[159],"strong":[161],"immune":[162],"phenotype":[163],"enriched":[166],"metabolic":[168],"nutrient-digestion":[170],"pathways.":[171],"NS2":[172],"showed":[173],"pronounced":[174],"neuroendocrine":[175],"differentiation":[176],"enrichment":[178,191],"neuronal":[180],"secretory":[182],"programs.":[183],"NS3":[184,205],"global":[188],"hypermethylation,":[190],"DNA-replication":[193],"pathways,":[194],"significantly":[196],"poorer":[197],"prognosis":[198],"(10-year":[199],"OS:":[200],"51.9%":[201],"vs.":[202],"83.2\u201383.9%":[203],"vs":[206],"NS1/NS2;":[207],"p":[208],"=":[209],"3":[210],"\u00d7":[211],"10":[212],"\u22124":[213],").":[214],"NSs":[215],"location":[221],"retained":[223],"prognostic":[225],"significance":[226],"models":[229],"adjusting":[230],"age,":[232],"sex,":[233],"TNM":[234],"stage":[235],"site.":[238],"an":[241],"cohort":[243],"confirmed":[244],"the":[245,272],"robustness":[246],"these":[248],"findings.":[249],"new":[251],"classification":[253],"reveals":[256],"convergent":[257],"biological":[258],"traits":[259],"potentially":[262],"targetable":[263],"vulnerabilities,":[264],"providing":[265],"framework":[267],"biomarker":[269],"development":[270],"rational":[273],"design":[274],"novel":[276],"therapeutic":[277],"strategies.":[278]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}
