{"id":"https://openalex.org/W7225320528","doi":"https://doi.org/10.64898/2026.11.04.26367324","title":"Risk-benefit assessment of oral anticoagulation in atrial fibrillation using virtual clinical trials","display_name":"Risk-benefit assessment of oral anticoagulation in atrial fibrillation using virtual clinical trials","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225320528","doi":"https://doi.org/10.64898/2026.11.04.26367324"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.26367324","doi":"https://doi.org/10.64898/2026.11.04.26367324","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.26367324","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.04.26367324.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.04.26367324.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5101149264","display_name":"Minsi Cai","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Minsi Cai","raw_affiliation_strings":["Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160290898","display_name":"Fateme Farahani","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]},{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT","NL"],"is_corresponding":false,"raw_author_name":"Fateme Farahani","raw_affiliation_strings":["Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","Department of Electrical, Electronic and Information Engineering \u2018Guglielmo Marconi\u2019, University of Bologna, Cesena, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Electrical, Electronic and Information Engineering \u2018Guglielmo Marconi\u2019, University of Bologna, Cesena, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5064509705","display_name":"Michiel Rienstra","orcid":"https://orcid.org/0000-0002-2581-070X","observed_orcids":["https://orcid.org/0000-0002-2581-070X"]},"institutions":[{"id":"https://openalex.org/I1334415907","display_name":"University Medical Center Groningen","ror":"https://ror.org/03cv38k47","country_code":"NL","type":"healthcare","lineage":["https://openalex.org/I1334415907"]},{"id":"https://openalex.org/I169381384","display_name":"University of Groningen","ror":"https://ror.org/012p63287","country_code":"NL","type":"education","lineage":["https://openalex.org/I169381384"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Michiel Rienstra","raw_affiliation_strings":["Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-2581-070X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands","institution_ids":["https://openalex.org/I1334415907","https://openalex.org/I169381384"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009600398","display_name":"Stefano Severi","orcid":"https://orcid.org/0000-0003-4306-8294","observed_orcids":["https://orcid.org/0000-0003-4306-8294"]},"institutions":[{"id":"https://openalex.org/I9360294","display_name":"University of Bologna","ror":"https://ror.org/01111rn36","country_code":"IT","type":"education","lineage":["https://openalex.org/I9360294"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefano Severi","raw_affiliation_strings":["Department of Electrical, Electronic and Information Engineering \u2018Guglielmo Marconi\u2019, University of Bologna, Cesena, Italy"],"raw_orcid":"https://orcid.org/0000-0003-4306-8294","affiliations":[{"raw_affiliation_string":"Department of Electrical, Electronic and Information Engineering \u2018Guglielmo Marconi\u2019, University of Bologna, Cesena, Italy","institution_ids":["https://openalex.org/I9360294"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5090763481","display_name":"Harry J.G.M. Crijns","orcid":"https://orcid.org/0000-0003-1073-5337","observed_orcids":["https://orcid.org/0000-0003-1073-5337"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Harry J.G.M. Crijns","raw_affiliation_strings":["Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1073-5337","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046773983","display_name":"Ulrich Schotten","orcid":"https://orcid.org/0000-0003-1532-3315","observed_orcids":["https://orcid.org/0000-0003-1532-3315"]},"institutions":[{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Ulrich Schotten","raw_affiliation_strings":["Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","Department of Physiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0003-1532-3315","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Department of Physiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5040704388","display_name":"Jordi Heijman","orcid":"https://orcid.org/0000-0002-1418-108X","observed_orcids":["https://orcid.org/0000-0002-1418-108X"]},"institutions":[{"id":"https://openalex.org/I202276237","display_name":"Medical University of Graz","ror":"https://ror.org/02n0bts35","country_code":"AT","type":"education","lineage":["https://openalex.org/I202276237"]},{"id":"https://openalex.org/I34352273","display_name":"Maastricht University","ror":"https://ror.org/02jz4aj89","country_code":"NL","type":"education","lineage":["https://openalex.org/I34352273"]}],"countries":["AT","NL"],"is_corresponding":true,"raw_author_name":"Jordi Heijman","raw_affiliation_strings":["Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","Gottfried Schatz Research Center, Division of Medical Physics & Biophysics, Medical University of Graz, Graz, Austria"],"raw_orcid":"https://orcid.org/0000-0002-1418-108X","affiliations":[{"raw_affiliation_string":"Department of Cardiology, Cardiovascular Research Institute Maastricht, Faculty of Health, Medicine, and Life Sciences, Maastricht University, Maastricht, The Netherlands","institution_ids":["https://openalex.org/I34352273"]},{"raw_affiliation_string":"Gottfried Schatz Research Center, Division of Medical Physics & Biophysics, Medical University of Graz, Graz, Austria","institution_ids":["https://openalex.org/I202276237"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":5,"corresponding_author_ids":["https://openalex.org/A5040704388"],"corresponding_institution_ids":["https://openalex.org/I202276237","https://openalex.org/I34352273"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10065","display_name":"Atrial Fibrillation Management and Outcomes","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10227","display_name":"Acute Ischemic Stroke Management","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10285","display_name":"Venous Thromboembolism Diagnosis and Management","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2724","display_name":"Internal Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/oral-anticoagulation","display_name":"oral anticoagulation","score":0.8989999890327454},{"id":"https://openalex.org/keywords/atrial-fibrillation","display_name":"atrial fibrillation","score":1.0},{"id":"https://openalex.org/keywords/stroke-prevention","display_name":"stroke prevention","score":0.7149999737739563},{"id":"https://openalex.org/keywords/major-bleeding","display_name":"major bleeding","score":0.9430000185966492},{"id":"https://openalex.org/keywords/atrial-fibrillation-screening","display_name":"atrial fibrillation screening","score":0.781000018119812},{"id":"https://openalex.org/keywords/cha2ds2-vasc-score","display_name":"CHA2DS2-VASc score","score":0.8859999775886536},{"id":"https://openalex.org/keywords/continuous-rhythm-monitoring","display_name":"continuous rhythm monitoring","score":0.8690000176429749},{"id":"https://openalex.org/keywords/virtual-clinical-trials","display_name":"virtual clinical trials","score":0.7910000085830688},{"id":"https://openalex.org/keywords/markov-model","display_name":"Markov model","score":0.7400000095367432},{"id":"https://openalex.org/keywords/risk-benefit-trade-off","display_name":"risk-benefit trade-off","score":0.8230000138282776},{"id":"https://openalex.org/keywords/anticoagulation-adherence","display_name":"anticoagulation adherence","score":0.8169999718666077}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9225999712944031},{"id":"https://openalex.org/C2779161974","wikidata":"https://www.wikidata.org/wiki/Q815819","display_name":"Atrial fibrillation","level":2,"score":0.869700014591217},{"id":"https://openalex.org/C2780645631","wikidata":"https://www.wikidata.org/wiki/Q671554","display_name":"Stroke (engine)","level":2,"score":0.7695000171661377},{"id":"https://openalex.org/C3017811039","wikidata":"https://www.wikidata.org/wiki/Q166019","display_name":"Major bleeding","level":3,"score":0.6370000243186951},{"id":"https://openalex.org/C535046627","wikidata":"https://www.wikidata.org/wiki/Q30612","display_name":"Clinical trial","level":2,"score":0.5491999983787537},{"id":"https://openalex.org/C61511704","wikidata":"https://www.wikidata.org/wiki/Q1671857","display_name":"Incidence (geometry)","level":2,"score":0.5220999717712402},{"id":"https://openalex.org/C168563851","wikidata":"https://www.wikidata.org/wiki/Q1436668","display_name":"Randomized controlled trial","level":2,"score":0.4950000047683716},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.49059998989105225},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.4674000144004822},{"id":"https://openalex.org/C3020200829","wikidata":"https://www.wikidata.org/wiki/Q12202","display_name":"Stroke risk","level":4,"score":0.4253000020980835},{"id":"https://openalex.org/C197934379","wikidata":"https://www.wikidata.org/wiki/Q2047938","display_name":"Adverse effect","level":2,"score":0.3594000041484833},{"id":"https://openalex.org/C2779974597","wikidata":"https://www.wikidata.org/wiki/Q28448986","display_name":"Clinical Practice","level":2,"score":0.3578000068664551},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.33000001311302185},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.32010000944137573},{"id":"https://openalex.org/C82789193","wikidata":"https://www.wikidata.org/wiki/Q2142611","display_name":"Relative risk","level":3,"score":0.2985999882221222},{"id":"https://openalex.org/C2780065318","wikidata":"https://www.wikidata.org/wiki/Q2058605","display_name":"Heart Rhythm","level":2,"score":0.2930000126361847},{"id":"https://openalex.org/C2779668873","wikidata":"https://www.wikidata.org/wiki/Q6693756","display_name":"Lower risk","level":3,"score":0.29190000891685486},{"id":"https://openalex.org/C3018923921","wikidata":"https://www.wikidata.org/wiki/Q2585693","display_name":"Clinical effectiveness","level":2,"score":0.27459999918937683},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2574000060558319}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.26367324","doi":"https://doi.org/10.64898/2026.11.04.26367324","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.26367324","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.04.26367324.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.26367324","doi":"https://doi.org/10.64898/2026.11.04.26367324","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.26367324","pdf_url":"https://www.medrxiv.org/content/medrxiv/early/2026/11/05/2026.11.04.26367324.full.pdf","source":{"id":"https://openalex.org/S3005729997","display_name":"medRxiv","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core"],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310315909"],"host_organization_lineage_names":["Cold Spring Harbor Laboratory Press"],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"medRxiv","raw_type":"posted-content"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320320300","display_name":"European Commission","ror":"https://ror.org/00k4n6c32"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225320528.pdf","grobid_xml":"https://content.openalex.org/works/W7225320528.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1825229520","https://openalex.org/W1904978529","https://openalex.org/W1966458977","https://openalex.org/W1976575956","https://openalex.org/W1999468381","https://openalex.org/W2016936949","https://openalex.org/W2036855846","https://openalex.org/W2067443499","https://openalex.org/W2083482655","https://openalex.org/W2090544455","https://openalex.org/W2120112475","https://openalex.org/W2124601103","https://openalex.org/W2152623033","https://openalex.org/W2154328340","https://openalex.org/W2158311202","https://openalex.org/W2162586165","https://openalex.org/W2263555573","https://openalex.org/W2517057643","https://openalex.org/W2525173964","https://openalex.org/W2805943777","https://openalex.org/W2810058837","https://openalex.org/W2839803414","https://openalex.org/W2922501924","https://openalex.org/W2948008296","https://openalex.org/W3115240481","https://openalex.org/W3129415548","https://openalex.org/W3196294155","https://openalex.org/W3196502641","https://openalex.org/W3198148828","https://openalex.org/W4290773844","https://openalex.org/W4308635427","https://openalex.org/W4367856624","https://openalex.org/W4386153792","https://openalex.org/W4388609166","https://openalex.org/W4388609933","https://openalex.org/W4390339624","https://openalex.org/W4397289079","https://openalex.org/W4399654089","https://openalex.org/W4399676887","https://openalex.org/W4399954097","https://openalex.org/W4400224876","https://openalex.org/W4401906555","https://openalex.org/W4402049769","https://openalex.org/W4402103831","https://openalex.org/W4402104638","https://openalex.org/W4406821864","https://openalex.org/W4413499020","https://openalex.org/W4413855554","https://openalex.org/W7135425818"],"related_works":["https://openalex.org/W4410620694","https://openalex.org/W7127977827","https://openalex.org/W4391489418","https://openalex.org/W2105758234","https://openalex.org/W7116716967","https://openalex.org/W2052970701","https://openalex.org/W2781800454","https://openalex.org/W4414578844","https://openalex.org/W2567825792","https://openalex.org/W4388928428"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Oral":[2],"anticoagulation":[3],"(OAC)":[4],"reduces":[5],"stroke":[6,29,124,141,229],"risk":[7,142,150,186,261],"in":[8,76,177,191],"patients":[9,192],"with":[10,93,110,138,193,237],"atrial":[11],"fibrillation":[12],"(AF),":[13],"and":[14,21,31,40,45,54,74,85,103,122,125,219,231],"screening":[15,92,209],"can":[16],"enable":[17],"earlier":[18],"AF":[19,39,91],"detection":[20],"OAC":[22,41,95,109,139,170,173,212,217,252,257],"initiation.":[23],"However,":[24],"the":[25,66,205,244,267],"population-level":[26],"trade-off":[27,227],"between":[28,228],"prevention":[30],"OAC-related":[32],"major":[33,72],"bleeding":[34,126,149,185,195,220,232,260],"for":[35,163,167,233,240],"different":[36,77],"types":[37],"of":[38,69,89,208,248,269],"therapy":[42],"remains":[43],"uncertain,":[44],"large":[46],"randomized":[47],"trials":[48,272],"to":[49,263,273],"resolve":[50],"this":[51],"are":[52],"costly":[53],"time-consuming.":[55],"Methods":[56],"A":[57],"state-transition":[58],"Markov-like":[59],"model":[60,115,224],"was":[61,159],"developed":[62],"to:":[63],"1)":[64],"simulate":[65],"lifetime":[67],"course":[68],"AF,":[70],"stroke,":[71],"bleeding,":[73],"death":[75],"virtual":[78,246,270],"populations;":[79],"2)":[80],"quantify":[81],"benefits":[82],"(stroke":[83],"reduction)":[84],"harms":[86],"(major":[87],"bleeding)":[88],"systematic":[90,234],"screening-triggered":[94],"across":[96,128],"CHA":[97],"2":[98,100],"DS":[99],"-VA":[101],"scores;":[102],"3)":[104],"compare":[105],"rhythm-guided,":[106],"time-delimited":[107],"(\u201cpill-in-pocket\u201d)":[108],"continuous":[111,134,172,264],"OAC.":[112],"Results":[113],"The":[114],"synthesized":[116],"information":[117],"from":[118],"multiple":[119],"clinical":[120,129,271,275],"sources":[121],"reproduced":[123],"incidence":[127],"scenarios.":[130],"At":[131],"CHA\u2082DS\u2082-VA=2,":[132],"long-term":[133],"rhythm":[135],"monitoring":[136],"(LT-CRM)":[137],"lowered":[140],"(HR,":[143,151,179,187],"0.92":[144],"[95%CI,":[145,153],"0.88-0.96])":[146],"but":[147,165,183,197],"raised":[148],"1.17":[152],"1.07-1.27])":[154],"versus":[155],"no":[156,175],"screening.":[157],"Time-to-benefit":[158],"shorter":[160],"than":[161],"time-to-harm":[162],"CHA\u2082DS\u2082-VA\u22654,":[164],"longer":[166],"CHA\u2082DS\u2082-VA=0.":[168],"Pill-in-pocket":[169],"vs":[171],"showed":[174],"difference":[176],"stroke/mortality":[178],"1.03,":[180],"95%CI":[181],"[0.91-1.16])":[182],"lower":[184,259],"0.81,":[188],"95%CI:":[189],"0.68-0.96])":[190],"elevated":[194],"risk,":[196],"not":[198],"at":[199],"baseline.":[200],"Sensitivity":[201],"analyses":[202],"revealed":[203],"that":[204,255],"risk-benefit":[206],"profiles":[207],"or":[210],"pill-in-pocket":[211,256],"strategy":[213],"further":[214],"depend":[215],"on":[216],"adherence":[218],"risks.":[221],"Conclusions":[222],"Our":[223],"highlights":[225],"a":[226],"reduction":[230],"screening-initiated":[235],"OAC,":[236,265],"net":[238],"benefit":[239],"CHA\u2082DS\u2082-VA\u22654.":[241],"We":[242],"provide":[243],"first":[245],"implementation":[247],"an":[249],"ongoing":[250],"rhythm-guided":[251],"trial,":[253],"showing":[254],"may":[258],"compared":[262],"highlighting":[266],"potential":[268],"guide":[274],"trial":[276],"design.":[277]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-06T00:00:00"}