{"id":"https://openalex.org/W7225319982","doi":"https://doi.org/10.1038/s12276-026-01885-y","title":"The interaction between GPCR and Na+ channels via Go proteins in excitable cells","display_name":"The interaction between GPCR and Na+ channels via Go proteins in excitable cells","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225319982","doi":"https://doi.org/10.1038/s12276-026-01885-y","pmid":"https://pubmed.ncbi.nlm.nih.gov/42988869"},"language":"en","primary_location":{"id":"doi:10.1038/s12276-026-01885-y","doi":"https://doi.org/10.1038/s12276-026-01885-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-026-01885-y","pdf_url":"https://www.nature.com/articles/s12276-026-01885-y.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.nature.com/articles/s12276-026-01885-y.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160891586","display_name":"Malka Cohen-Armon","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I16391192","display_name":"Tel Aviv University","ror":"https://ror.org/04mhzgx49","country_code":"IL","type":"education","lineage":["https://openalex.org/I16391192"]}],"countries":["IL"],"is_corresponding":true,"raw_author_name":"Malka Cohen-Armon","raw_affiliation_strings":["Gray Faculty of Medicine and Health Sciences & Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. marmon@tauex.tau.ac.il"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Gray Faculty of Medicine and Health Sciences & Sagol School of Neuroscience, Tel-Aviv University, Tel-Aviv, Israel. marmon@tauex.tau.ac.il","institution_ids":["https://openalex.org/I16391192"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5160891586"],"corresponding_institution_ids":["https://openalex.org/I16391192"],"apc_list":{"value":4490,"currency":"USD","value_usd":4490},"apc_paid":{"value":4490,"currency":"USD","value_usd":4490},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10493","display_name":"Ion channel regulation and function","score":0.9932000041007996,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11178","display_name":"Receptor Mechanisms and Signaling","score":0.0038999998942017555,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10077","display_name":"Neuroscience and Neuropharmacology Research","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2804","display_name":"Cellular and Molecular Neuroscience"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/g-protein-coupled-receptors","display_name":"G protein-coupled receptors","score":0.8259999752044678},{"id":"https://openalex.org/keywords/voltage-gated-sodium-channels","display_name":"voltage-gated sodium channels","score":0.8090000152587891},{"id":"https://openalex.org/keywords/g-proteins","display_name":"G proteins","score":0.6710000038146973},{"id":"https://openalex.org/keywords/muscarinic-receptors","display_name":"muscarinic receptors","score":0.9629999995231628},{"id":"https://openalex.org/keywords/s6-segment","display_name":"S6 segment","score":0.7580000162124634},{"id":"https://openalex.org/keywords/voltage-sensor","display_name":"voltage sensor","score":0.7829999923706055},{"id":"https://openalex.org/keywords/excitable-cells","display_name":"excitable cells","score":0.9670000076293945}],"concepts":[{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.699999988079071},{"id":"https://openalex.org/C24530287","wikidata":"https://www.wikidata.org/wiki/Q424204","display_name":"Transmembrane protein","level":3,"score":0.5831000208854675},{"id":"https://openalex.org/C12554922","wikidata":"https://www.wikidata.org/wiki/Q7100","display_name":"Biophysics","level":1,"score":0.5608999729156494},{"id":"https://openalex.org/C135285700","wikidata":"https://www.wikidata.org/wiki/Q38173","display_name":"G protein-coupled receptor","level":3,"score":0.5145000219345093},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.47600001096725464},{"id":"https://openalex.org/C50254741","wikidata":"https://www.wikidata.org/wiki/Q62536","display_name":"Ion channel","level":3,"score":0.46230000257492065},{"id":"https://openalex.org/C50952357","wikidata":"https://www.wikidata.org/wiki/Q424960","display_name":"Sodium channel","level":3,"score":0.4603999853134155},{"id":"https://openalex.org/C144647389","wikidata":"https://www.wikidata.org/wiki/Q423042","display_name":"Membrane protein","level":3,"score":0.4090999960899353},{"id":"https://openalex.org/C11804247","wikidata":"https://www.wikidata.org/wiki/Q896177","display_name":"Protein\u2013protein interaction","level":2,"score":0.40549999475479126},{"id":"https://openalex.org/C118892022","wikidata":"https://www.wikidata.org/wiki/Q7834587","display_name":"Transmembrane domain","level":3,"score":0.3962000012397766},{"id":"https://openalex.org/C174510640","wikidata":"https://www.wikidata.org/wiki/Q489618","display_name":"HEK 293 cells","level":3,"score":0.3569999933242798},{"id":"https://openalex.org/C127162648","wikidata":"https://www.wikidata.org/wiki/Q16858953","display_name":"Channel (broadcasting)","level":2,"score":0.3167000114917755},{"id":"https://openalex.org/C41625074","wikidata":"https://www.wikidata.org/wiki/Q176088","display_name":"Membrane","level":2,"score":0.31470000743865967},{"id":"https://openalex.org/C187632348","wikidata":"https://www.wikidata.org/wiki/Q7834586","display_name":"Transmembrane channels","level":5,"score":0.3111000061035156},{"id":"https://openalex.org/C181911157","wikidata":"https://www.wikidata.org/wiki/Q389844","display_name":"Membrane potential","level":2,"score":0.2872999906539917},{"id":"https://openalex.org/C33789571","wikidata":"https://www.wikidata.org/wiki/Q410959","display_name":"Muscarinic acetylcholine receptor","level":3,"score":0.272599995136261},{"id":"https://openalex.org/C170493617","wikidata":"https://www.wikidata.org/wiki/Q208467","display_name":"Receptor","level":2,"score":0.2712000012397766},{"id":"https://openalex.org/C2778207910","wikidata":"https://www.wikidata.org/wiki/Q397610","display_name":"Agr\u00e9gation","level":3,"score":0.2678999900817871},{"id":"https://openalex.org/C2778106830","wikidata":"https://www.wikidata.org/wiki/Q29548","display_name":"Cell membrane","level":3,"score":0.2653999924659729},{"id":"https://openalex.org/C80631254","wikidata":"https://www.wikidata.org/wiki/Q407438","display_name":"G protein","level":3,"score":0.25949999690055847}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1038/s12276-026-01885-y","doi":"https://doi.org/10.1038/s12276-026-01885-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-026-01885-y","pdf_url":"https://www.nature.com/articles/s12276-026-01885-y.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},{"id":"pmid:42988869","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42988869","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & molecular medicine","raw_type":"Letter"}],"best_oa_location":{"id":"doi:10.1038/s12276-026-01885-y","doi":"https://doi.org/10.1038/s12276-026-01885-y","is_oa":true,"landing_page_url":"https://doi.org/10.1038/s12276-026-01885-y","pdf_url":"https://www.nature.com/articles/s12276-026-01885-y.pdf","source":{"id":"https://openalex.org/S57588113","display_name":"Experimental & Molecular Medicine","issn_l":"1226-3613","issn":["1226-3613","2092-6413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-a","jufo-1","kci-registered","medline","norway-1","oarl","poland-140","russia-white-list-1"],"host_organization":"https://openalex.org/P4310319965","host_organization_name":"Springer Nature","host_organization_lineage":["https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Experimental & Molecular Medicine","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225319982.pdf","grobid_xml":"https://content.openalex.org/works/W7225319982.grobid-xml"},"referenced_works_count":12,"referenced_works":["https://openalex.org/W1563079087","https://openalex.org/W1981587038","https://openalex.org/W2015242423","https://openalex.org/W2059799779","https://openalex.org/W2066355250","https://openalex.org/W2093985027","https://openalex.org/W2127858562","https://openalex.org/W2409861544","https://openalex.org/W2460762159","https://openalex.org/W2963870305","https://openalex.org/W4367857321","https://openalex.org/W4416265181"],"related_works":["https://openalex.org/W7163807000","https://openalex.org/W7203656428","https://openalex.org/W110540037","https://openalex.org/W2090152143","https://openalex.org/W291509653","https://openalex.org/W2417368735","https://openalex.org/W4396891549","https://openalex.org/W2279422544","https://openalex.org/W2240142947","https://openalex.org/W2408429336"],"abstract_inverted_index":{"Abstract":[0],"Our":[1],"findings":[2],"in":[3,47,66,78],"excitable":[4,49],"cells":[5],"support":[6],"the":[7,56,59,67,74,81],"recent":[8],"work":[9],"of":[10,58],"Kim":[11],"et":[12],"al.":[13],"(":[14],"Exp":[15],"Mol":[16],"Med":[17],"57:2717\u20132728,":[18],"2025),":[19],"which":[20],"describes":[21],"a":[22,33],"direct":[23,34],"interaction":[24,35,52],"between":[25,36],"ion":[26],"channels":[27,41],"and":[28,43,62],"G":[29,44],"proteins.":[30],"We":[31],"identified":[32],"muscarinic":[37],"receptors,":[38],"voltage-dependent":[39],"sodium":[40],"(VDSC),":[42],"o":[45],"proteins":[46],"mammalian":[48],"cells.":[50],"Their":[51],"was":[53],"dependent":[54],"on":[55],"opening":[57,77],"VDSC":[60,68,82],"pore,":[61],"it":[63],"implicated":[64],"modifications":[65],"transmembrane":[69],"S6":[70],"segments":[71],"that":[72],"orchestrate":[73],"channel":[75],"pore":[76],"coordination":[79],"with":[80],"voltage":[83],"sensors.":[84]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}