{"id":"https://openalex.org/W7225319898","doi":"https://doi.org/10.1021/acs.jafc.6c13537","title":"Innovative Research on the Agricultural Insecticidal Activity of Lotilaner and Its Derivatives","display_name":"Innovative Research on the Agricultural Insecticidal Activity of Lotilaner and Its Derivatives","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225319898","doi":"https://doi.org/10.1021/acs.jafc.6c13537"},"language":"en","primary_location":{"id":"doi:10.1021/acs.jafc.6c13537","doi":"https://doi.org/10.1021/acs.jafc.6c13537","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c13537","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160983044","display_name":"Senhui Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Senhui Wu","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5046045523","display_name":"Pan Zhou","orcid":"https://orcid.org/0000-0002-1862-4044","observed_orcids":["https://orcid.org/0000-0002-1862-4044"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pan Zhou","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-1862-4044","affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160912112","display_name":"Xinyu Zhuang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xinyu Zhuang","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160822520","display_name":"Jiahong Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jiahong Wu","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5091780544","display_name":"Yarong Li","orcid":"https://orcid.org/0009-0004-7240-6453","observed_orcids":["https://orcid.org/0009-0004-7240-6453"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongqiang Li","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038374346","display_name":"Hongjian Song","orcid":"https://orcid.org/0000-0001-7105-1196","observed_orcids":["https://orcid.org/0000-0001-7105-1196"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Hongjian Song","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":"https://orcid.org/0000-0001-7105-1196","affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086450307","display_name":"Yuxiu Liu","orcid":"https://orcid.org/0000-0003-0462-477X","observed_orcids":["https://orcid.org/0000-0003-0462-477X"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxiu Liu","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":"https://orcid.org/0000-0003-0462-477X","affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101052701","display_name":"Yi Ma","orcid":"https://orcid.org/0009-0008-8128-3108","observed_orcids":["https://orcid.org/0009-0008-8128-3108"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Yi Ma","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100689406","display_name":"Ziwen Wang","orcid":"https://orcid.org/0000-0001-9798-7021","observed_orcids":["https://orcid.org/0000-0001-9798-7021"]},"institutions":[{"id":"https://openalex.org/I15062923","display_name":"Tianjin Normal University","ror":"https://ror.org/05x2td559","country_code":"CN","type":"education","lineage":["https://openalex.org/I15062923"]},{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ziwen Wang","raw_affiliation_strings":["Nankai University , , ,","Tianjin Normal University , , ,"],"raw_orcid":"https://orcid.org/0000-0001-9798-7021","affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]},{"raw_affiliation_string":"Tianjin Normal University , , ,","institution_ids":["https://openalex.org/I15062923"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5042741534","display_name":"Qingmin Wang","orcid":"https://orcid.org/0000-0002-6062-3766","observed_orcids":["https://orcid.org/0000-0002-6062-3766","https://orcid.org/0009-0006-3036-4683"]},"institutions":[{"id":"https://openalex.org/I205237279","display_name":"Nankai University","ror":"https://ror.org/01y1kjr75","country_code":"CN","type":"education","lineage":["https://openalex.org/I205237279"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Qingmin Wang","raw_affiliation_strings":["Nankai University , , ,"],"raw_orcid":"https://orcid.org/0000-0002-6062-3766","affiliations":[{"raw_affiliation_string":"Nankai University , , ,","institution_ids":["https://openalex.org/I205237279"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5042741534","https://openalex.org/A5100689406","https://openalex.org/A5101052701"],"corresponding_institution_ids":["https://openalex.org/I15062923","https://openalex.org/I205237279"],"apc_list":{"value":4500,"currency":"USD","value_usd":4500},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.4666000008583069,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11065","display_name":"Insect Pest Control Strategies","score":0.4666000008583069,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11641","display_name":"Insect and Pesticide Research","score":0.3215000033378601,"subfield":{"id":"https://openalex.org/subfields/1109","display_name":"Insect Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11075","display_name":"Insect Resistance and Genetics","score":0.04830000177025795,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/lotilaner","display_name":"lotilaner","score":0.9990000128746033},{"id":"https://openalex.org/keywords/isoxazolines","display_name":"isoxazolines","score":0.8980000019073486},{"id":"https://openalex.org/keywords/insecticide-discovery","display_name":"insecticide discovery","score":0.6480000019073486},{"id":"https://openalex.org/keywords/plutella-xylostella","display_name":"Plutella xylostella","score":0.9369999766349792},{"id":"https://openalex.org/keywords/fall-armyworm","display_name":"Spodoptera frugiperda","score":0.996999979019165},{"id":"https://openalex.org/keywords/honey-bee-toxicity","display_name":"honey bee toxicity","score":0.859000027179718},{"id":"https://openalex.org/keywords/scaffold-modification","display_name":"scaffold modification","score":0.5440000295639038},{"id":"https://openalex.org/keywords/agricultural-insecticides","display_name":"agricultural insecticides","score":0.5709999799728394},{"id":"https://openalex.org/keywords/electronic-properties","display_name":"electronic properties","score":0.38600000739097595},{"id":"https://openalex.org/keywords/receptor-interaction","display_name":"receptor interaction","score":0.5130000114440918}],"concepts":[{"id":"https://openalex.org/C2993762632","wikidata":"https://www.wikidata.org/wiki/Q219174","display_name":"Agricultural pest","level":2,"score":0.572700023651123},{"id":"https://openalex.org/C116263406","wikidata":"https://www.wikidata.org/wiki/Q3299024","display_name":"Acute toxicity","level":3,"score":0.5094000101089478},{"id":"https://openalex.org/C29730261","wikidata":"https://www.wikidata.org/wiki/Q274160","display_name":"Toxicity","level":2,"score":0.46619999408721924},{"id":"https://openalex.org/C118518473","wikidata":"https://www.wikidata.org/wiki/Q11451","display_name":"Agriculture","level":2,"score":0.451200008392334},{"id":"https://openalex.org/C161176658","wikidata":"https://www.wikidata.org/wiki/Q131656","display_name":"Pesticide","level":2,"score":0.423799991607666},{"id":"https://openalex.org/C33070731","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Toxicology","level":1,"score":0.4189999997615814},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4002000093460083},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4000000059604645},{"id":"https://openalex.org/C486523","wikidata":"https://www.wikidata.org/wiki/Q494483","display_name":"Enantiomer","level":2,"score":0.3691999912261963},{"id":"https://openalex.org/C150903083","wikidata":"https://www.wikidata.org/wiki/Q7108","display_name":"Biotechnology","level":1,"score":0.3517000079154968},{"id":"https://openalex.org/C181647583","wikidata":"https://www.wikidata.org/wiki/Q903429","display_name":"Stereoselectivity","level":3,"score":0.34360000491142273},{"id":"https://openalex.org/C116073593","wikidata":"https://www.wikidata.org/wiki/Q864491","display_name":"Biological activity","level":3,"score":0.2922999858856201},{"id":"https://openalex.org/C193042331","wikidata":"https://www.wikidata.org/wiki/Q1772003","display_name":"Structure\u2013activity relationship","level":3,"score":0.2797999978065491},{"id":"https://openalex.org/C167552308","wikidata":"https://www.wikidata.org/wiki/Q711849","display_name":"Median lethal dose","level":3,"score":0.27219998836517334},{"id":"https://openalex.org/C2992837615","wikidata":"https://www.wikidata.org/wiki/Q3610615","display_name":"Insecticide resistance","level":2,"score":0.2709999978542328}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1021/acs.jafc.6c13537","doi":"https://doi.org/10.1021/acs.jafc.6c13537","is_oa":false,"landing_page_url":"https://doi.org/10.1021/acs.jafc.6c13537","pdf_url":null,"source":{"id":"https://openalex.org/S134644764","display_name":"Journal of Agricultural and Food Chemistry","issn_l":"0021-8561","issn":["0021-8561","1520-5118"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-b","jufo-3","ki-jl-2","medline","norway-2","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320006","host_organization_name":"American Chemical Society","host_organization_lineage":["https://openalex.org/P4310320006"],"host_organization_lineage_names":["American Chemical Society"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Agricultural and Food Chemistry","raw_type":"journal-article"}],"best_oa_location":null,"sustainable_development_goals":[{"score":0.4359000027179718,"id":"https://metadata.un.org/sdg/2","display_name":"Zero hunger"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320335777","display_name":"National Key Research and Development Program of China","ror":null}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":29,"referenced_works":["https://openalex.org/W2017603864","https://openalex.org/W2044550090","https://openalex.org/W2151148027","https://openalex.org/W2545650606","https://openalex.org/W2928792017","https://openalex.org/W2944907576","https://openalex.org/W4210577720","https://openalex.org/W4224227295","https://openalex.org/W4353014998","https://openalex.org/W4361223817","https://openalex.org/W4366368311","https://openalex.org/W4367601219","https://openalex.org/W4386944881","https://openalex.org/W4401022711","https://openalex.org/W4402082948","https://openalex.org/W4402581106","https://openalex.org/W4403514365","https://openalex.org/W4403685190","https://openalex.org/W4405888526","https://openalex.org/W4409145935","https://openalex.org/W4409208079","https://openalex.org/W4409405031","https://openalex.org/W4411002229","https://openalex.org/W4411121217","https://openalex.org/W4413004985","https://openalex.org/W4414038560","https://openalex.org/W4414161640","https://openalex.org/W4414377006","https://openalex.org/W4417279616"],"related_works":["https://openalex.org/W7225139747","https://openalex.org/W4392352331","https://openalex.org/W4402082948","https://openalex.org/W7166011203","https://openalex.org/W7213288327","https://openalex.org/W4408212905","https://openalex.org/W4408212488","https://openalex.org/W7134127976","https://openalex.org/W4402581106","https://openalex.org/W7167424262"],"abstract_inverted_index":{"Abstract":[0],"Isoxazolines":[1],"exhibit":[2],"potent":[3],"insecticidal":[4,76],"activity,":[5],"but":[6],"their":[7],"toxicity":[8],"to":[9,62,107,134],"beneficial":[10],"insects":[11],"limits":[12],"agricultural":[13,27,136],"applications.":[14],"Here,":[15],"we":[16],"first":[17],"explored":[18],"the":[19,96],"veterinary":[20],"isoxazoline":[21,137],"lotilaner":[22,65,106,129],"as":[23,130],"a":[24,34,131],"lead":[25],"for":[26,105,110],"insecticide":[28],"discovery.":[29],"We":[30],"designed":[31],"and":[32,83,92,119,142],"synthesized":[33],"series":[35],"of":[36,64,128],"diacylhydrazine-containing":[37],"derivatives.":[38],"Lotilaner":[39],"showed":[40],"strong":[41],"activity":[42,53,141],"against":[43,54],"P.":[44],"xylostella":[45],"(LC50":[46,57],"=":[47,58],"0.305":[48],"mg/L),":[49],"while":[50],"I-9S":[51,68],"exhibited":[52],"S.":[55],"frugiperda":[56],"2.69":[59],"mg/L)":[60],"comparable":[61],"that":[63],"(3.41":[66],"mg/L).":[67],"also":[69],"outperformed":[70],"its":[71],"enantiomer":[72],"I-9R,":[73],"indicating":[74],"stereoselective":[75],"activity.":[77],"Molecular":[78],"docking,":[79],"molecular":[80],"dynamics":[81],"simulations,":[82],"DFT":[84],"calculations":[85],"provided":[86],"insights":[87],"into":[88],"potential":[89],"receptor":[90],"interactions":[91],"electronic":[93],"properties.":[94],"Notably,":[95],"honeybee":[97,121,144],"acute":[98],"oral":[99],"LD50":[100,118],"increased":[101],"from":[102],"0.297":[103],"\u03bcg/bee":[104,109],"3.32":[108],"I-9S,":[111],"representing":[112],"an":[113],"approximately":[114],"11-fold":[115],"increase":[116],"in":[117],"reduced":[120],"toxicity.":[122],"These":[123],"findings":[124],"support":[125],"scaffold":[126],"modification":[127],"promising":[132],"approach":[133],"developing":[135],"insecticides":[138],"with":[139],"favorable":[140],"improved":[143],"safety.":[145]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}