{"id":"https://openalex.org/W7225318323","doi":"https://doi.org/10.6084/m9.figshare.34922865","title":"Euonymus alatus extract ameliorates DSS-induced experimental colitis and attenuates NLRP3 inflammasome-associated pyroptosis in macrophages","display_name":"Euonymus alatus extract ameliorates DSS-induced experimental colitis and attenuates NLRP3 inflammasome-associated pyroptosis in macrophages","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225318323","doi":"https://doi.org/10.6084/m9.figshare.34922865"},"language":"en","primary_location":{"id":"doi:10.6084/m9.figshare.34922865","doi":"https://doi.org/10.6084/m9.figshare.34922865","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922865","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["datacite"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.6084/m9.figshare.34922865","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5004978664","display_name":"Doeun Jeon","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Doeun Jeon","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5007555550","display_name":"Ami Lee","orcid":"https://orcid.org/0009-0002-7646-375X","observed_orcids":["https://orcid.org/0009-0002-7646-375X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ami Lee","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158892949","display_name":"Seong Eun Jin","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Seong Eun Jin","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5038360141","display_name":"\ud558\ud604\uc77c","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Hyunil Ha","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5107936782","display_name":"Han Na Kang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Han Na Kang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5139281679","display_name":"Jihee Choi","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jihee Choi","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5083544434","display_name":"Jin Ah Ryuk","orcid":"https://orcid.org/0000-0002-1811-2815","observed_orcids":["https://orcid.org/0000-0002-1811-2815"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jin Ah Ryuk","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5160830281","display_name":"Youn-Hwan Hwang","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Youn-Hwan Hwang","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10134","display_name":"Inflammatory Bowel Disease","score":0.9897000193595886,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13026","display_name":"Natural Compounds in Disease Treatment","score":0.002099999925121665,"subfield":{"id":"https://openalex.org/subfields/2707","display_name":"Complementary and alternative medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12346","display_name":"Phytochemistry and biological activity of medicinal plants","score":0.0017999999690800905,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/euonymus-alatus","display_name":"Euonymus alatus","score":0.9589999914169312},{"id":"https://openalex.org/keywords/dss-induced-colitis","display_name":"DSS-induced colitis","score":0.8679999709129333},{"id":"https://openalex.org/keywords/inflammatory-bowel-disease","display_name":"inflammatory bowel disease","score":0.8029999732971191},{"id":"https://openalex.org/keywords/nlrp3-inflammasome","display_name":"NLRP3 inflammasome","score":0.9919999837875366},{"id":"https://openalex.org/keywords/pyroptosis","display_name":"pyroptosis","score":1.0},{"id":"https://openalex.org/keywords/intestinal-epithelial-barrier","display_name":"intestinal epithelial barrier","score":0.8090000152587891},{"id":"https://openalex.org/keywords/macrophages","display_name":"macrophages","score":0.9279999732971191},{"id":"https://openalex.org/keywords/flavonoids","display_name":"flavonoids","score":0.7889999747276306},{"id":"https://openalex.org/keywords/phenolic-compounds","display_name":"phenolic compounds","score":0.7630000114440918},{"id":"https://openalex.org/keywords/caspase-1","display_name":"caspase-1","score":0.8349999785423279},{"id":"https://openalex.org/keywords/interleukin-1beta","display_name":"IL-1\u03b2","score":0.8489999771118164},{"id":"https://openalex.org/keywords/il-18","display_name":"IL-18","score":0.968999981880188},{"id":"https://openalex.org/keywords/gasdermin-d","display_name":"gasdermin D","score":0.8339999914169312},{"id":"https://openalex.org/keywords/zo-1","display_name":"ZO-1","score":0.7059999704360962},{"id":"https://openalex.org/keywords/occludin","display_name":"occludin","score":0.9789999723434448},{"id":"https://openalex.org/keywords/plant-extracts","display_name":"plant extracts","score":0.5070000290870667},{"id":"https://openalex.org/keywords/caco-2-cells","display_name":"Caco-2 cells","score":0.652999997138977},{"id":"https://openalex.org/keywords/j774a-1-macrophages","display_name":"J774A.1 macrophages","score":0.9679999947547913}],"concepts":[{"id":"https://openalex.org/C2775862500","wikidata":"https://www.wikidata.org/wiki/Q2453464","display_name":"Colitis","level":2,"score":0.7832000255584717},{"id":"https://openalex.org/C2775962179","wikidata":"https://www.wikidata.org/wiki/Q2013337","display_name":"Occludin","level":3,"score":0.7753000259399414},{"id":"https://openalex.org/C17172800","wikidata":"https://www.wikidata.org/wiki/Q7263707","display_name":"Pyroptosis","level":4,"score":0.7734000086784363},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.535099983215332},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.5072000026702881},{"id":"https://openalex.org/C51911345","wikidata":"https://www.wikidata.org/wiki/Q4863604","display_name":"Barrier function","level":2,"score":0.4918000102043152},{"id":"https://openalex.org/C2779028967","wikidata":"https://www.wikidata.org/wiki/Q161113","display_name":"Euonymus","level":2,"score":0.48420000076293945},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.4620000123977661},{"id":"https://openalex.org/C164027704","wikidata":"https://www.wikidata.org/wiki/Q3491837","display_name":"Proinflammatory cytokine","level":3,"score":0.4496000111103058},{"id":"https://openalex.org/C2778260677","wikidata":"https://www.wikidata.org/wiki/Q917447","display_name":"Inflammatory bowel disease","level":3,"score":0.42559999227523804},{"id":"https://openalex.org/C2777209026","wikidata":"https://www.wikidata.org/wiki/Q412405","display_name":"Inflammasome","level":3,"score":0.37389999628067017},{"id":"https://openalex.org/C2780941987","wikidata":"https://www.wikidata.org/wiki/Q3796380","display_name":"Ileitis","level":4,"score":0.35190001130104065},{"id":"https://openalex.org/C153400128","wikidata":"https://www.wikidata.org/wiki/Q3150731","display_name":"Infiltration (HVAC)","level":2,"score":0.3490999937057495},{"id":"https://openalex.org/C177779419","wikidata":"https://www.wikidata.org/wiki/Q1053832","display_name":"Tight junction","level":2,"score":0.3483000099658966},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.3416999876499176},{"id":"https://openalex.org/C17991360","wikidata":"https://www.wikidata.org/wiki/Q21173843","display_name":"Tumor necrosis factor alpha","level":2,"score":0.3312999904155731},{"id":"https://openalex.org/C2776848411","wikidata":"https://www.wikidata.org/wiki/Q418374","display_name":"Naringenin","level":4,"score":0.3095000088214874},{"id":"https://openalex.org/C2780479503","wikidata":"https://www.wikidata.org/wiki/Q1477","display_name":"Ulcerative colitis","level":3,"score":0.3046000003814697},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.2989000082015991},{"id":"https://openalex.org/C2779655422","wikidata":"https://www.wikidata.org/wiki/Q1196166","display_name":"Glycyrrhiza uralensis","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C2779969877","wikidata":"https://www.wikidata.org/wiki/Q861699","display_name":"Phytotherapy","level":3,"score":0.2881999909877777},{"id":"https://openalex.org/C2779703632","wikidata":"https://www.wikidata.org/wiki/Q581996","display_name":"Anti-inflammatory","level":2,"score":0.2773999869823456},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.2741999924182892},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27219998836517334},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.26330000162124634},{"id":"https://openalex.org/C503630168","wikidata":"https://www.wikidata.org/wiki/Q178069","display_name":"Necrosis","level":2,"score":0.262800008058548},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25859999656677246},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.2572999894618988}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.6084/m9.figshare.34922865","doi":"https://doi.org/10.6084/m9.figshare.34922865","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922865","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},{"id":"doi:10.6084/m9.figshare.34922865.v1","doi":"https://doi.org/10.6084/m9.figshare.34922865.v1","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922865.v1","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"}],"best_oa_location":{"id":"doi:10.6084/m9.figshare.34922865","doi":"https://doi.org/10.6084/m9.figshare.34922865","is_oa":true,"landing_page_url":"https://doi.org/10.6084/m9.figshare.34922865","pdf_url":null,"source":{"id":"https://openalex.org/S4377196282","display_name":"Figshare","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I4210132348","host_organization_name":"Figshare (United Kingdom)","host_organization_lineage":["https://openalex.org/I4210132348"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":null,"is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"JournalArticle"},"sustainable_development_goals":[{"score":0.9391000270843506,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4224983009","https://openalex.org/W4400294790","https://openalex.org/W2897687536","https://openalex.org/W2805097160","https://openalex.org/W4406713764","https://openalex.org/W4385786399","https://openalex.org/W2609027890","https://openalex.org/W2802589349","https://openalex.org/W4319787500","https://openalex.org/W7148256625"],"abstract_inverted_index":{"Euonymus":[0],"alatus":[1,31],"(Thunb.)":[2],"Siebold":[3],"has":[4],"been":[5],"traditionally":[6],"used":[7],"in":[8,34,61,76,226],"East":[9],"Asian":[10],"medicine":[11],"for":[12],"dysentery":[13],"and":[14,23,40,45,80,96,105,112,121,123,129,154,157,167,170,182,187,193,202,207,215,221],"inflammatory":[15,206],"disorders.":[16],"However,":[17],"its":[18,234],"effects":[19],"on":[20],"intestinal":[21],"inflammation":[22],"barrier":[24,47,108,165],"injury":[25],"remain":[26],"unclear.":[27],"To":[28],"evaluate":[29],"E.":[30],"extract":[32],"(EEA)":[33],"dextran":[35],"sulfate":[36],"sodium":[37],"(DSS)-induced":[38],"colitis":[39,214],"examine":[41],"inflammatory,":[42,217],"inflammasome-related,":[43,218],"pyroptosis-associated,":[44],"epithelial":[46,94,219],"responses.":[48,223],"EEA":[49,118,133,151,163,176,210],"was":[50,59],"profiled":[51],"using":[52,70],"ultra-high-performance":[53],"liquid":[54],"chromatography\u2013tandem":[55],"mass":[56],"spectrometry.":[57],"Colitis":[58],"induced":[60],"male":[62],"C57BL/6":[63],"mice":[64],"(five":[65],"groups,":[66],"n":[67],"=":[68,147],"8/group)":[69],"two":[71],"cycles":[72],"of":[73,83],"2.0%":[74],"DSS":[75,84],"drinking":[77],"water":[78],"(6":[79],"5":[81],"days":[82],"exposure":[85],"separated":[86],"by":[87],"a":[88],"7-day":[89],"DSS-free":[90],"interval).":[91],"Cytokine-stimulated":[92],"Caco-2":[93,161],"cells":[95],"lipopolysaccharide/adenosine":[97],"triphosphate-stimulated":[98],"J774A.1":[99,174],"macrophages":[100],"were":[101,116],"also":[102],"used.":[103],"Histological":[104],"molecular":[106],"assessments,":[107],"assays,":[109],"RNA":[110],"sequencing,":[111],"network":[113,203],"pharmacology":[114],"analyses":[115,204],"performed.":[117],"contained":[119],"flavonoids":[120],"phenolic":[122],"reduced":[124,177],"weight":[125],"loss,":[126],"disease":[127],"activity,":[128],"histological":[130],"injury;":[131],"high-dose":[132],"increased":[134,168],"colon":[135],"length":[136],"from":[137],"6.67":[138],"\u00b1":[139,143],"0.18":[140],"to":[141,232,237],"7.58":[142],"0.13":[144],"cm":[145],"(p":[146],"0.003":[148],"vs.":[149],"N.C.).":[150],"decreased":[152],"MPO-":[153],"F4/80-positive":[155],"infiltration":[156],"inflammatory/inflammasome-related":[158],"transcripts.":[159],"In":[160,173],"cells,":[162],"improved":[164],"function":[166],"ZO-1":[169],"occludin":[171],"expression.":[172],"macrophages,":[175],"pyroptotic":[178],"cell":[179],"death,":[180],"IL-1\u03b2":[181],"IL-18":[183],"release,":[184],"ASC":[185],"oligomerization":[186],"specks,":[188],"cleaved":[189],"caspase-1,":[190],"mature":[191],"IL-1\u03b2,":[192],"GSDMD-NT.":[194],"Selected":[195],"phytochemicals":[196],"partly":[197],"reproduced":[198],"these":[199],"effects.":[200],"Transcriptomic":[201],"implicated":[205],"barrier-related":[208],"pathways.":[209],"attenuated":[211],"DSS-induced":[212],"experimental":[213,228],"modulated":[216],"barrier,":[220],"pyroptosis-associated":[222],"Further":[224],"validation":[225],"other":[227],"models":[229],"is":[230],"needed":[231],"establish":[233],"broader":[235],"relevance":[236],"IBD.":[238]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}