{"id":"https://openalex.org/W7225317902","doi":"https://doi.org/10.3389/fcell.2026.1971609","title":"The synergistic osteogenic effects of FGF1 and BMP2 gene modified bone marrow mesenchymal stem cells in spinal fusion","display_name":"The synergistic osteogenic effects of FGF1 and BMP2 gene modified bone marrow mesenchymal stem cells in spinal fusion","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225317902","doi":"https://doi.org/10.3389/fcell.2026.1971609"},"language":"en","primary_location":{"id":"doi:10.3389/fcell.2026.1971609","doi":"https://doi.org/10.3389/fcell.2026.1971609","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1971609","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1971609/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1971609/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160824161","display_name":"Pinhua Chen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Pinhua Chen","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160912516","display_name":"Yiren Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yiren Zhu","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160279896","display_name":"XueYi He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"XueYi He","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5018278349","display_name":"zhengchao zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhengchao Zhang","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160982981","display_name":"Ruoli Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ruoli Wang","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5129668269","display_name":"Qi Fang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Fang","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5001177084","display_name":"Zhixian Xu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhixian Xu","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160113990","display_name":"Wubing He","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I129708740","display_name":"Fujian Medical University","ror":"https://ror.org/050s6ns64","country_code":"CN","type":"education","lineage":["https://openalex.org/I129708740"]},{"id":"https://openalex.org/I4210143087","display_name":"Fujian Provincial Hospital","ror":"https://ror.org/045wzwx52","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210143087"]},{"id":"https://openalex.org/I80947539","display_name":"Fuzhou University","ror":"https://ror.org/011xvna82","country_code":"CN","type":"education","lineage":["https://openalex.org/I80947539"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wubing He","raw_affiliation_strings":["Department of Emergency Trauma Surgery, Fujian Provincial Hospital","Fujian Key Laboratory of Emergency Medicine","Fujian Trauma Medicine Center","Fuzhou University Affiliated Provincial Hospital","Shengli Clinical Medical College of Fujian Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Emergency Trauma Surgery, Fujian Provincial Hospital","institution_ids":["https://openalex.org/I4210143087"]},{"raw_affiliation_string":"Fujian Key Laboratory of Emergency Medicine","institution_ids":[]},{"raw_affiliation_string":"Fujian Trauma Medicine Center","institution_ids":[]},{"raw_affiliation_string":"Fuzhou University Affiliated Provincial Hospital","institution_ids":["https://openalex.org/I80947539"]},{"raw_affiliation_string":"Shengli Clinical Medical College of Fujian Medical University","institution_ids":["https://openalex.org/I129708740"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5160113990"],"corresponding_institution_ids":["https://openalex.org/I129708740","https://openalex.org/I4210143087","https://openalex.org/I80947539"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10238","display_name":"Spine and Intervertebral Disc Pathology","score":0.34200000762939453,"subfield":{"id":"https://openalex.org/subfields/2732","display_name":"Orthopedics and Sports Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.290800005197525,"subfield":{"id":"https://openalex.org/subfields/1307","display_name":"Cell Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.2838999927043915,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/spinal-fusion","display_name":"spinal fusion","score":0.9580000042915344},{"id":"https://openalex.org/keywords/bone-marrow-mesenchymal-stem-cells","display_name":"bone marrow mesenchymal stem cells","score":0.9729999899864197},{"id":"https://openalex.org/keywords/fgf1","display_name":"FGF1","score":0.9390000104904175},{"id":"https://openalex.org/keywords/bmp-2","display_name":"BMP-2","score":1.0},{"id":"https://openalex.org/keywords/osteogenic-differentiation","display_name":"osteogenic differentiation","score":0.8240000009536743},{"id":"https://openalex.org/keywords/new-bone-formation","display_name":"new bone formation","score":0.777999997138977},{"id":"https://openalex.org/keywords/angiogenesis","display_name":"angiogenesis","score":0.6200000047683716},{"id":"https://openalex.org/keywords/pi3k-akt-signaling","display_name":"PI3K/Akt signaling","score":0.8600000143051147},{"id":"https://openalex.org/keywords/mapk-signaling","display_name":"MAPK signaling","score":0.996999979019165},{"id":"https://openalex.org/keywords/biosafety","display_name":"biosafety","score":0.7680000066757202},{"id":"https://openalex.org/keywords/gene-therapy","display_name":"gene therapy","score":0.43700000643730164}],"concepts":[{"id":"https://openalex.org/C30352789","wikidata":"https://www.wikidata.org/wiki/Q14903153","display_name":"Bone morphogenetic protein 2","level":3,"score":0.6647999882698059},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.6119999885559082},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.5806000232696533},{"id":"https://openalex.org/C2780375110","wikidata":"https://www.wikidata.org/wiki/Q770609","display_name":"Spinal fusion","level":2,"score":0.569100022315979},{"id":"https://openalex.org/C111829193","wikidata":"https://www.wikidata.org/wiki/Q1108970","display_name":"Fusion gene","level":3,"score":0.5115000009536743},{"id":"https://openalex.org/C2780007613","wikidata":"https://www.wikidata.org/wiki/Q546523","display_name":"Bone marrow","level":2,"score":0.45730000734329224},{"id":"https://openalex.org/C31507581","wikidata":"https://www.wikidata.org/wiki/Q425383","display_name":"Bone morphogenetic protein","level":3,"score":0.4368000030517578},{"id":"https://openalex.org/C181628713","wikidata":"https://www.wikidata.org/wiki/Q14903748","display_name":"Bone morphogenetic protein 6","level":5,"score":0.4293999969959259},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.4187000095844269},{"id":"https://openalex.org/C92488253","wikidata":"https://www.wikidata.org/wiki/Q56592403","display_name":"Cell fusion","level":3,"score":0.3785000145435333},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3555999994277954},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.34200000762939453},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33880001306533813},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.32269999384880066},{"id":"https://openalex.org/C57074206","wikidata":"https://www.wikidata.org/wiki/Q14197552","display_name":"MAPK/ERK pathway","level":3,"score":0.31929999589920044},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.30550000071525574},{"id":"https://openalex.org/C204232928","wikidata":"https://www.wikidata.org/wiki/Q899285","display_name":"Immunohistochemistry","level":2,"score":0.30300000309944153},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.2996000051498413},{"id":"https://openalex.org/C102230213","wikidata":"https://www.wikidata.org/wiki/Q430117","display_name":"Transgene","level":3,"score":0.29899999499320984},{"id":"https://openalex.org/C150194340","wikidata":"https://www.wikidata.org/wiki/Q26972","display_name":"Gene expression","level":3,"score":0.2915000021457672},{"id":"https://openalex.org/C94105702","wikidata":"https://www.wikidata.org/wiki/Q777017","display_name":"dBm","level":4,"score":0.2824999988079071},{"id":"https://openalex.org/C125349252","wikidata":"https://www.wikidata.org/wiki/Q14903102","display_name":"Bone morphogenetic protein 7","level":4,"score":0.2599000036716461},{"id":"https://openalex.org/C111599444","wikidata":"https://www.wikidata.org/wiki/Q213901","display_name":"Genetic enhancement","level":3,"score":0.2574999928474426},{"id":"https://openalex.org/C123894998","wikidata":"https://www.wikidata.org/wiki/Q425158","display_name":"Fusion protein","level":4,"score":0.25540000200271606},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25519999861717224},{"id":"https://openalex.org/C35496256","wikidata":"https://www.wikidata.org/wiki/Q5104524","display_name":"Chondrogenesis","level":3,"score":0.25040000677108765}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fcell.2026.1971609","doi":"https://doi.org/10.3389/fcell.2026.1971609","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1971609","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1971609/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:fa6dcf20f18a490eb2cc6d4313e9f87c","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/fa6dcf20f18a490eb2cc6d4313e9f87c","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Cell and Developmental Biology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fcell.2026.1971609","doi":"https://doi.org/10.3389/fcell.2026.1971609","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fcell.2026.1971609","pdf_url":"https://www.frontiersin.org/journals/cell-and-developmental-biology/articles/10.3389/fcell.2026.1971609/pdf","source":{"id":"https://openalex.org/S2596924766","display_name":"Frontiers in Cell and Developmental Biology","issn_l":"2296-634X","issn":["2296-634X"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Cell and Developmental Biology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9789000153541565,"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225317902.pdf","grobid_xml":"https://content.openalex.org/works/W7225317902.grobid-xml"},"referenced_works_count":33,"referenced_works":["https://openalex.org/W1561364264","https://openalex.org/W2089071506","https://openalex.org/W2432481395","https://openalex.org/W2439593768","https://openalex.org/W2551559148","https://openalex.org/W2616502136","https://openalex.org/W2741185523","https://openalex.org/W2804663518","https://openalex.org/W2889398826","https://openalex.org/W2897700340","https://openalex.org/W2909042472","https://openalex.org/W2954019013","https://openalex.org/W3014917786","https://openalex.org/W3015018987","https://openalex.org/W3026116220","https://openalex.org/W3086330441","https://openalex.org/W3098179472","https://openalex.org/W3104525493","https://openalex.org/W3126387980","https://openalex.org/W3153538282","https://openalex.org/W3205884260","https://openalex.org/W4200362754","https://openalex.org/W4297911036","https://openalex.org/W4317545553","https://openalex.org/W4323318740","https://openalex.org/W4323318911","https://openalex.org/W4362506410","https://openalex.org/W4362733440","https://openalex.org/W4377695316","https://openalex.org/W4385273325","https://openalex.org/W4385872214","https://openalex.org/W4386945831","https://openalex.org/W4399756509"],"related_works":["https://openalex.org/W2120919706","https://openalex.org/W3030723814","https://openalex.org/W2147052103","https://openalex.org/W2465345803","https://openalex.org/W2060644720","https://openalex.org/W1575422331","https://openalex.org/W2168661074","https://openalex.org/W2526625943","https://openalex.org/W2068388230","https://openalex.org/W2066384748"],"abstract_inverted_index":{"Background":[0],"Spinal":[1],"fusion":[2,29,79,158,182],"is":[3],"essential":[4],"for":[5,160],"treating":[6],"spinal":[7,28,181],"disorders,":[8],"but":[9],"achieving":[10],"robust":[11],"bone":[12,147],"formation":[13,148],"remains":[14],"challenging.":[15],"This":[16],"study":[17],"evaluated":[18,71],"whether":[19],"FGF1":[20,174],"and":[21,48,64,73,78,85,97,113,122,133,140,167,175,180],"BMP2":[22,176],"co-expression":[23],"in":[24,53,69,149],"gene-modified":[25],"BMSCs":[26,35,90],"enhances":[27,178],"compared":[30],"to":[31],"single-gene":[32,101,196],"approaches.":[33,197],"Methods":[34],"were":[36,51,137],"transduced":[37],"with":[38,120,173],"lentiviruses":[39],"carrying":[40],"FGF1,":[41],"BMP2,":[42],"or":[43,102],"both.":[44],"Osteogenic":[45],"differentiation,":[46],"proliferation,":[47,96,111],"gene":[49],"expression":[50,128],"assessed":[52],"vitro":[54],"using":[55],"staining":[56],"assays,":[57],"qPCR,":[58],"Western":[59],"blotting,":[60],"CCK-8,":[61],"ALP":[62,98],"tests,":[63],"RNA-seq.":[65],"In":[66],"vivo":[67],"studies":[68],"rats":[70],"local":[72,127],"systemic":[74,131],"protein":[75],"levels,":[76],"biosafety,":[77,189],"outcomes":[80],"via":[81],"micro-CT,":[82],"histology,":[83],"immunohistochemistry,":[84],"manual":[86],"palpation.":[87],"Results":[88],"Dual-modified":[89],"showed":[91],"significantly":[92],"higher":[93],"transgene":[94],"expression,":[95],"activity":[99],"than":[100],"control":[103],"groups":[104],"(p":[105],"<":[106],"0.05).":[107],"RNA-seq":[108],"revealed":[109],"upregulated":[110],"angiogenesis,":[112],"osteogenic":[114],"genes,":[115,119],"alongside":[116],"suppressed":[117],"inflammatory":[118],"PI3K-Akt":[121],"MAPK":[123],"pathway":[124],"enrichment.":[125],"High":[126],"occurred":[129],"without":[130],"elevation,":[132],"no":[134],"organ":[135],"abnormalities":[136],"observed.":[138],"Micro-CT":[139],"histology":[141],"demonstrated":[142],"the":[143,150],"most":[144],"extensive":[145],"new":[146],"dual-gene":[151],"group.":[152],"Manual":[153],"palpation":[154],"confirmed":[155],"an":[156],"80%":[157],"rate":[159],"LV-FGF1-BMP2":[161],"versus":[162],"20%":[163],"(LV-BMP2),":[164],"0%":[165,168],"(LV-FGF1),":[166],"(LV-Vector).":[169],"Conclusion":[170],"Dual-gene":[171],"modification":[172],"markedly":[177],"osteogenesis":[179],"while":[183],"maintaining":[184],"a":[185,191],"certain":[186],"degree":[187],"of":[188],"representing":[190],"promising":[192],"therapeutic":[193],"advance":[194],"over":[195]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
