{"id":"https://openalex.org/W7225317713","doi":"https://doi.org/10.3389/fnagi.2026.1957233","title":"Psychosis with continuous delivery of subcutaneous levodopa: importance of the correct patient profile","display_name":"Psychosis with continuous delivery of subcutaneous levodopa: importance of the correct patient profile","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225317713","doi":"https://doi.org/10.3389/fnagi.2026.1957233"},"language":"en","primary_location":{"id":"doi:10.3389/fnagi.2026.1957233","doi":"https://doi.org/10.3389/fnagi.2026.1957233","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1957233","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1957233/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1957233/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5032235791","display_name":"\u041a. Ray Chaudhuri","orcid":"https://orcid.org/0000-0003-2815-0505","observed_orcids":["https://orcid.org/0000-0003-2815-0505"]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"K. Ray Chaudhuri","raw_affiliation_strings":["Dementech Neuroscience Clinical Academic Centre","Parkinson's Centre of Excellence, King's College Hospital London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Dementech Neuroscience Clinical Academic Centre","institution_ids":[]},{"raw_affiliation_string":"Parkinson's Centre of Excellence, King's College Hospital London","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035236946","display_name":"Karolina Pop\u0142awska-Domaszewicz","orcid":"https://orcid.org/0000-0002-9154-389X","observed_orcids":["https://orcid.org/0000-0002-9154-389X"]},"institutions":[{"id":"https://openalex.org/I120230055","display_name":"Poznan University of Medical Sciences","ror":"https://ror.org/02zbb2597","country_code":"PL","type":"education","lineage":["https://openalex.org/I120230055"]}],"countries":["PL"],"is_corresponding":false,"raw_author_name":"Karolina Poplawska-Domaszewicz","raw_affiliation_strings":["Department of Neurology, Institute of Neurological Disorders, Poznan University of Medical Sciences"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Institute of Neurological Disorders, Poznan University of Medical Sciences","institution_ids":["https://openalex.org/I120230055"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072187912","display_name":"Bruno A. Bergmans","orcid":"https://orcid.org/0000-0002-1463-8262","observed_orcids":["https://orcid.org/0000-0002-1463-8262"]},"institutions":[{"id":"https://openalex.org/I2801227569","display_name":"Ghent University Hospital","ror":"https://ror.org/00xmkp704","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I2801227569"]},{"id":"https://openalex.org/I32597200","display_name":"Ghent University","ror":"https://ror.org/00cv9y106","country_code":"BE","type":"education","lineage":["https://openalex.org/I32597200"]},{"id":"https://openalex.org/I4210123377","display_name":"AZ Sint-Jan","ror":"https://ror.org/030h1vb90","country_code":"BE","type":"healthcare","lineage":["https://openalex.org/I4210123377"]}],"countries":["BE"],"is_corresponding":false,"raw_author_name":"Bruno Bergmans","raw_affiliation_strings":["Department of Head and Skin, Faculty of Medicine and Health Sciences, University of Ghent","Department of Neurology, AZ St-Jan Brugge","Department of Neurology, Ghent University Hospital"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Head and Skin, Faculty of Medicine and Health Sciences, University of Ghent","institution_ids":["https://openalex.org/I32597200"]},{"raw_affiliation_string":"Department of Neurology, AZ St-Jan Brugge","institution_ids":["https://openalex.org/I4210123377"]},{"raw_affiliation_string":"Department of Neurology, Ghent University Hospital","institution_ids":["https://openalex.org/I2801227569"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5033436519","display_name":"Vinod Metta","orcid":"https://orcid.org/0000-0002-8970-8595","observed_orcids":["https://orcid.org/0000-0002-8970-8595"]},"institutions":[{"id":"https://openalex.org/I4210153400","display_name":"King's College Hospital","ror":"https://ror.org/044nptt90","country_code":"GB","type":"healthcare","lineage":["https://openalex.org/I4210111135","https://openalex.org/I4210153400"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Vinod Metta","raw_affiliation_strings":["Department of Medicine, King's College Hospital","Parkinson's Centre of Excellence, King's College Hospital London"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Medicine, King's College Hospital","institution_ids":["https://openalex.org/I4210153400"]},{"raw_affiliation_string":"Parkinson's Centre of Excellence, King's College Hospital London","institution_ids":["https://openalex.org/I4210153400"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009097001","display_name":"Per Odin","orcid":"https://orcid.org/0000-0002-0756-7478","observed_orcids":["https://orcid.org/0000-0002-0756-7478"]},"institutions":[{"id":"https://openalex.org/I187531555","display_name":"Lund University","ror":"https://ror.org/012a77v79","country_code":"SE","type":"education","lineage":["https://openalex.org/I187531555"]}],"countries":["SE"],"is_corresponding":false,"raw_author_name":"Per Odin","raw_affiliation_strings":["Department of Neurology, Lund University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Lund University","institution_ids":["https://openalex.org/I187531555"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017772681","display_name":"Wolfgang H. Jost","orcid":"https://orcid.org/0000-0002-8574-3297","observed_orcids":["https://orcid.org/0000-0002-8574-3297"]},"institutions":[{"id":"https://openalex.org/I4210155454","display_name":"Parkinson-Klinik Ortenau","ror":"https://ror.org/055w00q26","country_code":"DE","type":"healthcare","lineage":["https://openalex.org/I4210155454"]},{"id":"https://openalex.org/I91712215","display_name":"Saarland University","ror":"https://ror.org/01jdpyv68","country_code":"DE","type":"education","lineage":["https://openalex.org/I91712215"]}],"countries":["DE"],"is_corresponding":false,"raw_author_name":"Wolfgang H. Jost","raw_affiliation_strings":["Parkinson-Klinik Ortenau","Saarland University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Parkinson-Klinik Ortenau","institution_ids":["https://openalex.org/I4210155454"]},{"raw_affiliation_string":"Saarland University","institution_ids":["https://openalex.org/I91712215"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5035897327","display_name":"Ali Shalash","orcid":"https://orcid.org/0000-0001-7012-5907","observed_orcids":["https://orcid.org/0000-0001-7012-5907"]},"institutions":[{"id":"https://openalex.org/I107720978","display_name":"Ain Shams University","ror":"https://ror.org/00cb9w016","country_code":"EG","type":"education","lineage":["https://openalex.org/I107720978"]}],"countries":["EG"],"is_corresponding":false,"raw_author_name":"Ali Shalash","raw_affiliation_strings":["Department of Neurology, Faculty of Medicine, Ain Shams University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Medicine, Ain Shams University","institution_ids":["https://openalex.org/I107720978"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5052879462","display_name":"Riaan van Coller","orcid":"https://orcid.org/0000-0001-6250-363X","observed_orcids":["https://orcid.org/0000-0001-6250-363X"]},"institutions":[{"id":"https://openalex.org/I69552723","display_name":"University of Pretoria","ror":"https://ror.org/00g0p6g84","country_code":"ZA","type":"education","lineage":["https://openalex.org/I69552723"]}],"countries":["ZA"],"is_corresponding":false,"raw_author_name":"Riaan van Coller","raw_affiliation_strings":["Department of Neurology, Faculty of Health Sciences, University of Pretoria"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, Faculty of Health Sciences, University of Pretoria","institution_ids":["https://openalex.org/I69552723"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5019039155","display_name":"Cristian Falup\u2010Pecurariu","orcid":"https://orcid.org/0000-0002-7394-7161","observed_orcids":["https://orcid.org/0000-0002-7394-7161"]},"institutions":[{"id":"https://openalex.org/I3123573182","display_name":"Transilvania University of Bra\u0219ov","ror":"https://ror.org/01cg9ws23","country_code":"RO","type":"education","lineage":["https://openalex.org/I3123573182"]}],"countries":["RO"],"is_corresponding":false,"raw_author_name":"Cristian Falup-Pecurariu","raw_affiliation_strings":["Department of Neurology, County Clinic Hospital","Faculty of Medicine, Transilvania University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Neurology, County Clinic Hospital","institution_ids":[]},{"raw_affiliation_string":"Faculty of Medicine, Transilvania University","institution_ids":["https://openalex.org/I3123573182"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5052133972","display_name":"Angelo Antonini","orcid":"https://orcid.org/0000-0003-1040-2807","observed_orcids":["https://orcid.org/0000-0003-1040-2807"]},"institutions":[{"id":"https://openalex.org/I138689650","display_name":"University of Padua","ror":"https://ror.org/00240q980","country_code":"IT","type":"education","lineage":["https://openalex.org/I138689650"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Angelo Antonini","raw_affiliation_strings":["Neurodegenerative Diseases Unit, Department of Neuroscience, Padova Neuroscience Center (PNC), University of Padova"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Neurodegenerative Diseases Unit, Department of Neuroscience, Padova Neuroscience Center (PNC), University of Padova","institution_ids":["https://openalex.org/I138689650"]}]}],"institutions":[],"countries_distinct_count":9,"institutions_distinct_count":12,"corresponding_author_ids":["https://openalex.org/A5032235791"],"corresponding_institution_ids":["https://openalex.org/I4210153400"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10085","display_name":"Parkinson's Disease Mechanisms and Treatments","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10919","display_name":"Deep Brain Stimulation and Movement Disorders","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2728","display_name":"Clinical Neurology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10023","display_name":"Schizophrenia research and treatment","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2738","display_name":"Psychiatry and Mental health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/psychosis","display_name":"psychosis","score":0.8080000281333923},{"id":"https://openalex.org/keywords/levodopa","display_name":"levodopa","score":0.6679999828338623},{"id":"https://openalex.org/keywords/foslevodopa-foscarbidopa","display_name":"foslevodopa/foscarbidopa","score":0.878000020980835},{"id":"https://openalex.org/keywords/subcutaneous-infusion","display_name":"subcutaneous infusion","score":0.796999990940094},{"id":"https://openalex.org/keywords/advanced-parkinson-s-disease","display_name":"advanced Parkinson's disease","score":0.9539999961853027},{"id":"https://openalex.org/keywords/neuropsychiatric-side-effects","display_name":"neuropsychiatric adverse effects","score":0.8090000152587891},{"id":"https://openalex.org/keywords/hallucinations","display_name":"hallucinations","score":0.9729999899864197},{"id":"https://openalex.org/keywords/patient-selection","display_name":"patient selection","score":0.9300000071525574},{"id":"https://openalex.org/keywords/comorbidity","display_name":"comorbidities","score":0.6399999856948853},{"id":"https://openalex.org/keywords/elderly-patients","display_name":"elderly patients","score":0.5820000171661377},{"id":"https://openalex.org/keywords/medication-discontinuation","display_name":"drug discontinuation","score":0.4490000009536743}],"concepts":[{"id":"https://openalex.org/C2778715236","wikidata":"https://www.wikidata.org/wiki/Q55622662","display_name":"Discontinuation","level":2,"score":0.7523999810218811},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7265999913215637},{"id":"https://openalex.org/C2779727114","wikidata":"https://www.wikidata.org/wiki/Q170082","display_name":"Psychosis","level":2,"score":0.715399980545044},{"id":"https://openalex.org/C2777288759","wikidata":"https://www.wikidata.org/wiki/Q4164182","display_name":"Dosing","level":2,"score":0.7103000283241272},{"id":"https://openalex.org/C2780304432","wikidata":"https://www.wikidata.org/wiki/Q300989","display_name":"Levodopa","level":4,"score":0.5845000147819519},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.40799999237060547},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.40220001339912415},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.33550000190734863},{"id":"https://openalex.org/C118552586","wikidata":"https://www.wikidata.org/wiki/Q7867","display_name":"Psychiatry","level":1,"score":0.28859999775886536},{"id":"https://openalex.org/C2779253243","wikidata":"https://www.wikidata.org/wiki/Q410412","display_name":"Carbamazepine","level":3,"score":0.267300009727478},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.265500009059906},{"id":"https://openalex.org/C187212893","wikidata":"https://www.wikidata.org/wiki/Q123028","display_name":"Pediatrics","level":1,"score":0.25940001010894775}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fnagi.2026.1957233","doi":"https://doi.org/10.3389/fnagi.2026.1957233","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1957233","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1957233/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:c05ad82ca418445394638b5bd3c734ff","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/c05ad82ca418445394638b5bd3c734ff","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Aging Neuroscience, Vol 18 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fnagi.2026.1957233","doi":"https://doi.org/10.3389/fnagi.2026.1957233","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fnagi.2026.1957233","pdf_url":"https://www.frontiersin.org/journals/aging-neuroscience/articles/10.3389/fnagi.2026.1957233/pdf","source":{"id":"https://openalex.org/S118428158","display_name":"Frontiers in Aging Neuroscience","issn_l":"1663-4365","issn":["1663-4365"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Aging Neuroscience","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225317713.pdf","grobid_xml":"https://content.openalex.org/works/W7225317713.grobid-xml"},"referenced_works_count":46,"referenced_works":["https://openalex.org/W1114757218","https://openalex.org/W1901854321","https://openalex.org/W2026127054","https://openalex.org/W2059614355","https://openalex.org/W2061530817","https://openalex.org/W2067807847","https://openalex.org/W2082718353","https://openalex.org/W2083220625","https://openalex.org/W2111993699","https://openalex.org/W2125458229","https://openalex.org/W2288778951","https://openalex.org/W2563578531","https://openalex.org/W2579373654","https://openalex.org/W2589302021","https://openalex.org/W2900522968","https://openalex.org/W2990688225","https://openalex.org/W3014686614","https://openalex.org/W3126351743","https://openalex.org/W3130488227","https://openalex.org/W3152099035","https://openalex.org/W4205537462","https://openalex.org/W4238432391","https://openalex.org/W4309650806","https://openalex.org/W4309668972","https://openalex.org/W4382010783","https://openalex.org/W4386189439","https://openalex.org/W4391720973","https://openalex.org/W4392639128","https://openalex.org/W4392658466","https://openalex.org/W4394783462","https://openalex.org/W4400167184","https://openalex.org/W4408943173","https://openalex.org/W4412455103","https://openalex.org/W4412693225","https://openalex.org/W4412755491","https://openalex.org/W4414051636","https://openalex.org/W4414062115","https://openalex.org/W4414103939","https://openalex.org/W4416236295","https://openalex.org/W4416386577","https://openalex.org/W4416854676","https://openalex.org/W7124454590","https://openalex.org/W7125644668","https://openalex.org/W7154568163","https://openalex.org/W7160497035","https://openalex.org/W7203983210"],"related_works":["https://openalex.org/W7203983210","https://openalex.org/W7225173592","https://openalex.org/W7225170379","https://openalex.org/W7204804977","https://openalex.org/W7167462473","https://openalex.org/W7124454590","https://openalex.org/W7225198377","https://openalex.org/W7224130822","https://openalex.org/W4409534932","https://openalex.org/W7165614455"],"abstract_inverted_index":{"Continuous":[0],"24-h":[1,48],"subcutaneous":[2,18,47],"infusion":[3,19],"of":[4,10,27,44,56,70,105,117,138,161,166,183],"foslevodopa/foscarbidopa":[5],"(LDp/CDp),":[6],"a":[7,15],"soluble":[8],"formulation":[9],"levodopa":[11,49],"prodrugs":[12],"delivered":[13],"through":[14],"minimally":[16],"invasive":[17],"system,":[20],"is":[21],"currently":[22],"available":[23],"for":[24],"the":[25,42,122,136,153,164],"management":[26],"advanced":[28],"Parkinson\u2019s":[29],"disease":[30],"(APD)":[31],"in":[32,52,54,66,91,108,143],"many":[33],"countries.":[34],"Pivotal":[35],"licensing":[36],"studies":[37,40],"and":[38,62,79,89,131,163,168,177,179],"open-label":[39],"confirm":[41],"efficacy":[43],"this":[45],"first":[46],"delivery":[50],"option":[51],"APD":[53],"terms":[55],"motor":[57],"effects,":[58],"early-morning":[59],"off":[60],"periods,":[61],"sleep":[63],"benefits.":[64],"However,":[65],"addition":[67],"to":[68,97,129,135],"reports":[69,119,160],"skin":[71],"reactions,":[72],"there":[73,146],"are":[74],"also":[75],"case":[76,159],"report":[77],"series":[78],"case-based":[80],"concerns":[81],"regarding":[82],"neuropsychiatric":[83],"side":[84],"effects":[85],"such":[86,118],"as":[87],"psychosis":[88,162],"hallucinations":[90],"some":[92,144],"centres.":[93],"The":[94],"pattern":[95],"appears":[96],"be":[98],"either":[99],"an":[100],"early":[101],"or":[102],"late":[103],"occurrence":[104],"psychosis,":[106,130],"often":[107],"older":[109],"patients":[110],"with":[111],"significant":[112],"comorbidities.":[113],"A":[114],"critical":[115],"review":[116,152],"shows":[120],"that":[121],"selected":[123],"cases":[124],"might":[125],"have":[126],"been":[127],"vulnerable":[128],"potential":[132],"corrective":[133],"adjustments":[134],"dosing":[137],"LDp/CDp":[139,167,184],"were":[140,147],"not":[141],"evident;":[142],"cases,":[145],"unusual":[148],"initiation":[149],"processes.":[150],"We":[151],"entire":[154],"published":[155],"literature":[156],"on":[157,173,180],"clinical":[158],"use":[165],"provide":[169],"expert":[170],"opinion-based":[171],"tips":[172],"correct":[174],"patient":[175],"profiling":[176],"selection":[178],"avoiding":[181],"discontinuation":[182],"therapy.":[185]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}