{"id":"https://openalex.org/W7225316684","doi":"https://doi.org/10.64898/2026.11.04.763188","title":"Sexual interactions and local selection shape reproductive gene diversity and divergence","display_name":"Sexual interactions and local selection shape reproductive gene diversity and divergence","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225316684","doi":"https://doi.org/10.64898/2026.11.04.763188"},"language":"en","primary_location":{"id":"doi:10.64898/2026.11.04.763188","doi":"https://doi.org/10.64898/2026.11.04.763188","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.763188","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.763188.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.763188.full.pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160751611","display_name":"Katelyn J Dykhuizen","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katelyn J. Dykhuizen","raw_affiliation_strings":["Department of Biology, Miami University, Oxford OH 45056"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biology, Miami University, Oxford OH 45056","institution_ids":["https://openalex.org/I83328450"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088954916","display_name":"Dean M. Castillo","orcid":"https://orcid.org/0000-0003-2626-6547","observed_orcids":["https://orcid.org/0000-0003-2626-6547"]},"institutions":[{"id":"https://openalex.org/I83328450","display_name":"Miami University","ror":"https://ror.org/05nbqxr67","country_code":"US","type":"education","lineage":["https://openalex.org/I83328450"]}],"countries":["US"],"is_corresponding":true,"raw_author_name":"Dean M. Castillo","raw_affiliation_strings":["Department of Biological Sciences, Miami University, Hamilton 45011"],"raw_orcid":"https://orcid.org/0000-0003-2626-6547","affiliations":[{"raw_affiliation_string":"Department of Biological Sciences, Miami University, Hamilton 45011","institution_ids":["https://openalex.org/I83328450"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5088954916"],"corresponding_institution_ids":["https://openalex.org/I83328450"],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11764","display_name":"Evolution and Genetic Dynamics","score":0.6937999725341797,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10174","display_name":"Animal Behavior and Reproduction","score":0.1624000072479248,"subfield":{"id":"https://openalex.org/subfields/1105","display_name":"Ecology, Evolution, Behavior and Systematics"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10012","display_name":"Genetic diversity and population structure","score":0.09969999641180038,"subfield":{"id":"https://openalex.org/subfields/1311","display_name":"Genetics"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/sex-peptide","display_name":"sex peptide","score":0.7910000085830688},{"id":"https://openalex.org/keywords/sperm-competition","display_name":"sperm competition","score":0.9570000171661377},{"id":"https://openalex.org/keywords/balancing-selection","display_name":"balancing selection","score":0.8100000023841858},{"id":"https://openalex.org/keywords/local-selection","display_name":"local selection","score":0.6650000214576721},{"id":"https://openalex.org/keywords/nucleotide-diversity","display_name":"nucleotide diversity","score":0.8180000185966492},{"id":"https://openalex.org/keywords/population-divergence","display_name":"population divergence","score":0.8740000128746033},{"id":"https://openalex.org/keywords/fst","display_name":"FST","score":0.3880000114440918},{"id":"https://openalex.org/keywords/fruitless","display_name":"fruitless","score":0.5849999785423279},{"id":"https://openalex.org/keywords/drosophila-melanogaster","display_name":"Drosophila melanogaster","score":0.8759999871253967},{"id":"https://openalex.org/keywords/reproductive-genes","display_name":"reproductive genes","score":0.3630000054836273}],"concepts":[{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.8496999740600586},{"id":"https://openalex.org/C104317684","wikidata":"https://www.wikidata.org/wiki/Q7187","display_name":"Gene","level":2,"score":0.6256999969482422},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.5924999713897705},{"id":"https://openalex.org/C2780104201","wikidata":"https://www.wikidata.org/wiki/Q130888","display_name":"Drosophila melanogaster","level":3,"score":0.5878000259399414},{"id":"https://openalex.org/C130981225","wikidata":"https://www.wikidata.org/wiki/Q206913","display_name":"Sexual selection","level":2,"score":0.5861999988555908},{"id":"https://openalex.org/C54355233","wikidata":"https://www.wikidata.org/wiki/Q7162","display_name":"Genetics","level":1,"score":0.5782999992370605},{"id":"https://openalex.org/C2776833037","wikidata":"https://www.wikidata.org/wiki/Q1419238","display_name":"Sperm competition","level":3,"score":0.5555999875068665},{"id":"https://openalex.org/C2776453541","wikidata":"https://www.wikidata.org/wiki/Q376596","display_name":"Courtship","level":2,"score":0.527999997138977},{"id":"https://openalex.org/C2908647359","wikidata":"https://www.wikidata.org/wiki/Q2625603","display_name":"Population","level":2,"score":0.49779999256134033},{"id":"https://openalex.org/C33009525","wikidata":"https://www.wikidata.org/wiki/Q208841","display_name":"Coevolution","level":2,"score":0.4814000129699707},{"id":"https://openalex.org/C514575182","wikidata":"https://www.wikidata.org/wiki/Q228395","display_name":"Mating","level":2,"score":0.45890000462532043},{"id":"https://openalex.org/C207390915","wikidata":"https://www.wikidata.org/wiki/Q1230525","display_name":"Divergence (linguistics)","level":2,"score":0.42329999804496765},{"id":"https://openalex.org/C135763542","wikidata":"https://www.wikidata.org/wiki/Q106016","display_name":"Genotype","level":3,"score":0.40139999985694885},{"id":"https://openalex.org/C81917197","wikidata":"https://www.wikidata.org/wiki/Q628760","display_name":"Selection (genetic algorithm)","level":2,"score":0.37610000371932983},{"id":"https://openalex.org/C54779947","wikidata":"https://www.wikidata.org/wiki/Q1209263","display_name":"Mate choice","level":3,"score":0.3517000079154968},{"id":"https://openalex.org/C2776041557","wikidata":"https://www.wikidata.org/wiki/Q3715451","display_name":"Drosophila (subgenus)","level":3,"score":0.3359000086784363},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.3325999975204468},{"id":"https://openalex.org/C26589402","wikidata":"https://www.wikidata.org/wiki/Q7068267","display_name":"Nucleotide diversity","level":5,"score":0.32420000433921814},{"id":"https://openalex.org/C2776998849","wikidata":"https://www.wikidata.org/wiki/Q3766082","display_name":"Melanogaster","level":4,"score":0.31949999928474426},{"id":"https://openalex.org/C91306197","wikidata":"https://www.wikidata.org/wiki/Q45767","display_name":"Competition (biology)","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C2779157341","wikidata":"https://www.wikidata.org/wiki/Q2992545","display_name":"Sexual conflict","level":3,"score":0.3098999857902527},{"id":"https://openalex.org/C2781087480","wikidata":"https://www.wikidata.org/wiki/Q17145","display_name":"Sperm","level":2,"score":0.30169999599456787},{"id":"https://openalex.org/C2777379243","wikidata":"https://www.wikidata.org/wiki/Q1054318","display_name":"Drosophilidae","level":4,"score":0.2865999937057495},{"id":"https://openalex.org/C109186463","wikidata":"https://www.wikidata.org/wiki/Q1230536","display_name":"Genetic divergence","level":4,"score":0.2849000096321106},{"id":"https://openalex.org/C150108168","wikidata":"https://www.wikidata.org/wiki/Q4770895","display_name":"Antagonistic Coevolution","level":4,"score":0.2822999954223633},{"id":"https://openalex.org/C54809848","wikidata":"https://www.wikidata.org/wiki/Q1918189","display_name":"Meiotic drive","level":4,"score":0.2815000116825104},{"id":"https://openalex.org/C2780432970","wikidata":"https://www.wikidata.org/wiki/Q1314678","display_name":"Drosophila pseudoobscura","level":3,"score":0.26820001006126404},{"id":"https://openalex.org/C26772143","wikidata":"https://www.wikidata.org/wiki/Q572872","display_name":"Reproductive isolation","level":3,"score":0.2506999969482422},{"id":"https://openalex.org/C7386963","wikidata":"https://www.wikidata.org/wiki/Q3954859","display_name":"Negative selection","level":4,"score":0.25049999356269836}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.64898/2026.11.04.763188","doi":"https://doi.org/10.64898/2026.11.04.763188","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.763188","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.763188.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.64898/2026.11.04.763188","doi":"https://doi.org/10.64898/2026.11.04.763188","is_oa":true,"landing_page_url":"https://doi.org/10.64898/2026.11.04.763188","pdf_url":"https://www.biorxiv.org/content/biorxiv/early/2026/11/05/2026.11.04.763188.full.pdf","source":{"id":"https://openalex.org/S4306402567","display_name":"bioRxiv (Cold Spring Harbor Laboratory)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I2750212522","host_organization_name":"Cold Spring Harbor Laboratory","host_organization_lineage":["https://openalex.org/I2750212522"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"bioRxiv","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225316684.pdf","grobid_xml":"https://content.openalex.org/works/W7225316684.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W562542233","https://openalex.org/W1964558095","https://openalex.org/W1967585098","https://openalex.org/W1974848203","https://openalex.org/W1982050164","https://openalex.org/W2037062284","https://openalex.org/W2042992947","https://openalex.org/W2046630500","https://openalex.org/W2051444055","https://openalex.org/W2052886690","https://openalex.org/W2052955546","https://openalex.org/W2104817567","https://openalex.org/W2128040384","https://openalex.org/W2135370544","https://openalex.org/W2149427617","https://openalex.org/W2151300540","https://openalex.org/W2152085111","https://openalex.org/W2152195140","https://openalex.org/W2159945558","https://openalex.org/W2164362495","https://openalex.org/W2169441963","https://openalex.org/W2576484578","https://openalex.org/W2610215291","https://openalex.org/W2623819953","https://openalex.org/W2789498807","https://openalex.org/W2796445871","https://openalex.org/W2890323346","https://openalex.org/W2942908404","https://openalex.org/W2971739435","https://openalex.org/W2996561254","https://openalex.org/W3131442893","https://openalex.org/W3161124071","https://openalex.org/W3175068159","https://openalex.org/W4220975370","https://openalex.org/W4223485707","https://openalex.org/W4282920593","https://openalex.org/W4282925893","https://openalex.org/W4312277008","https://openalex.org/W4360610010","https://openalex.org/W4367598492","https://openalex.org/W4385618111","https://openalex.org/W4386089808","https://openalex.org/W4390265438","https://openalex.org/W4393064647","https://openalex.org/W4393064703","https://openalex.org/W4394903675","https://openalex.org/W4399854170","https://openalex.org/W4405527822","https://openalex.org/W4416227746"],"related_works":["https://openalex.org/W4414065248","https://openalex.org/W4412702538","https://openalex.org/W2143264942","https://openalex.org/W2138392128","https://openalex.org/W2104665612","https://openalex.org/W2094513869","https://openalex.org/W2225534487","https://openalex.org/W2054953428","https://openalex.org/W3083160628","https://openalex.org/W3139010165"],"abstract_inverted_index":{"ABSTRACT":[0],"Genes":[1],"involved":[2],"in":[3,71],"genotype":[4,6],"x":[5,102],"coevolution":[7],"display":[8],"unique":[9],"patterns":[10],"of":[11,50,111],"nucleotide":[12],"diversity":[13],"and":[14,37,68,86,90,127,144],"population":[15],"divergence.":[16],"In":[17],"Drosophila":[18],"melanogaster,":[19],"Sex":[20,96],"Peptide":[21,97],"is":[22,29,43],"a":[23,80,128],"key":[24],"sperm":[25,142],"competition":[26,143],"gene":[27,131],"that":[28,83,93,140],"an":[30,109],"outlier":[31],"for":[32,114],"both":[33,141],"\u03c0":[34,67,103],"within":[35],"populations":[36,74],"Fst":[38],"between":[39],"populations.":[40],"This":[41],"pattern":[42],"not":[44],"predicted":[45],"by":[46],"current":[47],"theoretical":[48],"expectations":[49],"selective":[51],"sweeps":[52],"highlighting":[53],"the":[54],"need":[55],"to":[56,59,75,118,149],"develop":[57],"predictions":[58],"identify":[60,76],"genes":[61,78,92,112],"experiencing":[62],"balancing":[63],"selection.":[64,151],"We":[65],"compared":[66],"F":[69,100],"ST":[70,101],"D.":[72],"melanogaster":[73],"other":[77],"following":[79],"co-evolutionary":[81,150],"model":[82],"generates":[84],"divergence":[85],"diversity.":[87],"Multiple":[88],"male":[89],"female":[91,129],"interact":[94],"with":[95],"exhibited":[98],"elevated":[99],"values.":[104],"Genome-wide":[105],"analyses":[106],"also":[107],"revealed":[108],"enrichment":[110],"critical":[113],"neuronal":[115],"development,":[116],"pointing":[117],"courtship":[119],"evolution.":[120],"Specifically,":[121],"fruitless":[122],",":[123],"its":[124],"interacting":[125],"genes,":[126],"behavior":[130],"were":[132],"identified":[133],"as":[134],"outliers.":[135],"These":[136],"parallel":[137],"findings":[138],"indicate":[139],"mating":[145],"behaviors":[146],"are":[147],"subject":[148]},"counts_by_year":[],"updated_date":"2026-11-11T12:16:26.678958","created_date":"2026-11-06T00:00:00"}
