{"id":"https://openalex.org/W7225316648","doi":"https://doi.org/10.20944/preprints202611.0465.v1","title":"HSP90 in Tissue-Migrating Nematodes: Therapeutic Potential and Implications for Parasite-Induced Pulmonary Injury","display_name":"HSP90 in Tissue-Migrating Nematodes: Therapeutic Potential and Implications for Parasite-Induced Pulmonary Injury","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225316648","doi":"https://doi.org/10.20944/preprints202611.0465.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202611.0465.v1","doi":"https://doi.org/10.20944/preprints202611.0465.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0465.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202611.0465.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5158707478","display_name":"Pavel A. Solopov","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Pavel A. Solopov","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5057831537","display_name":"John D. Catravas","orcid":"https://orcid.org/0000-0002-5098-295X","observed_orcids":["https://orcid.org/0000-0002-5098-295X"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"John D. Catravas","raw_affiliation_strings":[],"raw_orcid":null,"affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5158707478"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10695","display_name":"Parasites and Host Interactions","score":0.3937999904155731,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11074","display_name":"Helminth infection and control","score":0.3831000030040741,"subfield":{"id":"https://openalex.org/subfields/2405","display_name":"Parasitology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T11702","display_name":"Parasitic Diseases Research and Treatment","score":0.15039999783039093,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hsp90","display_name":"HSP90","score":0.8100000023841858},{"id":"https://openalex.org/keywords/hsp90-inhibitors","display_name":"Hsp90 inhibitors","score":0.9359999895095825},{"id":"https://openalex.org/keywords/toxocara","display_name":"Toxocara","score":0.8159999847412109},{"id":"https://openalex.org/keywords/ascaris","display_name":"Ascaris","score":0.9980000257492065},{"id":"https://openalex.org/keywords/strongyloides","display_name":"Strongyloides","score":1.0},{"id":"https://openalex.org/keywords/lung-injury","display_name":"lung injury","score":0.6100000143051147},{"id":"https://openalex.org/keywords/larval-migration","display_name":"larval migration","score":0.9190000295639038},{"id":"https://openalex.org/keywords/anthelmintic-treatment","display_name":"anthelmintic treatment","score":0.8370000123977661},{"id":"https://openalex.org/keywords/vascular-permeability","display_name":"vascular permeability","score":0.7170000076293945},{"id":"https://openalex.org/keywords/endothelial-dysfunction","display_name":"endothelial dysfunction","score":0.8339999914169312},{"id":"https://openalex.org/keywords/pulmonary-inflammation","display_name":"lung inflammation","score":0.3790000081062317},{"id":"https://openalex.org/keywords/alveolar-capillary-barrier","display_name":"alveolar-capillary barrier","score":0.7670000195503235},{"id":"https://openalex.org/keywords/host-parasite-interactions","display_name":"host-parasite interactions","score":0.699999988079071},{"id":"https://openalex.org/keywords/tissue-repair","display_name":"tissue repair","score":0.6660000085830688},{"id":"https://openalex.org/keywords/host-immunity","display_name":"host immunity","score":0.3529999852180481}],"concepts":[{"id":"https://openalex.org/C205260736","wikidata":"https://www.wikidata.org/wiki/Q418939","display_name":"Heat shock protein","level":3,"score":0.7218000292778015},{"id":"https://openalex.org/C2775932338","wikidata":"https://www.wikidata.org/wiki/Q24772687","display_name":"Hsp90","level":4,"score":0.5823000073432922},{"id":"https://openalex.org/C2777714996","wikidata":"https://www.wikidata.org/wiki/Q7886","display_name":"Lung","level":2,"score":0.4878999888896942},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.48669999837875366},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.4740000069141388},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.43939998745918274},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.3824000060558319},{"id":"https://openalex.org/C2779341262","wikidata":"https://www.wikidata.org/wiki/Q182581","display_name":"Immunity","level":3,"score":0.38190001249313354},{"id":"https://openalex.org/C2776992346","wikidata":"https://www.wikidata.org/wiki/Q111140","display_name":"Endothelium","level":2,"score":0.37310001254081726},{"id":"https://openalex.org/C2777560012","wikidata":"https://www.wikidata.org/wiki/Q5924361","display_name":"Hsp90 inhibitor","level":5,"score":0.3643999993801117},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.36070001125335693},{"id":"https://openalex.org/C2780297055","wikidata":"https://www.wikidata.org/wiki/Q904475","display_name":"Geldanamycin","level":5,"score":0.3352999985218048},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.32839998602867126},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.3253999948501587},{"id":"https://openalex.org/C68991219","wikidata":"https://www.wikidata.org/wiki/Q419102","display_name":"Hsp70","level":4,"score":0.32499998807907104},{"id":"https://openalex.org/C164007495","wikidata":"https://www.wikidata.org/wiki/Q24721374","display_name":"Arginase","level":4,"score":0.3208000063896179},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.31450000405311584},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3052999973297119},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.298799991607666},{"id":"https://openalex.org/C123012128","wikidata":"https://www.wikidata.org/wiki/Q5376430","display_name":"Endothelial stem cell","level":3,"score":0.28439998626708984},{"id":"https://openalex.org/C161921814","wikidata":"https://www.wikidata.org/wiki/Q493743","display_name":"SMA*","level":2,"score":0.2750999927520752},{"id":"https://openalex.org/C2780940725","wikidata":"https://www.wikidata.org/wiki/Q206280","display_name":"Pulmonary artery","level":2,"score":0.2662999927997589},{"id":"https://openalex.org/C2775962898","wikidata":"https://www.wikidata.org/wiki/Q5073152","display_name":"Chaperone (clinical)","level":2,"score":0.2623000144958496},{"id":"https://openalex.org/C71928629","wikidata":"https://www.wikidata.org/wiki/Q804206","display_name":"Parasite hosting","level":2,"score":0.25130000710487366},{"id":"https://openalex.org/C2777237215","wikidata":"https://www.wikidata.org/wiki/Q65021","display_name":"Plasmodium berghei","level":3,"score":0.25049999356269836},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.2500999867916107},{"id":"https://openalex.org/C113045295","wikidata":"https://www.wikidata.org/wiki/Q7916465","display_name":"Vascular permeability","level":2,"score":0.25}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202611.0465.v1","doi":"https://doi.org/10.20944/preprints202611.0465.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0465.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202611.0465.v1","doi":"https://doi.org/10.20944/preprints202611.0465.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0465.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":0.9763000011444092,"display_name":"Good health and well-being"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W2432728900","https://openalex.org/W2970354782","https://openalex.org/W1964424740","https://openalex.org/W7128466816","https://openalex.org/W2058995176","https://openalex.org/W2085927978","https://openalex.org/W2059301290","https://openalex.org/W2963773920","https://openalex.org/W3044318019","https://openalex.org/W2158397840"],"abstract_inverted_index":{"Tissue-migrating":[0],"nematodes,":[1,97],"including":[2],"Toxocara":[3],"spp.,":[4,6,9],"Ascaris":[5],"and":[7,28,64,76,91,116,128,132,158,180,185,190],"Strongyloides":[8],"can":[10],"cause":[11],"substantial":[12],"pulmonary":[13,46,113,156,174],"injury":[14,119],"during":[15],"larval":[16],"migration,":[17],"characterized":[18],"by":[19,120,147],"inflammatory":[20,125],"cell":[21],"infiltration,":[22],"disruption":[23],"of":[24,44,86,187],"the":[25,42],"alveolar\u2013capillary":[26],"barrier,":[27],"increased":[29],"vascular":[30,133,157],"permeability.":[31],"New":[32],"therapeutic":[33,70,145],"approaches":[34],"should":[35],"prioritize":[36],"parasite":[37,89,150],"control":[38],"while":[39,152],"also":[40],"considering":[41],"recovery":[43],"injured":[45],"tissue.":[47],"Heat":[48],"shock":[49],"protein":[50,60],"90":[51],"(HSP90),":[52],"a":[53,68,143],"highly":[54],"conserved":[55],"molecular":[56],"chaperone":[57],"involved":[58],"in":[59,72,94],"folding,":[61],"stress":[62],"adaptation,":[63],"cellular":[65],"signaling,":[66],"represents":[67],"potential":[69,100,167],"target":[71],"both":[73],"parasitic":[74],"nematodes":[75,171],"host":[77,155,183],"tissues.":[78],"Experimental":[79],"studies":[80],"have":[81,108],"demonstrated":[82,109],"that":[83,138],"pharmacological":[84],"inhibition":[85,140],"HSP90":[87,106,139,164],"reduces":[88],"viability":[90],"microfilarial":[92],"output":[93],"selected":[95],"filarial":[96],"supporting":[98],"its":[99],"as":[101,166,195],"an":[102],"anthelmintic":[103,168],"strategy.":[104],"Independently,":[105],"inhibitors":[107,165],"protective":[110,188],"effects":[111],"against":[112,170],"endothelial":[114],"dysfunction":[115],"experimental":[117],"lung":[118],"preserving":[121],"intercellular":[122],"junctions,":[123],"modulating":[124],"signaling":[126],"pathways,":[127],"attenuating":[129],"cytoskeletal":[130],"rearrangement":[131],"hyperpermeability.":[134],"These":[135],"findings":[136],"suggest":[137],"may":[141],"offer":[142],"dual":[144],"approach":[146],"interfering":[148],"with":[149,173],"survival":[151],"simultaneously":[153],"limiting":[154],"tissue":[159,191],"injury.":[160],"This":[161],"review":[162],"evaluates":[163],"agents":[169],"associated":[172],"disease,":[175],"particularly":[176],"tissue-migrating":[177],"larvae.":[178],"Species-":[179],"stage-specific":[181],"susceptibility,":[182],"toxicity,":[184],"preservation":[186],"immunity":[189],"repair":[192],"are":[193],"discussed":[194],"key":[196],"translational":[197],"challenges.":[198]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}
