{"id":"https://openalex.org/W7225316300","doi":"https://doi.org/10.20944/preprints202611.0549.v1","title":"Hibernomics: A Multi-Omic Blueprint for Decoding and Harnessing Hibernation","display_name":"Hibernomics: A Multi-Omic Blueprint for Decoding and Harnessing Hibernation","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225316300","doi":"https://doi.org/10.20944/preprints202611.0549.v1"},"language":"en","primary_location":{"id":"doi:10.20944/preprints202611.0549.v1","doi":"https://doi.org/10.20944/preprints202611.0549.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0549.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"volume":null,"type":"preprint","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.20944/preprints202611.0549.v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5036736896","display_name":"\u88f4\u4fca\u5148","orcid":"https://orcid.org/0009-0002-0286-6134","observed_orcids":["https://orcid.org/0009-0002-0286-6134"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junxian Pei","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0002-0286-6134","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005631932","display_name":"\u5f20\u8096\u840c","orcid":"https://orcid.org/0009-0001-2892-4315","observed_orcids":["https://orcid.org/0009-0001-2892-4315"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Xiaomeng Zhang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0001-2892-4315","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5061071175","display_name":"Fengcheng Song","orcid":"https://orcid.org/0009-0000-3238-4051","observed_orcids":["https://orcid.org/0009-0000-3238-4051"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Fengcheng Song","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-3238-4051","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160870266","display_name":"Ranxi Zheng","orcid":"https://orcid.org/0009-0007-6927-4463","observed_orcids":["https://orcid.org/0009-0007-6927-4463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ranxi Zheng","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-6927-4463","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5012653502","display_name":"Ziyang Liu","orcid":"https://orcid.org/0000-0001-5419-1250","observed_orcids":["https://orcid.org/0000-0001-5419-1250","https://orcid.org/0009-0007-2996-9455"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Ziyang Liu","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0007-2996-9455","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160987947","display_name":"Junting Yang","orcid":"https://orcid.org/0009-0000-7738-1073","observed_orcids":["https://orcid.org/0009-0000-7738-1073"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Junting Yang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0000-7738-1073","affiliations":[]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160987412","display_name":"Jo Chong Gwang","orcid":"https://orcid.org/0009-0005-3445-5710","observed_orcids":["https://orcid.org/0009-0005-3445-5710"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jo Chong Gwang","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0009-0005-3445-5710","affiliations":[]},{"author_position":"last","author":{"id":"https://openalex.org/A5009387271","display_name":"Zhengrong Yuan","orcid":"https://orcid.org/0000-0002-5175-0675","observed_orcids":["https://orcid.org/0000-0002-5175-0675"]},"institutions":[],"countries":[],"is_corresponding":true,"raw_author_name":"Zhengrong Yuan","raw_affiliation_strings":[],"raw_orcid":"https://orcid.org/0000-0002-5175-0675","affiliations":[]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":["https://openalex.org/A5009387271"],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T11056","display_name":"Physiological and biochemical adaptations","score":0.9872999787330627,"subfield":{"id":"https://openalex.org/subfields/2303","display_name":"Ecology"},"field":{"id":"https://openalex.org/fields/23","display_name":"Environmental Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11861","display_name":"Thermal Regulation in Medicine","score":0.0024999999441206455,"subfield":{"id":"https://openalex.org/subfields/2706","display_name":"Critical Care and Intensive Care Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10342","display_name":"Circadian rhythm and melatonin","score":0.002400000113993883,"subfield":{"id":"https://openalex.org/subfields/2807","display_name":"Endocrine and Autonomic Systems"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/hibernation","display_name":"hibernation","score":0.9990000128746033},{"id":"https://openalex.org/keywords/energy-metabolism","display_name":"energy metabolism","score":0.7440000176429749},{"id":"https://openalex.org/keywords/neuroendocrine-immune-regulation","display_name":"neuroendocrine-immune regulation","score":0.9629999995231628},{"id":"https://openalex.org/keywords/cold-tolerance","display_name":"cold tolerance","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tissue-preservation","display_name":"tissue preservation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/hypothermia","display_name":"hypothermia","score":0.6349999904632568},{"id":"https://openalex.org/keywords/rewarming","display_name":"rewarming","score":0.8759999871253967},{"id":"https://openalex.org/keywords/organoids","display_name":"organoids","score":0.847000002861023},{"id":"https://openalex.org/keywords/organ-on-a-chip","display_name":"organ-on-a-chip","score":0.9900000095367432},{"id":"https://openalex.org/keywords/organ-preservation","display_name":"organ preservation","score":0.7649999856948853},{"id":"https://openalex.org/keywords/metabolic-medicine","display_name":"metabolic medicine","score":0.843999981880188},{"id":"https://openalex.org/keywords/long-duration-spaceflight","display_name":"long-duration spaceflight","score":0.8569999933242798},{"id":"https://openalex.org/keywords/trauma-care","display_name":"trauma care","score":0.5450000166893005}],"concepts":[{"id":"https://openalex.org/C119865680","wikidata":"https://www.wikidata.org/wiki/Q681126","display_name":"Hibernation (computing)","level":3,"score":0.6819999814033508},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6452000141143799},{"id":"https://openalex.org/C169760540","wikidata":"https://www.wikidata.org/wiki/Q207011","display_name":"Neuroscience","level":1,"score":0.521399974822998},{"id":"https://openalex.org/C66538056","wikidata":"https://www.wikidata.org/wiki/Q1651205","display_name":"Torpor","level":3,"score":0.5101000070571899},{"id":"https://openalex.org/C188147891","wikidata":"https://www.wikidata.org/wiki/Q147638","display_name":"Cognitive science","level":1,"score":0.4738999903202057},{"id":"https://openalex.org/C70721500","wikidata":"https://www.wikidata.org/wiki/Q177005","display_name":"Computational biology","level":1,"score":0.41359999775886536},{"id":"https://openalex.org/C155911762","wikidata":"https://www.wikidata.org/wiki/Q422321","display_name":"Blueprint","level":2,"score":0.38679999113082886},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.3833000063896179},{"id":"https://openalex.org/C2986317502","wikidata":"https://www.wikidata.org/wiki/Q570714","display_name":"Energy metabolism","level":2,"score":0.36890000104904175},{"id":"https://openalex.org/C12713177","wikidata":"https://www.wikidata.org/wiki/Q1900281","display_name":"Perspective (graphical)","level":2,"score":0.3569999933242798},{"id":"https://openalex.org/C78458016","wikidata":"https://www.wikidata.org/wiki/Q840400","display_name":"Evolutionary biology","level":1,"score":0.3384999930858612},{"id":"https://openalex.org/C98045186","wikidata":"https://www.wikidata.org/wiki/Q205663","display_name":"Process (computing)","level":2,"score":0.33410000801086426},{"id":"https://openalex.org/C2992884146","wikidata":"https://www.wikidata.org/wiki/Q719725","display_name":"Budding yeast","level":4,"score":0.32269999384880066},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.31139999628067017},{"id":"https://openalex.org/C137858568","wikidata":"https://www.wikidata.org/wiki/Q7239","display_name":"Organism","level":2,"score":0.3068000078201294},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.30239999294281006},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.296099990606308},{"id":"https://openalex.org/C19843653","wikidata":"https://www.wikidata.org/wiki/Q213907","display_name":"Model organism","level":3,"score":0.28859999775886536},{"id":"https://openalex.org/C2776759703","wikidata":"https://www.wikidata.org/wiki/Q1066907","display_name":"Longevity","level":2,"score":0.28690001368522644},{"id":"https://openalex.org/C177606310","wikidata":"https://www.wikidata.org/wiki/Q5674297","display_name":"Adaptability","level":2,"score":0.27630001306533813},{"id":"https://openalex.org/C153991713","wikidata":"https://www.wikidata.org/wiki/Q17142856","display_name":"Niche","level":2,"score":0.2583000063896179},{"id":"https://openalex.org/C2522767166","wikidata":"https://www.wikidata.org/wiki/Q2374463","display_name":"Data science","level":1,"score":0.25780001282691956}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.20944/preprints202611.0549.v1","doi":"https://doi.org/10.20944/preprints202611.0549.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0549.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.20944/preprints202611.0549.v1","doi":"https://doi.org/10.20944/preprints202611.0549.v1","is_oa":true,"landing_page_url":"https://doi.org/10.20944/preprints202611.0549.v1","pdf_url":null,"source":{"id":"https://openalex.org/S6309402219","display_name":"Preprints.org","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W7171202290","https://openalex.org/W2145960092","https://openalex.org/W3084193054","https://openalex.org/W1973175580","https://openalex.org/W7164299564","https://openalex.org/W4200540349","https://openalex.org/W4321333024","https://openalex.org/W7220008795","https://openalex.org/W4413138795","https://openalex.org/W2068667467"],"abstract_inverted_index":{"Hibernation":[0],"is":[1],"one":[2,331],"of":[3,42,77,97,103,119,181,222,228,240,260,310,347],"the":[4,30,60,74,95,100,179,212,220,229,235,246,345],"most":[5,44],"striking":[6],"survival":[7],"strategies":[8,277],"in":[9,13,50,238,266,337],"animals,":[10],"a":[11,90,117,124,327],"state":[12],"which":[14,52,202,289],"metabolism":[15],"drops":[16],"to":[17,32,57,112,155,169,211,253,285,321],"levels":[18],"that":[19,93,204,232,332],"would":[20],"ordinarily":[21],"threaten":[22],"viability":[23],"while":[24],"tissues":[25],"remain":[26],"unexpectedly":[27],"stable.":[28],"Although":[29],"research":[31,79,91,143],"date":[33],"has":[34,53,206],"described":[35],"many":[36],"relevant":[37],"molecular":[38],"and":[39,65,80,106,126,166,174,184,190,243,256,263,272,281,301,306,344],"physiological":[40,172,214],"features":[41],"significance,":[43],"studies":[45,94],"have":[46],"examined":[47,136],"these":[48,287,317],"layers":[49],"isolation,":[51],"limited":[54],"our":[55],"ability":[56],"understand":[58],"how":[59],"process":[61],"unfolds":[62],"across":[63,66,83,195],"time":[64],"biological":[67],"scales.":[68],"In":[69],"this":[70,138],"review,":[71],"we":[72],"trace":[73],"historical":[75],"trajectory":[76],"hibernation":[78,82,98,111],"examine":[81],"complementary":[84],"omics":[85,274],"dimensions,":[86],"introducing":[87],"Hibernomics":[88,320],"as":[89,116,123,270,299],"framework":[92],"phenomenon":[96],"through":[99,137],"dynamic":[101,279],"integration":[102],"multi-omic":[104],"technologies":[105,268],"approaches.":[107],"This":[108],"perspective":[109],"allows":[110],"be":[113],"viewed":[114],"not":[115],"collection":[118],"independent":[120],"traits":[121],"but":[122],"coordinated":[125],"highly":[127],"structured":[128],"adaptation,":[129],"shaped":[130],"by":[131,294],"its":[132],"temporal":[133],"rhythm.":[134],"When":[135],"lens,":[139],"three":[140],"interlinked":[141],"core":[142],"threads":[144],"emerge:":[145],"energy":[146],"metabolism,":[147],"focusing":[148],"on":[149,160,178],"hypothermic":[150],"metabolic":[151,340],"reprogramming":[152],"from":[153,250,323],"genome":[154],"metabolites;":[156],"neuroendocrine-immune":[157],"regulation,":[158],"centered":[159],"integrating":[161],"environmental":[162],"cues,":[163],"endocrine":[164],"signaling":[165],"immune":[167],"remodeling":[168],"coordinate":[170],"systemic":[171],"transitions;":[173],"cold":[175],"tolerance,":[176],"concentrating":[177],"preservation":[180],"tissue":[182],"integrity":[183],"functional":[185],"resilience":[186],"during":[187],"prolonged":[188],"hypothermia":[189],"rewarming.":[191],"These":[192],"themes":[193],"appear":[194],"species":[196],"even":[197],"though":[198],"individual":[199],"mechanisms":[200],"vary,":[201],"suggests":[203],"evolution":[205],"assembled":[207],"different":[208,244],"workable":[209],"solutions":[210],"same":[213],"challenge.":[215],"Important":[216],"gaps":[217],"remain,":[218],"including":[219],"difficulty":[221],"harmonizing":[223],"heterogeneous":[224],"datasets,":[225],"incomplete":[226],"grasp":[227],"neural":[230],"events":[231],"initiate":[233],"hibernation,":[234],"technical":[236],"obstacles":[237],"terms":[239],"resolution,":[241],"dynamics,":[242],"species,":[245],"wide":[247],"translational":[248],"gap":[249],"animal":[251],"models":[252],"human":[254],"application,":[255],"certain":[257],"enduring":[258],"enigmas":[259],"basic":[261],"physiology":[262],"evolution.":[264],"Advances":[265],"high-resolution":[267],"such":[269,298],"single-cell":[271],"spatial":[273],"coupled":[275],"with":[276],"for":[278],"sampling":[280],"monitoring,":[282],"are":[283,290],"beginning":[284],"address":[286],"challenges,":[288],"further":[291],"being":[292],"empowered":[293],"novel":[295],"experimental":[296],"platforms":[297],"organoids":[300],"organs-on-chips,":[302],"targeted":[303],"perturbation":[304],"tools,":[305],"computational":[307],"methods":[308],"capable":[309],"inferring":[311],"or":[312],"proving":[313],"causal":[314],"relationships.":[315],"Together,":[316],"developments":[318],"position":[319],"move":[322],"descriptive":[324],"synthesis":[325],"towards":[326,350],"predictive,":[328],"mechanism-oriented":[329],"framework,":[330],"may":[333],"eventually":[334],"guide":[335],"innovations":[336],"organ":[338],"preservation,":[339],"medicine,":[341],"trauma":[342],"care":[343],"management":[346],"long-duration":[348],"spaceflight":[349],"transformative":[351],"applications.":[352]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}