{"id":"https://openalex.org/W7225316224","doi":"https://doi.org/10.1186/s12879-026-14757-7","title":"Whole-genome sequencing of Providencia rettgeri co-producing NDM-1 and VIM-1 carbapenemases in clinical settings: genomic insights, therapeutic considerations, and literature overview","display_name":"Whole-genome sequencing of Providencia rettgeri co-producing NDM-1 and VIM-1 carbapenemases in clinical settings: genomic insights, therapeutic considerations, and literature overview","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225316224","doi":"https://doi.org/10.1186/s12879-026-14757-7"},"language":"en","primary_location":{"id":"doi:10.1186/s12879-026-14757-7","doi":"https://doi.org/10.1186/s12879-026-14757-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12879-026-14757-7","pdf_url":null,"source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1186/s12879-026-14757-7","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5114528781","display_name":"Claudia Caparrelli","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Caparrelli","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5147041327","display_name":"Claudia Maestripieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Maestripieri","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114343927","display_name":"Claudia Rotondo","orcid":"https://orcid.org/0009-0008-4214-2812","observed_orcids":["https://orcid.org/0009-0008-4214-2812"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Claudia Rotondo","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5082727449","display_name":"Anna Altieri","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Anna Altieri","raw_affiliation_strings":["Laboratory of Clinical Microbiology, Policlinico Tor Vergata, Rome, 00133, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Microbiology, Policlinico Tor Vergata, Rome, 00133, Italy","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5026053749","display_name":"Cartesio D\u2019Agostini","orcid":"https://orcid.org/0000-0001-9199-3340","observed_orcids":["https://orcid.org/0000-0001-9199-3340"]},"institutions":[{"id":"https://openalex.org/I4210138843","display_name":"Policlinico Tor Vergata","ror":"https://ror.org/03z475876","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210138843"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Cartesio D\u2019Agostini","raw_affiliation_strings":["Laboratory of Clinical Microbiology, Policlinico Tor Vergata, Rome, 00133, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Laboratory of Clinical Microbiology, Policlinico Tor Vergata, Rome, 00133, Italy","institution_ids":["https://openalex.org/I4210138843"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5150015078","display_name":"Alessandra Lodi","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Alessandra Lodi","raw_affiliation_strings":["Systemic and Immune Depression-Associated Infections Unit, Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systemic and Immune Depression-Associated Infections Unit, Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036917727","display_name":"Carolina C. Venditti","orcid":"https://orcid.org/0000-0002-2644-1862","observed_orcids":["https://orcid.org/0000-0002-2644-1862"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carolina Venditti","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114343928","display_name":"Michele Properzi","orcid":"https://orcid.org/0009-0008-1768-6017","observed_orcids":["https://orcid.org/0009-0008-1768-6017"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Michele Properzi","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5036744082","display_name":"Ornella Butera","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Ornella Butera","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","UOS Technical Health Professions, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]},{"raw_affiliation_string":"UOS Technical Health Professions, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5057461406","display_name":"Carla Nisii","orcid":"https://orcid.org/0000-0001-5369-0437","observed_orcids":["https://orcid.org/0000-0001-5369-0437"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Nisii","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063748250","display_name":"Stefania Cicalini","orcid":"https://orcid.org/0000-0002-0754-6917","observed_orcids":["https://orcid.org/0000-0002-0754-6917"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Stefania Cicalini","raw_affiliation_strings":["Systemic and Immune Depression-Associated Infections Unit, Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Systemic and Immune Depression-Associated Infections Unit, Clinical Department, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5028919045","display_name":"Carla Fontana","orcid":"https://orcid.org/0000-0003-2198-1947","observed_orcids":["https://orcid.org/0000-0003-2198-1947"]},"institutions":[{"id":"https://openalex.org/I4210091493","display_name":"Istituto Nazionale per le Malattie Infettive Lazzaro Spallanzani","ror":"https://ror.org/00kv87w35","country_code":"IT","type":"healthcare","lineage":["https://openalex.org/I4210091493","https://openalex.org/I4210153126"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Carla Fontana","raw_affiliation_strings":["Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Microbiology and Biobank Unit, National Institute for Infectious Diseases \u201cLazzaro Spallanzani\u201d, IRCCS, Rome, 00149, Italy","institution_ids":["https://openalex.org/I4210091493"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5150015078"],"corresponding_institution_ids":["https://openalex.org/I4210091493"],"apc_list":{"value":3090,"currency":"USD","value_usd":3090},"apc_paid":{"value":3090,"currency":"USD","value_usd":3090},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10147","display_name":"Antibiotic Resistance in Bacteria","score":0.9990000128746033,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12824","display_name":"Infections and bacterial resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2726","display_name":"Microbiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10897","display_name":"Antibiotic Use and Resistance","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/2725","display_name":"Infectious Diseases"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/providencia-rettgeri","display_name":"Providencia rettgeri","score":0.9990000128746033},{"id":"https://openalex.org/keywords/ndm-1","display_name":"NDM-1","score":0.9779999852180481},{"id":"https://openalex.org/keywords/vim-1","display_name":"VIM-1","score":0.9990000128746033},{"id":"https://openalex.org/keywords/carbapenemase","display_name":"carbapenemase","score":0.8169999718666077},{"id":"https://openalex.org/keywords/metallo-beta-lactamase","display_name":"metallo-beta-lactamase","score":0.7829999923706055},{"id":"https://openalex.org/keywords/multidrug-resistance","display_name":"multidrug resistance","score":0.7839999794960022},{"id":"https://openalex.org/keywords/nosocomial-pathogens","display_name":"nosocomial pathogens","score":0.8429999947547913},{"id":"https://openalex.org/keywords/inca-c-plasmids","display_name":"IncA/C plasmids","score":0.7689999938011169},{"id":"https://openalex.org/keywords/antimicrobial-resistance-surveillance","display_name":"antimicrobial resistance surveillance","score":0.7020000219345093},{"id":"https://openalex.org/keywords/antimicrobial-susceptibility","display_name":"antimicrobial susceptibility","score":0.5630000233650208},{"id":"https://openalex.org/keywords/enterobacterales","display_name":"Enterobacterales","score":0.7229999899864197}],"concepts":[{"id":"https://openalex.org/C2779259085","wikidata":"https://www.wikidata.org/wiki/Q418946","display_name":"Colistin","level":3,"score":0.7513999938964844},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.6801999807357788},{"id":"https://openalex.org/C2777027569","wikidata":"https://www.wikidata.org/wiki/Q420595","display_name":"Tigecycline","level":3,"score":0.6327000260353088},{"id":"https://openalex.org/C2776666601","wikidata":"https://www.wikidata.org/wiki/Q3457855","display_name":"Resistome","level":5,"score":0.5465999841690063},{"id":"https://openalex.org/C2777427914","wikidata":"https://www.wikidata.org/wiki/Q408529","display_name":"Amikacin","level":3,"score":0.4864000082015991},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.45969998836517334},{"id":"https://openalex.org/C190139176","wikidata":"https://www.wikidata.org/wiki/Q598976","display_name":"Medical microbiology","level":2,"score":0.420199990272522},{"id":"https://openalex.org/C94665300","wikidata":"https://www.wikidata.org/wiki/Q63391344","display_name":"Antibiotic resistance","level":3,"score":0.33959999680519104},{"id":"https://openalex.org/C190612196","wikidata":"https://www.wikidata.org/wiki/Q180502","display_name":"Parasitology","level":2,"score":0.33880001306533813},{"id":"https://openalex.org/C2776685102","wikidata":"https://www.wikidata.org/wiki/Q410897","display_name":"Carbapenem","level":3,"score":0.336899995803833},{"id":"https://openalex.org/C114851261","wikidata":"https://www.wikidata.org/wiki/Q12147416","display_name":"Drug resistance","level":2,"score":0.3359000086784363},{"id":"https://openalex.org/C24432333","wikidata":"https://www.wikidata.org/wiki/Q2068526","display_name":"Whole genome sequencing","level":4,"score":0.3197000026702881},{"id":"https://openalex.org/C2776307328","wikidata":"https://www.wikidata.org/wiki/Q25841585","display_name":"Cronobacter sakazakii","level":3,"score":0.2669999897480011}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1186/s12879-026-14757-7","doi":"https://doi.org/10.1186/s12879-026-14757-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12879-026-14757-7","pdf_url":null,"source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1186/s12879-026-14757-7","doi":"https://doi.org/10.1186/s12879-026-14757-7","is_oa":true,"landing_page_url":"https://doi.org/10.1186/s12879-026-14757-7","pdf_url":null,"source":{"id":"https://openalex.org/S171015910","display_name":"BMC Infectious Diseases","issn_l":"1471-2334","issn":["1471-2334"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["anvur-scientific","cwts-core","doaj","dongbi-d","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320256","host_organization_name":"BioMed Central","host_organization_lineage":["https://openalex.org/P4310320256","https://openalex.org/P4310319965"],"host_organization_lineage_names":["BioMed Central","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMC Infectious Diseases","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.98580002784729,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321781","display_name":"Ministero della Salute","ror":"https://ror.org/00789fa95"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4205436838","https://openalex.org/W3101839339","https://openalex.org/W4392453523","https://openalex.org/W7164340522","https://openalex.org/W2121668112","https://openalex.org/W4387304332","https://openalex.org/W4396553857","https://openalex.org/W6958307908","https://openalex.org/W4385496595","https://openalex.org/W2746995602"],"abstract_inverted_index":{"Abstract":[0],"Background":[1],"Providencia":[2],"rettgeri":[3,29,54,109,226,269],"is":[4],"an":[5,18,130,164,218,274],"emerging":[6,275],"nosocomial":[7,277],"pathogen":[8,278],"with":[9,282],"expected":[10],"resistant":[11,174],"phenotype":[12],"to":[13,21,102,122,157,175,204,207],"colistin":[14],"and":[15,17,36,45,60,66,90,126,128,135,138,177,183,197,230,249,260],"tigecycline":[16],"increasing":[19],"capacity":[20],"acquire":[22],"clinically":[23],"relevant":[24],"carbapenemases.":[25],"Although":[26],"metallo-\u03b2-lactamase-producing":[27],"P.":[28,53,108,225,268],"has":[30],"been":[31],"reported,":[32],"co-production":[33],"of":[34,167,221,239,245,253,279],"NDM":[35],"VIM":[37],"among":[38],"highly":[39,168,222],"genomically":[40,169,223],"related":[41,170,224],"isolates":[42,55,117,153,227],"remains":[43],"uncommon":[44,240],"warrants":[46],"detailed":[47],"genomic":[48,215],"characterization.":[49],"Methods":[50],"Five":[51],"clinical":[52,280],"recovered":[56],"between":[57],"January":[58],"2024":[59],"December":[61],"2025":[62],"through":[63],"routine":[64],"diagnostic":[65],"regional":[67],"antimicrobial":[68,257],"resistance":[69,258],"surveillance":[70,259],"activities":[71],"in":[72,119,186,232],"Latium,":[73],"Italy,":[74],"were":[75,94,173],"analyzed.":[76],"Antimicrobial":[77],"susceptibility":[78],"testing,":[79],"phenotypic":[80],"carbapenemase":[81,247],"detection,":[82],"whole-genome":[83,254],"sequencing,":[84],"resistome":[85],"analysis,":[86],"plasmid":[87],"replicon":[88],"typing,":[89],"clonal":[91],"relationship":[92],"assessment":[93],"performed.":[95],"A":[96],"structured":[97],"literature":[98],"overview":[99],"was":[100,190],"conducted":[101],"contextualize":[103],"available":[104],"evidence":[105],"on":[106],"NDM/VIM-producing":[107,267],".":[110],"Results":[111],"Four":[112],"Intensive":[113],"Care":[114],"Unit":[115],"(ICU)-associated":[116],"collected":[118],"2025,":[120],"PR-1":[121,196],"PR-4,":[123],"co-produced":[124],"NDM-1":[125,229],"VIM-1":[127,231],"shared":[129],"extensive":[131],"multidrug-resistance":[132],"profile,":[133],"IncA/C":[134],"IncFIB(pQil)":[136],"replicons,":[137],"the":[139,208,237,251],"same":[140],"ribosomal":[141],"sequence":[142,147],"type,":[143],"rST219654.":[144],"Core-genome":[145],"multi-locus":[146],"typing":[148],"(cgMLST)":[149],"showed":[150],"that":[151],"these":[152],"differed":[154],"by":[155],"0":[156],"13":[158],"alleles,":[159],"supporting":[160],"their":[161],"description":[162],"as":[163,192,243,273],"ICU-associated":[165,219],"group":[166,220],"isolates.":[171],"They":[172],"carbapenems":[176],"most":[178],"\u03b2-lactam/\u03b2-lactamase":[179],"inhibitor":[180],"combinations.":[181],"Gentamicin":[182],"amikacin":[184],"retained":[185],"vitro":[187],"activity.":[188],"Aztreonam":[189],"categorized":[191],"susceptible":[193],"(S)":[194],"for":[195,202],"susceptible,":[198],"increased":[199],"exposure":[200],"(I)":[201],"PR-2":[203],"PR-4":[205],"according":[206],"retrospective":[209],"EUCAST":[210],"(v16.0)":[211],"interpretation.":[212],"Conclusions":[213],"Comparative":[214],"analysis":[216],"identified":[217],"co-producing":[228],"Italy.":[233],"These":[234],"findings":[235],"highlight":[236],"role":[238],"Enterobacterales":[241],"species":[242],"reservoirs":[244],"mobile":[246],"determinants":[248],"support":[250],"integration":[252],"sequencing":[255],"into":[256],"infection-control":[261],"programs.":[262],"In":[263],"critically":[264],"ill":[265],"patients,":[266],"should":[270],"be":[271],"regarded":[272],"multidrug-resistant":[276],"concern":[281],"limited":[283],"therapeutic":[284],"options.":[285]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}
