{"id":"https://openalex.org/W7225316088","doi":"https://doi.org/10.3390/polym18212750","title":"Electrospun Polymer Nanofibers for Biomedical Interfaces: Polymer Selection, Architecture, Bioactivation, and Translational Challenges","display_name":"Electrospun Polymer Nanofibers for Biomedical Interfaces: Polymer Selection, Architecture, Bioactivation, and Translational Challenges","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225316088","doi":"https://doi.org/10.3390/polym18212750"},"language":"en","primary_location":{"id":"doi:10.3390/polym18212750","doi":"https://doi.org/10.3390/polym18212750","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym18212750","pdf_url":null,"source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.3390/polym18212750","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5091760045","display_name":"Gianluca Ciarleglio","orcid":"https://orcid.org/0000-0002-1029-8766","observed_orcids":["https://orcid.org/0000-0002-1029-8766"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":true,"raw_author_name":"Gianluca Ciarleglio","raw_affiliation_strings":["Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-1029-8766","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5066262156","display_name":"Maria Gabriella Santonicola","orcid":"https://orcid.org/0000-0002-2736-8580","observed_orcids":["https://orcid.org/0000-0002-2736-8580"]},"institutions":[{"id":"https://openalex.org/I861853513","display_name":"Sapienza University of Rome","ror":"https://ror.org/02be6w209","country_code":"IT","type":"education","lineage":["https://openalex.org/I861853513"]}],"countries":["IT"],"is_corresponding":false,"raw_author_name":"Maria Gabriella Santonicola","raw_affiliation_strings":["Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy"],"raw_orcid":"https://orcid.org/0000-0002-2736-8580","affiliations":[{"raw_affiliation_string":"Department of Chemical Engineering Materials Environment, Sapienza University of Rome, Via del Castro Laurenziano 7, 00161 Rome, Italy","institution_ids":["https://openalex.org/I861853513"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5091760045"],"corresponding_institution_ids":["https://openalex.org/I861853513"],"apc_list":{"value":2700,"currency":"CHF","value_usd":3258},"apc_paid":{"value":2700,"currency":"CHF","value_usd":3258},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"18","issue":"21","first_page":"2750","last_page":"2750"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},"topics":[{"id":"https://openalex.org/T10729","display_name":"Electrospun Nanofibers in Biomedical Applications","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T11966","display_name":"Silk-based biomaterials and applications","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2502","display_name":"Biomaterials"},"field":{"id":"https://openalex.org/fields/25","display_name":"Materials Science"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10059","display_name":"Bone Tissue Engineering Materials","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2204","display_name":"Biomedical Engineering"},"field":{"id":"https://openalex.org/fields/22","display_name":"Engineering"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/electrospun-nanofibers","display_name":"electrospun nanofibers","score":0.9850000143051147},{"id":"https://openalex.org/keywords/polymer-selection","display_name":"polymer selection","score":0.6740000247955322},{"id":"https://openalex.org/keywords/fiber-architecture","display_name":"fiber architecture","score":0.8109999895095825},{"id":"https://openalex.org/keywords/core-shell-nanofibers","display_name":"core-shell nanofibers","score":0.8949999809265137},{"id":"https://openalex.org/keywords/aligned-nanofibers","display_name":"aligned nanofibers","score":0.8360000252723694},{"id":"https://openalex.org/keywords/controlled-release","display_name":"controlled release","score":0.5879999995231628},{"id":"https://openalex.org/keywords/surface-functionalization","display_name":"surface functionalization","score":0.7829999923706055},{"id":"https://openalex.org/keywords/stimulus-responsive-materials","display_name":"stimulus-responsive materials","score":0.5849999785423279},{"id":"https://openalex.org/keywords/biodegradable-polymers","display_name":"biodegradable polymers","score":0.9269999861717224},{"id":"https://openalex.org/keywords/natural-polymers","display_name":"natural polymers","score":0.8209999799728394},{"id":"https://openalex.org/keywords/wound-dressings","display_name":"wound dressings","score":0.8429999947547913},{"id":"https://openalex.org/keywords/implant-coatings","display_name":"implant coatings","score":0.8650000095367432},{"id":"https://openalex.org/keywords/sterilization","display_name":"sterilization","score":0.824999988079071},{"id":"https://openalex.org/keywords/manufacturing-reproducibility","display_name":"manufacturing reproducibility","score":0.546999990940094}],"concepts":[{"id":"https://openalex.org/C144796933","wikidata":"https://www.wikidata.org/wiki/Q1533542","display_name":"Electrospinning","level":3,"score":0.8471999764442444},{"id":"https://openalex.org/C192562407","wikidata":"https://www.wikidata.org/wiki/Q228736","display_name":"Materials science","level":0,"score":0.7186999917030334},{"id":"https://openalex.org/C91129048","wikidata":"https://www.wikidata.org/wiki/Q594196","display_name":"Nanofiber","level":2,"score":0.7064999938011169},{"id":"https://openalex.org/C171250308","wikidata":"https://www.wikidata.org/wiki/Q11468","display_name":"Nanotechnology","level":1,"score":0.6057000160217285},{"id":"https://openalex.org/C521977710","wikidata":"https://www.wikidata.org/wiki/Q81163","display_name":"Polymer","level":2,"score":0.573199987411499},{"id":"https://openalex.org/C115537861","wikidata":"https://www.wikidata.org/wiki/Q7645993","display_name":"Surface modification","level":2,"score":0.5573999881744385},{"id":"https://openalex.org/C134066672","wikidata":"https://www.wikidata.org/wiki/Q1424639","display_name":"Payload (computing)","level":3,"score":0.46950000524520874},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.41350001096725464},{"id":"https://openalex.org/C45211672","wikidata":"https://www.wikidata.org/wiki/Q4119016","display_name":"Biodegradable polymer","level":3,"score":0.3181999921798706},{"id":"https://openalex.org/C519885992","wikidata":"https://www.wikidata.org/wiki/Q161","display_name":"Fiber","level":2,"score":0.31450000405311584},{"id":"https://openalex.org/C1318750","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biocompatible material","level":2,"score":0.29170000553131104},{"id":"https://openalex.org/C2909316542","wikidata":"https://www.wikidata.org/wiki/Q422649","display_name":"Natural polymers","level":3,"score":0.29159998893737793},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.2890999913215637},{"id":"https://openalex.org/C2778414984","wikidata":"https://www.wikidata.org/wiki/Q865663","display_name":"Biomaterial","level":2,"score":0.2867000102996826}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3390/polym18212750","doi":"https://doi.org/10.3390/polym18212750","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym18212750","pdf_url":null,"source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},{"id":"pmh:oai:iris.uniroma1.it:11573/1780951","doi":null,"is_oa":false,"landing_page_url":"https://hdl.handle.net/11573/1780951","pdf_url":null,"source":{"id":"https://openalex.org/S4377196107","display_name":"IRIS Research product catalog (Sapienza University of Rome)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":null,"raw_type":"info:eu-repo/semantics/article"}],"best_oa_location":{"id":"doi:10.3390/polym18212750","doi":"https://doi.org/10.3390/polym18212750","is_oa":true,"landing_page_url":"https://doi.org/10.3390/polym18212750","pdf_url":null,"source":{"id":"https://openalex.org/S123288148","display_name":"Polymers","issn_l":"2073-4360","issn":["2073-4360"],"is_oa":true,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310310987","host_organization_name":"Multidisciplinary Digital Publishing Institute","host_organization_lineage":["https://openalex.org/P4310310987"],"host_organization_lineage_names":["Multidisciplinary Digital Publishing Institute"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Polymers","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.46810001134872437,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320322510","display_name":"Sapienza Universit\u00e0 di Roma","ror":"https://ror.org/02be6w209"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":128,"referenced_works":["https://openalex.org/W1509303906","https://openalex.org/W1993456710","https://openalex.org/W1995707214","https://openalex.org/W1997552417","https://openalex.org/W2003249353","https://openalex.org/W2005355024","https://openalex.org/W2006219975","https://openalex.org/W2008805549","https://openalex.org/W2014750067","https://openalex.org/W2019657866","https://openalex.org/W2024653308","https://openalex.org/W2028905758","https://openalex.org/W2032195777","https://openalex.org/W2053472561","https://openalex.org/W2082516633","https://openalex.org/W2084818285","https://openalex.org/W2087032263","https://openalex.org/W2106727463","https://openalex.org/W2157248428","https://openalex.org/W2157908104","https://openalex.org/W2157976579","https://openalex.org/W2299775765","https://openalex.org/W2322204209","https://openalex.org/W2478980140","https://openalex.org/W2523057478","https://openalex.org/W2528925814","https://openalex.org/W2594299805","https://openalex.org/W2728423944","https://openalex.org/W2732787775","https://openalex.org/W2785956172","https://openalex.org/W2903114953","https://openalex.org/W2923638025","https://openalex.org/W2929722587","https://openalex.org/W2949815973","https://openalex.org/W2953936298","https://openalex.org/W2960112487","https://openalex.org/W2987007465","https://openalex.org/W2993159261","https://openalex.org/W3015490367","https://openalex.org/W3015801809","https://openalex.org/W3036037809","https://openalex.org/W3049389954","https://openalex.org/W3125781270","https://openalex.org/W3129729380","https://openalex.org/W3151745729","https://openalex.org/W3155419610","https://openalex.org/W3166991028","https://openalex.org/W3184825273","https://openalex.org/W3217358624","https://openalex.org/W4200621731","https://openalex.org/W4224038031","https://openalex.org/W4225972078","https://openalex.org/W4293235616","https://openalex.org/W4311097936","https://openalex.org/W4318269889","https://openalex.org/W4321377034","https://openalex.org/W4361006531","https://openalex.org/W4382751383","https://openalex.org/W4384563220","https://openalex.org/W4385226453","https://openalex.org/W4385308007","https://openalex.org/W4387019296","https://openalex.org/W4387108211","https://openalex.org/W4389079963","https://openalex.org/W4390586937","https://openalex.org/W4390706828","https://openalex.org/W4390741413","https://openalex.org/W4390804641","https://openalex.org/W4391754737","https://openalex.org/W4392508915","https://openalex.org/W4393061544","https://openalex.org/W4394620428","https://openalex.org/W4394690481","https://openalex.org/W4394933503","https://openalex.org/W4395701351","https://openalex.org/W4396844810","https://openalex.org/W4396872100","https://openalex.org/W4399443194","https://openalex.org/W4399481548","https://openalex.org/W4400264294","https://openalex.org/W4401112199","https://openalex.org/W4401728447","https://openalex.org/W4402191397","https://openalex.org/W4402375713","https://openalex.org/W4402513626","https://openalex.org/W4402994045","https://openalex.org/W4403595927","https://openalex.org/W4404426981","https://openalex.org/W4405388937","https://openalex.org/W4405455683","https://openalex.org/W4405824650","https://openalex.org/W4407007347","https://openalex.org/W4407085011","https://openalex.org/W4407428398","https://openalex.org/W4407668526","https://openalex.org/W4407818841","https://openalex.org/W4408675323","https://openalex.org/W4409209794","https://openalex.org/W4409351983","https://openalex.org/W4409483368","https://openalex.org/W4409906764","https://openalex.org/W4410498394","https://openalex.org/W4410590457","https://openalex.org/W4411339305","https://openalex.org/W4411615436","https://openalex.org/W4412654956","https://openalex.org/W4412656974","https://openalex.org/W4412697112","https://openalex.org/W4413039721","https://openalex.org/W4414534381","https://openalex.org/W4414994472","https://openalex.org/W4415400207","https://openalex.org/W4416125164","https://openalex.org/W4416256765","https://openalex.org/W4416561106","https://openalex.org/W4417283871","https://openalex.org/W4417431661","https://openalex.org/W7086910113","https://openalex.org/W7117466200","https://openalex.org/W7125923447","https://openalex.org/W7130388738","https://openalex.org/W7130531826","https://openalex.org/W7150091117","https://openalex.org/W7155419477","https://openalex.org/W7167645854","https://openalex.org/W7204162310","https://openalex.org/W7206160157","https://openalex.org/W7216117764"],"related_works":["https://openalex.org/W2336469802","https://openalex.org/W3188813967","https://openalex.org/W171233382","https://openalex.org/W2311645690","https://openalex.org/W2028926100","https://openalex.org/W2750737577","https://openalex.org/W4367179931","https://openalex.org/W142416214","https://openalex.org/W2519733928","https://openalex.org/W2596120309"],"abstract_inverted_index":{"Electrospun":[0],"nanofibers":[1],"provide":[2],"high":[3],"surface":[4,22,89],"area,":[5],"interconnected":[6],"porosity,":[7],"and":[8,21,47,54,57,67,86,93,109,130,147,165,173],"extracellular-matrix-like":[9],"architectures":[10],"that":[11],"can":[12],"be":[13],"combined":[14],"with":[15,63],"controlled":[16],"degradation,":[17],"local":[18],"therapeutic":[19,76],"delivery,":[20],"biofunctionalization.":[23],"This":[24],"review":[25],"examines":[26],"bioactive":[27,142],"electrospun":[28,157],"materials":[29,159],"from":[30],"a":[31],"materials-design":[32],"perspective,":[33],"focusing":[34],"on":[35],"the":[36,154],"relationships":[37],"among":[38],"polymer":[39],"selection,":[40],"electrospinning":[41],"conditions,":[42],"fiber":[43],"architecture,":[44],"bioactive-agent":[45,166],"localization,":[46],"application-specific":[48,150],"performance.":[49],"Synthetic":[50],"biodegradable":[51],"polymers,":[52,56],"natural":[53],"bio-derived":[55],"hybrid":[58],"systems":[59],"are":[60,99,176],"discussed":[61],"together":[62],"random,":[64],"aligned,":[65],"multilayer,":[66],"core\u2013shell":[68,81],"architectures.":[69],"Bioactivation":[70],"strategies":[71],"include":[72],"direct":[73],"incorporation":[74,167],"of":[75,141,156],"agents":[77],"or":[78,111],"functional":[79,131],"nanophases,":[80],"localization":[82],"for":[83],"payload":[84],"protection":[85],"release":[87],"control,":[88],"functionalization,":[90],"endogenous-factor":[91],"recruitment,":[92],"stimulus-responsive":[94],"activation.":[95],"Three":[96],"biomedical":[97,158],"interfaces":[98],"considered":[100],"as":[101],"contrasting":[102],"application":[103],"models:":[104],"wound":[105],"dressings,":[106],"urological":[107],"repair,":[108],"implant":[110],"biomedical-device":[112],"coatings.":[113],"Their":[114],"comparison":[115],"highlights":[116],"distinct":[117],"requirements":[118],"related":[119],"to":[120,137,168],"hydration,":[121],"mechanical":[122],"loading,":[123],"microbial":[124],"exposure,":[125],"tissue":[126],"interaction,":[127],"coating\u2013substrate":[128],"integrity,":[129],"lifetime.":[132],"Particular":[133],"attention":[134],"is":[135],"given":[136],"wet-state":[138],"stability,":[139],"preservation":[140],"function,":[143],"sterilization,":[144],"manufacturing":[145],"reproducibility,":[146],"validation":[148],"against":[149],"failure":[151],"modes.":[152],"Overall,":[153],"assessment":[155],"should":[160],"extend":[161],"beyond":[162],"as-fabricated":[163],"morphology":[164],"establish":[169],"whether":[170],"structural,":[171],"interfacial,":[172],"biological":[174],"functions":[175],"retained":[177],"under":[178],"application-relevant":[179],"conditions.":[180]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}