{"id":"https://openalex.org/W7225315831","doi":"https://doi.org/10.3389/fbioe.2026.1918151","title":"Mechanisms and translational strategies for extrahepatic bile duct regeneration: a review","display_name":"Mechanisms and translational strategies for extrahepatic bile duct regeneration: a review","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225315831","doi":"https://doi.org/10.3389/fbioe.2026.1918151"},"language":"en","primary_location":{"id":"doi:10.3389/fbioe.2026.1918151","doi":"https://doi.org/10.3389/fbioe.2026.1918151","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1918151","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1918151/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1918151/pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146236970","display_name":"Xiaofan Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xiaofan Ma","raw_affiliation_strings":["Department of General Surgery, Shengjing Hospital of China Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shengjing Hospital of China Medical University","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160807724","display_name":"Yongkang Yin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yongkang Yin","raw_affiliation_strings":["Department of General Surgery, Shengjing Hospital of China Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shengjing Hospital of China Medical University","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5146177045","display_name":"Ziqi Jia","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ziqi Jia","raw_affiliation_strings":["Department of General Surgery, Shengjing Hospital of China Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shengjing Hospital of China Medical University","institution_ids":["https://openalex.org/I2800370534"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5051415080","display_name":"Ying Fan","orcid":"https://orcid.org/0000-0002-2925-507X","observed_orcids":["https://orcid.org/0000-0002-2925-507X"]},"institutions":[{"id":"https://openalex.org/I2800370534","display_name":"Sheng Jing Hospital","ror":"https://ror.org/0202bj006","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800370534"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Ying Fan","raw_affiliation_strings":["Department of General Surgery, Shengjing Hospital of China Medical University"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of General Surgery, Shengjing Hospital of China Medical University","institution_ids":["https://openalex.org/I2800370534"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5051415080"],"corresponding_institution_ids":["https://openalex.org/I2800370534"],"apc_list":{"value":3150,"currency":"CHF","value_usd":3801},"apc_paid":{"value":3150,"currency":"CHF","value_usd":3801},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"14","issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10966","display_name":"Liver physiology and pathology","score":0.7621999979019165,"subfield":{"id":"https://openalex.org/subfields/2721","display_name":"Hepatology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.1808999925851822,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10518","display_name":"Gallbladder and Bile Duct Disorders","score":0.02199999988079071,"subfield":{"id":"https://openalex.org/subfields/2715","display_name":"Gastroenterology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cholangiocytes","display_name":"cholangiocytes","score":0.8669999837875366},{"id":"https://openalex.org/keywords/peribiliary-glands","display_name":"peribiliary glands","score":0.9950000047683716},{"id":"https://openalex.org/keywords/stromal-microenvironment","display_name":"stromal microenvironment","score":0.871999979019165},{"id":"https://openalex.org/keywords/redox-regulation","display_name":"redox regulation","score":0.9580000042915344},{"id":"https://openalex.org/keywords/tissue-mechanics","display_name":"tissue mechanics","score":0.9940000176429749},{"id":"https://openalex.org/keywords/epithelial-cell-proliferation","display_name":"epithelial cell proliferation","score":0.9179999828338623},{"id":"https://openalex.org/keywords/fibrotic-remodeling","display_name":"fibrotic remodeling","score":0.8730000257492065},{"id":"https://openalex.org/keywords/cell-therapy","display_name":"cell therapy","score":0.7149999737739563},{"id":"https://openalex.org/keywords/tissue-engineering-scaffolds","display_name":"tissue engineering scaffolds","score":0.7630000114440918},{"id":"https://openalex.org/keywords/pharmacological-interventions","display_name":"pharmacological interventions","score":0.7440000176429749}],"concepts":[{"id":"https://openalex.org/C2779777945","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile duct","level":2,"score":0.7067000269889832},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5565999746322632},{"id":"https://openalex.org/C16930146","wikidata":"https://www.wikidata.org/wiki/Q4381253","display_name":"Stromal cell","level":2,"score":0.5356000065803528},{"id":"https://openalex.org/C3020000205","wikidata":"https://www.wikidata.org/wiki/Q2412849","display_name":"Narrative review","level":2,"score":0.436599999666214},{"id":"https://openalex.org/C3020610862","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue repair","level":2,"score":0.39660000801086426},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.39320001006126404},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3727000057697296},{"id":"https://openalex.org/C2781212128","wikidata":"https://www.wikidata.org/wiki/Q2256181","display_name":"Duct (anatomy)","level":2,"score":0.37059998512268066},{"id":"https://openalex.org/C2909716000","wikidata":"https://www.wikidata.org/wiki/Q460433","display_name":"Iatrogenic injury","level":2,"score":0.36090001463890076},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.3578999936580658},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.34130001068115234},{"id":"https://openalex.org/C60644358","wikidata":"https://www.wikidata.org/wiki/Q128570","display_name":"Bioinformatics","level":1,"score":0.3188999891281128},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3102000057697296},{"id":"https://openalex.org/C2775982439","wikidata":"https://www.wikidata.org/wiki/Q3562150","display_name":"Biliary tract","level":2,"score":0.3050999939441681},{"id":"https://openalex.org/C149364088","wikidata":"https://www.wikidata.org/wiki/Q185917","display_name":"Translation (biology)","level":4,"score":0.30059999227523804},{"id":"https://openalex.org/C2910372796","wikidata":"https://www.wikidata.org/wiki/Q851111","display_name":"Bile Duct Diseases","level":3,"score":0.2924000024795532},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.28780001401901245},{"id":"https://openalex.org/C541997718","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemia","level":2,"score":0.2842999994754791},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.2833000123500824},{"id":"https://openalex.org/C2910796902","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelial tissue","level":3,"score":0.2822999954223633},{"id":"https://openalex.org/C49892992","wikidata":"https://www.wikidata.org/wiki/Q1540285","display_name":"Tissue engineering","level":2,"score":0.26910001039505005},{"id":"https://openalex.org/C2780559512","wikidata":"https://www.wikidata.org/wiki/Q605709","display_name":"Fibrosis","level":2,"score":0.26739999651908875},{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.26109999418258667},{"id":"https://openalex.org/C2993714741","wikidata":"https://www.wikidata.org/wiki/Q188151","display_name":"Ischemic injury","level":3,"score":0.2515000104904175}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.3389/fbioe.2026.1918151","doi":"https://doi.org/10.3389/fbioe.2026.1918151","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1918151","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1918151/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:doaj.org/article:b61208f4c34941a59f08b368c06c0df0","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/b61208f4c34941a59f08b368c06c0df0","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Frontiers in Bioengineering and Biotechnology, Vol 14 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.3389/fbioe.2026.1918151","doi":"https://doi.org/10.3389/fbioe.2026.1918151","is_oa":true,"landing_page_url":"https://doi.org/10.3389/fbioe.2026.1918151","pdf_url":"https://www.frontiersin.org/journals/bioengineering-and-biotechnology/articles/10.3389/fbioe.2026.1918151/pdf","source":{"id":"https://openalex.org/S2595131146","display_name":"Frontiers in Bioengineering and Biotechnology","issn_l":"2296-4185","issn":["2296-4185"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","jufo-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320527","host_organization_name":"Frontiers Media","host_organization_lineage":["https://openalex.org/P4310320527"],"host_organization_lineage_names":["Frontiers Media"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Frontiers in Bioengineering and Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225315831.pdf","grobid_xml":"https://content.openalex.org/works/W7225315831.grobid-xml"},"referenced_works_count":54,"referenced_works":["https://openalex.org/W1580893558","https://openalex.org/W1780008722","https://openalex.org/W1986279293","https://openalex.org/W2071941078","https://openalex.org/W2163597980","https://openalex.org/W2220809577","https://openalex.org/W2340874693","https://openalex.org/W2706066070","https://openalex.org/W2735448218","https://openalex.org/W2765489579","https://openalex.org/W2767823610","https://openalex.org/W2902745319","https://openalex.org/W2909722404","https://openalex.org/W2944380538","https://openalex.org/W2945951917","https://openalex.org/W2970928074","https://openalex.org/W2987506313","https://openalex.org/W3003625209","https://openalex.org/W3021424058","https://openalex.org/W3112935818","https://openalex.org/W3119998677","https://openalex.org/W3129440616","https://openalex.org/W3172571061","https://openalex.org/W3194026093","https://openalex.org/W3196869859","https://openalex.org/W3200272914","https://openalex.org/W3213709423","https://openalex.org/W4200044553","https://openalex.org/W4210445166","https://openalex.org/W4225256535","https://openalex.org/W4225464088","https://openalex.org/W4286767150","https://openalex.org/W4306654043","https://openalex.org/W4307923466","https://openalex.org/W4308638870","https://openalex.org/W4311582579","https://openalex.org/W4318933541","https://openalex.org/W4366605275","https://openalex.org/W4386337255","https://openalex.org/W4387522994","https://openalex.org/W4388020857","https://openalex.org/W4391102482","https://openalex.org/W4398761918","https://openalex.org/W4400015256","https://openalex.org/W4402338923","https://openalex.org/W4405032124","https://openalex.org/W4405992463","https://openalex.org/W4412087159","https://openalex.org/W4412491719","https://openalex.org/W4413116161","https://openalex.org/W4413352512","https://openalex.org/W4415190327","https://openalex.org/W4416252853","https://openalex.org/W7128799911"],"related_works":["https://openalex.org/W2039686383","https://openalex.org/W4396959463","https://openalex.org/W4413116161","https://openalex.org/W4281641942","https://openalex.org/W2706066070","https://openalex.org/W2088859734","https://openalex.org/W4415190327","https://openalex.org/W2096103464","https://openalex.org/W2002266653","https://openalex.org/W3110664453"],"abstract_inverted_index":{"Extrahepatic":[0],"bile":[1],"duct":[2],"(EHBD)":[3],"injury":[4,87],"remains":[5,93],"a":[6],"major":[7],"challenge":[8],"in":[9],"hepatobiliary":[10],"medicine,":[11],"because":[12],"effective":[13],"repair":[14],"requires":[15],"sustained":[16,108],"epithelial":[17,59,76,105],"integrity,":[18],"structural":[19,80],"continuity,":[20],"and":[21,41,50,61,82,88,107,122],"luminal":[22],"patency.":[23],"In":[24],"this":[25],"narrative":[26],"review,":[27],"we":[28],"examine":[29],"the":[30,42],"biological":[31],"basis":[32],"of":[33,115],"EHBD":[34],"regeneration,":[35],"focusing":[36],"on":[37],"cholangiocytes,":[38],"peribiliary":[39],"glands":[40],"surrounding":[43],"stromal":[44],"microenvironment.":[45],"We":[46,64],"highlight":[47],"redox":[48],"regulation":[49],"tissue":[51],"mechanics,":[52],"along":[53],"with":[54,96,119],"signaling":[55],"pathways":[56],"that":[57],"influence":[58],"proliferation":[60],"fibrotic":[62],"remodeling.":[63],"also":[65],"compare":[66],"regenerative":[67],"strategies":[68],"by":[69],"intended":[70],"application,":[71],"including":[72],"cell-based":[73],"approaches":[74],"for":[75,79],"restoration,":[77],"scaffolds":[78],"reconstruction,":[81],"pharmacological":[83],"interventions":[84],"to":[85],"modify":[86],"repair.":[89],"However,":[90],"current":[91],"evidence":[92],"predominantly":[94],"experimental,":[95],"limited":[97],"clinical":[98],"validation.":[99],"Future":[100],"translation":[101],"will":[102],"require":[103],"functional":[104],"recovery":[106],"patency":[109],"beyond":[110],"scaffold":[111],"degradation":[112],"or":[113],"withdrawal":[114],"temporary":[116],"support,":[117],"together":[118],"reproducible":[120],"manufacturing":[121],"safety":[123],"assessment.":[124]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
