{"id":"https://openalex.org/W7225312364","doi":"https://doi.org/10.1111/febs.70786","title":"PDCD10 \u2010 STK24 /25 signaling is a gatekeeper of tubular cell homeostasis and protects against chronic kidney disease","display_name":"PDCD10 \u2010 STK24 /25 signaling is a gatekeeper of tubular cell homeostasis and protects against chronic kidney disease","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225312364","doi":"https://doi.org/10.1111/febs.70786","pmid":"https://pubmed.ncbi.nlm.nih.gov/42984450"},"language":"en","primary_location":{"id":"doi:10.1111/febs.70786","doi":"https://doi.org/10.1111/febs.70786","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.70786","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5100408467","display_name":"Yixuan Wang","orcid":"https://orcid.org/0000-0002-4154-5934","observed_orcids":["https://orcid.org/0000-0002-4154-5934"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yixuan Wang","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5005380670","display_name":"Yang Xi","orcid":"https://orcid.org/0000-0002-0648-1728","observed_orcids":["https://orcid.org/0000-0002-0648-1728"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210167311","display_name":"Institute of Zoology","ror":"https://ror.org/05skxkv18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]},{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xi Yang","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology, Chinese Academy of Sciences  Beijing China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]},{"raw_affiliation_string":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology, Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160964196","display_name":"Min Zheng","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Min Zheng","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160801533","display_name":"Junxia Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Junxia Zhang","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114152175","display_name":"Baotao Ma","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Baotao Ma","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160777913","display_name":"Lirong Zhu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Lirong Zhu","raw_affiliation_strings":["Department of Bioinformatics, School of Basic Medical Sciences Tianjin Medical University  Tianjin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Bioinformatics, School of Basic Medical Sciences Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160831042","display_name":"Jieying Zhang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jieying Zhang","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5079744067","display_name":"Renjing Liu","orcid":"https://orcid.org/0000-0001-9099-0076","observed_orcids":["https://orcid.org/0000-0001-9099-0076"]},"institutions":[{"id":"https://openalex.org/I19514445","display_name":"Victor Chang Cardiac Research Institute","ror":"https://ror.org/03trvqr13","country_code":"AU","type":"nonprofit","lineage":["https://openalex.org/I19514445"]},{"id":"https://openalex.org/I31746571","display_name":"UNSW Sydney","ror":"https://ror.org/03r8z3t63","country_code":"AU","type":"education","lineage":["https://openalex.org/I31746571"]}],"countries":["AU"],"is_corresponding":true,"raw_author_name":"Renjing Liu","raw_affiliation_strings":["Vascular Epigenetics Laboratory, School of Clinical Medicine, Faculty of Medicine and Health Victor Chang Cardiac Research Institute, University of New South Wales  Sydney Australia"],"raw_orcid":"https://orcid.org/0000-0001-9099-0076","affiliations":[{"raw_affiliation_string":"Vascular Epigenetics Laboratory, School of Clinical Medicine, Faculty of Medicine and Health Victor Chang Cardiac Research Institute, University of New South Wales  Sydney Australia","institution_ids":["https://openalex.org/I19514445","https://openalex.org/I31746571"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5041103773","display_name":"Zhiming Han","orcid":"https://orcid.org/0000-0003-0997-1236","observed_orcids":["https://orcid.org/0000-0003-0997-1236"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210167311","display_name":"Institute of Zoology","ror":"https://ror.org/05skxkv18","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]},{"id":"https://openalex.org/I4405265004","display_name":"Beijing Institute for Stem Cell and Regenerative Medicine","ror":"https://ror.org/03jqz2y95","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4405265004"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Zhiming Han","raw_affiliation_strings":["Beijing Institute for Stem Cell and Regenerative Medicine  Beijing China","State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology, Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0000-0003-0997-1236","affiliations":[{"raw_affiliation_string":"Beijing Institute for Stem Cell and Regenerative Medicine  Beijing China","institution_ids":["https://openalex.org/I4405265004"]},{"raw_affiliation_string":"State Key Laboratory of Organ Regeneration and Reconstruction Institute of Zoology, Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210167311"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5080273967","display_name":"Xiangjian Zheng","orcid":"https://orcid.org/0000-0001-6277-5168","observed_orcids":["https://orcid.org/0000-0001-6277-5168","https://orcid.org/0000-0002-9570-1269"]},"institutions":[{"id":"https://openalex.org/I5740404","display_name":"Tianjin Medical University","ror":"https://ror.org/02mh8wx89","country_code":"CN","type":"education","lineage":["https://openalex.org/I5740404"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Xiangjian Zheng","raw_affiliation_strings":["Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China"],"raw_orcid":"https://orcid.org/0000-0001-6277-5168","affiliations":[{"raw_affiliation_string":"Department of Pharmacology, Tianjin Key Laboratory of Inflammation Biology, School of Basic Medical Sciences, Center for Cardiovascular Diseases Tianjin Medical University  Tianjin China","institution_ids":["https://openalex.org/I5740404"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5041103773","https://openalex.org/A5079744067","https://openalex.org/A5080273967"],"corresponding_institution_ids":["https://openalex.org/I19514445","https://openalex.org/I19820366","https://openalex.org/I31746571","https://openalex.org/I4210167311","https://openalex.org/I4405265004","https://openalex.org/I5740404"],"apc_list":{"value":5000,"currency":"USD","value_usd":5000},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10684","display_name":"Acute Kidney Injury Research","score":0.7310000061988831,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10408","display_name":"Chronic Kidney Disease and Diabetes","score":0.10599999874830246,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11029","display_name":"Renal Diseases and Glomerulopathies","score":0.09700000286102295,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/pdcd10","display_name":"PDCD10","score":0.9430000185966492},{"id":"https://openalex.org/keywords/stk25","display_name":"STK25","score":1.0},{"id":"https://openalex.org/keywords/chronic-kidney-disease","display_name":"chronic kidney disease","score":0.8199999928474426},{"id":"https://openalex.org/keywords/neutrophil-gelatinase-associated-lipocalin","display_name":"neutrophil gelatinase-associated lipocalin","score":0.7329999804496765},{"id":"https://openalex.org/keywords/complement-pathway","display_name":"complement pathway","score":0.6589999794960022},{"id":"https://openalex.org/keywords/renal-inflammation","display_name":"renal inflammation","score":0.7229999899864197},{"id":"https://openalex.org/keywords/tubulointerstitial-injury","display_name":"tubulointerstitial injury","score":0.8659999966621399},{"id":"https://openalex.org/keywords/kidney-failure","display_name":"renal failure","score":0.8209999799728394}],"concepts":[{"id":"https://openalex.org/C2780091579","wikidata":"https://www.wikidata.org/wiki/Q9377","display_name":"Kidney","level":2,"score":0.7168999910354614},{"id":"https://openalex.org/C2781231759","wikidata":"https://www.wikidata.org/wiki/Q58184","display_name":"Nephron","level":3,"score":0.6894000172615051},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.6345999836921692},{"id":"https://openalex.org/C2778653478","wikidata":"https://www.wikidata.org/wiki/Q1054718","display_name":"Kidney disease","level":2,"score":0.6136999726295471},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5809999704360962},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5149999856948853},{"id":"https://openalex.org/C20299238","wikidata":"https://www.wikidata.org/wiki/Q363928","display_name":"Lipocalin","level":2,"score":0.5029000043869019},{"id":"https://openalex.org/C2780472472","wikidata":"https://www.wikidata.org/wiki/Q424337","display_name":"Acute kidney injury","level":2,"score":0.4731999933719635},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.4357999861240387},{"id":"https://openalex.org/C63645605","wikidata":"https://www.wikidata.org/wiki/Q103191","display_name":"Homeostasis","level":2,"score":0.4189000129699707},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.396699994802475},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.384799987077713},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.37299999594688416},{"id":"https://openalex.org/C12387725","wikidata":"https://www.wikidata.org/wiki/Q937024","display_name":"Phenocopy","level":4,"score":0.3452000021934509},{"id":"https://openalex.org/C529295009","wikidata":"https://www.wikidata.org/wiki/Q41301","display_name":"Epithelium","level":2,"score":0.3447999954223633},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3424000144004822},{"id":"https://openalex.org/C138798377","wikidata":"https://www.wikidata.org/wiki/Q7312502","display_name":"Renal stem cell","level":4,"score":0.3400000035762787},{"id":"https://openalex.org/C2777632694","wikidata":"https://www.wikidata.org/wiki/Q2336077","display_name":"Kidney development","level":4,"score":0.3391999900341034},{"id":"https://openalex.org/C54847362","wikidata":"https://www.wikidata.org/wiki/Q177635","display_name":"Nephrology","level":2,"score":0.33899998664855957},{"id":"https://openalex.org/C162317418","wikidata":"https://www.wikidata.org/wiki/Q252857","display_name":"Transcriptome","level":4,"score":0.337799996137619},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.33500000834465027},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.3328999876976013},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3239000141620636},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.32269999384880066},{"id":"https://openalex.org/C2991844318","wikidata":"https://www.wikidata.org/wiki/Q476921","display_name":"Renal injury","level":3,"score":0.2976999878883362},{"id":"https://openalex.org/C56906281","wikidata":"https://www.wikidata.org/wiki/Q4391435","display_name":"Reabsorption","level":3,"score":0.2921000123023987},{"id":"https://openalex.org/C2780942790","wikidata":"https://www.wikidata.org/wiki/Q372016","display_name":"Pathogenesis","level":2,"score":0.29190000891685486},{"id":"https://openalex.org/C203014093","wikidata":"https://www.wikidata.org/wiki/Q101929","display_name":"Immunology","level":1,"score":0.27399998903274536},{"id":"https://openalex.org/C136449434","wikidata":"https://www.wikidata.org/wiki/Q428253","display_name":"Innate immune system","level":3,"score":0.26460000872612},{"id":"https://openalex.org/C127716648","wikidata":"https://www.wikidata.org/wiki/Q104053","display_name":"Phenotype","level":3,"score":0.262800008058548},{"id":"https://openalex.org/C182704531","wikidata":"https://www.wikidata.org/wiki/Q1364740","display_name":"Knockout mouse","level":3,"score":0.25049999356269836},{"id":"https://openalex.org/C2778437025","wikidata":"https://www.wikidata.org/wiki/Q7850936","display_name":"Tubular fluid","level":4,"score":0.25}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1111/febs.70786","doi":"https://doi.org/10.1111/febs.70786","is_oa":false,"landing_page_url":"https://doi.org/10.1111/febs.70786","pdf_url":null,"source":{"id":"https://openalex.org/S37672443","display_name":"FEBS Journal","issn_l":"1742-464X","issn":["1742-464X","1742-4658"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["cwts-core","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS Journal","raw_type":"journal-article"},{"id":"pmid:42984450","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42984450","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"The FEBS journal","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320321001","display_name":"National Natural Science Foundation of China","ror":"https://ror.org/01h0zpd94"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":42,"referenced_works":["https://openalex.org/W1858957840","https://openalex.org/W1964405385","https://openalex.org/W1977732091","https://openalex.org/W2001370885","https://openalex.org/W2002240598","https://openalex.org/W2018343961","https://openalex.org/W2025914300","https://openalex.org/W2039294916","https://openalex.org/W2041736631","https://openalex.org/W2045421375","https://openalex.org/W2066031882","https://openalex.org/W2074214268","https://openalex.org/W2088454405","https://openalex.org/W2104473080","https://openalex.org/W2136066292","https://openalex.org/W2137321379","https://openalex.org/W2138561620","https://openalex.org/W2176521677","https://openalex.org/W2415942083","https://openalex.org/W2800146875","https://openalex.org/W2972792305","https://openalex.org/W2986414847","https://openalex.org/W3117130981","https://openalex.org/W3123923504","https://openalex.org/W3127407868","https://openalex.org/W3174492734","https://openalex.org/W3177168460","https://openalex.org/W4224243429","https://openalex.org/W4229508150","https://openalex.org/W4302362767","https://openalex.org/W4386132991","https://openalex.org/W4388765001","https://openalex.org/W4393854155","https://openalex.org/W4394768552","https://openalex.org/W4399352421","https://openalex.org/W4401558282","https://openalex.org/W4404611508","https://openalex.org/W4406861092","https://openalex.org/W4408491157","https://openalex.org/W4411317497","https://openalex.org/W4412465698","https://openalex.org/W4416660269"],"related_works":["https://openalex.org/W2044747742","https://openalex.org/W4403812256","https://openalex.org/W2766305969","https://openalex.org/W6891665620","https://openalex.org/W4386458460","https://openalex.org/W7154994596","https://openalex.org/W7202270610","https://openalex.org/W7170502690","https://openalex.org/W4396988962","https://openalex.org/W4397025036"],"abstract_inverted_index":{"Inherited":[0],"tubulopathies":[1],"or":[2],"injured":[3],"kidney":[4,16,20,84],"tubules":[5,169],"can":[6],"initiate":[7],"inflammatory":[8,75],"signaling":[9,183],"and":[10,19,66,78,86,92,124,138,165],"drive":[11],"the":[12,90,115,160],"progression":[13,210],"of":[14,48,69,112,141,156,163],"chronic":[15,58],"disease":[17],"(CKD)":[18],"failure.":[21],"The":[22],"early":[23,87,197],"molecular":[24],"triggers":[25],"connecting":[26],"tubular":[27,70,198],"dysfunction":[28],"to":[29,83],"sustained":[30],"renal":[31,59,117,122,188],"inflammation":[32],"remain":[33],"poorly":[34],"defined.":[35],"Here,":[36],"we":[37],"show":[38],"that":[39,56,181,196,206],"deleting":[40],"Pdcd10,":[41],"specifically":[42],"in":[43,107,114,129,144,147,167],"distal":[44,130,168],"nephron":[45],"epithelial":[46,118,189,212],"cells":[47,119],"mice,":[49],"causes":[50],"a":[51,99,203],"rapid":[52],"intrinsic":[53],"injury":[54,101,123],"response":[55,205],"precipitates":[57],"damage.":[60],"Pdcd10-deficient":[61,108],"kidneys":[62],"exhibit":[63],"an":[64],"immediate":[65],"robust":[67],"upregulation":[68],"injury-response":[71],"genes,":[72],"followed":[73],"by":[74],"cell":[76,190],"infiltration,":[77],"progressive":[79],"tubulointerstitial":[80],"damage":[81],"leading":[82],"failure":[85],"mortality.":[88],"Among":[89],"earliest":[91],"most":[93],"strongly":[94],"induced":[95],"genes":[96,137],"is":[97,184],"Lcn2,":[98],"known":[100,151],"marker,":[102],"whose":[103],"expression":[104],"increases":[105],"significantly":[106],"kidneys.":[109],"Concurrent":[110],"deletion":[111,162],"Lcn2":[113,199],"same":[116],"further":[120],"exacerbates":[121],"shortens":[125],"survival.":[126],"Pdcd10":[127,171],"deficiency":[128],"nephrons":[131],"also":[132],"upregulates":[133],"multiple":[134],"complement":[135,142],"pathway":[136],"promotes":[139],"accumulation":[140],"complexes":[143],"glomeruli.":[145],"Finally,":[146],"line":[148],"with":[149,153,175],"PCDC10's":[150],"interaction":[152],"GCKIII":[154],"subfamily":[155],"sterile-20":[157],"like":[158],"kinases,":[159],"combined":[161],"Stk24":[164],"Stk25":[166],"phenocopies":[170],"knockout":[172],"phenotype,":[173],"albeit":[174],"later":[176],"onset.":[177],"Our":[178],"results":[179],"demonstrate":[180],"PDCD10-STK24/25":[182],"essential":[185],"for":[186],"maintaining":[187],"homeostasis.":[191],"Additionally,":[192],"our":[193],"findings":[194],"reveal":[195],"induction":[200],"serves":[201],"as":[202],"protective":[204],"helps":[207],"limit":[208],"CKD":[209],"following":[211],"injury.":[213]},"counts_by_year":[],"updated_date":"2026-11-07T11:25:07.637180","created_date":"2026-11-06T00:00:00"}
