{"id":"https://openalex.org/W7225312196","doi":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","title":"Bridging laboratory and clinical practice: timelines and challenges in wet lab research","display_name":"Bridging laboratory and clinical practice: timelines and challenges in wet lab research","publication_year":2026,"publication_date":"2026-11-06","ids":{"openalex":"https://openalex.org/W7225312196","doi":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","pmid":"https://pubmed.ncbi.nlm.nih.gov/42987941","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13739427"},"language":"en","primary_location":{"id":"doi:10.1302/2046-3758.1511.bjr-2026-0221.r1","doi":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","is_oa":true,"landing_page_url":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","pdf_url":"https://boneandjoint.org.uk/article/10.1302/2046-3758.1511.BJR-2026-0221.R1/pdf","source":{"id":"https://openalex.org/S2765027627","display_name":"Bone and Joint Research","issn_l":"2046-3758","issn":["2046-3758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311768","host_organization_name":"Journal of Bone and Joint Surgery","host_organization_lineage":["https://openalex.org/P4310311768"],"host_organization_lineage_names":["Journal of Bone and Joint Surgery"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone & Joint Research","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://boneandjoint.org.uk/article/10.1302/2046-3758.1511.BJR-2026-0221.R1/pdf","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5012583385","display_name":"Nisreen Mohammed Al-Namnam","orcid":"https://orcid.org/0000-0003-1832-8496","observed_orcids":["https://orcid.org/0000-0003-1832-8496"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":true,"raw_author_name":"Nisreen Al-Namnam","raw_affiliation_strings":["Department of Orthopaedics and Trauma, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":"https://orcid.org/0000-0003-1832-8496","affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Trauma, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5104199726","display_name":"Steph Collishaw","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Steph Collishaw","raw_affiliation_strings":["Department of Orthopaedics and Trauma, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Trauma, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5038793046","display_name":"Melanie Wheeldon","orcid":"https://orcid.org/0000-0002-3575-5767","observed_orcids":["https://orcid.org/0000-0002-3575-5767"]},"institutions":[{"id":"https://openalex.org/I98677209","display_name":"University of Edinburgh","ror":"https://ror.org/01nrxwf90","country_code":"GB","type":"education","lineage":["https://openalex.org/I98677209"]}],"countries":["GB"],"is_corresponding":false,"raw_author_name":"Melanie Wheeldon","raw_affiliation_strings":["Department of Orthopaedics and Trauma, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Orthopaedics and Trauma, College of Medicine and Veterinary Medicine, University of Edinburgh, Edinburgh, UK","institution_ids":["https://openalex.org/I98677209"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":["https://openalex.org/A5012583385"],"corresponding_institution_ids":["https://openalex.org/I98677209"],"apc_list":{"value":1300,"currency":"GBP","value_usd":1594},"apc_paid":{"value":1300,"currency":"GBP","value_usd":1594},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"11","first_page":"1350","last_page":"1353"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12168","display_name":"Health and Medical Research Impacts","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T12168","display_name":"Health and Medical Research Impacts","score":0.9965999722480774,"subfield":{"id":"https://openalex.org/subfields/2739","display_name":"Public Health, Environmental and Occupational Health"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12766","display_name":"Interdisciplinary Research and Collaboration","score":0.003000000026077032,"subfield":{"id":"https://openalex.org/subfields/1207","display_name":"History and Philosophy of Science"},"field":{"id":"https://openalex.org/fields/12","display_name":"Arts and Humanities"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T14185","display_name":"Research, Science, and Academia","score":9.999999747378752e-05,"subfield":{"id":"https://openalex.org/subfields/1405","display_name":"Management of Technology and Innovation"},"field":{"id":"https://openalex.org/fields/14","display_name":"Business, Management and Accounting"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/surgical-residents","display_name":"surgical residents","score":0.7559999823570251},{"id":"https://openalex.org/keywords/orthopaedic-research","display_name":"orthopaedic research","score":0.6480000019073486},{"id":"https://openalex.org/keywords/research-timeline","display_name":"research timeline","score":0.6650000214576721},{"id":"https://openalex.org/keywords/tissue-handling","display_name":"tissue handling","score":0.9760000109672546},{"id":"https://openalex.org/keywords/assay-optimization","display_name":"assay optimization","score":0.9610000252723694},{"id":"https://openalex.org/keywords/regulatory-approval","display_name":"regulatory approval","score":0.7770000100135803},{"id":"https://openalex.org/keywords/clinician-scientist-collaboration","display_name":"clinician-scientist collaboration","score":0.7919999957084656},{"id":"https://openalex.org/keywords/reproducibility","display_name":"reproducibility","score":0.9610000252723694}],"concepts":[{"id":"https://openalex.org/C4438859","wikidata":"https://www.wikidata.org/wiki/Q186117","display_name":"Timeline","level":2,"score":0.9247000217437744},{"id":"https://openalex.org/C22467394","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary approach","level":2,"score":0.6502000093460083},{"id":"https://openalex.org/C174348530","wikidata":"https://www.wikidata.org/wiki/Q188635","display_name":"Bridging (networking)","level":2,"score":0.5490999817848206},{"id":"https://openalex.org/C509550671","wikidata":"https://www.wikidata.org/wiki/Q126945","display_name":"Medical education","level":1,"score":0.5012000203132629},{"id":"https://openalex.org/C55587333","wikidata":"https://www.wikidata.org/wiki/Q1133029","display_name":"Engineering ethics","level":1,"score":0.45820000767707825},{"id":"https://openalex.org/C127413603","wikidata":"https://www.wikidata.org/wiki/Q11023","display_name":"Engineering","level":0,"score":0.4458000063896179},{"id":"https://openalex.org/C18762648","wikidata":"https://www.wikidata.org/wiki/Q42213","display_name":"Work (physics)","level":2,"score":0.41280001401901245},{"id":"https://openalex.org/C110354214","wikidata":"https://www.wikidata.org/wiki/Q6314146","display_name":"Engineering management","level":1,"score":0.3785000145435333},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.34049999713897705},{"id":"https://openalex.org/C19527891","wikidata":"https://www.wikidata.org/wiki/Q1120908","display_name":"Medical physics","level":1,"score":0.30059999227523804},{"id":"https://openalex.org/C3020000666","wikidata":"https://www.wikidata.org/wiki/Q17112037","display_name":"Bench to bedside","level":2,"score":0.2996000051498413},{"id":"https://openalex.org/C2993043200","wikidata":"https://www.wikidata.org/wiki/Q7239206","display_name":"Preclinical research","level":2,"score":0.2994000017642975},{"id":"https://openalex.org/C128544194","wikidata":"https://www.wikidata.org/wiki/Q474859","display_name":"Translational research","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C2989236134","wikidata":"https://www.wikidata.org/wiki/Q31207","display_name":"Patient care","level":2,"score":0.28600001335144043},{"id":"https://openalex.org/C15744967","wikidata":"https://www.wikidata.org/wiki/Q9418","display_name":"Psychology","level":0,"score":0.28220000863075256},{"id":"https://openalex.org/C2986762682","wikidata":"https://www.wikidata.org/wiki/Q964754","display_name":"Basic research","level":2,"score":0.26669999957084656},{"id":"https://openalex.org/C2780616401","wikidata":"https://www.wikidata.org/wiki/Q1133673","display_name":"Cornerstone","level":2,"score":0.265500009059906},{"id":"https://openalex.org/C41008148","wikidata":"https://www.wikidata.org/wiki/Q21198","display_name":"Computer science","level":0,"score":0.2558000087738037},{"id":"https://openalex.org/C3020501284","wikidata":"https://www.wikidata.org/wiki/Q849359","display_name":"Multidisciplinary team","level":2,"score":0.25540000200271606},{"id":"https://openalex.org/C2781400479","wikidata":"https://www.wikidata.org/wiki/Q11640","display_name":"Outreach","level":2,"score":0.25029999017715454}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1302/2046-3758.1511.bjr-2026-0221.r1","doi":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","is_oa":true,"landing_page_url":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","pdf_url":"https://boneandjoint.org.uk/article/10.1302/2046-3758.1511.BJR-2026-0221.R1/pdf","source":{"id":"https://openalex.org/S2765027627","display_name":"Bone and Joint Research","issn_l":"2046-3758","issn":["2046-3758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311768","host_organization_name":"Journal of Bone and Joint Surgery","host_organization_lineage":["https://openalex.org/P4310311768"],"host_organization_lineage_names":["Journal of Bone and Joint Surgery"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone & Joint Research","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13739427","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13739427/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13739427/pdf/BJR-15-2046-3758.1511.BJR-2026-0221.R1.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone Joint Res","raw_type":"Text"},{"id":"pmid:42987941","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42987941","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone & joint research","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1302/2046-3758.1511.bjr-2026-0221.r1","doi":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","is_oa":true,"landing_page_url":"https://doi.org/10.1302/2046-3758.1511.bjr-2026-0221.r1","pdf_url":"https://boneandjoint.org.uk/article/10.1302/2046-3758.1511.BJR-2026-0221.R1/pdf","source":{"id":"https://openalex.org/S2765027627","display_name":"Bone and Joint Research","issn_l":"2046-3758","issn":["2046-3758"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310311768","host_organization_name":"Journal of Bone and Joint Surgery","host_organization_lineage":["https://openalex.org/P4310311768"],"host_organization_lineage_names":["Journal of Bone and Joint Surgery"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Bone & Joint Research","raw_type":"journal-article"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225312196.pdf","grobid_xml":"https://content.openalex.org/works/W7225312196.grobid-xml"},"referenced_works_count":9,"referenced_works":["https://openalex.org/W198705282","https://openalex.org/W2020782362","https://openalex.org/W2081732737","https://openalex.org/W2098136907","https://openalex.org/W3112323886","https://openalex.org/W4292244520","https://openalex.org/W4409706096","https://openalex.org/W4412586119","https://openalex.org/W4413966794"],"related_works":["https://openalex.org/W2004880386","https://openalex.org/W4409230691","https://openalex.org/W310006252","https://openalex.org/W117455793","https://openalex.org/W127266027","https://openalex.org/W2401929182","https://openalex.org/W2905098216","https://openalex.org/W47983627","https://openalex.org/W165535535","https://openalex.org/W2041148441"],"abstract_inverted_index":{"For":[0],"surgical":[1],"trainees":[2,89],"embarking":[3],"on":[4,37,53],"a":[5,32,58],"period":[6],"of":[7,49,57,114],"laboratory":[8,34,66],"research,":[9],"the":[10,47,54],"transition":[11],"from":[12],"operating":[13],"theatre":[14],"to":[15,97,130],"bench":[16],"science":[17],"can":[18,116],"be":[19,44],"both":[20],"rewarding":[21],"and":[22,73,87,110,125,134,141],"disorienting.":[23],"This":[24],"annotation":[25],"is":[26,95],"written":[27],"specifically":[28],"for":[29,77],"clinicians":[30],"entering":[31],"wet":[33],"environment,":[35],"typically":[36],"an":[38],"out-of-programme":[39],"research":[40,61,85],"placement,":[41],"who":[42],"may":[43],"unfamiliar":[45],"with":[46],"realities":[48],"experimental":[50,98],"science.":[51],"Drawing":[52],"first-hand":[55],"experiences":[56],"multidisciplinary":[59],"orthopaedic":[60],"team,":[62],"it":[63],"explains":[64],"why":[65],"timelines":[67],"are":[68,128,138],"often":[69],"longer":[70],"than":[71],"expected,":[72],"offers":[74],"practical":[75],"guidance":[76],"working":[78],"effectively":[79],"alongside":[80],"PhD-level":[81],"scientists,":[82],"postdoctoral":[83],"researchers,":[84],"technicians,":[86],"their":[88],"-":[90],"collaborators":[91],"whose":[92],"technical":[93],"expertise":[94],"indispensable":[96],"success.":[99],"Wet":[100],"lab":[101],"work":[102],"involves":[103],"complex":[104],"protocols,":[105],"tissue":[106],"handling,":[107],"assay":[108],"optimization,":[109],"regulatory":[111],"approvals,":[112],"all":[113],"which":[115],"significantly":[117],"extend":[118],"project":[119],"timelines.":[120],"Effective":[121],"communication,":[122],"realistic":[123],"planning,":[124],"mutual":[126],"respect":[127],"crucial":[129],"manage":[131],"unforeseen":[132],"challenges":[133],"ensure":[135],"that":[136],"experiments":[137],"reliable,":[139],"reproducible,":[140],"clinically":[142],"meaningful.":[143]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}