{"id":"https://openalex.org/W7225308489","doi":"https://doi.org/10.1002/cam4.72249","title":"Oncogenic hsa_circ_0000247 Promotes Breast Cancer Malignancy Through hsa\u2010let\u20107i\u20105p Sponging\u2010Mediated HMGA1 Upregulation","display_name":"Oncogenic hsa_circ_0000247 Promotes Breast Cancer Malignancy Through hsa\u2010let\u20107i\u20105p Sponging\u2010Mediated HMGA1 Upregulation","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225308489","doi":"https://doi.org/10.1002/cam4.72249","pmid":"https://pubmed.ncbi.nlm.nih.gov/42984310","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735887"},"language":"en","primary_location":{"id":"doi:10.1002/cam4.72249","doi":"https://doi.org/10.1002/cam4.72249","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.72249","pdf_url":null,"source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/cam4.72249","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160820771","display_name":"Mingming Qin","orcid":"https://orcid.org/0009-0009-7279-4827","observed_orcids":["https://orcid.org/0009-0009-7279-4827"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Mingming Qin","raw_affiliation_strings":["Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":"https://orcid.org/0009-0009-7279-4827","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5014896488","display_name":"Xue Chai","orcid":"https://orcid.org/0000-0002-9398-0305","observed_orcids":["https://orcid.org/0000-0002-9398-0305"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Xue Chai","raw_affiliation_strings":["Department of Urology The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Urology The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160736345","display_name":"Kai Ye","orcid":"https://orcid.org/0009-0004-0852-0577","observed_orcids":["https://orcid.org/0009-0004-0852-0577"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Kai Ye","raw_affiliation_strings":["Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":"https://orcid.org/0009-0004-0852-0577","affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5112888720","display_name":"Ping Zhu","orcid":"https://orcid.org/0000-0002-3480-2488","observed_orcids":["https://orcid.org/0000-0002-3480-2488"]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Ping Zhu","raw_affiliation_strings":["Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5126350172","display_name":"Tong Lu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tong Lu","raw_affiliation_strings":["Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5034766806","display_name":"Zhifeng Hu","orcid":"https://orcid.org/0009-0001-5158-2632","observed_orcids":["https://orcid.org/0009-0001-5158-2632"]},"institutions":[{"id":"https://openalex.org/I4210167381","display_name":"First Affiliated Hospital of Wannan Medical College","ror":"https://ror.org/05wbpaf14","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210167381"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhifeng Hu","raw_affiliation_strings":["Interventional Department The First Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Interventional Department The First Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I4210167381"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160737646","display_name":"Zhiyong Zhao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Zhiyong Zhao","raw_affiliation_strings":["Department of Thyroid and Breast Surgery The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast Surgery The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160867887","display_name":"Jun Bao","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jun Bao","raw_affiliation_strings":["Department of Thyroid and Breast Surgery The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Thyroid and Breast Surgery The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160736587","display_name":"Jing Wu","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I100357981","display_name":"Wannan Medical College","ror":"https://ror.org/037ejjy86","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I100357981"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jing Wu","raw_affiliation_strings":["Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Laboratory Medicine The Second Affiliated Hospital of Wannan Medical College  Wuhu Anhui P.R. China","institution_ids":["https://openalex.org/I100357981"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":["https://openalex.org/A5160736587","https://openalex.org/A5160867887"],"corresponding_institution_ids":["https://openalex.org/I100357981"],"apc_list":{"value":4700,"currency":"USD","value_usd":4700},"apc_paid":{"value":4700,"currency":"USD","value_usd":4700},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72778783,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"15","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T11765","display_name":"Circular RNAs in diseases","score":1.0,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10515","display_name":"Cancer-related molecular mechanisms research","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10062","display_name":"MicroRNA in disease regulation","score":0.0,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/circular-rna","display_name":"circular RNA","score":0.9259999990463257},{"id":"https://openalex.org/keywords/breast-cancer","display_name":"breast cancer","score":0.9150000214576721},{"id":"https://openalex.org/keywords/hmga1","display_name":"HMGA1","score":0.9610000252723694},{"id":"https://openalex.org/keywords/microrna-sponging","display_name":"microRNA sponging","score":0.8880000114440918},{"id":"https://openalex.org/keywords/3-untranslated-region","display_name":"3' untranslated region","score":0.6639999747276306},{"id":"https://openalex.org/keywords/oncogenic-circular-rna","display_name":"oncogenic circular RNA","score":0.7369999885559082},{"id":"https://openalex.org/keywords/cell-proliferation","display_name":"cell proliferation","score":0.8619999885559082},{"id":"https://openalex.org/keywords/cell-migration-and-invasion","display_name":"cell migration and invasion","score":0.9409999847412109},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.9440000057220459},{"id":"https://openalex.org/keywords/tumor-progression","display_name":"tumor progression","score":0.4779999852180481},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.7009999752044678}],"concepts":[{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.8830000162124634},{"id":"https://openalex.org/C173396325","wikidata":"https://www.wikidata.org/wiki/Q1501275","display_name":"Gene knockdown","level":3,"score":0.7771000266075134},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.7426000237464905},{"id":"https://openalex.org/C530470458","wikidata":"https://www.wikidata.org/wiki/Q128581","display_name":"Breast cancer","level":3,"score":0.6442999839782715},{"id":"https://openalex.org/C2779399171","wikidata":"https://www.wikidata.org/wiki/Q1483951","display_name":"Malignancy","level":2,"score":0.5846999883651733},{"id":"https://openalex.org/C179185449","wikidata":"https://www.wikidata.org/wiki/Q219699","display_name":"Suppressor","level":3,"score":0.5532000064849854},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.5001000165939331},{"id":"https://openalex.org/C121608353","wikidata":"https://www.wikidata.org/wiki/Q12078","display_name":"Cancer","level":2,"score":0.4708000123500824},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.4569000005722046},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.41850000619888306},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.390500009059906},{"id":"https://openalex.org/C14036430","wikidata":"https://www.wikidata.org/wiki/Q3736076","display_name":"Function (biology)","level":2,"score":0.30880001187324524},{"id":"https://openalex.org/C96232424","wikidata":"https://www.wikidata.org/wiki/Q4118072","display_name":"Cancer cell","level":3,"score":0.303600013256073},{"id":"https://openalex.org/C2779013556","wikidata":"https://www.wikidata.org/wiki/Q181876","display_name":"Metastasis","level":3,"score":0.30000001192092896},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.29350000619888306},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.28850001096725464},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.287200003862381},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.28209999203681946},{"id":"https://openalex.org/C62203573","wikidata":"https://www.wikidata.org/wiki/Q15087973","display_name":"Long non-coding RNA","level":4,"score":0.28130000829696655},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.26829999685287476}],"mesh":[{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D000079962","descriptor_name":"RNA, Circular","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D000095482","descriptor_name":"RNA, Competitive Endogenous","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D001943","descriptor_name":"Breast Neoplasms","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D002465","descriptor_name":"Cell Movement","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015854","descriptor_name":"Up-Regulation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015972","descriptor_name":"Gene Expression Regulation, Neoplastic","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true},{"descriptor_ui":"D017209","descriptor_name":"Apoptosis","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D025741","descriptor_name":"HMGA1a Protein","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D025741","descriptor_name":"HMGA1a Protein","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D035683","descriptor_name":"MicroRNAs","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D045744","descriptor_name":"Cell Line, Tumor","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D049109","descriptor_name":"Cell Proliferation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D061986","descriptor_name":"MCF-7 Cells","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":4,"locations":[{"id":"doi:10.1002/cam4.72249","doi":"https://doi.org/10.1002/cam4.72249","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.72249","pdf_url":null,"source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},{"id":"pmid:42984310","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42984310","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer medicine","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735887","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735887/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Med","raw_type":"Text"},{"id":"pmh:oai:doaj.org/article:1f8599f2928847618d41c4c70cbf7139","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/1f8599f2928847618d41c4c70cbf7139","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Cancer Medicine, Vol 15, Iss 11, Pp n/a-n/a (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1002/cam4.72249","doi":"https://doi.org/10.1002/cam4.72249","is_oa":true,"landing_page_url":"https://doi.org/10.1002/cam4.72249","pdf_url":null,"source":{"id":"https://openalex.org/S2754843627","display_name":"Cancer Medicine","issn_l":"2045-7634","issn":["2045-7634"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-70","russia-white-list-2","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cancer Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","display_name":"Good health and well-being","score":0.9537000060081482}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":24,"referenced_works":["https://openalex.org/W2149296442","https://openalex.org/W2950770590","https://openalex.org/W3015617364","https://openalex.org/W4285147179","https://openalex.org/W4309144630","https://openalex.org/W4313597483","https://openalex.org/W4321107062","https://openalex.org/W4360600073","https://openalex.org/W4380480330","https://openalex.org/W4385563896","https://openalex.org/W4388291715","https://openalex.org/W4389117384","https://openalex.org/W4390946922","https://openalex.org/W4392003475","https://openalex.org/W4392601814","https://openalex.org/W4393343245","https://openalex.org/W4393375501","https://openalex.org/W4401725502","https://openalex.org/W4403965090","https://openalex.org/W4406061842","https://openalex.org/W4408058326","https://openalex.org/W4409087486","https://openalex.org/W4410719074","https://openalex.org/W7164742872"],"related_works":["https://openalex.org/W4313812379","https://openalex.org/W4313399507","https://openalex.org/W3189857743","https://openalex.org/W4284881505","https://openalex.org/W2911113405","https://openalex.org/W2912077818","https://openalex.org/W7150917017","https://openalex.org/W3010073858","https://openalex.org/W3203141892","https://openalex.org/W3092704961"],"abstract_inverted_index":{"Circular":[0],"RNAs":[1,8],"(circRNAs)":[2],"are":[3],"stable,":[4],"evolutionarily":[5],"conserved":[6],"non-coding":[7],"with":[9],"covalently":[10],"closed-loop":[11],"structures,":[12],"which":[13,126],"function":[14],"as":[15],"oncogenes":[16],"or":[17],"tumor":[18],"suppressors":[19],"to":[20],"regulate":[21],"cancer":[22,100,148],"cell":[23,107,113],"proliferation,":[24,114],"invasion,":[25,117],"metastasis,":[26],"and":[27,34,48,54,69,78,86,102,105,116,118,149,161],"apoptosis.":[28,120],"This":[29],"study":[30],"explored":[31],"the":[32,128,136,154],"role":[33],"regulatory":[35],"mechanism":[36],"of":[37,45,98,110,130,133,138],"hsa_circ_0000247":[38,111,122,139,143],"in":[39,95,146],"breast":[40,99,147,165],"cancer.":[41,166],"The":[42,73],"expression":[43],"levels":[44],"hsa_circ_0000247,":[46,76],"hsa-let-7i-5p,":[47,77,125],"HMGA1":[49,79],"were":[50,59,80,89],"detected":[51],"by":[52,82],"RT-qPCR":[53],"western":[55],"blotting.":[56],"Biological":[57],"functions":[58],"evaluated":[60],"using":[61],"CCK-8,":[62],"EdU,":[63],"colony":[64],"formation,":[65],"Transwell,":[66],"flow":[67],"cytometry,":[68],"electron":[70],"microscopy":[71],"assays.":[72],"interactions":[74],"among":[75],"verified":[81],"dual-luciferase":[83],"reporter":[84],"assays,":[85],"rescue":[87],"experiments":[88],"conducted.":[90],"Hsa_circ_0000247":[91],"was":[92],"significantly":[93],"upregulated":[94,145],"30":[96],"pairs":[97],"tissues":[101],"MCF-7,":[103],"MDA-MB-231,":[104],"BT-474":[106],"lines.":[108],"Knockdown":[109],"inhibited":[112],"migration,":[115],"promoted":[119],"Mechanistically,":[121],"directly":[123],"sponged":[124],"targeted":[127],"3'UTR":[129],"HMGA1.":[131],"Inhibition":[132],"hsa-let-7i-5p":[134],"reversed":[135],"effects":[137],"silencing.":[140],"In":[141],"conclusion,":[142],"is":[144],"promotes":[150],"malignant":[151],"progression":[152],"via":[153],"hsa_circ_0000247/hsa-let-7i-5p/HMGA1":[155],"axis,":[156],"providing":[157],"a":[158],"potential":[159],"diagnostic":[160],"therapeutic":[162],"target":[163],"for":[164]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
