{"id":"https://openalex.org/W7225308203","doi":"https://doi.org/10.1039/d6ra08884h","title":"Synthesis and preclinical evaluation of a novel 2-[ 18 F]fluoropyridine-bearing rhodamine for myocardial perfusion imaging with PET","display_name":"Synthesis and preclinical evaluation of a novel 2-[ 18 F]fluoropyridine-bearing rhodamine for myocardial perfusion imaging with PET","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7225308203","doi":"https://doi.org/10.1039/d6ra08884h","pmid":"https://pubmed.ncbi.nlm.nih.gov/42991686","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13738243"},"language":"en","primary_location":{"id":"doi:10.1039/d6ra08884h","doi":"https://doi.org/10.1039/d6ra08884h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra08884h","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1039/d6ra08884h","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5018014974","display_name":"Maya Mahmood","orcid":"https://orcid.org/0009-0004-1511-0509","observed_orcids":["https://orcid.org/0009-0004-1511-0509"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Maya Mahmood","raw_affiliation_strings":["McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada"],"raw_orcid":"https://orcid.org/0009-0004-1511-0509","affiliations":[{"raw_affiliation_string":"McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5084383481","display_name":"Emily Murrell","orcid":"https://orcid.org/0000-0002-9546-681X","observed_orcids":["https://orcid.org/0000-0002-9546-681X"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]},{"id":"https://openalex.org/I185261750","display_name":"University of Toronto","ror":"https://ror.org/03dbr7087","country_code":"CA","type":"education","lineage":["https://openalex.org/I185261750"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Emily Murrell","raw_affiliation_strings":["Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada","Department of Psychiatry, University of Toronto, Toronto, ON, M5T1R8, Canada"],"raw_orcid":"https://orcid.org/0000-0002-9546-681X","affiliations":[{"raw_affiliation_string":"Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada","institution_ids":["https://openalex.org/I1338135719"]},{"raw_affiliation_string":"Department of Psychiatry, University of Toronto, Toronto, ON, M5T1R8, Canada","institution_ids":["https://openalex.org/I185261750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5065755465","display_name":"Seniha Yolcular \u00d6zy\u00fcnc\u00fc","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Seniha Ozyuncu","raw_affiliation_strings":["McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5063648717","display_name":"Junchao Tong","orcid":"https://orcid.org/0000-0001-9299-0045","observed_orcids":["https://orcid.org/0000-0001-9299-0045"]},"institutions":[{"id":"https://openalex.org/I1338135719","display_name":"Centre for Addiction and Mental Health","ror":"https://ror.org/03e71c577","country_code":"CA","type":"healthcare","lineage":["https://openalex.org/I1338135719"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Junchao Tong","raw_affiliation_strings":["Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Brain Health Imaging Centre, Centre for Addiction and Mental Health, Toronto, ON, M5T 1R8, Canada","institution_ids":["https://openalex.org/I1338135719"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5118266722","display_name":"Angelina Lui","orcid":"https://orcid.org/0009-0000-5806-7935","observed_orcids":["https://orcid.org/0009-0000-5806-7935"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":false,"raw_author_name":"Angelina Lui","raw_affiliation_strings":["McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada","institution_ids":["https://openalex.org/I98251732"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5063108701","display_name":"James A. H. Inkster","orcid":"https://orcid.org/0000-0001-5977-7349","observed_orcids":["https://orcid.org/0000-0001-5977-7349"]},"institutions":[{"id":"https://openalex.org/I98251732","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29","country_code":"CA","type":"education","lineage":["https://openalex.org/I98251732"]}],"countries":["CA"],"is_corresponding":true,"raw_author_name":"James A. H. Inkster","raw_affiliation_strings":["McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada"],"raw_orcid":"https://orcid.org/0000-0001-5977-7349","affiliations":[{"raw_affiliation_string":"McMaster University, Department of Chemistry and Chemical Biology, Hamilton, ON, L8S 4M1, Canada","institution_ids":["https://openalex.org/I98251732"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5063108701"],"corresponding_institution_ids":["https://openalex.org/I98251732"],"apc_list":{"value":850,"currency":"GBP","value_usd":1042},"apc_paid":{"value":850,"currency":"GBP","value_usd":1042},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.82919204,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11395","display_name":"Radiopharmaceutical Chemistry and Applications","score":0.9253000020980835,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10372","display_name":"Cardiac Imaging and Diagnostics","score":0.05939999967813492,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10522","display_name":"Medical Imaging Techniques and Applications","score":0.00419999985024333,"subfield":{"id":"https://openalex.org/subfields/2741","display_name":"Radiology, Nuclear Medicine and Imaging"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/rhodamine","display_name":"rhodamine","score":0.8420000076293945},{"id":"https://openalex.org/keywords/myocardial-perfusion-imaging","display_name":"myocardial perfusion imaging","score":0.8880000114440918},{"id":"https://openalex.org/keywords/pet-radiotracer","display_name":"PET radiotracer","score":0.7950000166893005},{"id":"https://openalex.org/keywords/sex-differences-in-metabolism","display_name":"sex differences in metabolism","score":0.6850000023841858},{"id":"https://openalex.org/keywords/myocardial-retention","display_name":"myocardial retention","score":0.8339999914169312},{"id":"https://openalex.org/keywords/heart-to-liver-ratio","display_name":"heart-to-liver ratio","score":0.8519999980926514},{"id":"https://openalex.org/keywords/micropet-imaging","display_name":"microPET imaging","score":0.5519999861717224}],"concepts":[{"id":"https://openalex.org/C146957229","wikidata":"https://www.wikidata.org/wiki/Q1266915","display_name":"Perfusion","level":2,"score":0.6972000002861023},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.5992000102996826},{"id":"https://openalex.org/C2779916640","wikidata":"https://www.wikidata.org/wiki/Q420410","display_name":"Rhodamine","level":3,"score":0.5878999829292297},{"id":"https://openalex.org/C135691158","wikidata":"https://www.wikidata.org/wiki/Q7168308","display_name":"Perfusion scanning","level":3,"score":0.45089998841285706},{"id":"https://openalex.org/C2776002898","wikidata":"https://www.wikidata.org/wiki/Q429022","display_name":"Rhodamine B","level":4,"score":0.42980000376701355},{"id":"https://openalex.org/C2778405248","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial perfusion imaging","level":3,"score":0.4271000027656555},{"id":"https://openalex.org/C136229726","wikidata":"https://www.wikidata.org/wiki/Q327092","display_name":"Biomedical engineering","level":1,"score":0.38440001010894775},{"id":"https://openalex.org/C2910541568","wikidata":"https://www.wikidata.org/wiki/Q1956679","display_name":"Myocardial imaging","level":2,"score":0.3725999891757965},{"id":"https://openalex.org/C3017724952","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Pet imaging","level":3,"score":0.3499000072479248},{"id":"https://openalex.org/C2989005","wikidata":"https://www.wikidata.org/wiki/Q214963","display_name":"Nuclear medicine","level":1,"score":0.3294000029563904},{"id":"https://openalex.org/C2778589691","wikidata":"https://www.wikidata.org/wiki/Q3429577","display_name":"Rhodamine 123","level":4,"score":0.3278999924659729},{"id":"https://openalex.org/C2775842073","wikidata":"https://www.wikidata.org/wiki/Q208376","display_name":"Positron emission tomography","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.27059999108314514},{"id":"https://openalex.org/C177322064","wikidata":"https://www.wikidata.org/wiki/Q750955","display_name":"Radiochemistry","level":1,"score":0.25839999318122864}],"mesh":[],"locations_count":3,"locations":[{"id":"doi:10.1039/d6ra08884h","doi":"https://doi.org/10.1039/d6ra08884h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra08884h","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13738243","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738243/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13738243/pdf/RA-OLF-D6RA08884H.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Adv","raw_type":"Text"},{"id":"pmid:42991686","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42991686","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC advances","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1039/d6ra08884h","doi":"https://doi.org/10.1039/d6ra08884h","is_oa":true,"landing_page_url":"https://doi.org/10.1039/d6ra08884h","pdf_url":null,"source":{"id":"https://openalex.org/S2481244646","display_name":"RSC Advances","issn_l":"2046-2069","issn":["2046-2069"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320556","host_organization_name":"Royal Society of Chemistry","host_organization_lineage":["https://openalex.org/P4310320556"],"host_organization_lineage_names":["Royal Society of Chemistry"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"RSC Advances","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.8560000061988831,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320311526","display_name":"McMaster University","ror":"https://ror.org/02fa3aq29"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225308203.pdf","grobid_xml":"https://content.openalex.org/works/W7225308203.grobid-xml"},"referenced_works_count":20,"referenced_works":["https://openalex.org/W1888328500","https://openalex.org/W1910848219","https://openalex.org/W1991087280","https://openalex.org/W1997027818","https://openalex.org/W2003821677","https://openalex.org/W2010946968","https://openalex.org/W2103312948","https://openalex.org/W2108595830","https://openalex.org/W2114388515","https://openalex.org/W2121054506","https://openalex.org/W2122577534","https://openalex.org/W2515012586","https://openalex.org/W2517763372","https://openalex.org/W2597341277","https://openalex.org/W2749874805","https://openalex.org/W3012517583","https://openalex.org/W3044663668","https://openalex.org/W4361004868","https://openalex.org/W4400416432","https://openalex.org/W4406813600"],"related_works":["https://openalex.org/W2143986115","https://openalex.org/W2062693481","https://openalex.org/W2344474663","https://openalex.org/W2099017594","https://openalex.org/W2122577534","https://openalex.org/W2749874805","https://openalex.org/W1934795257","https://openalex.org/W1977146793","https://openalex.org/W2410034061","https://openalex.org/W2010946968"],"abstract_inverted_index":{"F]Rho6G-DEG-Py-F":[0],"exhibited":[1],"complete":[2],"stability":[3],"in":[4,17,37,59,62,70],"rat":[5],"and":[6,52,76],"mouse":[7],"serum":[8],"over":[9],"120":[10,47,65,89],"min":[11,33],"(37":[12],"\u00b0C).":[13],"A":[14],"radiometabolite":[15],"assay":[16],"two":[18],"rats":[19,38],"showed":[20],"differing":[21],"metabolic":[22],"profiles":[23],"between":[24],"sexes,":[25],"but":[26],"similar":[27,68],"%":[28],"intact":[29],"tracer":[30],"at":[31,46,64,88],"60":[32],"(32-34%).":[34],"Micro-PET":[35],"imaging":[36],"demonstrated":[39],"extended":[40],"myocardial":[41],"retention":[42],"(SUV":[43,79],">":[44],"1.0":[45,87],"min),":[48],"gradual":[49],"liver":[50,56,84],"washout,":[51],"high":[53],"heart":[54,74,82],":":[55,83],"ratios":[57],"(3.7":[58],"male,":[60],"2.5":[61],"female":[63],"min);":[66],"however,":[67],"experiments":[69],"mice":[71],"revealed":[72],"low":[73],"uptake":[75],"rapid":[77],"metabolism":[78],"\u223c":[80],"0.3;":[81],"ratio":[85],"=":[86],"min).":[90]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-06T00:00:00"}