{"id":"https://openalex.org/W7225299809","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","title":"718 CD28 co-stimulation induces PCK2 expression which sustains T cell function in solid tumors","display_name":"718 CD28 co-stimulation induces PCK2 expression which sustains T cell function in solid tumors","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225299809","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0718"},"language":"en","primary_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0718","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A812.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"volume":null,"type":"conference-abstract","is_traditional":false,"indexed_in":["crossref","doaj"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://jitc.bmj.com/content/14/Suppl_2/A812.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5159176072","display_name":"Thomas A. Williams","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Thomas A Williams","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5039550594","display_name":"Katherine Wallis","orcid":"https://orcid.org/0000-0002-0424-1165","observed_orcids":["https://orcid.org/0000-0002-0424-1165"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Katherine Wallis","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5008004447","display_name":"Latambria Hampton","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Latambria Hampton","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5011058214","display_name":"Jacob L Edmondson","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jacob L Edmondson","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109076390","display_name":"Lora J. Rogers","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Lora J Rogers","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5159216848","display_name":"Grant T. Dawson","orcid":"https://orcid.org/0009-0001-9388-2756","observed_orcids":["https://orcid.org/0009-0001-9388-2756"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Grant T Dawson","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000282172","display_name":"Jessica L. Kelliher","orcid":"https://orcid.org/0000-0001-7875-3158","observed_orcids":["https://orcid.org/0000-0001-7875-3158","https://orcid.org/0000-0001-7734-8337"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jessica L Kelliher","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5077570589","display_name":"Sydnye L. Shuttleworth","orcid":"https://orcid.org/0000-0003-0400-7106","observed_orcids":["https://orcid.org/0000-0003-0400-7106"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Sydnye L Shuttleworth","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160937824","display_name":"Jadyn Wilhite","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I107363760","display_name":"Harding University Main Campus","ror":"https://ror.org/00t4cvq91","country_code":"US","type":"education","lineage":["https://openalex.org/I107363760"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Jadyn Wilhite","raw_affiliation_strings":["Harding University, Searcy, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Harding University, Searcy, AR, USA","institution_ids":["https://openalex.org/I107363760"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5086106198","display_name":"Daniel Fil","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Daniel Fil","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5072138764","display_name":"Marie Burdine","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Marie Burdine","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5001260304","display_name":"Brian S. Koss","orcid":"https://orcid.org/0000-0003-0155-4809","observed_orcids":["https://orcid.org/0000-0003-0155-4809"]},"institutions":[{"id":"https://openalex.org/I79620101","display_name":"University of Arkansas for Medical Sciences","ror":"https://ror.org/00xcryt71","country_code":"US","type":"education","lineage":["https://openalex.org/I79620101"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Koss","raw_affiliation_strings":["University of Arkansas for Medical Sciences, Little Rock, AR, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"University of Arkansas for Medical Sciences, Little Rock, AR, USA","institution_ids":["https://openalex.org/I79620101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":2,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":{"value":2490,"currency":"USD","value_usd":2490},"apc_paid":{"value":2490,"currency":"USD","value_usd":2490},"fwci":null,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":"A812","last_page":"A813"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10031","display_name":"T-cell and B-cell Immunology","score":0.7261000275611877,"subfield":{"id":"https://openalex.org/subfields/2403","display_name":"Immunology"},"field":{"id":"https://openalex.org/fields/24","display_name":"Immunology and Microbiology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10631","display_name":"Cancer, Hypoxia, and Metabolism","score":0.10419999808073044,"subfield":{"id":"https://openalex.org/subfields/1306","display_name":"Cancer Research"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10158","display_name":"Cancer Immunotherapy and Biomarkers","score":0.09200000017881393,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cd28-costimulation","display_name":"CD28 costimulation","score":0.9359999895095825},{"id":"https://openalex.org/keywords/pck2","display_name":"PCK2","score":0.9419999718666077},{"id":"https://openalex.org/keywords/phosphoenolpyruvate-carboxykinase","display_name":"phosphoenolpyruvate carboxykinase","score":0.9620000123977661},{"id":"https://openalex.org/keywords/t-cell-metabolism","display_name":"T cell metabolism","score":0.7200000286102295},{"id":"https://openalex.org/keywords/mitochondrial-metabolism","display_name":"mitochondrial metabolism","score":0.5600000023841858},{"id":"https://openalex.org/keywords/cd8-t-cells","display_name":"CD8+ T cells","score":0.8399999737739563},{"id":"https://openalex.org/keywords/solid-tumors","display_name":"solid tumors","score":0.6639999747276306},{"id":"https://openalex.org/keywords/tumor-microenvironment","display_name":"tumor microenvironment","score":0.7699999809265137},{"id":"https://openalex.org/keywords/t-cell-activation","display_name":"T cell activation","score":0.4970000088214874},{"id":"https://openalex.org/keywords/mtor","display_name":"mTOR","score":0.5709999799728394},{"id":"https://openalex.org/keywords/rapamycin","display_name":"rapamycin","score":0.7329999804496765},{"id":"https://openalex.org/keywords/t-cell-proliferation","display_name":"T cell proliferation","score":0.4790000021457672},{"id":"https://openalex.org/keywords/t-cell-persistence","display_name":"T cell persistence","score":0.609000027179718},{"id":"https://openalex.org/keywords/cd28-signaling","display_name":"CD28 signaling","score":0.550000011920929},{"id":"https://openalex.org/keywords/4-1bb","display_name":"4-1BB","score":0.7319999933242798},{"id":"https://openalex.org/keywords/cancer-immunotherapy","display_name":"cancer immunotherapy","score":0.34599998593330383},{"id":"https://openalex.org/keywords/proteomic-profiling","display_name":"proteomic profiling","score":0.37599998712539673}],"concepts":[{"id":"https://openalex.org/C148125776","wikidata":"https://www.wikidata.org/wiki/Q1622348","display_name":"CD28","level":4,"score":0.6610000133514404},{"id":"https://openalex.org/C77255625","wikidata":"https://www.wikidata.org/wiki/Q402093","display_name":"Reprogramming","level":3,"score":0.5566999912261963},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.5432999730110168},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.4936999976634979},{"id":"https://openalex.org/C79879829","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Intracellular","level":2,"score":0.48429998755455017},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.47600001096725464},{"id":"https://openalex.org/C167672396","wikidata":"https://www.wikidata.org/wiki/Q417800","display_name":"CD8","level":3,"score":0.4650999903678894},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4641000032424927},{"id":"https://openalex.org/C2776090121","wikidata":"https://www.wikidata.org/wiki/Q193529","display_name":"T cell","level":3,"score":0.4490000009536743},{"id":"https://openalex.org/C51785407","wikidata":"https://www.wikidata.org/wiki/Q2627568","display_name":"Effector","level":2,"score":0.43700000643730164},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4357999861240387},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.38339999318122864},{"id":"https://openalex.org/C62478195","wikidata":"https://www.wikidata.org/wiki/Q828130","display_name":"Signal transduction","level":2,"score":0.3224000036716461},{"id":"https://openalex.org/C165864922","wikidata":"https://www.wikidata.org/wiki/Q411391","display_name":"Regulation of gene expression","level":3,"score":0.31470000743865967},{"id":"https://openalex.org/C190062978","wikidata":"https://www.wikidata.org/wiki/Q79899","display_name":"Cytoplasm","level":2,"score":0.3109999895095825},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.30809998512268066},{"id":"https://openalex.org/C28859421","wikidata":"https://www.wikidata.org/wiki/Q39572","display_name":"Mitochondrion","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.28189998865127563},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.26649999618530273},{"id":"https://openalex.org/C62231903","wikidata":"https://www.wikidata.org/wiki/Q1057","display_name":"Metabolism","level":2,"score":0.2551000118255615},{"id":"https://openalex.org/C114684123","wikidata":"https://www.wikidata.org/wiki/Q419458","display_name":"CD3","level":4,"score":0.25040000677108765}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/jitc-2026-sitc2026.0718","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A812.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},{"id":"pmh:oai:doaj.org/article:9b4b5eac6d18469faaa87c748739ca02","doi":null,"is_oa":false,"landing_page_url":"https://doaj.org/article/9b4b5eac6d18469faaa87c748739ca02","pdf_url":null,"source":{"id":"https://openalex.org/S4306401280","display_name":"DOAJ (DOAJ: Directory of Open Access Journals)","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"submittedVersion","is_accepted":false,"is_published":false,"raw_source_name":"Journal for ImmunoTherapy of Cancer, Vol 14, Iss Suppl 2 (2026)","raw_type":"article"}],"best_oa_location":{"id":"doi:10.1136/jitc-2026-sitc2026.0718","doi":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","is_oa":true,"landing_page_url":"https://doi.org/10.1136/jitc-2026-sitc2026.0718","pdf_url":"https://jitc.bmj.com/content/14/Suppl_2/A812.full.pdf","source":{"id":"https://openalex.org/S2754803477","display_name":"Journal for ImmunoTherapy of Cancer","issn_l":"2051-1426","issn":["2051-1426"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-2","ki-jl-2","medline","norway-2","oarl","poland-140","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Regular Abstracts","raw_type":"proceedings-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9537000060081482,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225299809.pdf","grobid_xml":"https://content.openalex.org/works/W7225299809.grobid-xml"},"referenced_works_count":0,"referenced_works":[],"related_works":["https://openalex.org/W4415900134","https://openalex.org/W4404052925","https://openalex.org/W3075398090","https://openalex.org/W4313374398","https://openalex.org/W4409266623","https://openalex.org/W4410083418","https://openalex.org/W4402874744","https://openalex.org/W4415163632","https://openalex.org/W4390979663","https://openalex.org/W4289641136"],"abstract_inverted_index":{"Background":[0],"Within":[1],"nutrient-limited":[2],"solid-tumor":[3,380],"microenvironments,":[4],"T":[5,51,68,77,143,175,208,265,290,305,317,333,419,423,473,498],"cells":[6,69,78,93,144,266,291,306,318,334,424,499],"require":[7],"metabolic":[8,23,71,167,353],"reprogramming":[9,19],"to":[10,58,269,387],"support":[11],"activation,":[12],"proliferation,":[13],"persistence,":[14],"and":[15,62,65,99,110,115,117,130,140,158,168,205,288,311,366,394,429,437,502],"effector":[16],"function.":[17],"This":[18,382],"is":[20,371,488],"supported":[21],"by":[22,26,101,113,286],"programs":[24],"promoted":[25],"CD28":[27,87,126,164,229,248,255,349,385,449],"co-stimulation,":[28],"a":[29,46,244,398],"central":[30],"regulator":[31],"of":[32,56,91,125,171,201,220,227,238,242,247,303,338,390,401],"T-cell":[33,376,402,460],"activation.":[34],"Using":[35],"unbiased":[36],"proteomic":[37,435],"profiling,":[38],"we":[39],"identified":[40],"mitochondrial":[41,61,352,391],"phosphoenolpyruvate":[42],"carboxykinase,":[43],"PCK2,":[44,355],"as":[45,397],"key":[47,245,399],"CD28-upregulated":[48],"protein":[49,111,222,252,359],"in":[50,70,88,149,203,217,260,276,280,295,299,368,404,417,484],"cells.":[52,420],"PCK2":[53,103,136,177,202,221,233,251,342,370,396,415,441,445,470],"catalyzes":[54],"conversion":[55],"oxaloacetate":[57],"phosphoenolpyruvate,":[59,339],"linking":[60],"cytoplasmic":[63],"pathways":[64,170],"potentially":[66],"benefitting":[67],"stress.Methods":[72],"Na\u00efve":[73],"murine":[74,138,204],"CD8":[75,173],"+":[76,174],"were":[79,94,120,147,425],"activated":[80,172],"with":[81,122,131,155,272,324,427,492],"anti-CD3":[82,85],"alone":[83],"or":[84],"plus":[86],"the":[89,108,180,358,379],"presence":[90],"IL-2;":[92],"harvested":[95],"on":[96],"day":[97,432],"4":[98],"analyzed":[100,430],"proteomics.":[102],"regulation":[104,236,389],"was":[105,178,292],"assessed":[106],"at":[107,357,431],"transcript":[109],"levels":[112,337],"qPCR":[114],"immunoblotting,":[116],"CD28-signaling":[118],"requirements":[119],"evaluated":[121,148],"CRISPR/Cas9-mediated":[123],"disruption":[124],"intracellular":[127,228],"signaling":[128,230],"motifs":[129,231],"pharmacologic":[132],"inhibition.":[133],"To":[134],"define":[135],"function,":[137],"PCK2WT":[139,270,287,304],"PCK2KO":[141,264,289,316,332],"CD8+":[142,207,375,418,422,472,497],"(OT-I":[145],"background)":[146],"antigen-driven":[150,364,465],"proliferation":[151,277,365,487],"assays,":[152,283],"serial":[153,281,476],"co-cultures":[154],"tumor":[156,160,284,297,309,461,481],"cells,":[157,209,271],"adoptive-transfer":[159],"models":[161],"(B16.F10SIINFEKL,":[162],"MC38SIINFEKL).Results":[163],"co-stimulation":[165,256,350,386,411],"enriched":[166],"inflammatory":[169],"cells;":[176,474],"among":[179],"most":[181],"significantly":[182,307],"upregulated":[183],"proteins":[184],"(0.719":[185],"=":[186,191],"log2":[187],"fold":[188],"change,":[189],"p":[190],"1.3":[192],"\u00d7":[193],"10\u22128).":[194],"CD28,":[195],"but":[196,223,494],"not":[197,224,320,495],"4-1BB,":[198],"induced":[199],"upregulation":[200,416],"human":[206],"suggesting":[210,235,340],"specificity":[211],"for":[212,363,373],"CD28-associated":[213],"signaling.":[214],"CD28-co-stimulation":[215],"resulted":[216],"increased":[218],"abundance":[219,253],"mRNA.":[225],"Disruption":[226],"reduced":[232],"levels,":[234],"downstream":[237],"CD28.":[239],"Rapamycin-induced":[240],"inhibition":[241],"mTOR,":[243],"mediator":[246],"signaling,":[249],"decreased":[250,336],"after":[254,479],"(figure":[257,321],"1).":[258],"After":[259],"vivo":[261,300,485],"ovalbumin":[262],"stimulation,":[263],"proliferated":[267],"comparably":[268],"no":[273],"significant":[274],"difference":[275],"index,":[278],"and,":[279],"co-culture":[282],"control":[285,462],"comparable.":[293],"However,":[294],"both":[296],"models,":[298],"adoptive":[301],"transfer":[302],"delayed":[308],"progression":[310],"improved":[312],"host":[313],"survival,":[314],"whereas":[315],"did":[319],"2).":[322],"Consistent":[323],"this":[325],"context-dependent":[326],"requirement,":[327],"metabolomic":[328],"profiling":[329],"revealed":[330],"that":[331,341,348],"had":[335],"supports":[343,458],"biosynthetic":[344],"metabolism.Conclusions":[345],"We":[346],"showed":[347],"upregulates":[351],"enzyme":[354],"primarily":[356],"level.":[360],"Although":[361],"dispensable":[362],"cytotoxicity":[367],"vitro,":[369],"required":[372],"optimal":[374],"function":[377],"within":[378],"microenvironment.":[381],"work":[383],"links":[384],"post-transcriptional":[388,414],"carbon":[392],"metabolism":[393],"defines":[395],"determinant":[400],"fitness":[403],"metabolically":[405],"hostile":[406],"tumors.Abstract":[407],"718":[408,455],"Figure":[409,456],"1CD28":[410],"selectively":[412],"induces":[413],"Murine":[421],"stimulated":[426],"CD3\u00b1CD28":[428],"4.":[433],"(A\u2013C)":[434],"changes":[436],"pathway":[438],"enrichment;":[439],"(D\u2013E)":[440,490],"immunoblot":[442,468],"validation;":[443],"(F\u2013H)":[444],"mRNA/protein":[446],"levels;":[447],"I,":[448],"motif":[450],"editing;":[451],"(J)":[452],"rapamycin/mTOR":[453],"inhibitionAbstract":[454],"2PCK2":[457],"sustained":[459],"without":[463],"altering":[464],"proliferation.":[466],"(A)":[467],"confirms":[469],"WT/OE/KO":[471],"(B)":[475],"B16-SIINFEKL":[477],"killing":[478],"repeated":[480],"rechallenge;":[482],"(C)":[483],"OVA-driven":[486],"unchanged;":[489],"ACT":[491],"WT,":[493],"KO,":[496],"improves":[500],"B16":[501],"MC38":[503],"control/survival":[504]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
