{"id":"https://openalex.org/W7225293173","doi":"https://doi.org/10.1136/bmjmed-2025-001738","title":"Advances in the management of mitral valve disease: contemporary review for clinicians","display_name":"Advances in the management of mitral valve disease: contemporary review for clinicians","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225293173","doi":"https://doi.org/10.1136/bmjmed-2025-001738","pmid":"https://pubmed.ncbi.nlm.nih.gov/42988532"},"language":"en","primary_location":{"id":"doi:10.1136/bmjmed-2025-001738","doi":"https://doi.org/10.1136/bmjmed-2025-001738","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjmed-2025-001738","pdf_url":"https://bmjmedicine.bmj.com/content/5/1/e001738.full.pdf","source":{"id":"https://openalex.org/S4282813161","display_name":"BMJ Medicine","issn_l":"2754-0413","issn":["2754-0413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Medicine","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://bmjmedicine.bmj.com/content/5/1/e001738.full.pdf","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5070945651","display_name":"Susan Keen","orcid":"https://orcid.org/0000-0003-1238-7006","observed_orcids":["https://orcid.org/0000-0003-1238-7006"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Susan Keen","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, USA"],"raw_orcid":"https://orcid.org/0000-0003-1238-7006","affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5143776781","display_name":"Tom Kai Ming Wang","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Tom Kai Ming Wang","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5088924413","display_name":"Brian P. Griffin","orcid":"https://orcid.org/0000-0001-6831-8611","observed_orcids":["https://orcid.org/0000-0001-6831-8611"]},"institutions":[{"id":"https://openalex.org/I1316902750","display_name":"Cleveland Clinic","ror":"https://ror.org/03xjacd83","country_code":"US","type":"healthcare","lineage":["https://openalex.org/I1316902750"]}],"countries":["US"],"is_corresponding":false,"raw_author_name":"Brian Griffin","raw_affiliation_strings":["Cleveland Clinic, Cleveland, Ohio, USA"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Cleveland Clinic, Cleveland, Ohio, USA","institution_ids":["https://openalex.org/I1316902750"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":1,"corresponding_author_ids":[],"corresponding_institution_ids":["https://openalex.org/I1316902750"],"apc_list":{"value":3000,"currency":"GBP","value_usd":3679},"apc_paid":{"value":3000,"currency":"GBP","value_usd":3679},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66911765,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"5","issue":"1","first_page":"e001738","last_page":"e001738"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10172","display_name":"Cardiac Valve Diseases and Treatments","score":1.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12598","display_name":"Cardiac Structural Anomalies and Repair","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11217","display_name":"Cardiac Arrhythmias and Treatments","score":0.0,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mitral-valve-disease","display_name":"mitral valve disease","score":1.0},{"id":"https://openalex.org/keywords/mitral-regurgitation","display_name":"mitral regurgitation","score":0.9929999709129333},{"id":"https://openalex.org/keywords/mitral-stenosis","display_name":"mitral stenosis","score":0.972000002861023},{"id":"https://openalex.org/keywords/primary-mitral-regurgitation","display_name":"degenerative mitral regurgitation","score":0.949999988079071},{"id":"https://openalex.org/keywords/secondary-mitral-regurgitation","display_name":"functional mitral regurgitation","score":0.9210000038146973},{"id":"https://openalex.org/keywords/rheumatic-heart-disease","display_name":"rheumatic heart disease","score":0.9110000133514404},{"id":"https://openalex.org/keywords/mitral-valve-surgery","display_name":"mitral valve surgery","score":0.7730000019073486},{"id":"https://openalex.org/keywords/transcatheter-edge-to-edge-repair","display_name":"transcatheter edge-to-edge repair","score":0.8859999775886536},{"id":"https://openalex.org/keywords/transcatheter-mitral-valve-replacement","display_name":"transcatheter mitral valve replacement","score":0.996999979019165},{"id":"https://openalex.org/keywords/multimodality-cardiac-imaging","display_name":"multimodality cardiac imaging","score":0.8679999709129333},{"id":"https://openalex.org/keywords/pathophysiology","display_name":"pathophysiology","score":0.6460000276565552}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.8044999837875366},{"id":"https://openalex.org/C177713679","wikidata":"https://www.wikidata.org/wiki/Q679690","display_name":"Intensive care medicine","level":1,"score":0.49619999527931213},{"id":"https://openalex.org/C2777543888","wikidata":"https://www.wikidata.org/wiki/Q369939","display_name":"Mitral valve","level":2,"score":0.4878999888896942},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.34940001368522644},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.3296999931335449},{"id":"https://openalex.org/C2779473830","wikidata":"https://www.wikidata.org/wiki/Q1540899","display_name":"MEDLINE","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.2815999984741211},{"id":"https://openalex.org/C141071460","wikidata":"https://www.wikidata.org/wiki/Q40821","display_name":"Surgery","level":1,"score":0.2721000015735626},{"id":"https://openalex.org/C2776229121","wikidata":"https://www.wikidata.org/wiki/Q215620","display_name":"Heart valve","level":2,"score":0.23160000145435333},{"id":"https://openalex.org/C2780703314","wikidata":"https://www.wikidata.org/wiki/Q1140794","display_name":"Mitral valve stenosis","level":3,"score":0.22579999268054962}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1136/bmjmed-2025-001738","doi":"https://doi.org/10.1136/bmjmed-2025-001738","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjmed-2025-001738","pdf_url":"https://bmjmedicine.bmj.com/content/5/1/e001738.full.pdf","source":{"id":"https://openalex.org/S4282813161","display_name":"BMJ Medicine","issn_l":"2754-0413","issn":["2754-0413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Medicine","raw_type":"journal-article"},{"id":"pmid:42988532","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42988532","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ medicine","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1136/bmjmed-2025-001738","doi":"https://doi.org/10.1136/bmjmed-2025-001738","is_oa":true,"landing_page_url":"https://doi.org/10.1136/bmjmed-2025-001738","pdf_url":"https://bmjmedicine.bmj.com/content/5/1/e001738.full.pdf","source":{"id":"https://openalex.org/S4282813161","display_name":"BMJ Medicine","issn_l":"2754-0413","issn":["2754-0413"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-2","norway-1","oarl","vabb-shw"],"host_organization":"https://openalex.org/P4310319945","host_organization_name":"BMJ","host_organization_lineage":["https://openalex.org/P4310319945"],"host_organization_lineage_names":["BMJ"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"BMJ Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":1.0}],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":true,"pdf":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225293173.pdf","grobid_xml":"https://content.openalex.org/works/W7225293173.grobid-xml"},"referenced_works_count":110,"referenced_works":["https://openalex.org/W1541385862","https://openalex.org/W1978611932","https://openalex.org/W1980115704","https://openalex.org/W1984036026","https://openalex.org/W1984647396","https://openalex.org/W1985156472","https://openalex.org/W1991574984","https://openalex.org/W1992961253","https://openalex.org/W2004316705","https://openalex.org/W2004917521","https://openalex.org/W2015790980","https://openalex.org/W2016220105","https://openalex.org/W2016232273","https://openalex.org/W2020746679","https://openalex.org/W2021201885","https://openalex.org/W2026749484","https://openalex.org/W2029101054","https://openalex.org/W2031573094","https://openalex.org/W2032910151","https://openalex.org/W2033934679","https://openalex.org/W2041391163","https://openalex.org/W2061279476","https://openalex.org/W2067573076","https://openalex.org/W2070351043","https://openalex.org/W2072869146","https://openalex.org/W2078782997","https://openalex.org/W2085229203","https://openalex.org/W2089419646","https://openalex.org/W2089831249","https://openalex.org/W2092153594","https://openalex.org/W2099845815","https://openalex.org/W2112323503","https://openalex.org/W2117846884","https://openalex.org/W2132760295","https://openalex.org/W2135675752","https://openalex.org/W2146255936","https://openalex.org/W2148602695","https://openalex.org/W2149795152","https://openalex.org/W2151173136","https://openalex.org/W2155596187","https://openalex.org/W2160191160","https://openalex.org/W2160641761","https://openalex.org/W2165630255","https://openalex.org/W2171832505","https://openalex.org/W2193164360","https://openalex.org/W2193849676","https://openalex.org/W2283636770","https://openalex.org/W2298280587","https://openalex.org/W2323812521","https://openalex.org/W2398424955","https://openalex.org/W2466053537","https://openalex.org/W2596797126","https://openalex.org/W2611890005","https://openalex.org/W2618403520","https://openalex.org/W2772717375","https://openalex.org/W2802445017","https://openalex.org/W2805959090","https://openalex.org/W2885627232","https://openalex.org/W2888290077","https://openalex.org/W2888658222","https://openalex.org/W2889688444","https://openalex.org/W2903194993","https://openalex.org/W2904560400","https://openalex.org/W2904754296","https://openalex.org/W2920784209","https://openalex.org/W2946754497","https://openalex.org/W2965017770","https://openalex.org/W2971316760","https://openalex.org/W3011448762","https://openalex.org/W3021528551","https://openalex.org/W3034366592","https://openalex.org/W3038634625","https://openalex.org/W3091916999","https://openalex.org/W3092731547","https://openalex.org/W3111930466","https://openalex.org/W3121012557","https://openalex.org/W3127999083","https://openalex.org/W3130348394","https://openalex.org/W3135697067","https://openalex.org/W3137594084","https://openalex.org/W3146225553","https://openalex.org/W3153532194","https://openalex.org/W3154976280","https://openalex.org/W3156246622","https://openalex.org/W3156916651","https://openalex.org/W3203187630","https://openalex.org/W3214415180","https://openalex.org/W4200436813","https://openalex.org/W4206381626","https://openalex.org/W4220830589","https://openalex.org/W4220837239","https://openalex.org/W4292290582","https://openalex.org/W4293410833","https://openalex.org/W4308363201","https://openalex.org/W4368359961","https://openalex.org/W4379207961","https://openalex.org/W4381855116","https://openalex.org/W4385330259","https://openalex.org/W4387882070","https://openalex.org/W4393176885","https://openalex.org/W4394894407","https://openalex.org/W4399749660","https://openalex.org/W4400879024","https://openalex.org/W4401500415","https://openalex.org/W4401566779","https://openalex.org/W4402092075","https://openalex.org/W4409023007","https://openalex.org/W4409419696","https://openalex.org/W4413812823","https://openalex.org/W7138993707"],"related_works":["https://openalex.org/W4231368983","https://openalex.org/W2020561302","https://openalex.org/W3024440574","https://openalex.org/W2407370657","https://openalex.org/W4412736441","https://openalex.org/W2467025589","https://openalex.org/W4205231968","https://openalex.org/W429308986","https://openalex.org/W2462975357","https://openalex.org/W2024658436"],"abstract_inverted_index":{"Mitral":[0],"valve":[1,119,147],"disease":[2],"is":[3,39],"a":[4],"major":[5],"global":[6],"contributor":[7],"to":[8,133],"cardiovascular":[9],"morbidity":[10],"and":[11,20,42,58,65,80,83,86,108,111,116,154,159,161],"mortality,":[12],"with":[13,92],"its":[14],"epidemiology":[15,144],"shaped":[16],"by":[17,104],"regional":[18],"characteristics":[19],"changing":[21],"causes.":[22],"In":[23,53],"high":[24,128],"income":[25,67],"countries,":[26],"degenerative":[27],"mitral":[28,37,51,56,118,146,157],"regurgitation":[29,38,59,158],"predominates,":[30],"resulting":[31],"from":[32],"ageing":[33],"populations,":[34],"although":[35],"functional":[36],"increasingly":[40],"recognised":[41],"constitutes":[43],"an":[44],"increasing":[45],"proportion":[46],"of":[47,50,78,142,145],"the":[48,76,98,139,143,149],"burden":[49],"regurgitation.":[52],"contrast,":[54],"rheumatic":[55],"stenosis":[57],"affect":[60],"younger":[61],"patients":[62,126],"in":[63,70],"low":[64],"middle":[66],"areas.":[68],"Advances":[69],"multimodality":[71],"cardiac":[72],"imaging":[73,152],"have":[74],"enhanced":[75],"precision":[77],"diagnostic":[79,151],"prognostic":[81],"evaluation,":[82],"periprocedural":[84],"planning":[85],"guidance.":[87],"Management":[88],"strategies":[89],"are":[90,121],"evolving,":[91],"surgical":[93],"repair":[94,115],"or":[95,130],"replacement":[96,120],"remaining":[97],"standard":[99],"for":[100,125,156],"eligible":[101],"patients,":[102],"supported":[103],"minimally":[105],"invasive":[106],"approaches":[107],"optimal":[109],"timing":[110],"indications.":[112],"Transcatheter":[113],"edge-to-edge":[114],"transcatheter":[117],"new":[122],"treatment":[123],"options":[124],"at":[127],"risk":[129],"previously":[131],"considered":[132],"be":[134],"inoperable.":[135],"This":[136],"review":[137],"summarises":[138],"contemporary":[140],"perspectives":[141],"disease,":[148],"pathophysiology,":[150],"modalities,":[153],"treatments":[155],"stenosis,":[160],"outlines":[162],"future":[163],"directions.":[164]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}
