{"id":"https://openalex.org/W7225291237","doi":"https://doi.org/10.1002/jcsm.70419","title":"S100A9 Mediates Neuroblastoma\u2010Associated Skeletal Muscle Atrophy via O\u2010GlcNAcylation Repression and Activate Mitophagy Activation","display_name":"S100A9 Mediates Neuroblastoma\u2010Associated Skeletal Muscle Atrophy via O\u2010GlcNAcylation Repression and Activate Mitophagy Activation","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225291237","doi":"https://doi.org/10.1002/jcsm.70419","pmid":"https://pubmed.ncbi.nlm.nih.gov/42984296","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13735905"},"language":"en","primary_location":{"id":"doi:10.1002/jcsm.70419","doi":"https://doi.org/10.1002/jcsm.70419","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcsm.70419","pdf_url":null,"source":{"id":"https://openalex.org/S173726759","display_name":"Journal of Cachexia Sarcopenia and Muscle","issn_l":"2190-5991","issn":["2190-5991","2190-6009"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cachexia, Sarcopenia and Muscle","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1002/jcsm.70419","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5124925886","display_name":"Jianwei Lin","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jianwei Lin","raw_affiliation_strings":["Department of Oncology (Ward 2), Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology (Ward 2), Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100398011","display_name":"Yuxin Zhang","orcid":"https://orcid.org/0000-0001-5106-4125","observed_orcids":["https://orcid.org/0000-0001-5106-4125"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuxin Zhang","raw_affiliation_strings":["Department of Anesthesiology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":"https://orcid.org/0000-0001-5106-4125","affiliations":[{"raw_affiliation_string":"Department of Anesthesiology, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5000292726","display_name":"Qi Wang","orcid":"https://orcid.org/0000-0001-5419-9551","observed_orcids":["https://orcid.org/0000-0001-5419-9551"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I2800570007","display_name":"Renji Hospital","ror":"https://ror.org/03ypbx660","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I2800570007"]},{"id":"https://openalex.org/I4210110011","display_name":"Shanghai Cancer Institute","ror":"https://ror.org/01ty4bg86","country_code":"CN","type":"facility","lineage":["https://openalex.org/I4210110011"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Qi Wang","raw_affiliation_strings":["Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China"],"raw_orcid":"https://orcid.org/0000-0001-5419-9551","affiliations":[{"raw_affiliation_string":"Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine, Institute of Molecular Medicine, State Key Laboratory of Systems Medicine for Cancer, Shanghai Cancer Institute Renji Hospital, School of Medicine, Shanghai Jiao Tong University  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I2800570007","https://openalex.org/I4210110011"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5158985723","display_name":"Jingchun Lv","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Jingchun Lv","raw_affiliation_strings":["Department of Oncology (Ward 2), Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Oncology (Ward 2), Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5133018133","display_name":"Bingqiang Han","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Bingqiang Han","raw_affiliation_strings":["Department of Pediatric Orthopedics, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Pediatric Orthopedics, Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101431295","display_name":"Dapeng Jiang","orcid":"https://orcid.org/0000-0002-7360-1662","observed_orcids":["https://orcid.org/0000-0002-7360-1662"]},"institutions":[{"id":"https://openalex.org/I183067930","display_name":"Shanghai Jiao Tong University","ror":"https://ror.org/0220qvk04","country_code":"CN","type":"education","lineage":["https://openalex.org/I183067930"]},{"id":"https://openalex.org/I4210092101","display_name":"Shanghai Children's Medical Center","ror":"https://ror.org/00cd9s024","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210092101"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Dapeng Jiang","raw_affiliation_strings":["Department of Oncology (Ward 2), Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China"],"raw_orcid":"https://orcid.org/0000-0002-7360-1662","affiliations":[{"raw_affiliation_string":"Department of Oncology (Ward 2), Shanghai Children's Medical Center Shanghai Jiao Tong University School of Medicine  Shanghai China","institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5101431295"],"corresponding_institution_ids":["https://openalex.org/I183067930","https://openalex.org/I4210092101"],"apc_list":{"value":5400,"currency":"USD","value_usd":5400},"apc_paid":{"value":5400,"currency":"USD","value_usd":5400},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.72674242,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"17","issue":"6","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10441","display_name":"Muscle Physiology and Disorders","score":0.9911999702453613,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T10397","display_name":"Nutrition and Health in Aging","score":0.0032999999821186066,"subfield":{"id":"https://openalex.org/subfields/2737","display_name":"Physiology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12226","display_name":"Neuroblastoma Research and Treatments","score":0.00039999998989515007,"subfield":{"id":"https://openalex.org/subfields/2730","display_name":"Oncology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/s100a9","display_name":"S100A9","score":0.9129999876022339},{"id":"https://openalex.org/keywords/neuroblastoma","display_name":"neuroblastoma","score":0.9940000176429749},{"id":"https://openalex.org/keywords/skeletal-muscle-atrophy","display_name":"skeletal muscle atrophy","score":0.9829999804496765},{"id":"https://openalex.org/keywords/o-glcnacylation","display_name":"O-GlcNAcylation","score":0.9750000238418579},{"id":"https://openalex.org/keywords/rage","display_name":"RAGE","score":0.8410000205039978},{"id":"https://openalex.org/keywords/mitophagy","display_name":"mitophagy","score":0.9940000176429749},{"id":"https://openalex.org/keywords/bnip3","display_name":"BNIP3","score":0.8700000047683716},{"id":"https://openalex.org/keywords/bnip3l","display_name":"BNIP3L","score":0.9800000190734863},{"id":"https://openalex.org/keywords/thiamet-g","display_name":"Thiamet G","score":0.9919999837875366},{"id":"https://openalex.org/keywords/inflammation","display_name":"inflammation","score":0.6269999742507935},{"id":"https://openalex.org/keywords/cachexia","display_name":"cachexia","score":0.746999979019165},{"id":"https://openalex.org/keywords/therapeutic-target","display_name":"therapeutic target","score":0.8790000081062317}],"concepts":[{"id":"https://openalex.org/C2776263037","wikidata":"https://www.wikidata.org/wiki/Q1557686","display_name":"Muscle atrophy","level":3,"score":0.8476999998092651},{"id":"https://openalex.org/C2779959927","wikidata":"https://www.wikidata.org/wiki/Q1048687","display_name":"Skeletal muscle","level":2,"score":0.801800012588501},{"id":"https://openalex.org/C2781172350","wikidata":"https://www.wikidata.org/wiki/Q194520","display_name":"Atrophy","level":2,"score":0.7318000197410583},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.5338000059127808},{"id":"https://openalex.org/C2779324830","wikidata":"https://www.wikidata.org/wiki/Q1806192","display_name":"Mitophagy","level":4,"score":0.48350000381469727},{"id":"https://openalex.org/C2776307749","wikidata":"https://www.wikidata.org/wiki/Q18031354","display_name":"S100A9","level":3,"score":0.43149998784065247},{"id":"https://openalex.org/C207200792","wikidata":"https://www.wikidata.org/wiki/Q428914","display_name":"Myocyte","level":2,"score":0.4302000105381012},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.40549999475479126},{"id":"https://openalex.org/C2107291","wikidata":"https://www.wikidata.org/wiki/Q14886885","display_name":"Mediator","level":2,"score":0.4016999900341034},{"id":"https://openalex.org/C134018914","wikidata":"https://www.wikidata.org/wiki/Q162606","display_name":"Endocrinology","level":1,"score":0.4002000093460083},{"id":"https://openalex.org/C2776914184","wikidata":"https://www.wikidata.org/wiki/Q101991","display_name":"Inflammation","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.3718000054359436},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.3476000130176544},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.335099995136261},{"id":"https://openalex.org/C127561419","wikidata":"https://www.wikidata.org/wiki/Q224527","display_name":"Downregulation and upregulation","level":3,"score":0.3181000053882599},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.2906000018119812},{"id":"https://openalex.org/C2909765735","wikidata":"https://www.wikidata.org/wiki/Q4116663","display_name":"Muscle disorder","level":2,"score":0.26930001378059387},{"id":"https://openalex.org/C142724271","wikidata":"https://www.wikidata.org/wiki/Q7208","display_name":"Pathology","level":1,"score":0.26249998807907104},{"id":"https://openalex.org/C181709278","wikidata":"https://www.wikidata.org/wiki/Q18028020","display_name":"ITGA7","level":3,"score":0.2624000012874603}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D004195","descriptor_name":"Disease Models, Animal","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006031","descriptor_name":"Glycosylation","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000209","qualifier_name":"etiology","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009133","descriptor_name":"Muscular Atrophy","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000150","qualifier_name":"complications","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D009447","descriptor_name":"Neuroblastoma","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":true},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D018482","descriptor_name":"Muscle, Skeletal","qualifier_ui":"Q000473","qualifier_name":"pathology","is_major_topic":false},{"descriptor_ui":"D040502","descriptor_name":"Calgranulin B","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D063306","descriptor_name":"Mitophagy","qualifier_ui":null,"qualifier_name":null,"is_major_topic":true}],"locations_count":3,"locations":[{"id":"doi:10.1002/jcsm.70419","doi":"https://doi.org/10.1002/jcsm.70419","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcsm.70419","pdf_url":null,"source":{"id":"https://openalex.org/S173726759","display_name":"Journal of Cachexia Sarcopenia and Muscle","issn_l":"2190-5991","issn":["2190-5991","2190-6009"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cachexia, Sarcopenia and Muscle","raw_type":"journal-article"},{"id":"pmid:42984296","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42984296","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of cachexia, sarcopenia and muscle","raw_type":"Journal Article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13735905","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13735905/","pdf_url":null,"source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"J Cachexia Sarcopenia Muscle","raw_type":"Text"}],"best_oa_location":{"id":"doi:10.1002/jcsm.70419","doi":"https://doi.org/10.1002/jcsm.70419","is_oa":true,"landing_page_url":"https://doi.org/10.1002/jcsm.70419","pdf_url":null,"source":{"id":"https://openalex.org/S173726759","display_name":"Journal of Cachexia Sarcopenia and Muscle","issn_l":"2190-5991","issn":["2190-5991","2190-6009"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-a","doyens","jufo-2","ki-jl-2","medline","norway-1","oarl","poland-200","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310319900","host_organization_name":"Springer Science+Business Media","host_organization_lineage":["https://openalex.org/P4310319900","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Springer Science+Business Media","Springer Nature"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Journal of Cachexia, Sarcopenia and Muscle","raw_type":"journal-article"},"sustainable_development_goals":[{"score":1.0,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":38,"referenced_works":["https://openalex.org/W2048478983","https://openalex.org/W2130025116","https://openalex.org/W2336832442","https://openalex.org/W2557895031","https://openalex.org/W2808640273","https://openalex.org/W3010817160","https://openalex.org/W3151502832","https://openalex.org/W3153396515","https://openalex.org/W3176449475","https://openalex.org/W3195448820","https://openalex.org/W3208187444","https://openalex.org/W3210919596","https://openalex.org/W4224282954","https://openalex.org/W4224313132","https://openalex.org/W4289519993","https://openalex.org/W4321371287","https://openalex.org/W4321749341","https://openalex.org/W4322767303","https://openalex.org/W4323653012","https://openalex.org/W4361195513","https://openalex.org/W4385610938","https://openalex.org/W4387439837","https://openalex.org/W4387451386","https://openalex.org/W4390569784","https://openalex.org/W4399133757","https://openalex.org/W4400061017","https://openalex.org/W4403417425","https://openalex.org/W4403484828","https://openalex.org/W4403574383","https://openalex.org/W4407275094","https://openalex.org/W4408047679","https://openalex.org/W4413042681","https://openalex.org/W4414159414","https://openalex.org/W4414571745","https://openalex.org/W4415939347","https://openalex.org/W4416738515","https://openalex.org/W7160710469","https://openalex.org/W7166812871"],"related_works":["https://openalex.org/W7201912366","https://openalex.org/W2899278816","https://openalex.org/W7225065080","https://openalex.org/W2620108944","https://openalex.org/W2969976316","https://openalex.org/W7154628232","https://openalex.org/W4414159414","https://openalex.org/W4312176370","https://openalex.org/W4384564350","https://openalex.org/W6958724236"],"abstract_inverted_index":{"BACKGROUND:":[0],"In":[1],"patients":[2,89,153],"with":[3,154],"neuroblastoma":[4],"(NB),":[5],"skeletal":[6,106,181,218,263,283],"muscle":[7,46,59,83,107,148,155,182,201,219,264,284,308],"atrophy":[8,60,156,187,202,206,230,265,285],"is":[9,41],"a":[10,42,278,287,294,300],"key":[11,54],"factor":[12],"linked":[13],"to":[14,51,77,97,105,119,139,306],"poor":[15],"survival":[16],"and":[17,32,61,90,112,134,157,184,203,298,310],"decreased":[18],"long-term":[19],"quality":[20],"of":[21,44,73,102,124,146,166,238,255,281],"life.":[22],"Nevertheless,":[23],"there":[24],"are":[25],"still":[26],"insufficient":[27],"therapeutic":[28,296],"methods":[29],"that":[30,241],"work,":[31],"the":[33,53,64,99,121,142,167,186,209,235,256],"underlying":[34,143],"mechanisms":[35],"remain":[36],"unclear.":[37],"As":[38],"persistent":[39],"inflammation":[40],"hallmark":[43],"tumour-related":[45],"atrophy,":[47],"this":[48,244,249],"study":[49,274],"aims":[50],"identify":[52,78],"inflammatory":[55,80,110],"mediators":[56,81],"causing":[57,82],"NB-related":[58],"systematically":[62],"elucidate":[63],"downstream":[65],"molecular":[66,144],"mechanism.":[67],"METHODS:":[68],"The":[69],"adverse":[70],"biological":[71],"features":[72],"NB":[74,88,91,152,158,210,267],"were":[75,94,115,137],"used":[76,96,138],"potential":[79,295],"atrophy.":[84,108,149],"Serum":[85],"samples":[86],"from":[87,243],"mouse":[92,159,176],"models":[93,160],"then":[95],"confirm":[98],"clinical":[100],"relevance":[101],"these":[103,205],"candidates":[104],"Recombinant":[109,175],"proteins":[111],"certain":[113],"inhibitors":[114],"given":[116],"in":[117,190,208,252,266],"vivo":[118,253],"define":[120],"functional":[122],"impact":[123],"mediators.":[125],"Additionally,":[126],"RNA":[127],"sequencing":[128],"(RNA-seq),":[129],"quantitative":[130],"real-time":[131],"PCR":[132],"(qPCR)":[133],"Western":[135],"blotting":[136],"methodically":[140],"examine":[141],"pathways":[145],"NB-induced":[147],"RESULTS:":[150],"Both":[151],"had":[161],"considerably":[162,261],"higher":[163],"serum":[164],"levels":[165],"pro-inflammatory":[168],"mediator":[169,280],"S100A9":[170,177,216,276,292],"protein":[171,178,220],"(p":[172,192,212,226,269],"<":[173,193,213,227,270],"0.001).":[174,214],"functionally":[179],"reduced":[180,200,262],"weight":[183],"upregulated":[185],"markers":[188,207],"TRIM63/FBXO32":[189],"mice":[191,268],"0.05),":[194],"whereas":[195],"its":[196,223],"inhibitor,":[197],"ABR-238901,":[198],"successfully":[199],"downregulated":[204],"model":[211],"Mechanistically,":[215],"inhibited":[217],"O-GlcNAcylation":[221,257],"via":[222],"receptor":[224],"RAGE":[225],"0.05).":[228,271],"Muscle":[229],"was":[231],"ultimately":[232],"caused":[233],"by":[234,247],"abnormal":[236],"activation":[237],"BNIP3/BNIP3L-mediated":[239],"mitophagy":[240,250],"resulted":[242],"suppression.":[245],"Lastly,":[246],"inhibiting":[248],"route,":[251],"administration":[254],"agonist":[258],"Thiamet":[259],"G":[260],"CONCLUSIONS:":[272],"Our":[273],"identifies":[275],"as":[277,293],"critical":[279],"NB-associated":[282],"through":[286],"novel":[288],"RAGE/O-GlcNAcylation/mitophagy":[289],"axis,":[290],"establishing":[291],"target":[297],"providing":[299],"rationale":[301],"for":[302],"early":[303],"interventional":[304],"strategies":[305],"preserve":[307],"mass":[309],"improve":[311],"patient":[312],"outcomes.":[313]},"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-06T00:00:00"}