{"id":"https://openalex.org/W7225273190","doi":"https://doi.org/10.21203/rs.3.rs-11222166/v1","title":"Decellularized Human Amnion-Chorion Membrane as a Novel Scaffold for Expansion of Human Umbilical Cord Tissue- Derived Mesenchymal Stem Cells and Production of Chlorogenic Acid-Loaded Extracellular Vesicles Against Glioblastoma","display_name":"Decellularized Human Amnion-Chorion Membrane as a Novel Scaffold for Expansion of Human Umbilical Cord Tissue- Derived Mesenchymal Stem Cells and Production of Chlorogenic Acid-Loaded Extracellular Vesicles Against Glioblastoma","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225273190","doi":"https://doi.org/10.21203/rs.3.rs-11222166/v1"},"language":"en","primary_location":{"id":"doi:10.21203/rs.3.rs-11222166/v1","doi":"https://doi.org/10.21203/rs.3.rs-11222166/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11222166/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"volume":null,"type":"preprint","indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"green","oa_url":"https://doi.org/10.21203/rs.3.rs-11222166/v1","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5160665783","display_name":"Jaseem Batchaa\u00b9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Jaseem Batchaa\u00b9","raw_affiliation_strings":["Acadicell Innovations International Pvt. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acadicell Innovations International Pvt. Ltd","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5156373187","display_name":"Raghu Babu Pothireddy","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Raghu Babu Pothireddy\u00b9","raw_affiliation_strings":["Acadicell Innovations International Pvt. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acadicell Innovations International Pvt. Ltd","institution_ids":[]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160674255","display_name":"Praveen Kumar L\u00b9","orcid":null,"observed_orcids":[]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Praveen Kumar L\u00b9","raw_affiliation_strings":["Acadicell Innovations International Pvt. Ltd"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Acadicell Innovations International Pvt. Ltd","institution_ids":[]}]}],"institutions":[],"countries_distinct_count":0,"institutions_distinct_count":0,"corresponding_author_ids":[],"corresponding_institution_ids":[],"apc_list":null,"apc_paid":null,"fwci":null,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":null,"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T10773","display_name":"Extracellular vesicles in disease","score":0.9613999724388123,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12264","display_name":"Tissue Engineering and Regenerative Medicine","score":0.017000000923871994,"subfield":{"id":"https://openalex.org/subfields/2746","display_name":"Surgery"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10176","display_name":"Mesenchymal stem cell research","score":0.005900000222027302,"subfield":{"id":"https://openalex.org/subfields/2716","display_name":"Genetics (clinical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[],"concepts":[{"id":"https://openalex.org/C2908689518","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicle","level":5,"score":0.6460999846458435},{"id":"https://openalex.org/C198826908","wikidata":"https://www.wikidata.org/wiki/Q1922379","display_name":"Mesenchymal stem cell","level":2,"score":0.631600022315979},{"id":"https://openalex.org/C190672674","wikidata":"https://www.wikidata.org/wiki/Q3866591","display_name":"Decellularization","level":3,"score":0.5846999883651733},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.58160001039505},{"id":"https://openalex.org/C2778227246","wikidata":"https://www.wikidata.org/wiki/Q1365309","display_name":"Glioma","level":2,"score":0.5654000043869019},{"id":"https://openalex.org/C28328180","wikidata":"https://www.wikidata.org/wiki/Q48196","display_name":"Stem cell","level":2,"score":0.5139999985694885},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.499099999666214},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.46549999713897705},{"id":"https://openalex.org/C28406088","wikidata":"https://www.wikidata.org/wiki/Q5571762","display_name":"Extracellular","level":2,"score":0.46320000290870667},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.4424999952316284},{"id":"https://openalex.org/C2778120352","wikidata":"https://www.wikidata.org/wiki/Q3870163","display_name":"Nanoparticle tracking analysis","level":5,"score":0.42559999227523804},{"id":"https://openalex.org/C2776194525","wikidata":"https://www.wikidata.org/wiki/Q282142","display_name":"Glioblastoma","level":2,"score":0.41100001335144043},{"id":"https://openalex.org/C130316041","wikidata":"https://www.wikidata.org/wiki/Q189206","display_name":"Vesicle","level":3,"score":0.4009999930858612},{"id":"https://openalex.org/C189165786","wikidata":"https://www.wikidata.org/wiki/Q193825","display_name":"Extracellular matrix","level":2,"score":0.382999986410141},{"id":"https://openalex.org/C100787162","wikidata":"https://www.wikidata.org/wiki/Q17009135","display_name":"Cord lining","level":5,"score":0.37940001487731934},{"id":"https://openalex.org/C2776955114","wikidata":"https://www.wikidata.org/wiki/Q172563","display_name":"Umbilical cord","level":2,"score":0.3578999936580658},{"id":"https://openalex.org/C2992929900","wikidata":"https://www.wikidata.org/wiki/Q21097485","display_name":"Extracellular vesicles","level":2,"score":0.3172999918460846},{"id":"https://openalex.org/C55427017","wikidata":"https://www.wikidata.org/wiki/Q1638475","display_name":"Cancer stem cell","level":3,"score":0.31529998779296875},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.3093000054359436},{"id":"https://openalex.org/C89429830","wikidata":"https://www.wikidata.org/wiki/Q735710","display_name":"Scaffold","level":2,"score":0.30570000410079956},{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.2865999937057495},{"id":"https://openalex.org/C2778630268","wikidata":"https://www.wikidata.org/wiki/Q17113277","display_name":"Cell sorting","level":3,"score":0.28299999237060547},{"id":"https://openalex.org/C10116572","wikidata":"https://www.wikidata.org/wiki/Q18033097","display_name":"LGR5","level":4,"score":0.2784999907016754},{"id":"https://openalex.org/C10854531","wikidata":"https://www.wikidata.org/wiki/Q1061415","display_name":"Regenerative medicine","level":3,"score":0.27549999952316284},{"id":"https://openalex.org/C1491633281","wikidata":"https://www.wikidata.org/wiki/Q7868","display_name":"Cell","level":2,"score":0.27469998598098755},{"id":"https://openalex.org/C2781018059","wikidata":"https://www.wikidata.org/wiki/Q207609","display_name":"Oncogene","level":4,"score":0.2606000006198883},{"id":"https://openalex.org/C2778402981","wikidata":"https://www.wikidata.org/wiki/Q221694","display_name":"Blood\u2013brain barrier","level":3,"score":0.2547000050544739},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.25209999084472656}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.21203/rs.3.rs-11222166/v1","doi":"https://doi.org/10.21203/rs.3.rs-11222166/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11222166/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"}],"best_oa_location":{"id":"doi:10.21203/rs.3.rs-11222166/v1","doi":"https://doi.org/10.21203/rs.3.rs-11222166/v1","is_oa":true,"landing_page_url":"https://doi.org/10.21203/rs.3.rs-11222166/v1","pdf_url":null,"source":{"id":"https://openalex.org/S4306525896","display_name":"Research Square","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":null,"host_organization_name":null,"host_organization_lineage":[],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"acceptedVersion","is_accepted":true,"is_published":false,"raw_source_name":"Research Square","raw_type":"posted-content"},"sustainable_development_goals":[],"study_designs":[],"awards":[],"funders":[],"has_content":{"grobid_xml":false,"pdf":false},"content_urls":null,"referenced_works_count":15,"referenced_works":["https://openalex.org/W2025371271","https://openalex.org/W2096287682","https://openalex.org/W2567501064","https://openalex.org/W2789259361","https://openalex.org/W2900756811","https://openalex.org/W3082762444","https://openalex.org/W4283836686","https://openalex.org/W4367053375","https://openalex.org/W4381683394","https://openalex.org/W4391614007","https://openalex.org/W4396763537","https://openalex.org/W4400014053","https://openalex.org/W4403484465","https://openalex.org/W4403777928","https://openalex.org/W4414083724"],"related_works":[],"abstract_inverted_index":{"Abstract":[0],"Background:":[1],"Brain":[2],"cancer":[3],"named":[4],"glioblastoma":[5,133,236,323],"multiforme":[6,237],"often":[7],"called":[8],"GBM":[9],"is":[10],"hard":[11],"to":[12,16,20,84,110,192,217,291],"manage.":[13],"Survival":[14],"tends":[15],"stretch":[17],"just":[18],"14":[19],"16":[21],"months,":[22],"despite":[23],"aggressive":[24,129,337],"therapies.":[25],"Research":[26],"now":[27],"turns":[28],"toward":[29],"tiny":[30],"bubbles":[31],"released":[32],"by":[33,297],"mesenchymal":[34],"stem":[35,112],"cells,":[36,170,238],"known":[37,105],"as":[38,106,288],"extracellular":[39,121],"vesicles.":[40],"These":[41],"particles":[42,276],"slip":[43],"through":[44,141,272],"the":[45,70,85,196,249,263,305],"blood-brain":[46],"barrier":[47],"without":[48,160],"trouble.":[49],"Meanwhile,":[50],"attention":[51],"grows":[52],"around":[53],"caffeic":[54],"acid,":[55],"a":[56,98,142,227,333],"substance":[57],"found":[58],"in":[59,69,155,262,335],"plants.":[60],"Early":[61],"findings":[62],"hint":[63],"it":[64],"may":[65,329],"slow":[66],"tumor":[67],"growth":[68,295],"brain.":[71],"Yet":[72],"issues":[73],"remain.":[74],"Poor":[75],"absorption":[76],"into":[77,195],"tissues":[78],"marks":[79],"one":[80,330],"limitation,":[81],"while":[82],"access":[83],"brain":[86,130,338],"proves":[87],"especially":[88],"difficult.":[89],"A":[90,340],"new":[91],"approach":[92],"emerges":[93],"here.":[94],"In":[95],"this":[96,328],"study,":[97],"biological":[99],"layer":[100],"decellularized":[101],"human":[102],"amnion-chorion":[103],"membrane,":[104],"dHACM":[107,136,310],"was":[108,190,212,226,270],"tested":[109],"cultivate":[111],"cells":[113,293],"from":[114,167],"umbilical":[115],"cords,":[116],"labeled":[117],"hUCT-MSCs.":[118],"From":[119,135],"these,":[120],"vesicles":[122,165,197],"form,":[123],"capable":[124,318],"of":[125,230,248,257,316,319],"transporting":[126],"CGA":[127,194,220,231,242,283,298,321],"against":[128,322],"tumors":[131],"like":[132,327],"multiforme.":[134,324],"tissue,":[137],"MSCs":[138],"were":[139],"isolated":[140],"targeted":[143],"technique,":[144],"afterward":[145],"verifying":[146],"cell":[147],"identity":[148],"with":[149,179,205],"precision.":[150],"Flow":[151],"cytometry":[152],"joined":[153],"karyotyping":[154],"confirming":[156],"traits,":[157],"ensuring":[158],"accuracy":[159],"reliance":[161],"on":[162],"assumptions.":[163],"Extracellular":[164],"emerged":[166],"these":[168],"cultured":[169],"captured":[171],"for":[172],"further":[173],"study.":[174],"Nanoparticle":[175],"tracking":[176],"analysis,":[177],"along":[178],"transmission":[180],"electron":[181],"microscopy,":[182],"revealed":[183,294],"their":[184],"physical":[185],"details":[186],"clearly.":[187],"Microwave-assisted":[188],"loading":[189],"applied":[191,213],"insert":[193],"successfully.":[198],"Each":[199],"phase":[200],"unfolded":[201],"systematically,":[202],"maintaining":[203],"alignment":[204],"initial":[206],"design":[207],"goals.":[208],"Moreover,":[209],"network":[210],"pharmacology":[211],"alongside":[214],"molecular":[215],"docking":[216],"explore":[218],"how":[219],"behaves.":[221],"It":[222],"turned":[223],"out":[224],"EGFR":[225,285],"key":[228],"target":[229],"activity.":[232],"When":[233],"examining":[234],"U87":[235,292],"both":[239],"EVs":[240,303,317],"and":[241,259,284],"showed":[243],"measurable":[244],"effects.":[245],"Health":[246],"status":[247],"hUCT-MSCs":[250],"remained":[251,267],"strong":[252],"throughout":[253],"testing.":[254],"Abundant":[255],"levels":[256],"CD90":[258],"CD105":[260],"appeared":[261],"sample,":[264],"yet":[265],"CD31":[266],"low.":[268],"Viability":[269],"confirmed":[271],"standard":[273],"measures.":[274],"With":[275],"falling":[277],"within":[278],"expected":[279],"dimensions,":[280],"binding":[281],"between":[282],"occurred":[286],"exactly":[287],"intended.":[289],"Exposure":[290],"inhibition":[296],"alone;":[299],"effects":[300],"intensified":[301],"once":[302],"entered":[304],"mix.":[306],"Findings":[307],"highlight":[308],"freeze-thawed":[309],"supports":[311],"MSC":[312],"expansion,":[313],"enabling":[314],"production":[315],"delivering":[320],"Natural":[325],"compounds":[326],"day":[331],"play":[332],"role":[334],"targeting":[336],"tumors.":[339],"single":[341],"advance,":[342],"but":[343],"meaningful.":[344]},"counts_by_year":[],"updated_date":"2026-11-05T12:25:35.769452","created_date":"2026-11-05T00:00:00"}
