{"id":"https://openalex.org/W7225264451","doi":"https://doi.org/10.1155/cdr/1092234","title":"Trajectories of a Composite Lipid, Glucose, and Refined Obesity Index Predict Cardiovascular Disease","display_name":"Trajectories of a Composite Lipid, Glucose, and Refined Obesity Index Predict Cardiovascular Disease","publication_year":2026,"publication_date":"2026-01-01","ids":{"openalex":"https://openalex.org/W7225264451","doi":"https://doi.org/10.1155/cdr/1092234","pmid":"https://pubmed.ncbi.nlm.nih.gov/42979946","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13732808"},"language":"en","primary_location":{"id":"doi:10.1155/cdr/1092234","doi":"https://doi.org/10.1155/cdr/1092234","is_oa":true,"landing_page_url":"https://doi.org/10.1155/cdr/1092234","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cdr/1092234","source":{"id":"https://openalex.org/S73613154","display_name":"Cardiovascular Therapeutics","issn_l":"1755-5914","issn":["1755-5914","1755-5922"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapeutics","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cdr/1092234","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5077333817","display_name":"Linying Xia","orcid":"https://orcid.org/0000-0001-7733-2933","observed_orcids":["https://orcid.org/0000-0001-7733-2933"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Linying Xia","raw_affiliation_strings":["Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China"],"raw_orcid":"https://orcid.org/0000-0001-7733-2933","affiliations":[{"raw_affiliation_string":"Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5128274941","display_name":"Tengfei Ji","orcid":"https://orcid.org/0009-0004-2599-8599","observed_orcids":["https://orcid.org/0009-0004-2599-8599"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tengfei Ji","raw_affiliation_strings":["Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China"],"raw_orcid":"https://orcid.org/0009-0004-2599-8599","affiliations":[{"raw_affiliation_string":"Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160648709","display_name":"Yuan Wang","orcid":"https://orcid.org/0009-0008-9954-6463","observed_orcids":["https://orcid.org/0009-0008-9954-6463"]},"institutions":[],"countries":[],"is_corresponding":false,"raw_author_name":"Yuan Wang","raw_affiliation_strings":["Shaanxi International Travel Healthcare Center (Xi\u2032an Customs Port Outpatient Department)  Xi\u2032an Shaanxi China"],"raw_orcid":"https://orcid.org/0009-0008-9954-6463","affiliations":[{"raw_affiliation_string":"Shaanxi International Travel Healthcare Center (Xi\u2032an Customs Port Outpatient Department)  Xi\u2032an Shaanxi China","institution_ids":[]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160605248","display_name":"Danni Li","orcid":"https://orcid.org/0009-0005-2230-7243","observed_orcids":["https://orcid.org/0009-0005-2230-7243"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Danni Li","raw_affiliation_strings":["Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China"],"raw_orcid":"https://orcid.org/0009-0005-2230-7243","affiliations":[{"raw_affiliation_string":"Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5160617498","display_name":"Yuyu Sun","orcid":"https://orcid.org/0009-0008-4589-8674","observed_orcids":["https://orcid.org/0009-0008-4589-8674"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuyu Sun","raw_affiliation_strings":["Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China"],"raw_orcid":"https://orcid.org/0009-0008-4589-8674","affiliations":[{"raw_affiliation_string":"Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115695052","display_name":"Wenwen Wang","orcid":"https://orcid.org/0000-0003-1547-5714","observed_orcids":["https://orcid.org/0000-0003-1547-5714"]},"institutions":[{"id":"https://openalex.org/I9916479","display_name":"Air Force Medical University","ror":"https://ror.org/00ms48f15","country_code":"CN","type":"education","lineage":["https://openalex.org/I9916479"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Wenwen Wang","raw_affiliation_strings":["Department of Epidemiology Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Fourth Military Medical University  Xi\u2032an Shaanxi China  fmmu.edu.cn"],"raw_orcid":"https://orcid.org/0000-0003-1547-5714","affiliations":[{"raw_affiliation_string":"Department of Epidemiology Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment School of Public Health Fourth Military Medical University  Xi\u2032an Shaanxi China  fmmu.edu.cn","institution_ids":["https://openalex.org/I9916479"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5160606438","display_name":"Jie Deng","orcid":"https://orcid.org/0009-0006-9497-9329","observed_orcids":["https://orcid.org/0009-0006-9497-9329"]},"institutions":[{"id":"https://openalex.org/I4210131893","display_name":"Second Affiliated Hospital of Xi'an Jiaotong University","ror":"https://ror.org/03aq7kf18","country_code":"CN","type":"healthcare","lineage":["https://openalex.org/I4210131893"]},{"id":"https://openalex.org/I87445476","display_name":"Xi'an Jiaotong University","ror":"https://ror.org/017zhmm22","country_code":"CN","type":"education","lineage":["https://openalex.org/I87445476"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Jie Deng","raw_affiliation_strings":["Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China"],"raw_orcid":"https://orcid.org/0009-0006-9497-9329","affiliations":[{"raw_affiliation_string":"Department of Cardiology The Second Affiliated Hospital of Xi\u2032an Jiaotong University  Xi\u2032an Shaanxi China","institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5115695052","https://openalex.org/A5160606438"],"corresponding_institution_ids":["https://openalex.org/I4210131893","https://openalex.org/I87445476","https://openalex.org/I9916479"],"apc_list":{"value":2160,"currency":"USD","value_usd":2160},"apc_paid":{"value":2160,"currency":"USD","value_usd":2160},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.86441089,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"2026","issue":"1","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T10027","display_name":"Diabetes, Cardiovascular Risks, and Lipoproteins","score":0.9951000213623047,"subfield":{"id":"https://openalex.org/subfields/2712","display_name":"Endocrinology, Diabetes and Metabolism"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T13522","display_name":"Cardiovascular Health and Risk Factors","score":0.001500000013038516,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T12979","display_name":"Cardiovascular Disease and Adiposity","score":0.0010000000474974513,"subfield":{"id":"https://openalex.org/subfields/2705","display_name":"Cardiology and Cardiovascular Medicine"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/cardiovascular-risk-prediction","display_name":"cardiovascular risk prediction","score":0.7360000014305115},{"id":"https://openalex.org/keywords/composite-index","display_name":"composite index","score":0.48100000619888306},{"id":"https://openalex.org/keywords/waist-circumference","display_name":"waist circumference","score":0.6370000243186951},{"id":"https://openalex.org/keywords/abdominal-obesity","display_name":"abdominal obesity","score":0.8360000252723694},{"id":"https://openalex.org/keywords/insulin-resistance","display_name":"insulin resistance","score":0.8989999890327454},{"id":"https://openalex.org/keywords/longitudinal-trajectories","display_name":"longitudinal trajectories","score":0.8220000267028809},{"id":"https://openalex.org/keywords/cumulative-exposure","display_name":"cumulative exposure","score":0.984000027179718},{"id":"https://openalex.org/keywords/framingham-risk-score","display_name":"Framingham risk score","score":0.953000009059906},{"id":"https://openalex.org/keywords/risk-stratification","display_name":"risk stratification","score":0.8190000057220459},{"id":"https://openalex.org/keywords/middle-aged-and-older-adults","display_name":"middle-aged and older adults","score":0.9210000038146973}],"concepts":[{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.9018999934196472},{"id":"https://openalex.org/C126322002","wikidata":"https://www.wikidata.org/wiki/Q11180","display_name":"Internal medicine","level":1,"score":0.5652999877929688},{"id":"https://openalex.org/C11783203","wikidata":"https://www.wikidata.org/wiki/Q5478027","display_name":"Framingham Risk Score","level":3,"score":0.5569000244140625},{"id":"https://openalex.org/C2778098375","wikidata":"https://www.wikidata.org/wiki/Q19596433","display_name":"Composite index","level":3,"score":0.5569000244140625},{"id":"https://openalex.org/C50382708","wikidata":"https://www.wikidata.org/wiki/Q223218","display_name":"Proportional hazards model","level":2,"score":0.5372999906539917},{"id":"https://openalex.org/C3019719930","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value","level":2,"score":0.5360000133514404},{"id":"https://openalex.org/C511355011","wikidata":"https://www.wikidata.org/wiki/Q12174","display_name":"Obesity","level":2,"score":0.5045999884605408},{"id":"https://openalex.org/C2780221984","wikidata":"https://www.wikidata.org/wiki/Q131191","display_name":"Body mass index","level":2,"score":0.48890000581741333},{"id":"https://openalex.org/C12725497","wikidata":"https://www.wikidata.org/wiki/Q810247","display_name":"Baseline (sea)","level":2,"score":0.4657000005245209},{"id":"https://openalex.org/C188816634","wikidata":"https://www.wikidata.org/wiki/Q2113324","display_name":"Prospective cohort study","level":2,"score":0.4652999937534332},{"id":"https://openalex.org/C2779134260","wikidata":"https://www.wikidata.org/wiki/Q12136","display_name":"Disease","level":2,"score":0.4496999979019165},{"id":"https://openalex.org/C2777382242","wikidata":"https://www.wikidata.org/wiki/Q6017816","display_name":"Index (typography)","level":2,"score":0.439300000667572},{"id":"https://openalex.org/C2777895361","wikidata":"https://www.wikidata.org/wiki/Q1758614","display_name":"Longitudinal study","level":2,"score":0.42579999566078186},{"id":"https://openalex.org/C555293320","wikidata":"https://www.wikidata.org/wiki/Q12206","display_name":"Diabetes mellitus","level":2,"score":0.41679999232292175},{"id":"https://openalex.org/C50440223","wikidata":"https://www.wikidata.org/wiki/Q1475848","display_name":"Risk factor","level":2,"score":0.41659998893737793},{"id":"https://openalex.org/C111815664","wikidata":"https://www.wikidata.org/wiki/Q1440693","display_name":"Framingham Heart Study","level":4,"score":0.4052000045776367},{"id":"https://openalex.org/C198433322","wikidata":"https://www.wikidata.org/wiki/Q3910099","display_name":"Predictive value of tests","level":2,"score":0.40299999713897705},{"id":"https://openalex.org/C2780578515","wikidata":"https://www.wikidata.org/wiki/Q657193","display_name":"Metabolic syndrome","level":3,"score":0.39399999380111694},{"id":"https://openalex.org/C152877465","wikidata":"https://www.wikidata.org/wiki/Q208042","display_name":"Regression analysis","level":2,"score":0.3928000032901764},{"id":"https://openalex.org/C164705383","wikidata":"https://www.wikidata.org/wiki/Q10379","display_name":"Cardiology","level":1,"score":0.3813999891281128},{"id":"https://openalex.org/C12174686","wikidata":"https://www.wikidata.org/wiki/Q1058438","display_name":"Risk assessment","level":2,"score":0.3564000129699707},{"id":"https://openalex.org/C48921125","wikidata":"https://www.wikidata.org/wiki/Q10861030","display_name":"Linear regression","level":2,"score":0.3433000147342682},{"id":"https://openalex.org/C63817138","wikidata":"https://www.wikidata.org/wiki/Q3455889","display_name":"Quantile regression","level":2,"score":0.3391000032424927},{"id":"https://openalex.org/C83546350","wikidata":"https://www.wikidata.org/wiki/Q1139051","display_name":"Regression","level":2,"score":0.3077000081539154},{"id":"https://openalex.org/C105795698","wikidata":"https://www.wikidata.org/wiki/Q12483","display_name":"Statistics","level":1,"score":0.30390000343322754},{"id":"https://openalex.org/C122048520","wikidata":"https://www.wikidata.org/wiki/Q2913954","display_name":"Percentile","level":2,"score":0.29899999499320984},{"id":"https://openalex.org/C185265303","wikidata":"https://www.wikidata.org/wiki/Q7309537","display_name":"Regression dilution","level":4,"score":0.2881999909877777},{"id":"https://openalex.org/C84393581","wikidata":"https://www.wikidata.org/wiki/Q82642","display_name":"Blood pressure","level":2,"score":0.2858999967575073},{"id":"https://openalex.org/C45804977","wikidata":"https://www.wikidata.org/wiki/Q7239673","display_name":"Predictive modelling","level":2,"score":0.26489999890327454},{"id":"https://openalex.org/C77350462","wikidata":"https://www.wikidata.org/wiki/Q1125472","display_name":"Confounding","level":2,"score":0.2630000114440918},{"id":"https://openalex.org/C20685875","wikidata":"https://www.wikidata.org/wiki/Q7239678","display_name":"Predictive validity","level":2,"score":0.2621999979019165},{"id":"https://openalex.org/C58471807","wikidata":"https://www.wikidata.org/wiki/Q327120","display_name":"Receiver operating characteristic","level":2,"score":0.2612999975681305},{"id":"https://openalex.org/C2992405062","wikidata":"https://www.wikidata.org/wiki/Q18208028","display_name":"Composite indicator","level":2,"score":0.26100000739097595},{"id":"https://openalex.org/C2994039464","wikidata":"https://www.wikidata.org/wiki/Q217690","display_name":"Cumulative risk","level":2,"score":0.251800000667572},{"id":"https://openalex.org/C2777180221","wikidata":"https://www.wikidata.org/wiki/Q3025883","display_name":"Type 2 diabetes","level":3,"score":0.25060001015663147},{"id":"https://openalex.org/C149923435","wikidata":"https://www.wikidata.org/wiki/Q37732","display_name":"Demography","level":1,"score":0.25029999017715454},{"id":"https://openalex.org/C3018284874","wikidata":"https://www.wikidata.org/wiki/Q389735","display_name":"Cardiovascular health","level":3,"score":0.2502000033855438}],"mesh":[{"descriptor_ui":"D000082742","descriptor_name":"Heart Disease Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D000368","descriptor_name":"Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000032","qualifier_name":"analysis","is_major_topic":true},{"descriptor_ui":"D001786","descriptor_name":"Blood Glucose","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D002318","descriptor_name":"Cardiovascular Diseases","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D005260","descriptor_name":"Female","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D006801","descriptor_name":"Humans","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D007333","descriptor_name":"Insulin Resistance","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008055","descriptor_name":"Lipids","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D008297","descriptor_name":"Male","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D008875","descriptor_name":"Middle Aged","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D009765","descriptor_name":"Obesity","qualifier_ui":"Q000503","qualifier_name":"physiopathology","is_major_topic":true},{"descriptor_ui":"D011237","descriptor_name":"Predictive Value of Tests","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011379","descriptor_name":"Prognosis","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D011446","descriptor_name":"Prospective Studies","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D012307","descriptor_name":"Risk Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D013997","descriptor_name":"Time Factors","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D015415","descriptor_name":"Biomarkers","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":false},{"descriptor_ui":"D015994","descriptor_name":"Incidence","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D018570","descriptor_name":"Risk Assessment","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050154","descriptor_name":"Adiposity","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000097","qualifier_name":"blood","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000175","qualifier_name":"diagnosis","is_major_topic":true},{"descriptor_ui":"D050171","descriptor_name":"Dyslipidemias","qualifier_ui":"Q000453","qualifier_name":"epidemiology","is_major_topic":true},{"descriptor_ui":"D055105","descriptor_name":"Waist Circumference","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1155/cdr/1092234","doi":"https://doi.org/10.1155/cdr/1092234","is_oa":true,"landing_page_url":"https://doi.org/10.1155/cdr/1092234","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cdr/1092234","source":{"id":"https://openalex.org/S73613154","display_name":"Cardiovascular Therapeutics","issn_l":"1755-5914","issn":["1755-5914","1755-5922"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapeutics","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13732808","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732808/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732808/pdf/CDR-2026-1092234.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovasc Ther","raw_type":"Text"},{"id":"pmid:42979946","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42979946","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular therapeutics","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1155/cdr/1092234","doi":"https://doi.org/10.1155/cdr/1092234","is_oa":true,"landing_page_url":"https://doi.org/10.1155/cdr/1092234","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1155/cdr/1092234","source":{"id":"https://openalex.org/S73613154","display_name":"Cardiovascular Therapeutics","issn_l":"1755-5914","issn":["1755-5914","1755-5922"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-c","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-2"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by","license_id":"https://openalex.org/licenses/cc-by","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Cardiovascular Therapeutics","raw_type":"journal-article"},"sustainable_development_goals":[{"id":"https://metadata.un.org/sdg/3","score":1.0,"display_name":"Good health and well-being"}],"study_designs":[{"id":"https://openalex.org/study-designs/observational-study","display_name":"Observational Study"}],"awards":[],"funders":[],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225264451.pdf","grobid_xml":"https://content.openalex.org/works/W7225264451.grobid-xml"},"referenced_works_count":47,"referenced_works":["https://openalex.org/W1976616659","https://openalex.org/W1983069289","https://openalex.org/W1986019364","https://openalex.org/W1988973837","https://openalex.org/W1990757970","https://openalex.org/W2013480805","https://openalex.org/W2014465141","https://openalex.org/W2028320377","https://openalex.org/W2033045278","https://openalex.org/W2125944762","https://openalex.org/W2128573775","https://openalex.org/W2441693614","https://openalex.org/W2558627163","https://openalex.org/W2815491376","https://openalex.org/W2888814360","https://openalex.org/W2986758610","https://openalex.org/W3005741169","https://openalex.org/W3113178943","https://openalex.org/W3152705473","https://openalex.org/W3160515305","https://openalex.org/W4282962678","https://openalex.org/W4284890877","https://openalex.org/W4293813126","https://openalex.org/W4297977810","https://openalex.org/W4310714298","https://openalex.org/W4382056313","https://openalex.org/W4390640401","https://openalex.org/W4390752141","https://openalex.org/W4390838421","https://openalex.org/W4391232927","https://openalex.org/W4391678647","https://openalex.org/W4399117870","https://openalex.org/W4402584394","https://openalex.org/W4403986557","https://openalex.org/W4404591194","https://openalex.org/W4406309773","https://openalex.org/W4407199619","https://openalex.org/W4408029761","https://openalex.org/W4408295858","https://openalex.org/W4411452495","https://openalex.org/W4414487033","https://openalex.org/W4414798590","https://openalex.org/W4416204777","https://openalex.org/W4416827171","https://openalex.org/W7124846483","https://openalex.org/W7128064320","https://openalex.org/W7135399706"],"related_works":["https://openalex.org/W7169521747","https://openalex.org/W7164925085","https://openalex.org/W7223667321","https://openalex.org/W7221193331","https://openalex.org/W7166732479","https://openalex.org/W7163685521","https://openalex.org/W4416204777","https://openalex.org/W7202162060","https://openalex.org/W7147346810","https://openalex.org/W7167425511"],"abstract_inverted_index":{"BACKGROUND:":[0],"Insulin":[1],"resistance":[2],"and":[3,17,35,46,60,72,83,103,121,126,141,155,161],"central":[4],"adiposity":[5],"are":[6],"key":[7],"drivers":[8],"of":[9,31,64,93,106,145,164,173,177],"cardiovascular":[10],"disease":[11],"(CVD).":[12],"Although":[13],"the":[14,28,146],"CHG":[15],"index":[16],"obesity-related":[18],"indicators":[19,179],"can":[20],"separately":[21],"predict":[22],"metabolic":[23],"risks,":[24],"this":[25],"study":[26],"explored":[27],"predictive":[29,84,139],"value":[30],"their":[32],"composite":[33,66,107,166],"indices":[34,108,167],"longitudinal":[36,62],"trajectories":[37,63,105,160],"for":[38],"incident":[39],"CVD.":[40,96,174],"METHODS:":[41],"Based":[42],"on":[43],"4164":[44],"middle-aged":[45],"elderly":[47],"participants":[48,94],"from":[49],"a":[50],"national":[51],"prospective":[52],"cohort,":[53],"we":[54],"analyzed":[55],"baseline":[56,98,119],"levels,":[57],"cumulative":[58,101,162],"exposures":[59,163],"K-means-defined":[61],"CHG-related":[65],"indices.":[67],"Cox":[68],"regression,":[69],"ROC":[70],"analysis,":[71],"weighted":[73],"quantile":[74],"sum":[75],"regression":[76],"were":[77,109],"adopted":[78],"to":[79,111,124],"explore":[80],"CVD":[81,113,129,182],"associations":[82],"efficiency.":[85],"RESULTS:":[86],"During":[87],"an":[88],"8-year":[89],"median":[90],"follow-up,":[91],"22.14%":[92],"developed":[95],"Elevated":[97],"values,":[99],"increased":[100],"exposure,":[102],"unfavorable":[104],"linked":[110],"higher":[112,128],"risk.":[114],"Per":[115],"1-SD":[116],"rise":[117],"in":[118,138],"CHG-WC":[120],"CHG-CVAI":[122],"corresponded":[123],"19%":[125],"17%":[127],"risk,":[130],"respectively.":[131],"Their":[132],"addition":[133],"produced":[134],"statistically":[135],"significant":[136],"improvements":[137],"performance":[140],"risk":[142,183],"stratifying":[143],"capacity":[144],"Framingham":[147],"Risk":[148],"Score,":[149],"as":[150,169],"further":[151],"supported":[152],"by":[153],"NRI":[154],"IDI":[156],"analyses.":[157],"CONCLUSION:":[158],"Longitudinal":[159],"CHG-obesity":[165],"serve":[168],"reliable":[170],"independent":[171],"predictors":[172],"Dynamic":[175],"monitoring":[176],"these":[178],"facilitates":[180],"early":[181],"stratification.":[184]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-05T00:00:00"}