{"id":"https://openalex.org/W7225258863","doi":"https://doi.org/10.1016/j.prmcm.2026.100899","title":"Mentha canadensis leaves induce anti-tumor activity in Ehrlich ascites carcinoma cells through caspase-dependent apoptosis and Bcl-2 interaction","display_name":"Mentha canadensis leaves induce anti-tumor activity in Ehrlich ascites carcinoma cells through caspase-dependent apoptosis and Bcl-2 interaction","publication_year":2026,"publication_date":"2026-11-05","ids":{"openalex":"https://openalex.org/W7225258863","doi":"https://doi.org/10.1016/j.prmcm.2026.100899"},"language":"en","primary_location":{"id":"doi:10.1016/j.prmcm.2026.100899","doi":"https://doi.org/10.1016/j.prmcm.2026.100899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2026.100899","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://doi.org/10.1016/j.prmcm.2026.100899","any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5146748613","display_name":"Asma Ul Husna Biswas","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Asma Ul Husna Biswas","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5114999090","display_name":"Chandan Barai","orcid":"https://orcid.org/0009-0008-5078-062X","observed_orcids":["https://orcid.org/0009-0008-5078-062X"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Chandan Barai","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":"https://orcid.org/0009-0008-5078-062X","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116303557","display_name":"Tasnima Kamal","orcid":"https://orcid.org/0009-0002-3439-9163","observed_orcids":["https://orcid.org/0009-0002-3439-9163"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Tasnima Kamal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5027316836","display_name":"Azadur Rahman Bhuiyan","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Azadur Rahman Bhuiyan","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5111071307","display_name":"Mahmud Ismail","orcid":"https://orcid.org/0009-0009-7780-1184","observed_orcids":["https://orcid.org/0009-0009-7780-1184"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Mahmud Ismail","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5115777608","display_name":"Zinnat Ara Moni","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Zinnat Ara Moni","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5092546727","display_name":"Abdul Auwal","orcid":"https://orcid.org/0009-0007-9763-7313","observed_orcids":["https://orcid.org/0009-0007-9763-7313"]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Abdul Auwal","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5009312747","display_name":"Nitai Roy","orcid":"https://orcid.org/0000-0002-8454-6128","observed_orcids":["https://orcid.org/0000-0002-8454-6128"]},"institutions":[{"id":"https://openalex.org/I305407034","display_name":"Patuakhali Science and Technology University","ror":"https://ror.org/03m50n726","country_code":"BD","type":"education","lineage":["https://openalex.org/I305407034"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Nitai Roy","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, Patuakhali Science and Technology University, Patuakhali, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, Patuakhali Science and Technology University, Patuakhali, Bangladesh","institution_ids":["https://openalex.org/I305407034"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5101104516","display_name":"Md Tofazzal Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md Tofazzal Hossain","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5054541368","display_name":"Md. Shakhawoat Hossain","orcid":null,"observed_orcids":[]},"institutions":[{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["BD"],"is_corresponding":false,"raw_author_name":"Md. Shakhawoat Hossain","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh"],"raw_orcid":null,"affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5017414698","display_name":"Farhadul Islam","orcid":"https://orcid.org/0000-0001-5262-4702","observed_orcids":["https://orcid.org/0000-0001-5262-4702"]},"institutions":[{"id":"https://openalex.org/I11701301","display_name":"Griffith University","ror":"https://ror.org/02sc3r913","country_code":"AU","type":"education","lineage":["https://openalex.org/I11701301"]},{"id":"https://openalex.org/I902853133","display_name":"University of Rajshahi","ror":"https://ror.org/05nnyr510","country_code":"BD","type":"education","lineage":["https://openalex.org/I902853133"]}],"countries":["AU","BD"],"is_corresponding":true,"raw_author_name":"Farhadul Islam","raw_affiliation_strings":["Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Queensland 4222, Australia"],"raw_orcid":"https://orcid.org/0000-0001-5262-4702","affiliations":[{"raw_affiliation_string":"Department of Biochemistry and Molecular Biology, University of Rajshahi, Rajshahi, 6205, Bangladesh","institution_ids":["https://openalex.org/I902853133"]},{"raw_affiliation_string":"School of Medicine and Dentistry, Griffith University, Gold Coast Campus, Queensland 4222, Australia","institution_ids":["https://openalex.org/I11701301"]}]}],"institutions":[],"countries_distinct_count":2,"institutions_distinct_count":3,"corresponding_author_ids":["https://openalex.org/A5017414698"],"corresponding_institution_ids":["https://openalex.org/I11701301","https://openalex.org/I902853133"],"apc_list":{"value":1550,"currency":"USD","value_usd":1550},"apc_paid":{"value":1550,"currency":"USD","value_usd":1550},"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.0,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"21","issue":null,"first_page":"100899","last_page":"100899"},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},"topics":[{"id":"https://openalex.org/T14521","display_name":"Medicinal Plant Research","score":0.8661999702453613,"subfield":{"id":"https://openalex.org/subfields/1110","display_name":"Plant Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12215","display_name":"Phytochemical Studies and Bioactivities","score":0.03440000116825104,"subfield":{"id":"https://openalex.org/subfields/1605","display_name":"Organic Chemistry"},"field":{"id":"https://openalex.org/fields/16","display_name":"Chemistry"},"domain":{"id":"https://openalex.org/domains/3","display_name":"Physical Sciences"}},{"id":"https://openalex.org/T10225","display_name":"Essential Oils and Antimicrobial Activity","score":0.016599999740719795,"subfield":{"id":"https://openalex.org/subfields/1106","display_name":"Food Science"},"field":{"id":"https://openalex.org/fields/11","display_name":"Agricultural and Biological Sciences"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/mentha-canadensis","display_name":"Mentha canadensis","score":0.9449999928474426},{"id":"https://openalex.org/keywords/methanolic-leaf-extract","display_name":"methanolic leaf extract","score":0.777999997138977},{"id":"https://openalex.org/keywords/anticancer-activity","display_name":"anticancer activity","score":0.8050000071525574},{"id":"https://openalex.org/keywords/ehrlich-ascites-carcinoma","display_name":"Ehrlich ascites carcinoma","score":0.953000009059906},{"id":"https://openalex.org/keywords/apoptosis","display_name":"apoptosis","score":0.6980000138282776},{"id":"https://openalex.org/keywords/caspase-dependent-apoptosis","display_name":"caspase-dependent apoptosis","score":0.765999972820282},{"id":"https://openalex.org/keywords/bcl-2-inhibition","display_name":"BCL-2 inhibition","score":0.843999981880188},{"id":"https://openalex.org/keywords/phytochemicals","display_name":"phytochemicals","score":0.7850000262260437},{"id":"https://openalex.org/keywords/p53","display_name":"p53","score":0.8330000042915344},{"id":"https://openalex.org/keywords/bax","display_name":"Bax","score":0.9819999933242798},{"id":"https://openalex.org/keywords/bcl-2-bax-ratio","display_name":"Bcl-2/Bax ratio","score":0.5950000286102295},{"id":"https://openalex.org/keywords/tumor-bearing-mice","display_name":"tumor-bearing mice","score":0.5400000214576721},{"id":"https://openalex.org/keywords/hematological-parameters","display_name":"hematological parameters","score":0.6399999856948853},{"id":"https://openalex.org/keywords/dna-fragmentation","display_name":"DNA fragmentation","score":0.5680000185966492}],"concepts":[{"id":"https://openalex.org/C190283241","wikidata":"https://www.wikidata.org/wiki/Q14599311","display_name":"Apoptosis","level":2,"score":0.678600013256073},{"id":"https://openalex.org/C2776197502","wikidata":"https://www.wikidata.org/wiki/Q25326666","display_name":"Ehrlich ascites carcinoma","level":3,"score":0.5146999955177307},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.48669999837875366},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.4429999887943268},{"id":"https://openalex.org/C81885089","wikidata":"https://www.wikidata.org/wiki/Q189082","display_name":"Cell culture","level":2,"score":0.382099986076355},{"id":"https://openalex.org/C502942594","wikidata":"https://www.wikidata.org/wiki/Q3421914","display_name":"Cancer research","level":1,"score":0.35109999775886536},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.33489999175071716},{"id":"https://openalex.org/C109316439","wikidata":"https://www.wikidata.org/wiki/Q246181","display_name":"Cytotoxicity","level":3,"score":0.3292999863624573},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.30880001187324524},{"id":"https://openalex.org/C207001950","wikidata":"https://www.wikidata.org/wiki/Q141124","display_name":"In vivo","level":2,"score":0.3034000098705292},{"id":"https://openalex.org/C3020616263","wikidata":"https://www.wikidata.org/wiki/Q1216998","display_name":"Tumor cells","level":2,"score":0.3005000054836273},{"id":"https://openalex.org/C95444343","wikidata":"https://www.wikidata.org/wiki/Q7141","display_name":"Cell biology","level":1,"score":0.287200003862381},{"id":"https://openalex.org/C2776120743","wikidata":"https://www.wikidata.org/wiki/Q3271540","display_name":"Mechanism of action","level":3,"score":0.27959999442100525},{"id":"https://openalex.org/C553184892","wikidata":"https://www.wikidata.org/wiki/Q1141429","display_name":"Flow cytometry","level":2,"score":0.2793000042438507},{"id":"https://openalex.org/C29537977","wikidata":"https://www.wikidata.org/wiki/Q188941","display_name":"Cell cycle","level":3,"score":0.27810001373291016},{"id":"https://openalex.org/C2777546739","wikidata":"https://www.wikidata.org/wiki/Q33525","display_name":"Carcinoma","level":2,"score":0.27810001373291016},{"id":"https://openalex.org/C153911025","wikidata":"https://www.wikidata.org/wiki/Q7202","display_name":"Molecular biology","level":1,"score":0.2750999927520752},{"id":"https://openalex.org/C89611455","wikidata":"https://www.wikidata.org/wiki/Q6804646","display_name":"Mechanism (biology)","level":2,"score":0.26570001244544983},{"id":"https://openalex.org/C62112901","wikidata":"https://www.wikidata.org/wiki/Q189159","display_name":"Cell growth","level":2,"score":0.26249998807907104},{"id":"https://openalex.org/C8891405","wikidata":"https://www.wikidata.org/wiki/Q1059","display_name":"Immune system","level":2,"score":0.25940001010894775},{"id":"https://openalex.org/C202751555","wikidata":"https://www.wikidata.org/wiki/Q221681","display_name":"In vitro","level":2,"score":0.2522999942302704},{"id":"https://openalex.org/C556039675","wikidata":"https://www.wikidata.org/wiki/Q771035","display_name":"Traditional medicine","level":1,"score":0.25110000371932983}],"mesh":[],"locations_count":1,"locations":[{"id":"doi:10.1016/j.prmcm.2026.100899","doi":"https://doi.org/10.1016/j.prmcm.2026.100899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2026.100899","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"}],"best_oa_location":{"id":"doi:10.1016/j.prmcm.2026.100899","doi":"https://doi.org/10.1016/j.prmcm.2026.100899","is_oa":true,"landing_page_url":"https://doi.org/10.1016/j.prmcm.2026.100899","pdf_url":null,"source":{"id":"https://openalex.org/S4210232177","display_name":"Pharmacological Research - Modern Chinese Medicine","issn_l":"2667-1425","issn":["2667-1425"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","poland-20"],"host_organization":"https://openalex.org/P4310320990","host_organization_name":"Elsevier BV","host_organization_lineage":["https://openalex.org/P4310320990"],"host_organization_lineage_names":["Elsevier BV"],"type":"journal"},"license":"cc-by-nc-nd","license_id":"https://openalex.org/licenses/cc-by-nc-nd","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Pharmacological Research - Modern Chinese Medicine","raw_type":"journal-article"},"sustainable_development_goals":[{"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3","score":0.9763000011444092}],"study_designs":[],"awards":[],"funders":[{"id":"https://openalex.org/F4320329409","display_name":"Rajshahi University","ror":"https://ror.org/05nnyr510"}],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":45,"referenced_works":["https://openalex.org/W1031578623","https://openalex.org/W1492302205","https://openalex.org/W1583557840","https://openalex.org/W1963585912","https://openalex.org/W2009356149","https://openalex.org/W2011601475","https://openalex.org/W2012700578","https://openalex.org/W2015642465","https://openalex.org/W2086520960","https://openalex.org/W2128572087","https://openalex.org/W2131630923","https://openalex.org/W2134967712","https://openalex.org/W2170711116","https://openalex.org/W2555870966","https://openalex.org/W2893149049","https://openalex.org/W2902253099","https://openalex.org/W2943826122","https://openalex.org/W2953667394","https://openalex.org/W2979609812","https://openalex.org/W3087523850","https://openalex.org/W3106811398","https://openalex.org/W3112915907","https://openalex.org/W3137090641","https://openalex.org/W3137901308","https://openalex.org/W3138300258","https://openalex.org/W3202287440","https://openalex.org/W3207287796","https://openalex.org/W4200197704","https://openalex.org/W4283582006","https://openalex.org/W4323348503","https://openalex.org/W4362471397","https://openalex.org/W4384030293","https://openalex.org/W4387569294","https://openalex.org/W4389442773","https://openalex.org/W4389728011","https://openalex.org/W4391026334","https://openalex.org/W4391758145","https://openalex.org/W4395010444","https://openalex.org/W4403259546","https://openalex.org/W4405347313","https://openalex.org/W4408663412","https://openalex.org/W4410623596","https://openalex.org/W4410816248","https://openalex.org/W7117136711","https://openalex.org/W7129331579"],"related_works":["https://openalex.org/W1548121502","https://openalex.org/W2001906066","https://openalex.org/W2276369385","https://openalex.org/W4412585355","https://openalex.org/W2574442305","https://openalex.org/W2502122357","https://openalex.org/W2417112861","https://openalex.org/W2321643272","https://openalex.org/W2991253559","https://openalex.org/W2019975719"],"abstract_inverted_index":{"Background":[0],"Mentha":[1],"canadensis":[2,58,327],"(Bohe,":[3],"Herba":[4],"Menthae":[5],",":[6],"Wild":[7],"Mint)":[8],"belongs":[9],"to":[10,50,81,256],"the":[11,52,56,83,90,102,224,309,318,321,351],"Lamiaceae":[12],"family":[13],"and":[14,37,43,67,74,89,110,120,133,138,153,169,181,202,210,223,248,267,275,302,305],"has":[15],"a":[16,161,178,187,330,343],"long":[17],"history":[18],"of":[19,55,104,122,150,190,207,216,294,308,320,350],"use":[20],"in":[21,41,65,68,113,131,250,313,353],"Traditional":[22],"Chinese":[23,33],"Medicine":[24],"(TCM).":[25],"It":[26],"is":[27,38],"an":[28],"aromatic":[29],"herb":[30],"with":[31,147,165,232],"diverse":[32],"traditional":[34,348],"therapeutic":[35],"applications":[36],"also":[39,280],"used":[40],"food":[42],"beverage":[44],"applications.":[45],"Aims":[46],"This":[47,157],"study":[48,323],"aimed":[49],"investigate":[51],"anticancer":[53,191,339],"efficacy":[54,97],"M.":[57,326],"leaves":[59],"methanolic":[60],"extract":[61],"(MCLME)":[62],"using":[63],"both":[64,273],"silico":[66],"vivo":[69,95],"assays.":[70],"Methods":[71],"Molecular":[72],"docking":[73],"molecular":[75],"dynamics":[76],"simulations":[77],"were":[78,129],"carried":[79],"out":[80],"elucidate":[82],"binding":[84,143,148],"affinity":[85],"between":[86],"MCLME-derived":[87],"phytochemicals":[88],"anti-apoptotic":[91,310],"protein":[92],"Bcl-2.":[93],"In":[94],"antineoplastic":[96],"was":[98,219,227],"assessed":[99],"by":[100,199,221,229,342],"analyzing":[101],"inhibition":[103],"EAC":[105,196,260,285],"cell":[106,197,286],"growth,":[107],"survival":[108],"duration,":[109],"tumor":[111,225,257],"burden":[112,226],"tumor-bearing":[114],"mice,":[115],"hematological":[116],"parameters,":[117,243],"apoptotic":[118],"morphology,":[119],"expression":[121,307],"apoptosis-related":[123],"genes.":[124],"Results":[125],"Several":[126],"bioactive":[127],"compounds":[128],"identified":[130],"MCLME,":[132],"among":[134],"them,":[135],"CID":[136,139],"60157539":[137],"576686":[140],"exhibited":[141,262],"favorable":[142,171],"affinities":[144],"for":[145,333],"Bcl-2,":[146],"energies":[149],"\u22128.8":[151],"kcal/mol":[152],"\u22128.2":[154],"kcal/mol,":[155],"respectively.":[156,213],"interaction":[158],"could":[159,185],"provide":[160],"stable":[162],"protein\u2013ligand":[163],"complex":[164],"enhanced":[166],"structural":[167],"compactness":[168],"energetically":[170],"conformations":[172],"supports":[173],"their":[174],"potential":[175,188,254,331,338],"role":[176],"as":[177],"Bcl-2":[179,312],"inhibitor":[180],"suggests":[182],"that":[183,282,325],"MCLME":[184,193,240,283],"be":[186,329],"source":[189],"agents.":[192],"significantly":[194],"inhibited":[195],"growth":[198],"62.95%":[200],"(p<0.001)":[201,204],"45.655%":[203],"at":[205],"doses":[206],"200":[208],"mg/kg":[209],"100":[211],"mg/kg,":[212],"The":[214],"lifespan":[215],"EAC-bearing":[217,251],"mice":[218,234],"increased":[220],"50.66%,":[222],"reduced":[228],"35.24%":[230],"compared":[231],"control":[233],"(200mg/kg;":[235],"p":[236],"<":[237],"0.001).":[238],"Furthermore,":[239],"restored":[241],"blood":[242],"including":[244,356],"RBCs,":[245],"WBCs,":[246],"platelets,":[247],"hemoglobin,":[249],"animals,":[252],"suggesting":[253],"resistance":[255],"burden.":[258],"MCLME-treated":[259],"cells":[261],"membrane":[263],"blebbing,":[264],"chromatin":[265],"condensation,":[266],"nuclear":[268],"fragmentation":[269,279],"(apoptotic":[270],"features)":[271],"under":[272],"light":[274],"fluorescence":[276],"microscopy.":[277],"DNA":[278],"demonstrated":[281],"caused":[284],"death":[287],"via":[288],"apoptosis.":[289],"Moreover,":[290],"treatment":[291],"induced":[292],"upregulation":[293],"key":[295],"pro-apoptotic":[296],"genes":[297],"(":[298],"p53,":[299],"Bax,":[300],"caspase-9,":[301],"caspase-3":[303],")":[304],"suppressed":[306],"gene":[311],"treated":[314],"mice.":[315],"Conclusions":[316],"Together,":[317],"findings":[319],"present":[322],"show":[324],"might":[328],"resource":[332],"cancer":[334],"chemotherapy,":[335],"which":[336],"exhibits":[337],"activity":[340],"accompanied":[341],"caspase-dependent":[344],"pathway,":[345],"thus,":[346],"supporting":[347],"uses":[349],"plant":[352],"various":[354],"illnesses,":[355],"cancers.":[357]},"counts_by_year":[],"updated_date":"2026-11-13T13:42:25.865203","created_date":"2026-11-05T00:00:00"}
