{"id":"https://openalex.org/W7225256059","doi":"https://doi.org/10.1111/1751-7915.70469","title":"Reprogramming Native Cryptic Plasmids Enables Antibiotic\u2010Selection\u2010Free Urate Degradation by Escherichia coli Nissle 1917","display_name":"Reprogramming Native Cryptic Plasmids Enables Antibiotic\u2010Selection\u2010Free Urate Degradation by Escherichia coli Nissle 1917","publication_year":2026,"publication_date":"2026-11-01","ids":{"openalex":"https://openalex.org/W7225256059","doi":"https://doi.org/10.1111/1751-7915.70469","pmid":"https://pubmed.ncbi.nlm.nih.gov/42978372","pmcid":"https://www.ncbi.nlm.nih.gov/pmc/articles/13732112"},"language":"en","primary_location":{"id":"doi:10.1111/1751-7915.70469","doi":"https://doi.org/10.1111/1751-7915.70469","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1751-7915.70469","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.70469","source":{"id":"https://openalex.org/S4210238104","display_name":"Microbial Biotechnology","issn_l":"1751-7915","issn":["1751-7915","1751-7907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Biotechnology","raw_type":"journal-article"},"volume":null,"type":"article","is_traditional":true,"indexed_in":["crossref","doaj","pubmed"],"open_access":{"is_oa":true,"oa_status":"gold","oa_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.70469","any_repository_has_fulltext":true},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5134628706","display_name":"Yuan Chi","orcid":"https://orcid.org/0009-0002-4401-8053","observed_orcids":["https://orcid.org/0009-0002-4401-8053"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Yuan Chi","raw_affiliation_strings":["State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0009-0002-4401-8053","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5110549530","display_name":"Shiying Wu","orcid":"https://orcid.org/0009-0004-3634-8516","observed_orcids":["https://orcid.org/0009-0004-3634-8516"]},"institutions":[{"id":"https://openalex.org/I153374732","display_name":"Liaoning Normal University","ror":"https://ror.org/04c3cgg32","country_code":"CN","type":"education","lineage":["https://openalex.org/I153374732"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Shiying Wu","raw_affiliation_strings":["Key Laboratory of Plant Biotechnology of Liaoning Province School of Life Sciences, Liaoning Normal University  Dalian Liaoning China"],"raw_orcid":"https://orcid.org/0009-0004-3634-8516","affiliations":[{"raw_affiliation_string":"Key Laboratory of Plant Biotechnology of Liaoning Province School of Life Sciences, Liaoning Normal University  Dalian Liaoning China","institution_ids":["https://openalex.org/I153374732"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100759087","display_name":"Fei Lin","orcid":"https://orcid.org/0000-0002-1314-7410","observed_orcids":["https://orcid.org/0000-0002-1314-7410","https://orcid.org/0009-0001-3335-0694"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Fei Lin","raw_affiliation_strings":["State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0009-0001-3335-0694","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5049987263","display_name":"Tingwen Fan","orcid":"https://orcid.org/0000-0002-0891-5606","observed_orcids":["https://orcid.org/0000-0002-0891-5606"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":false,"raw_author_name":"Tingwen Fan","raw_affiliation_strings":["State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0000-0002-0891-5606","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5100411939","display_name":"Hongwei Liu","orcid":"https://orcid.org/0000-0001-6471-131X","observed_orcids":["https://orcid.org/0000-0001-6471-131X"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Hongwei Liu","raw_affiliation_strings":["State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0000-0001-6471-131X","affiliations":[{"raw_affiliation_string":"State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5101104010","display_name":"Huaiyi Yang","orcid":"https://orcid.org/0000-0003-2196-7811","observed_orcids":["https://orcid.org/0000-0003-2196-7811"]},"institutions":[{"id":"https://openalex.org/I19820366","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35","country_code":"CN","type":"government","lineage":["https://openalex.org/I19820366"]},{"id":"https://openalex.org/I4210134982","display_name":"Institute of Microbiology","ror":"https://ror.org/047yhep71","country_code":"CN","type":"facility","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"id":"https://openalex.org/I4210165038","display_name":"University of Chinese Academy of Sciences","ror":"https://ror.org/05qbk4x57","country_code":"CN","type":"education","lineage":["https://openalex.org/I19820366","https://openalex.org/I4210165038"]}],"countries":["CN"],"is_corresponding":true,"raw_author_name":"Huaiyi Yang","raw_affiliation_strings":["Beijing Key Laboratory of Genetic Element Biosourcing &amp; Intelligent Design for Biomanufacturing  Beijing China","State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","University of Chinese Academy of Sciences  Beijing China"],"raw_orcid":"https://orcid.org/0000-0003-2196-7811","affiliations":[{"raw_affiliation_string":"Beijing Key Laboratory of Genetic Element Biosourcing &amp; Intelligent Design for Biomanufacturing  Beijing China","institution_ids":[]},{"raw_affiliation_string":"State Key Laboratory of Microbial Diversity and Innovative Utilization, Institute of Microbiology Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982"]},{"raw_affiliation_string":"University of Chinese Academy of Sciences  Beijing China","institution_ids":["https://openalex.org/I4210165038"]}]}],"institutions":[],"countries_distinct_count":1,"institutions_distinct_count":4,"corresponding_author_ids":["https://openalex.org/A5100411939","https://openalex.org/A5101104010"],"corresponding_institution_ids":["https://openalex.org/I19820366","https://openalex.org/I4210134982","https://openalex.org/I4210165038"],"apc_list":{"value":4260,"currency":"USD","value_usd":4260},"apc_paid":{"value":4260,"currency":"USD","value_usd":4260},"fwci":0.0,"has_fulltext":true,"cited_by_count":0,"citation_normalized_percentile":{"value":0.85900632,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":"19","issue":"11","first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},"topics":[{"id":"https://openalex.org/T11139","display_name":"Gout, Hyperuricemia, Uric Acid","score":0.7437000274658203,"subfield":{"id":"https://openalex.org/subfields/2727","display_name":"Nephrology"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T10932","display_name":"Microbial Metabolic Engineering and Bioproduction","score":0.07919999957084656,"subfield":{"id":"https://openalex.org/subfields/1312","display_name":"Molecular Biology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}},{"id":"https://openalex.org/T12996","display_name":"Bacterial Cancer Therapy","score":0.04919999837875366,"subfield":{"id":"https://openalex.org/subfields/1305","display_name":"Biotechnology"},"field":{"id":"https://openalex.org/fields/13","display_name":"Biochemistry, Genetics and Molecular Biology"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/escherichia-coli-nissle-1917","display_name":"Escherichia coli Nissle 1917","score":0.9629999995231628},{"id":"https://openalex.org/keywords/urate-oxidase","display_name":"uricase","score":0.7670000195503235},{"id":"https://openalex.org/keywords/hyperuricemia","display_name":"hyperuricemia","score":0.8999999761581421},{"id":"https://openalex.org/keywords/engineered-probiotics","display_name":"engineered probiotics","score":0.7559999823570251},{"id":"https://openalex.org/keywords/cryptic-plasmid","display_name":"cryptic plasmid","score":0.8240000009536743},{"id":"https://openalex.org/keywords/low-oxygen-tolerance","display_name":"low oxygen tolerance","score":0.7179999947547913},{"id":"https://openalex.org/keywords/kidney-injury","display_name":"kidney injury","score":0.7960000038146973},{"id":"https://openalex.org/keywords/gut-microbiota","display_name":"gut microbiota","score":0.8560000061988831},{"id":"https://openalex.org/keywords/lactobacillus-johnsonii","display_name":"Lactobacillus johnsonii","score":0.9440000057220459},{"id":"https://openalex.org/keywords/bacteroides-acidifaciens","display_name":"Bacteroides acidifaciens","score":0.9929999709129333},{"id":"https://openalex.org/keywords/fecal-metabolomics","display_name":"fecal metabolomics","score":0.6570000052452087},{"id":"https://openalex.org/keywords/thiamine-monophosphate","display_name":"thiamine monophosphate","score":0.7179999947547913},{"id":"https://openalex.org/keywords/argininosuccinic-acid","display_name":"argininosuccinic acid","score":0.9890000224113464}],"concepts":[{"id":"https://openalex.org/C547475151","wikidata":"https://www.wikidata.org/wiki/Q25419","display_name":"Escherichia coli","level":3,"score":0.699400007724762},{"id":"https://openalex.org/C55493867","wikidata":"https://www.wikidata.org/wiki/Q7094","display_name":"Biochemistry","level":1,"score":0.5644000172615051},{"id":"https://openalex.org/C89423630","wikidata":"https://www.wikidata.org/wiki/Q7193","display_name":"Microbiology","level":1,"score":0.5612000226974487},{"id":"https://openalex.org/C2779881121","wikidata":"https://www.wikidata.org/wiki/Q105522","display_name":"Uric acid","level":2,"score":0.508400022983551},{"id":"https://openalex.org/C2776943133","wikidata":"https://www.wikidata.org/wiki/Q18057009","display_name":"Urate oxidase","level":3,"score":0.47350001335144043},{"id":"https://openalex.org/C185592680","wikidata":"https://www.wikidata.org/wiki/Q2329","display_name":"Chemistry","level":0,"score":0.4440999925136566},{"id":"https://openalex.org/C86803240","wikidata":"https://www.wikidata.org/wiki/Q420","display_name":"Biology","level":0,"score":0.43630000948905945},{"id":"https://openalex.org/C22744801","wikidata":"https://www.wikidata.org/wiki/Q172778","display_name":"Plasmid","level":3,"score":0.4235999882221222},{"id":"https://openalex.org/C2776985332","wikidata":"https://www.wikidata.org/wiki/Q311055","display_name":"Escherichia","level":4,"score":0.3910999894142151},{"id":"https://openalex.org/C2778910516","wikidata":"https://www.wikidata.org/wiki/Q380136","display_name":"Enterobacteriaceae","level":4,"score":0.31200000643730164},{"id":"https://openalex.org/C2779044325","wikidata":"https://www.wikidata.org/wiki/Q7159284","display_name":"Pediococcus acidilactici","level":5,"score":0.30720001459121704},{"id":"https://openalex.org/C3409486","wikidata":"https://www.wikidata.org/wiki/Q827489","display_name":"Pentose phosphate pathway","level":4,"score":0.3052000105381012},{"id":"https://openalex.org/C2779721657","wikidata":"https://www.wikidata.org/wiki/Q49970","display_name":"Hyperuricemia","level":3,"score":0.30320000648498535},{"id":"https://openalex.org/C2777402170","wikidata":"https://www.wikidata.org/wiki/Q4038096","display_name":"Enterobacter cloacae","level":5,"score":0.30149999260902405},{"id":"https://openalex.org/C2780206646","wikidata":"https://www.wikidata.org/wiki/Q1061596","display_name":"Lactobacillus","level":3,"score":0.3009999990463257},{"id":"https://openalex.org/C539455810","wikidata":"https://www.wikidata.org/wiki/Q739734","display_name":"Gut flora","level":2,"score":0.2971000075340271},{"id":"https://openalex.org/C2777186326","wikidata":"https://www.wikidata.org/wiki/Q24722788","display_name":"Arginine deiminase","level":4,"score":0.29339998960494995},{"id":"https://openalex.org/C2780543182","wikidata":"https://www.wikidata.org/wiki/Q2738168","display_name":"Pseudomonas putida","level":3,"score":0.29019999504089355},{"id":"https://openalex.org/C192989942","wikidata":"https://www.wikidata.org/wiki/Q68685","display_name":"Metabolic pathway","level":3,"score":0.28610000014305115},{"id":"https://openalex.org/C2778168646","wikidata":"https://www.wikidata.org/wiki/Q133186","display_name":"Bacteroides","level":3,"score":0.2858999967575073},{"id":"https://openalex.org/C2780047943","wikidata":"https://www.wikidata.org/wiki/Q415003","display_name":"Thiamine pyrophosphate","level":4,"score":0.2680000066757202},{"id":"https://openalex.org/C2909748322","wikidata":"https://www.wikidata.org/wiki/Q255933","display_name":"Inosine monophosphate","level":4,"score":0.2680000066757202},{"id":"https://openalex.org/C538909803","wikidata":"https://www.wikidata.org/wiki/Q116907","display_name":"Glutathione","level":3,"score":0.260699987411499}],"mesh":[{"descriptor_ui":"D000818","descriptor_name":"Animals","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D001426","descriptor_name":"Bacterial Proteins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D004926","descriptor_name":"Escherichia coli","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":true},{"descriptor_ui":"D010957","descriptor_name":"Plasmids","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D014503","descriptor_name":"Urate Oxidase","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D014503","descriptor_name":"Urate Oxidase","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false},{"descriptor_ui":"D014527","descriptor_name":"Uric Acid","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":true},{"descriptor_ui":"D033461","descriptor_name":"Hyperuricemia","qualifier_ui":"Q000628","qualifier_name":"therapy","is_major_topic":false},{"descriptor_ui":"D051379","descriptor_name":"Mice","qualifier_ui":null,"qualifier_name":null,"is_major_topic":false},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000235","qualifier_name":"genetics","is_major_topic":false},{"descriptor_ui":"D054793","descriptor_name":"Truncated Hemoglobins","qualifier_ui":"Q000378","qualifier_name":"metabolism","is_major_topic":false}],"locations_count":3,"locations":[{"id":"doi:10.1111/1751-7915.70469","doi":"https://doi.org/10.1111/1751-7915.70469","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1751-7915.70469","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.70469","source":{"id":"https://openalex.org/S4210238104","display_name":"Microbial Biotechnology","issn_l":"1751-7915","issn":["1751-7915","1751-7907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Biotechnology","raw_type":"journal-article"},{"id":"pmh:oai:pubmedcentral.nih.gov:13732112","doi":null,"is_oa":true,"landing_page_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732112/","pdf_url":"https://pmc.ncbi.nlm.nih.gov/articles/PMC13732112/pdf/MBT2-19-e70469.pdf","source":{"id":"https://openalex.org/S2764455111","display_name":"PubMed Central","issn_l":null,"issn":null,"is_oa":true,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microb Biotechnol","raw_type":"Text"},{"id":"pmid:42978372","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42978372","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial biotechnology","raw_type":"Journal Article"}],"best_oa_location":{"id":"doi:10.1111/1751-7915.70469","doi":"https://doi.org/10.1111/1751-7915.70469","is_oa":true,"landing_page_url":"https://doi.org/10.1111/1751-7915.70469","pdf_url":"https://onlinelibrary.wiley.com/doi/pdfdirect/10.1111/1751-7915.70469","source":{"id":"https://openalex.org/S4210238104","display_name":"Microbial Biotechnology","issn_l":"1751-7915","issn":["1751-7915","1751-7907"],"is_oa":true,"is_in_doaj":true,"is_core":true,"listed_in":["cwts-core","doaj","dongbi-b","doyens","jufo-1","ki-jl-1","medline","norway-1","oarl","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320595","host_organization_name":"Wiley","host_organization_lineage":["https://openalex.org/P4310320595"],"host_organization_lineage_names":["Wiley"],"type":"journal"},"license":"cc-by-nc","license_id":"https://openalex.org/licenses/cc-by-nc","version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"Microbial Biotechnology","raw_type":"journal-article"},"sustainable_development_goals":[{"score":0.9391000270843506,"display_name":"Good health and well-being","id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[{"id":"https://openalex.org/G6500709948","display_name":null,"funder_award_id":"XDB0810000","funder_id":"https://openalex.org/F4320321133","funder_display_name":"Chinese Academy of Sciences"}],"funders":[{"id":"https://openalex.org/F4320321133","display_name":"Chinese Academy of Sciences","ror":"https://ror.org/034t30j35"},{"id":"https://openalex.org/F4320335645","display_name":"Institute of Zoology, Chinese Academy of Sciences","ror":"https://ror.org/05skxkv18"}],"has_content":{"pdf":true,"grobid_xml":true},"content_urls":{"pdf":"https://content.openalex.org/works/W7225256059.pdf","grobid_xml":"https://content.openalex.org/works/W7225256059.grobid-xml"},"referenced_works_count":49,"referenced_works":["https://openalex.org/W1673751863","https://openalex.org/W1979012796","https://openalex.org/W1979192889","https://openalex.org/W1989676783","https://openalex.org/W2030513350","https://openalex.org/W2050548281","https://openalex.org/W2050629862","https://openalex.org/W2054129051","https://openalex.org/W2061385538","https://openalex.org/W2078599166","https://openalex.org/W2134229777","https://openalex.org/W2159295592","https://openalex.org/W2162133321","https://openalex.org/W2419604885","https://openalex.org/W2465086539","https://openalex.org/W2754579667","https://openalex.org/W2770591493","https://openalex.org/W2795852373","https://openalex.org/W2897611961","https://openalex.org/W2938918172","https://openalex.org/W2982684359","https://openalex.org/W2993480649","https://openalex.org/W2996159114","https://openalex.org/W3031656325","https://openalex.org/W3113295329","https://openalex.org/W3136974411","https://openalex.org/W3138309883","https://openalex.org/W3188678456","https://openalex.org/W4214686079","https://openalex.org/W4225261927","https://openalex.org/W4231686634","https://openalex.org/W4239736175","https://openalex.org/W4292534233","https://openalex.org/W4296167899","https://openalex.org/W4309778138","https://openalex.org/W4309859189","https://openalex.org/W4362458901","https://openalex.org/W4375946872","https://openalex.org/W4383186661","https://openalex.org/W4385555239","https://openalex.org/W4391234207","https://openalex.org/W4394843279","https://openalex.org/W4395012244","https://openalex.org/W4396939774","https://openalex.org/W4400778887","https://openalex.org/W4402573944","https://openalex.org/W4414695787","https://openalex.org/W7116708379","https://openalex.org/W7161629501"],"related_works":["https://openalex.org/W4225261927","https://openalex.org/W4389498609","https://openalex.org/W7133233695","https://openalex.org/W7160555224","https://openalex.org/W4402928299","https://openalex.org/W4392029001","https://openalex.org/W4384205063","https://openalex.org/W4412788232","https://openalex.org/W4375946872","https://openalex.org/W4309778138"],"abstract_inverted_index":{"Hyperuricemia":[0],"is":[1,18],"associated":[2],"with":[3,132],"renal":[4,101],"injury":[5],"and":[6,24,65,75,100,111,128,142,152,156],"disturbances":[7],"in":[8,73,115],"gut":[9],"microbial":[10,109],"ecology.":[11],"Intestinal":[12],"urate":[13,29,72,169],"clearance":[14],"by":[15,20],"engineered":[16],"probiotics":[17],"limited":[19],"antibiotic-free":[21],"functional":[22],"maintenance":[23],"the":[25,34,138],"oxygen":[26],"requirement":[27],"of":[28,38,125,164],"oxidase":[30],"(UOX).":[31],"We":[32],"reprogrammed":[33],"native":[35],"cryptic":[36],"plasmids":[37],"Escherichia":[39],"coli":[40],"Nissle":[41],"1917":[42],"(EcN)":[43],"to":[44,137],"construct":[45],"M12U,":[46],"a":[47,61,112],"marker-free":[48],"dual-plasmid":[49],"strain.":[50],"pMUT2":[51],"carried":[52],"an":[53],"HucR-regulated":[54],"urate-responsive":[55],"UOX":[56,63],"module,":[57],"while":[58],"pMUT1":[59],"encoded":[60],"low-oxygen-responsive":[62],"module":[64],"Tat-targeted":[66],"Vitreoscilla":[67],"haemoglobin":[68],"(tat-VHB).":[69],"M12U":[70,90],"degraded":[71],"vitro":[74],"retained":[76],"activity":[77],"under":[78],"low-oxygen":[79],"conditions.":[80],"In":[81],"hyperuricemic":[82],"mice":[83],"(n":[84],"=":[85],"5":[86],"per":[87],"group),":[88],"oral":[89],"reduced":[91,148],"serum":[92],"urate,":[93],"creatinine,":[94],"blood":[95],"urea":[96],"nitrogen,":[97],"inflammatory":[98],"cytokines":[99],"histopathological":[102],"injury.":[103],"16S":[104],"rRNA":[105],"profiling":[106],"showed":[107,147],"increased":[108,133,153],"richness":[110],"partial":[113],"shift":[114],"community":[116],"composition":[117],"toward":[118],"healthy":[119],"controls.":[120],"Shotgun":[121],"metagenomics":[122],"revealed":[123],"enrichment":[124],"Lactobacillus":[126],"johnsonii":[127],"Bacteroides":[129],"acidifaciens,":[130],"together":[131],"metabolic":[134],"potential":[135],"related":[136],"pentose":[139],"phosphate":[140],"pathway":[141],"glutathione":[143],"metabolism.":[144],"Faecal":[145],"metabolomics":[146],"uric":[149],"acid":[150],"abundance":[151],"thiamine":[154],"monophosphate":[155],"argininosuccinic":[157],"acid.":[158],"These":[159],"results":[160],"support":[161],"further":[162],"evaluation":[163],"dual-native-plasmid":[165],"architectures":[166],"for":[167],"gut-directed":[168],"clearance.":[170]},"counts_by_year":[],"updated_date":"2026-11-09T13:22:03.289127","created_date":"2026-11-05T00:00:00"}
