{"id":"https://openalex.org/W7225255754","doi":"https://doi.org/10.1007/s40263-026-01346-0","title":"From Toad Venom to Drug Development: The Clinical Pharmacology of Mebufotenin (5-MeO-DMT) in Treatment-Resistant Depression","display_name":"From Toad Venom to Drug Development: The Clinical Pharmacology of Mebufotenin (5-MeO-DMT) in Treatment-Resistant Depression","publication_year":2026,"publication_date":"2026-11-04","ids":{"openalex":"https://openalex.org/W7225255754","doi":"https://doi.org/10.1007/s40263-026-01346-0","pmid":"https://pubmed.ncbi.nlm.nih.gov/42983054"},"language":"en","primary_location":{"id":"doi:10.1007/s40263-026-01346-0","doi":"https://doi.org/10.1007/s40263-026-01346-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40263-026-01346-0","pdf_url":null,"source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},"volume":null,"type":"review","is_traditional":true,"indexed_in":["crossref","pubmed"],"open_access":{"is_oa":false,"oa_status":"closed","oa_url":null,"any_repository_has_fulltext":false},"authorships":[{"author_position":"first","author":{"id":"https://openalex.org/A5065495586","display_name":"Robert Liki\u0107","orcid":"https://orcid.org/0000-0003-1413-4862","observed_orcids":["https://orcid.org/0000-0003-1413-4862"]},"institutions":[{"id":"https://openalex.org/I138937732","display_name":"University Hospital Centre Zagreb","ror":"https://ror.org/00r9vb833","country_code":"HR","type":"healthcare","lineage":["https://openalex.org/I138937732"]},{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":true,"raw_author_name":"Robert Liki\u0107","raw_affiliation_strings":["Division of Clinical Pharmacology, Department of Internal Medicine, University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia. robert.likic@kbc-zagreb.hr"],"raw_orcid":"https://orcid.org/0000-0003-1413-4862","affiliations":[{"raw_affiliation_string":"Division of Clinical Pharmacology, Department of Internal Medicine, University Hospital Centre Zagreb and School of Medicine, University of Zagreb, Ki\u0161pati\u0107eva 12, 10000, Zagreb, Croatia. robert.likic@kbc-zagreb.hr","institution_ids":["https://openalex.org/I138937732","https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5013963079","display_name":"Igor Radanovi\u0107","orcid":"https://orcid.org/0000-0002-9486-4867","observed_orcids":["https://orcid.org/0000-0002-9486-4867"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Igor Radanovi\u0107","raw_affiliation_strings":["Centre for Human Drug Research (CHDR), Leiden, The Netherlands","Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-9486-4867","affiliations":[{"raw_affiliation_string":"Centre for Human Drug Research (CHDR), Leiden, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5017102704","display_name":"Deni Rkman","orcid":"https://orcid.org/0000-0002-8843-7535","observed_orcids":["https://orcid.org/0000-0002-8843-7535"]},"institutions":[{"id":"https://openalex.org/I2799976261","display_name":"Aalborg University Hospital","ror":"https://ror.org/02jk5qe80","country_code":"DK","type":"healthcare","lineage":["https://openalex.org/I2799976261"]},{"id":"https://openalex.org/I891191580","display_name":"Aalborg University","ror":"https://ror.org/04m5j1k67","country_code":"DK","type":"education","lineage":["https://openalex.org/I891191580"]}],"countries":["DK"],"is_corresponding":false,"raw_author_name":"Deni Rkman","raw_affiliation_strings":["Department of Clinical Medicine, Aalborg University, Aalborg, Denmark","Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark"],"raw_orcid":"https://orcid.org/0000-0002-8843-7535","affiliations":[{"raw_affiliation_string":"Department of Clinical Medicine, Aalborg University, Aalborg, Denmark","institution_ids":["https://openalex.org/I891191580"]},{"raw_affiliation_string":"Department of Psychiatry, Aalborg University Hospital, Aalborg, Denmark","institution_ids":["https://openalex.org/I2799976261"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5116846091","display_name":"Sanja Brni\u0107","orcid":"https://orcid.org/0000-0003-0949-787X","observed_orcids":["https://orcid.org/0000-0003-0949-787X"]},"institutions":[{"id":"https://openalex.org/I181343428","display_name":"University of Zagreb","ror":"https://ror.org/00mv6sv71","country_code":"HR","type":"education","lineage":["https://openalex.org/I181343428"]}],"countries":["HR"],"is_corresponding":false,"raw_author_name":"Sanja Brni\u0107","raw_affiliation_strings":["Croatian Institute for Health Insurance and University of Zagreb School of Medicine, Zagreb, Croatia"],"raw_orcid":"https://orcid.org/0000-0003-0949-787X","affiliations":[{"raw_affiliation_string":"Croatian Institute for Health Insurance and University of Zagreb School of Medicine, Zagreb, Croatia","institution_ids":["https://openalex.org/I181343428"]}]},{"author_position":"middle","author":{"id":"https://openalex.org/A5109038130","display_name":"Gabri\u00ebl E. Jacobs","orcid":"https://orcid.org/0000-0002-5140-9450","observed_orcids":["https://orcid.org/0000-0002-5140-9450"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Gabriel Jacobs","raw_affiliation_strings":["Centre for Human Drug Research (CHDR), Leiden, The Netherlands","Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-5140-9450","affiliations":[{"raw_affiliation_string":"Centre for Human Drug Research (CHDR), Leiden, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Department of Psychiatry, Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]},{"author_position":"last","author":{"id":"https://openalex.org/A5016359089","display_name":"Geert Jan Groeneveld","orcid":"https://orcid.org/0000-0002-4655-6667","observed_orcids":["https://orcid.org/0000-0002-4655-6667"]},"institutions":[{"id":"https://openalex.org/I2800006345","display_name":"Leiden University Medical Center","ror":"https://ror.org/05xvt9f17","country_code":"NL","type":"funder","lineage":["https://openalex.org/I2800006345"]},{"id":"https://openalex.org/I4210133171","display_name":"Centre for Human Drug Research","ror":"https://ror.org/044hshx49","country_code":"NL","type":"facility","lineage":["https://openalex.org/I4210133171"]}],"countries":["NL"],"is_corresponding":false,"raw_author_name":"Geert Jan Groeneveld","raw_affiliation_strings":["Centre for Human Drug Research (CHDR), Leiden, The Netherlands","Leiden University Medical Center, Leiden, The Netherlands"],"raw_orcid":"https://orcid.org/0000-0002-4655-6667","affiliations":[{"raw_affiliation_string":"Centre for Human Drug Research (CHDR), Leiden, The Netherlands","institution_ids":["https://openalex.org/I4210133171"]},{"raw_affiliation_string":"Leiden University Medical Center, Leiden, The Netherlands","institution_ids":["https://openalex.org/I2800006345"]}]}],"institutions":[],"countries_distinct_count":3,"institutions_distinct_count":6,"corresponding_author_ids":["https://openalex.org/A5065495586"],"corresponding_institution_ids":["https://openalex.org/I138937732","https://openalex.org/I181343428"],"apc_list":{"value":5090,"currency":"USD","value_usd":5090},"apc_paid":null,"fwci":0.0,"has_fulltext":false,"cited_by_count":0,"citation_normalized_percentile":{"value":0.66101224,"is_in_top_1_percent":false,"is_in_top_10_percent":false},"cited_by_percentile_year":null,"biblio":{"volume":null,"issue":null,"first_page":null,"last_page":null},"is_retracted":false,"is_paratext":false,"is_xpac":false,"primary_topic":{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},"topics":[{"id":"https://openalex.org/T12553","display_name":"Psychedelics and Drug Studies","score":0.9276999831199646,"subfield":{"id":"https://openalex.org/subfields/3203","display_name":"Clinical Psychology"},"field":{"id":"https://openalex.org/fields/32","display_name":"Psychology"},"domain":{"id":"https://openalex.org/domains/2","display_name":"Social Sciences"}},{"id":"https://openalex.org/T11071","display_name":"Treatment of Major Depression","score":0.06629999727010727,"subfield":{"id":"https://openalex.org/subfields/2736","display_name":"Pharmacology (medical)"},"field":{"id":"https://openalex.org/fields/27","display_name":"Medicine"},"domain":{"id":"https://openalex.org/domains/4","display_name":"Health Sciences"}},{"id":"https://openalex.org/T11337","display_name":"Tryptophan and brain disorders","score":0.0005000000237487257,"subfield":{"id":"https://openalex.org/subfields/2803","display_name":"Biological Psychiatry"},"field":{"id":"https://openalex.org/fields/28","display_name":"Neuroscience"},"domain":{"id":"https://openalex.org/domains/1","display_name":"Life Sciences"}}],"keywords":[{"id":"https://openalex.org/keywords/5-meo-dmt","display_name":"5-MeO-DMT","score":0.9950000047683716},{"id":"https://openalex.org/keywords/treatment-resistant-depression","display_name":"treatment-resistant depression","score":0.972000002861023},{"id":"https://openalex.org/keywords/clinical-pharmacology","display_name":"clinical pharmacology","score":0.800000011920929},{"id":"https://openalex.org/keywords/5-ht1a-receptor-agonism","display_name":"5-HT1A receptor agonism","score":0.8299999833106995},{"id":"https://openalex.org/keywords/bufotenine","display_name":"bufotenine","score":0.7990000247955322},{"id":"https://openalex.org/keywords/monoamine-oxidase-a","display_name":"monoamine oxidase A","score":0.7940000295639038},{"id":"https://openalex.org/keywords/pulmonary-drug-delivery","display_name":"pulmonary drug delivery","score":0.6039999723434448},{"id":"https://openalex.org/keywords/psychedelic-therapy","display_name":"psychedelic therapy","score":0.5249999761581421},{"id":"https://openalex.org/keywords/major-depressive-disorder","display_name":"major depressive disorder","score":0.5860000252723694}],"concepts":[{"id":"https://openalex.org/C63433958","wikidata":"https://www.wikidata.org/wiki/Q1774688","display_name":"Clinical pharmacology","level":2,"score":0.756600022315979},{"id":"https://openalex.org/C71924100","wikidata":"https://www.wikidata.org/wiki/Q11190","display_name":"Medicine","level":0,"score":0.7293000221252441},{"id":"https://openalex.org/C103709681","wikidata":"https://www.wikidata.org/wiki/Q1515727","display_name":"Psychopharmacology","level":2,"score":0.6912999749183655},{"id":"https://openalex.org/C2780035454","wikidata":"https://www.wikidata.org/wiki/Q8386","display_name":"Drug","level":2,"score":0.6711999773979187},{"id":"https://openalex.org/C98274493","wikidata":"https://www.wikidata.org/wiki/Q128406","display_name":"Pharmacology","level":1,"score":0.6671000123023987},{"id":"https://openalex.org/C2776867660","wikidata":"https://www.wikidata.org/wiki/Q1814941","display_name":"Depression (economics)","level":2,"score":0.6089000105857849},{"id":"https://openalex.org/C16568411","wikidata":"https://www.wikidata.org/wiki/Q83042","display_name":"Neurology","level":2,"score":0.39399999380111694},{"id":"https://openalex.org/C128188215","wikidata":"https://www.wikidata.org/wiki/Q3026765","display_name":"Neuropharmacology","level":2,"score":0.36910000443458557},{"id":"https://openalex.org/C2778166480","wikidata":"https://www.wikidata.org/wiki/Q6453151","display_name":"Toad","level":2,"score":0.34869998693466187},{"id":"https://openalex.org/C500440147","wikidata":"https://www.wikidata.org/wiki/Q701216","display_name":"Pharmacotherapy","level":2,"score":0.33329999446868896},{"id":"https://openalex.org/C2993714069","wikidata":"https://www.wikidata.org/wiki/Q3706669","display_name":"Psychotropic drug","level":3,"score":0.31349998712539673},{"id":"https://openalex.org/C2909214880","wikidata":"https://www.wikidata.org/wiki/Q5062120","display_name":"Cns depression","level":3,"score":0.313400000333786},{"id":"https://openalex.org/C2775858608","wikidata":"https://www.wikidata.org/wiki/Q576618","display_name":"Anticonvulsant","level":3,"score":0.29600000381469727},{"id":"https://openalex.org/C2780557958","wikidata":"https://www.wikidata.org/wiki/Q211036","display_name":"Stimulant","level":2,"score":0.2906999886035919},{"id":"https://openalex.org/C2992608137","wikidata":"https://www.wikidata.org/wiki/Q7218","display_name":"Clinical toxicology","level":2,"score":0.2870999872684479},{"id":"https://openalex.org/C3017944768","wikidata":"https://www.wikidata.org/wiki/Q1450463","display_name":"Poison control","level":2,"score":0.28540000319480896},{"id":"https://openalex.org/C42219234","wikidata":"https://www.wikidata.org/wiki/Q131130","display_name":"Anesthesia","level":1,"score":0.26649999618530273},{"id":"https://openalex.org/C2779448229","wikidata":"https://www.wikidata.org/wiki/Q3386847","display_name":"Venom","level":2,"score":0.25699999928474426}],"mesh":[],"locations_count":2,"locations":[{"id":"doi:10.1007/s40263-026-01346-0","doi":"https://doi.org/10.1007/s40263-026-01346-0","is_oa":false,"landing_page_url":"https://doi.org/10.1007/s40263-026-01346-0","pdf_url":null,"source":{"id":"https://openalex.org/S153913659","display_name":"CNS Drugs","issn_l":"1172-7047","issn":["1172-7047","1179-1934"],"is_oa":false,"is_in_doaj":false,"is_core":true,"listed_in":["anvur-scientific","cwts-core","dongbi-c","doyens","jufo-1","ki-jl-1","medline","norway-1","poland-100","russia-white-list-1","vabb-shw"],"host_organization":"https://openalex.org/P4310320330","host_organization_name":"Adis, Springer Healthcare","host_organization_lineage":["https://openalex.org/P4310320330","https://openalex.org/P4310319965"],"host_organization_lineage_names":["Adis, Springer Healthcare","Springer Nature"],"type":"journal"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS Drugs","raw_type":"journal-article"},{"id":"pmid:42983054","doi":null,"is_oa":false,"landing_page_url":"https://pubmed.ncbi.nlm.nih.gov/42983054","pdf_url":null,"source":{"id":"https://openalex.org/S4306525036","display_name":"PubMed","issn_l":null,"issn":null,"is_oa":false,"is_in_doaj":false,"is_core":false,"listed_in":[],"host_organization":"https://openalex.org/I1299303238","host_organization_name":"National Institutes of Health","host_organization_lineage":["https://openalex.org/I1299303238"],"host_organization_lineage_names":[],"type":"repository"},"license":null,"license_id":null,"version":"publishedVersion","is_accepted":true,"is_published":true,"raw_source_name":"CNS drugs","raw_type":"Journal Article"}],"best_oa_location":null,"sustainable_development_goals":[{"display_name":"Good health and well-being","score":0.9922999739646912,"id":"https://metadata.un.org/sdg/3"}],"study_designs":[],"awards":[],"funders":[],"has_content":{"pdf":false,"grobid_xml":false},"content_urls":null,"referenced_works_count":52,"referenced_works":["https://openalex.org/W1881562135","https://openalex.org/W1969549633","https://openalex.org/W1996279456","https://openalex.org/W2005997645","https://openalex.org/W2013163713","https://openalex.org/W2045893995","https://openalex.org/W2052466574","https://openalex.org/W2062787441","https://openalex.org/W2085670677","https://openalex.org/W2132324173","https://openalex.org/W2166952073","https://openalex.org/W2316998452","https://openalex.org/W2462443690","https://openalex.org/W2808301300","https://openalex.org/W2890770786","https://openalex.org/W2904505693","https://openalex.org/W2938570586","https://openalex.org/W2946661342","https://openalex.org/W2948816951","https://openalex.org/W2981329862","https://openalex.org/W2996702784","https://openalex.org/W3132500005","https://openalex.org/W3160183306","https://openalex.org/W3205688202","https://openalex.org/W3215098003","https://openalex.org/W4211131282","https://openalex.org/W4211181023","https://openalex.org/W4321033185","https://openalex.org/W4379469019","https://openalex.org/W4380872403","https://openalex.org/W4381433809","https://openalex.org/W4385257581","https://openalex.org/W4386580656","https://openalex.org/W4388941610","https://openalex.org/W4392809290","https://openalex.org/W4394797601","https://openalex.org/W4398774731","https://openalex.org/W4402657045","https://openalex.org/W4402965277","https://openalex.org/W4405955623","https://openalex.org/W4409659312","https://openalex.org/W4410976477","https://openalex.org/W4412433881","https://openalex.org/W4412553224","https://openalex.org/W4415246252","https://openalex.org/W7126174439","https://openalex.org/W7132842830","https://openalex.org/W7134115639","https://openalex.org/W7140229882","https://openalex.org/W7140287448","https://openalex.org/W7163421420","https://openalex.org/W7164032269"],"related_works":["https://openalex.org/W7223688582","https://openalex.org/W7130651199","https://openalex.org/W7166481212","https://openalex.org/W7204880821","https://openalex.org/W4211131282","https://openalex.org/W7140229882","https://openalex.org/W2109346033","https://openalex.org/W2329043459","https://openalex.org/W4409418234","https://openalex.org/W2079933769"],"abstract_inverted_index":null,"counts_by_year":[],"updated_date":"2026-11-08T12:12:28.789561","created_date":"2026-11-05T00:00:00"}